Cell line	Transcriptomic subgroup	Doxorubicin	Entinostat	Alvespimycin	Tanespimycin	Bortezomib	Selumetinib	Trametinib	Linsitinib	Dasatinib	Nutlin-3	Navitoclax	Tivantinib	Rapamycin	PF-04691502	Paclitaxel	Vinblastine	JNJ-38877605	PHA-665752	BLU-9931	Brivanib	Regorafenib	Refametinib	ICG-001	Decitabine	Sorafenib	Sorafenib_MK-2206	MK-2206	Resminostat	Sorafenib_Resminostat	Alisertib	CD532	Lenvatinib	Cabozantinib	Sorafenib_Trametinib	Sorafenib_Refametinib
Huh7	CL1	0.413	10	0.053	0.106	0.07	10	10	10	10	10	10	0.55	2.677	0.177	0.005	0.009	10	5.356	1.4	10	6	0.125	10	10	5.65	2.8	4.3	4.65	3	0.11	0.351	2.97	7.54	0.42	NA
SNU739	CL3	2.907	9.347	0.44	4.93	0.008	10	10	10	10	10	10	0.595	10	1.205	0.004	0.047	10	4.777	10	10	10	10	10	10	7.789	5.641	10	5.69	2.881	0.547	0.593	10	10	5.61	9.05
Hep3B	CL1	0.26	10	0.29	2.055	0.013	10	0.077	9.872	10	10	4.34	10	10	0.42	0.032	6.679	6.679	2.953	10	10	10	3.8	8.55	10	6.333	3.533	6.633	8.7	6.467	5.328	0.4	10	9.832	0.08	0.77
Huh6	CL1	0.152	5.71	0.378	2.45	0.027	10	10	9.49	5.025	10	3.365	0.545	10	0.64	0.003	0.006	10	5.498	10	10	10	10	9.65	10	4.826	3.254	4.67	4.656	1.66	10	5.037	10	2.316	1.49	1.50
HepG2	CL1	0.83	8.03	0.025	0.047	0.054	10	0.008	10	10	10	10	10	10	10	0.098	10	10	4.173	9.6	10	10	10	10	10	2.5	3.1	10	7.633	4.633	10	0.025	10	10	0.001	0.09
HepaRG	CL2	0.22	2.73	0.56	1.175	0.005	10	0.016	10	0.06	10	0.089	0.305	10	0.325	0.007	0.037	10	4.073	8.4	10	10	1.8	10	10	6.55	2.45	2.4	4.05	5.25	10	1.119	10	5.237	0.02	0.29
HLE	CL3	0.635	10	0.094	0.25	0.006	10	10	10	10	10	10	0.21	10	0.575	0.024	0.024	10	6.067	9.1	10	10	10	10	10	3.65	3.9	8.7	5.3	2.7	0.461	0.282	10	10	6.45	7.47
HLF	CL3	0.765	10	0.083	0.285	0.013	10	10	10	10	10	10	0.805	10	6.195	0.024	0.022	10	5.581	10	10	10	10	10	10	6.927	5.235	10	5.145	3.843	0.466	0.612	10	10	10.00	10.00
SNU182	CL3	0.215	10	1.785	6.715	0.23	10	10	10	1.48	10	8.93	5.625	10	2.28	0.374	0.015	10	6.005	10	10	10	10	10	10	9.245	2.368	6.266	9.75	4.4	10	1.559	10	10	5.96	4.71
SNU387	CL3	0.835	10	0.245	2.76	0.024	10	10	10	10	10	10	5.705	10	1.015	0.345	5.109	10	5.258	5.65	10	10	10	9.767	10	9.167	3.85	7.05	10	5.35	10	1.09	10	10	0.10	1.03
SNU398	CL3	0.185	10	0.4	0.71	0.053	10	10	10	8.935	10	8.485	1.08	5.011	0.29	0.003	0.013	10	4.609	9.6	10	10	10	10	10	5.115	5.102	10	9.24	5.699	0.188	0.237	10	7.8	2.18	2.11
SNU423	CL3	0.128	10	0.965	3.655	0.029	10	10	6.38	10	10	4.44	1.11	10	0.41	0.004	0.021	10	5.115	9.3	10	10	10	10	10	7.619	4.886	4.921	6.137	3.371	10	0.729	10	10	3.14	2.53
SNU449	CL3	3	10	3.56	10	0.02	10	10	10	10	10	10	10	10	0.455	5.324	5.285	10	5.493	10	10	9.75	10	10	10	6.768	4.026	8.196	10	4.615	10	1.392	10	10	3.58	4.02
SNU475	CL3	4.817	10	0.168	10	0.042	10	10	10	10	10	5.038	1.07	10	0.833	0.804	3.555	10	10	10	10	10	10	10	10	8.141	5.457	9.668	10	7.031	10	1.397	10	10	9.67	10.00
PLC/PRF5	CL1	0.795	10	0.033	0.078	0.038	10	10	10	10	10	10	3.34	10	0.195	0.012	0.035	10	4.129	10	10	10	10	10	10	10	4.9	10	6.85	5.35	10	2.128	10	10	9.09	8.32
Mahlavu	CL3	0.335	10	0.285	1.535	0.003	10	10	10	6.41	10	5.225	2.77	10	0.415	0.008	0.028	10	5.095	10	10	10	10	10	10	6.493	4.931	5.608	5.794	3.775	1.881	0.516	10	10	6.56	7.42
Li7	CL2	0.75	5.345	0.23	0.75	0.195	10	0.51	10	0.73	10	0.79	10	5.15	0.195	0.469	5.104	10	5.238	10	10	3.9	10	10	10	1.845	1.715	9.848	3.345	0.728	10	0.605	10	6.405	0.80	1.23
HCC-3	CL1	0.13	8.055	0.75	1.875	0.009	10	10	2.465	10	10	1.575	0.9	5.72	0.165	0.423	1.034	10	1.158	8.8	10	10	10	8.267	10	5.433	1.45	2.9	5.85	4.15	3.106	1.228	10	0.5439	2.22	2.31
B1	CL1	2.01	3.78	0.785	2.395	0.003	10	10	0.14	5.49	10	0.825	0.775	0.52	0.164	0.008	0.035	10	5.116	2.85	10	10	10	10	10	1.35	0.5	1.8	6.15	0.7	0.678	1.001	10	0.6266	0.02	0.99
HCC-1.1	CL3	0.635	10	0.081	0.17	0.007	10	1.055	10	2.48	10	4.59	0.105	10	0.375	0.021	0.005	10	4.383	4.75	10	10	10	10	10	7.526	2.844	3.923	6.214	4.485	0.145	1.655	10	3.505	0.72	1.44
HCC-1.2	CL1	0.41	9.275	0.05	0.14	0.02	9.725	0.047	8.045	0.285	10	1.555	0.615	10	0.175	0.005	0.009	10	5.198	4.867	10	10	2.15	10	10	6.467	2.4	4.15	5.5	3.55	10	4.275	10	8.101	0.03	0.54
Huh1	CL1	1.175	3.79	0.118	0.21	0.054	10	10	5.615	10	10	10	10	10	0.48	0.02	0.067	10	5.136	10	10	10	10	10	10	6.969	2.132	4.383	3.407	3.452	10	0.36	10	10	8.39	7.87
JHH1	Unclassified	2.645	8.26	0.52	1.195	0.006	0.235	0.008	10	0.02	10	6.935	10	10	0.16	0.052	0.036	10	5.617	7.433	10	10	0.45	9.65	10	10	1.633	1.567	0.767	1.1	10	0.352	10	10	0.01	0.33
JHH2	CL2	0.77	10	10	10	0.095	10	10	10	10	10	10	10	10	0.465	5.124	0.098	10	4.739	10	10	10	10	9.95	10	9.792	6.216	10	5.491	4.184	10	4.781	10	10	0.16	1.23
JHH4	CL3	0.18	3.925	1.57	7.843	0.03	10	10	10	0.145	10	5.085	0.353	10	0.11	0.045	0.032	10	5.544	10	10	10	10	10	10	5.495	2.157	6.427	10	4.913	1.167	2.314	7.02	2.111	0.53	1.68
JHH5	CL1	0.54	5.575	0.026	0.032	0.015	5.365	0.022	3.927	3.585	10	4.68	0.42	9.485	0.24	0.012	0.049	10	2.714	10	10	10	1.8	10	10	1.9	0.425	2.15	4.2	0.88	0.701	0.366	10	4.418	0.01	0.24
JHH6	CL3	0.367	9.927	0.47	1.143	0.076	10	10	10	10	10	10	0.755	8.485	0.59	0.006	0.061	10	4.137	10	10	10	10	10	10	7.55	3.55	4.25	10	5.65	6.241	0.313	10	10	5.52	6.99
JHH7	CL1	0.55	10	0.092	0.19	0.025	10	7.52	5.32	8.54	10	6.465	0.345	10	0.775	0.005	0.008	10	5.094	2.15	10	10	10	10	10	4.16	1.312	4.277	3.54	1.074	0.62	0.58	6.54	9.402	1.84	2.41
SNU354	CL2	4.53	5.995	0.425	1.005	0.01	10	8.49	10	7.025	10	3.56	0.605	10	0.49	0.226	3.371	10	5.364	10	10	10	10	10	10	3.027	2.444	5.216	2.136	0.515	10	3.014	10	10	1.06	2.02
SNU368	CL2	5.885	10	0.245	5.89	0.097	10	10	10	7.25	10	10	2.05	10	1.07	10	10	10	6.483	9.6	10	10	10	10	10	7.532	4.832	7.991	9.441	5.448	10	1.593	10	10	9.07	9.47
SNU761	CL2	1.51	10	2.61	10	0.052	10	0.305	10	10	10	10	10	10	0.9	10	10	10	5.505	10	10	10	9.55	10	10	9.237	4.604	9.479	7.507	3.05	10	5.314	10	10	0.12	1.31
SNU878	CL2	1	8.525	1.21	0.623	0.03	6.727	0.08	10	10	10	0.21	0.086	10	0.165	0.03	0.01	10	5.767	10	10	10	2.9	10	10	10	5.733	10	7.659	6.083	0.473	1.862	10	10	NA	1.92
SNU886	CL2	0.8	10	0.21	1.033	0.025	10	2.49	10	0.78	10	2.525	0.5	9.025	0.135	0.02	0.013	10	5.435	8.95	10	10	10	10	10	7.476	5.364	10	7.5	5.145	7.294	1.39	10	10	0.04	0.54
MHCC97H	CL2	5.855	10	0.39	1.32	0.024	10	10	10	10	10	10	0.915	10	0.66	0.079	0.06	0.083	0.154	7.5	10	10	10	10	10	10	3.076	2.435	3.31	2.715	10	3.65	10	0.0772	2.37	4.66