Protein Cell line HepG2 Hep3B HepaRG B1 HCC-1.2 HCC-3 HCC-1.1 SNU182 SNU387 SNU398 SNU423 SNU449 SNU475 Huh7 Mahlavu PLC/PRF5 HLE HLF Huh6 Li7 Huh1 JHH1 JHH2 JHH4 JHH5 JHH6 JHH7 SNU354 SNU368 SNU739 SNU761 SNU878 SNU886 MHCC97H P-GSK3-beta-Ser9 0.421 3.085 1.749 1.919 0.531 2.256 2.109 2.138 1.246 0.012 2.632 2.369 2.905 1.225 2.529 1.273 0.798 1.713 1.862 -0.035 0.287 0.821 3.054 0.504 1.245 1.476 1.258 1.942 1.864 2.341 2.674 3.594 1.734 0.706 P-AKT-Ser473 0.167 1.067 1.327 -2.992 -1.142 1.393 1.582 -0.254 -0.091 -1.530 2.086 1.482 3.313 -1.332 3.455 -1.078 -1.546 0.433 1.504 -4.560 -1.905 -0.376 2.791 -0.146 0.096 1.894 -1.257 1.030 0.786 1.342 2.126 1.140 0.049 -0.704 P-p70-S6-kinase-Thr389 0.008 1.383 1.286 0.973 0.528 -0.143 2.394 1.284 1.083 0.573 1.922 1.312 1.625 1.142 1.512 1.796 0.616 0.929 0.918 0.593 -0.001 0.555 1.168 0.325 0.636 1.203 0.759 1.254 1.459 1.067 0.628 2.872 1.117 0.423 EpCAM -0.975 0.276 -1.691 -1.347 -2.064 -2.895 -0.791 -1.295 -1.996 -1.616 -1.183 -1.499 -1.109 -1.982 -1.918 -1.598 -2.242 -1.828 0.028 -1.839 -1.093 1.098 -2.175 -1.832 0.174 -1.238 -0.815 -1.653 -0.828 -1.941 -1.542 0.034 -1.823 -0.849 Glutamine-synthetase -1.026 -0.580 -0.713 -0.550 -0.890 -0.669 -0.622 -0.771 -0.849 -1.040 -0.650 -0.608 -0.468 -1.162 -0.766 -0.909 -0.620 -0.884 -0.292 -0.521 -1.100 -0.178 -0.811 -0.743 -1.044 -0.418 -1.032 -0.880 -0.581 -0.673 -0.673 -0.410 -0.947 -0.706 P-S6-Ribosomal-Protein-Ser235-236 1.591 1.866 1.301 1.617 0.886 1.755 2.075 1.713 1.337 1.309 1.916 1.975 1.827 2.244 2.472 2.671 1.544 1.816 1.546 2.442 -0.344 -0.707 1.725 0.202 0.597 0.792 1.968 1.051 1.104 1.500 0.444 1.794 1.787 -0.185 AFP 1.152 1.745 0.815 0.092 0.397 0.690 1.492 0.678 1.411 0.485 2.863 0.616 1.258 2.279 1.326 1.095 0.509 0.914 1.087 0.575 0.152 0.221 0.403 0.556 0.117 0.708 1.054 0.083 1.152 0.629 0.115 0.698 0.074 -0.032 P-p70-S6-kinase-Thr421-Ser424 1.568 1.274 0.880 1.722 0.891 1.460 1.704 0.320 0.459 1.296 0.843 1.496 0.787 1.776 2.029 1.205 0.703 0.994 1.118 0.033 1.280 1.683 1.583 0.919 1.321 1.885 2.656 1.591 2.245 1.196 0.429 2.954 1.379 1.308 RSK2 1.920 -1.924 0.245 1.997 1.208 -4.199 0.517 1.780 0.594 -1.109 0.537 0.450 0.563 1.716 0.536 2.118 -0.276 -0.337 1.425 0.667 0.695 -0.636 0.638 0.188 1.251 0.687 2.315 1.100 0.982 0.540 0.620 1.746 0.585 0.782 KI67 1.505 1.538 2.218 2.559 1.834 2.481 2.237 1.535 1.623 2.233 2.374 2.250 1.422 2.034 2.522 2.300 1.613 2.127 1.799 2.793 1.643 1.721 1.649 1.529 2.126 2.576 2.176 1.729 2.141 1.618 0.828 2.467 2.029 1.615 Cytokeratin-19 0.929 1.849 2.598 1.074 1.799 -0.879 -0.597 0.430 -0.794 -0.861 2.110 -1.213 0.612 -0.489 -0.699 0.344 -0.889 -0.794 2.631 2.056 0.460 1.801 -0.777 1.321 1.386 -0.850 0.022 1.600 -0.314 -0.304 -0.774 2.914 1.660 1.618 E-cadherin -1.517 -0.042 -1.565 0.130 -0.679 -1.209 -0.934 -1.678 -2.118 -2.578 -1.590 -2.295 -1.359 -0.836 -1.631 -0.134 -1.936 -1.570 0.393 -1.214 -0.396 1.075 -1.718 -2.226 -0.618 -1.299 -0.750 -0.978 -0.221 -1.562 -0.743 0.137 -1.363 -1.352 C-reactive protein -0.422 -0.359 -0.676 -1.259 -1.001 -0.677 0.024 -0.309 -0.035 -0.776 -0.248 -0.569 -0.353 -0.257 -0.460 -0.738 -0.652 -0.428 -0.555 -0.534 -0.376 -0.724 -0.327 -0.560 -0.420 -0.337 -0.098 -0.295 -0.428 -0.404 -0.329 0.177 -0.504 -0.561 LCK -0.143 0.433 -0.273 -0.478 -0.035 -0.701 0.132 -0.727 -0.916 -0.752 -0.806 -0.818 0.428 0.188 -0.394 0.290 -1.012 0.072 -0.199 -0.982 -0.544 -0.975 -0.639 -0.808 -0.533 -0.248 -0.252 -0.460 -0.292 0.056 -0.472 1.467 -0.104 -0.250 MET -0.251 -0.403 -0.599 -1.250 -0.659 -0.819 0.329 -1.715 -0.645 -1.170 0.366 0.087 0.043 -0.282 -0.073 0.333 0.439 0.748 -0.492 -0.320 -1.265 0.033 -0.017 0.619 -0.796 0.597 0.967 0.429 0.417 0.175 -0.406 1.803 0.708 3.141 P-MEK1-2-Ser217-221 0.578 1.197 -1.027 -0.167 0.476 1.307 1.301 -0.762 -1.123 0.003 -0.057 0.389 -0.278 0.989 0.842 -0.253 -0.660 -0.411 1.828 0.558 1.330 -0.392 -0.198 0.757 -0.205 0.535 1.245 -0.183 0.939 -0.458 -0.523 2.025 -0.381 2.315 P-p42-44-MAPK-Thr202-Tyr204 0.475 3.024 0.537 -0.007 1.628 1.340 3.603 2.103 2.332 0.937 1.928 2.546 1.933 1.278 2.674 0.157 1.527 1.384 2.596 0.160 0.632 2.041 1.938 2.431 1.055 2.414 1.686 1.016 1.054 1.862 2.432 2.925 1.249 2.274 Beta-catenin -0.182 -0.632 -0.985 -0.713 -1.520 -1.421 -0.050 -2.082 -1.714 -0.542 -1.164 -1.346 -0.279 -1.089 -0.989 -1.476 -2.087 -1.213 -0.232 -1.663 -2.042 -0.803 -0.752 -1.261 -1.406 -0.839 -0.745 -0.646 0.056 -1.191 -0.848 0.135 -0.646 -1.256 P-mTOR-Ser2448 0.874 1.129 0.786 1.676 0.032 0.888 1.704 0.477 0.300 1.308 1.081 1.250 0.904 1.075 1.906 1.541 1.099 0.483 0.468 0.908 -0.756 0.582 0.819 0.765 -0.047 1.412 1.322 1.422 1.618 0.998 0.832 3.279 1.184 0.646 PCNA 0.612 0.821 0.475 -0.717 -0.017 0.267 1.171 -0.265 0.296 0.236 0.280 0.238 0.653 0.817 0.835 0.741 -0.128 0.601 0.690 -0.307 -0.308 0.342 -0.564 0.512 0.788 0.916 0.877 0.573 1.071 0.512 0.090 1.637 0.623 0.519 P-TSC2-Ser939 -0.034 0.097 0.686 0.338 -0.924 0.001 1.234 -0.704 -0.415 -2.271 0.739 0.568 0.841 -1.045 1.966 -2.160 -0.689 -0.281 0.257 -7.467 -1.550 -0.387 1.097 -0.045 -0.761 0.471 0.363 0.701 1.028 0.709 0.745 0.390 -1.695 0.085 P-STAT3-Tyr705_1438 -0.799 -0.808 -0.613 -0.789 -1.163 -3.033 0.334 -2.157 -0.928 -1.475 -1.387 -1.697 -0.258 -0.824 -0.010 -0.856 -1.164 -0.596 -0.549 -2.030 -1.896 -0.227 -0.877 -0.913 -1.007 -0.103 -0.224 -0.297 -0.192 -0.730 -0.402 0.834 -0.280 -0.199 FGFR4 1.434 1.154 -1.035 1.350 0.155 1.566 0.007 -2.600 -1.714 -1.153 -1.281 -0.354 -0.452 1.191 -0.749 1.334 -1.261 -0.958 0.983 -0.377 -0.699 0.195 -1.144 0.201 0.205 -0.722 0.725 0.618 0.879 -0.799 -0.814 1.037 -0.428 0.162 P-MET-Tyr1234-1235 0.482 0.657 -0.687 -0.236 0.117 0.112 1.474 -1.056 0.037 0.477 -0.053 -0.653 -0.119 0.262 -0.178 -0.483 0.013 -0.026 0.105 -0.463 0.003 0.723 0.398 0.933 0.250 0.504 0.675 0.848 1.289 0.009 -0.310 1.474 -0.092 5.662 ATM 0.279 -0.937 0.904 -0.059 -0.777 -0.182 -1.266 -0.977 -1.001 0.245 -0.703 -0.148 -0.381 -0.152 0.467 -0.171 0.085 -1.027 -1.506 NA 0.255 -0.261 -1.668 0.257 -0.713 0.322 0.576 0.579 -0.225 -0.470 -1.738 -1.277 -0.250 0.041 Bcl-xL -0.416 -0.307 -0.152 0.169 -1.012 0.745 -1.581 -1.425 -1.502 -0.744 -1.813 0.055 -1.168 -0.673 -0.596 -0.629 -1.202 -1.034 0.204 NA -0.383 -0.630 -1.179 -0.128 -1.098 -0.623 -0.657 -0.519 0.466 -1.056 -0.813 -1.058 -0.580 -1.022 P-beta-catenin-Ser675 -1.473 -1.006 0.233 -0.057 -1.056 -1.826 -0.221 -0.089 0.507 -0.276 -0.630 -0.585 0.470 -1.163 0.171 -1.685 0.204 1.118 -0.584 NA -1.086 -0.838 0.017 0.867 -1.532 -0.423 -1.397 0.115 0.194 0.977 0.034 -1.123 0.729 -1.738 Cyclin-D1 0.889 -0.113 -1.441 1.230 2.220 0.849 0.395 2.131 2.339 1.817 0.414 0.752 1.062 0.902 -1.667 0.496 0.923 0.164 0.985 NA 0.646 1.331 0.499 1.621 1.361 1.489 1.553 2.756 0.329 0.893 3.276 4.195 3.949 -0.101 P-EGFR-Tyr1173 0.012 0.199 0.421 0.235 -0.349 0.229 -0.828 0.417 0.208 0.719 -2.270 0.134 -1.018 -0.780 0.114 0.516 0.153 -0.078 -0.749 NA 0.832 -0.581 0.143 -0.519 -0.158 -0.694 0.475 -0.455 -0.005 -0.166 -0.493 -0.142 -0.087 -0.033 HER3 -0.393 -0.288 -0.299 0.524 -0.369 -0.004 -1.817 -0.818 -0.729 -0.572 -2.040 -0.514 -1.663 -0.559 -1.725 0.485 -0.288 -0.682 -0.137 NA 0.601 -0.388 -0.082 -1.660 -0.417 -1.623 0.276 -0.516 -1.022 -1.133 -1.246 -0.383 -0.631 -0.139 AMPK-alpha -1.895 -1.423 -1.302 -0.727 -1.455 -1.136 -1.653 -1.556 -2.024 -1.317 -1.502 -1.544 -1.276 -1.498 -1.390 -1.105 -1.541 -1.187 -1.418 NA -1.363 -0.923 -1.795 -0.827 -1.574 -1.498 -0.562 -0.707 -0.458 -0.906 -1.136 -1.391 -1.110 -0.827 BCL2 0.006 -0.014 0.136 0.135 -0.396 0.730 -1.130 -1.865 0.000 0.364 -0.642 -0.173 -1.775 -0.521 -0.451 -0.365 -0.817 -0.359 -0.249 NA -0.270 0.059 -1.658 -0.295 -0.843 -1.053 0.644 -0.979 -0.106 -0.378 -1.355 -2.214 -0.098 -0.590 P-DNAPK-Ser2612 -0.928 -0.483 -0.550 0.078 -1.053 0.103 -1.126 -1.155 -1.170 -0.239 -1.258 -0.533 -1.335 -0.934 -0.737 -0.928 -1.193 -1.460 -0.885 NA -0.873 -0.648 -0.314 -1.042 -1.853 -1.122 -0.595 -0.990 -1.128 -0.630 -1.175 -1.199 -0.827 -0.345 P-H2AX 2.322 1.268 1.287 2.248 1.787 2.891 0.409 1.352 0.544 2.943 0.677 1.492 0.526 1.885 1.315 1.102 0.967 1.039 1.572 NA 2.243 1.367 1.272 0.760 1.051 1.322 1.372 1.239 0.916 1.198 0.309 0.771 1.381 1.133 Hsp90-alpha -0.806 -1.039 -0.802 -0.881 -1.068 -0.633 -1.637 -1.233 -1.506 -0.227 -1.315 -0.213 -1.379 -1.012 -1.341 -1.139 -1.340 -1.352 -1.289 NA -1.392 -1.109 -1.813 -1.242 -1.420 -0.993 -1.270 -1.397 -1.478 -1.354 -1.623 -1.826 -1.335 -1.225 Hsp90-beta 1.442 0.393 0.460 1.600 0.387 1.506 -0.188 -0.157 -0.014 1.015 0.084 0.743 -0.221 -0.049 -0.018 0.981 0.592 0.667 -0.332 NA 0.641 0.337 -0.129 -0.134 0.224 0.042 0.590 0.428 0.074 0.628 -0.959 -0.087 0.399 -0.142 IGF1-Receptor beta 0.877 -0.338 0.833 1.975 0.740 0.256 1.351 0.328 -1.181 0.471 -1.045 0.745 0.770 0.180 -0.644 -0.080 -0.224 -0.069 0.832 NA 1.342 1.477 -1.581 -2.329 0.195 -0.462 2.421 -1.051 1.335 1.858 -0.051 0.733 0.927 0.229 Cleaved-Notch1-Val1744 -0.161 -0.544 0.171 -0.117 -0.496 0.078 -0.541 0.145 -0.269 0.419 0.260 0.276 -0.702 -0.896 -0.568 -0.144 -0.414 -0.210 -0.248 NA 0.195 -0.142 -0.386 -0.463 -0.642 -0.309 -0.191 -0.466 -0.204 -0.357 -0.561 -0.742 -0.306 -0.572 P-SMAD2-Ser465-467_SMAD3-Ser423-425 -0.500 -0.069 1.829 1.571 0.393 0.060 0.744 0.927 1.230 -0.515 1.350 1.518 0.652 -0.563 0.321 1.264 1.544 1.454 0.624 NA 1.108 1.953 1.156 0.671 0.061 1.496 0.205 1.864 1.878 0.558 0.855 1.608 1.638 2.642 SFRP1 -0.373 -0.173 0.157 0.601 -0.521 -2.427 0.392 2.296 -0.230 -0.091 2.127 -0.456 -0.187 -0.812 -0.245 -0.208 -0.350 -0.350 0.019 NA 0.013 -0.255 -0.542 -0.380 -0.620 -0.283 0.582 -0.233 -0.140 0.352 -0.222 -1.071 -0.311 -0.454 PKM2 1.053 0.665 2.521 0.842 1.684 1.498 1.562 1.732 2.469 1.692 1.619 1.129 2.170 0.823 1.391 1.740 0.938 1.516 0.538 NA 2.530 0.874 2.522 1.836 1.323 1.851 0.787 1.308 1.784 1.881 1.731 2.960 2.709 2.662 Survivin 0.556 0.007 0.652 0.309 0.081 0.458 -0.266 -0.257 0.012 1.266 -0.276 0.283 -0.631 0.016 0.272 -0.136 -0.158 -0.065 0.013 NA 0.499 -0.424 -0.883 -0.021 -0.220 0.095 0.804 -0.106 0.171 -0.119 -0.457 -0.654 -0.198 -0.043 AXIN1 1.323 -1.808 0.049 1.996 0.395 1.100 -1.933 -0.416 0.190 1.899 -1.460 -1.590 -1.647 -0.034 0.547 0.787 0.654 0.024 0.843 NA -1.593 0.050 0.507 0.113 -0.120 -0.960 -0.475 -0.212 -1.736 0.025 -0.020 -2.156 -0.257 0.735 H2AX -0.284 -0.909 -0.871 -0.377 -0.400 -0.029 -1.390 -0.227 -0.159 -0.022 -0.096 -1.112 -0.806 -0.737 -0.188 -0.051 -0.035 -0.558 -2.322 NA -0.141 0.171 -1.217 -0.055 -0.080 0.549 -0.491 -1.837 -0.897 -0.574 -1.900 -1.160 -1.136 -1.140 LEF1 -0.146 0.112 0.116 0.453 -0.169 -0.025 0.310 0.381 -0.040 2.337 0.186 0.062 0.258 0.044 0.475 0.566 -0.129 0.010 0.045 NA -0.201 -0.078 -0.243 -0.012 -0.048 0.275 -0.125 0.047 0.192 0.211 0.153 -0.530 0.169 0.066 NF-kappa-B-p65 -0.816 -0.470 -0.416 -0.001 -1.333 0.114 -0.419 -0.471 -0.473 -0.124 -0.733 -0.510 -0.094 -1.285 -0.070 0.544 0.065 -0.028 -2.675 NA -0.333 -0.064 -1.071 -0.871 0.313 -0.117 -0.602 -0.170 -0.521 -0.114 0.105 -1.480 -0.453 -0.200 P-NF-kappa-B-p65-Ser536 -0.507 0.060 0.265 0.692 -0.001 -0.124 -0.102 0.061 0.178 -0.325 0.832 0.379 -0.179 -0.798 0.297 1.394 0.561 0.115 -1.092 NA -0.249 -0.268 0.068 -0.333 -0.287 0.455 -0.578 0.235 0.536 0.109 0.406 -0.107 0.352 -0.443 TSC2 0.219 0.034 0.572 1.003 0.487 -0.080 0.615 1.495 0.816 -3.084 0.773 0.648 0.798 0.116 1.013 -1.467 0.673 -0.067 0.204 NA 0.065 0.516 1.125 -0.022 0.486 0.319 -0.075 0.472 0.092 1.246 1.370 -3.168 -3.155 0.649 TGF-beta-I-III -0.310 -0.162 0.106 0.133 -0.278 0.513 -0.027 0.757 0.567 0.712 0.489 0.412 0.445 -0.586 0.126 -0.154 0.115 0.133 -0.789 NA 0.064 -0.315 0.370 -0.043 -0.163 -0.052 -1.308 -0.188 -0.596 -0.074 0.122 -0.139 0.087 -0.063 PKA-C-alpha -1.069 -0.595 -0.529 0.539 -0.298 -0.598 -1.848 0.237 -0.334 -1.031 -1.865 -1.328 -0.980 -1.082 -2.193 -0.293 -1.458 -1.382 -0.452 NA -0.402 -1.430 -1.275 -1.516 -0.627 -1.586 -1.854 -0.849 -0.801 -1.178 -0.564 -0.543 -0.683 -0.908 P-beta-catenin-Ser552_1245 -1.137 -0.808 -0.235 0.478 -0.363 -1.072 -0.899 0.213 -0.880 -2.289 -0.820 -0.694 0.185 -1.069 -0.802 -0.959 -1.143 -1.169 -0.165 NA -0.453 -0.008 0.436 -1.192 -0.559 -0.537 -2.413 -0.306 -0.673 -1.243 0.048 -1.037 -0.568 -1.323 DNA-PK -0.226 0.566 0.010 -0.031 -0.240 0.580 -0.423 -0.077 0.240 0.195 0.040 0.578 -0.104 0.203 0.263 -0.027 0.103 -0.554 0.047 NA 0.350 0.152 0.278 0.074 -0.022 0.251 -0.244 -0.276 -0.287 0.223 0.311 -0.184 0.004 0.518 HER2 1.095 0.296 -0.232 0.119 0.276 0.296 -0.213 0.034 0.665 1.033 -0.135 0.480 -0.108 0.828 -0.297 -0.387 -0.061 -0.113 0.223 NA 0.111 0.963 -0.098 0.130 0.421 -0.259 0.281 -0.229 0.079 0.015 -0.242 -0.524 -0.078 0.161 hTERT 0.568 0.271 0.306 0.778 0.186 0.541 0.578 0.680 0.373 1.941 1.568 0.616 -0.040 0.861 0.189 0.381 0.319 0.879 -0.034 NA 2.070 0.686 1.376 0.236 0.049 0.249 -0.618 -0.048 -0.432 0.381 1.606 -0.268 0.275 0.269 p190A -0.278 0.760 -0.356 0.941 0.359 0.946 -0.630 -0.067 -0.714 -0.875 -0.524 -0.836 0.488 -0.247 -0.393 -0.373 0.113 0.072 -0.197 NA 0.717 -0.084 0.834 0.622 1.052 -2.719 -0.828 -0.343 -0.525 -0.699 0.902 0.977 0.348 0.799 EGFR -1.349 -0.185 -0.417 -1.153 -0.802 -0.410 -0.007 -0.832 -0.560 -1.479 -1.057 -0.029 -0.023 0.731 0.085 -0.449 -0.113 1.134 -0.881 NA -1.168 -0.296 -0.004 0.238 -0.476 1.075 -1.349 0.025 0.291 -0.442 1.328 -0.533 0.328 -0.449 P-HER2-Tyr1221-1222 0.696 0.352 0.264 1.002 0.412 -0.043 0.282 -0.223 -1.518 0.614 -0.109 0.175 0.263 1.040 0.047 0.254 -0.239 -0.032 -0.047 NA 0.362 0.110 0.046 0.169 0.015 0.376 -0.568 -0.152 0.140 0.057 0.012 -0.525 -0.064 0.327 P-HER3-Tyr1289 0.807 0.419 -0.087 -0.199 0.348 0.642 0.279 -0.236 0.059 0.943 0.409 0.752 0.526 1.218 0.110 0.097 -0.065 0.323 0.027 NA 0.284 0.073 0.332 0.269 0.240 0.378 -0.309 0.223 0.239 0.431 0.325 -0.132 0.304 1.271 TRAIL -0.461 -0.136 -0.005 0.708 0.109 0.018 -0.104 -0.787 -0.098 -0.060 0.219 0.164 -0.130 -0.292 -0.111 -0.043 -0.595 -0.433 -0.456 NA -0.254 -0.129 -0.486 -0.479 -0.599 -0.371 -1.160 -0.400 -0.390 -0.200 -0.393 -0.619 -0.597 -0.086 XIAP -0.825 -0.735 0.015 0.844 0.396 0.070 -0.754 0.372 0.519 -0.752 1.190 0.613 0.415 -0.749 0.310 0.068 0.687 0.290 -1.092 NA 0.328 -0.288 0.774 0.078 -0.109 0.576 -0.104 0.335 -0.114 -0.230 1.512 -0.023 0.029 0.615 NQO1 1.851 -1.734 -1.150 -0.390 2.424 -1.150 1.453 0.105 0.608 -0.550 1.591 -0.733 3.391 1.686 -0.956 0.865 0.749 0.493 -0.350 NA 2.725 0.280 -0.308 -0.913 2.448 0.413 1.104 0.863 1.385 -0.048 0.253 0.097 -0.552 0.368 FGF19 -0.245 0.341 -0.066 -0.122 2.257 -0.507 -0.471 0.797 1.079 -0.201 0.171 0.381 0.046 -0.342 -0.318 -0.413 -0.596 -0.590 -0.611 NA 0.396 0.177 0.223 0.226 0.006 0.483 0.249 -0.021 -0.243 -0.181 0.487 2.085 -0.128 -0.659 DDR1 -0.252 -0.242 0.904 -0.187 0.172 -0.047 -0.903 1.224 0.897 -0.321 0.558 1.008 1.569 -0.315 -1.157 0.611 0.867 -1.290 -0.619 NA 0.380 0.135 0.863 0.480 0.051 -0.489 -0.291 0.250 -0.824 -0.032 0.453 0.384 0.232 0.511 PTEN -0.187 -0.142 0.370 -0.599 0.309 -3.047 -0.561 0.012 -0.076 0.273 -1.880 -4.864 -0.494 0.113 -0.527 -0.441 0.600 0.243 -0.125 NA 0.004 -0.640 -0.990 -0.480 0.087 -0.102 0.251 -0.082 -0.401 0.052 0.397 0.496 0.321 -0.030 P-calnexin-S583 0.156 -1.218 -0.607 -0.306 -0.377 -0.066 -0.617 -0.434 -0.172 -0.931 -0.441 -0.663 -0.299 0.373 0.116 -0.492 -0.325 -0.761 -0.380 NA -0.098 -0.336 -0.833 -1.117 -0.480 -0.142 -0.409 -0.581 -0.028 -0.149 -1.024 -0.158 -0.753 -0.281 p190B -0.453 -0.739 0.145 -0.200 -0.438 -0.877 -0.790 0.587 -0.401 0.377 0.056 0.306 0.150 2.186 -0.448 -0.353 -0.485 -0.566 0.239 NA 0.349 -0.254 0.433 -0.458 -0.631 -0.223 0.452 0.017 -0.170 0.000 -0.302 -0.726 0.311 -0.062 Bax 0.325 0.316 0.477 -2.466 NA -0.148 0.993 0.498 -0.240 1.131 NA 0.477 -0.592 0.557 0.056 0.332 0.025 0.405 0.637 -2.579 0.413 1.400 1.199 0.714 -0.295 -0.207 -1.266 0.145 -0.011 -0.753 0.284 -0.316 -1.047 -1.487 Beclin-1 -0.364 0.215 0.195 -2.526 NA -0.513 -1.536 -0.049 0.082 0.071 NA 0.520 -1.585 0.119 0.071 0.207 -0.386 0.246 -0.038 -2.426 -0.230 0.412 0.624 0.412 -0.069 -0.293 -1.622 0.098 0.059 -0.969 -0.407 -2.297 -1.586 -2.002 P-c-Jun-Ser63 0.490 1.127 0.299 -1.972 NA -0.020 0.065 0.456 0.048 0.739 NA -1.814 -0.792 0.403 -1.099 0.261 0.305 0.946 0.325 -1.741 0.564 0.867 1.087 -0.097 0.292 0.954 -0.567 -0.668 0.236 -0.898 0.436 -0.980 0.679 -0.866 P-Cdc6-Ser106 0.243 0.313 0.337 -1.787 NA -0.249 -0.990 0.965 0.121 0.191 NA 0.065 -1.476 0.070 -0.468 0.489 0.385 0.898 0.521 -1.720 0.534 0.781 0.664 -0.069 0.047 0.824 -0.413 -0.927 -0.472 -0.787 -0.507 -1.152 0.085 -0.906 Cytokeratin7 -0.317 -0.513 0.312 -3.042 NA -1.181 -2.057 0.195 -0.044 0.677 NA -0.595 -2.000 -0.037 -1.729 -0.583 -0.343 -0.319 0.566 -2.129 0.390 0.301 0.591 -0.432 -0.628 0.029 -1.489 -0.717 -0.876 -1.610 -0.047 -2.198 0.189 -1.403 Cyclin-B1 0.987 0.627 0.995 0.411 NA 2.311 0.604 2.383 1.187 2.013 NA 2.455 0.546 2.480 1.985 1.264 2.458 0.746 2.733 0.236 1.836 1.224 1.352 2.360 2.676 2.040 0.260 1.340 0.957 0.284 0.804 0.021 1.400 0.328 ERCC1 -1.998 0.550 0.209 -2.362 NA -0.259 -2.170 0.442 0.745 0.883 NA -0.926 -0.975 0.625 0.369 -0.253 -0.132 1.083 -0.084 -1.126 0.061 0.663 0.841 0.996 -0.006 0.097 -1.565 -0.411 -0.980 -1.062 0.109 -1.503 -0.045 -0.956 P-ATM-Ser-Thr-ATR-S-T-QG -0.977 -0.786 1.031 0.928 NA 0.985 1.641 0.780 0.647 1.370 NA 1.449 -0.284 1.595 0.066 1.121 0.953 -0.501 0.859 -0.108 0.844 1.597 1.223 1.432 -0.058 0.293 -0.600 0.847 1.064 -1.146 -0.191 0.415 -0.109 -0.805 P-ATM-ser1981 -0.019 -0.571 0.540 -1.086 NA -0.485 -1.319 -0.456 -0.435 0.248 NA 0.378 -1.422 0.838 0.166 0.046 -0.200 -0.270 -0.515 -1.634 0.130 0.465 -0.525 0.681 0.022 0.078 -1.212 0.620 -0.259 -1.397 -1.103 -1.833 -0.917 -1.189 Cdk5 -0.069 -0.272 0.685 0.035 NA -0.247 0.592 1.482 0.906 1.939 NA -0.274 -0.046 0.356 -0.058 1.399 0.397 -0.169 0.416 -1.449 0.869 1.323 1.783 1.044 -0.239 0.256 -0.499 1.866 1.435 0.300 0.558 0.005 0.760 0.167 P-FANCD2-Ser222 -0.968 -1.549 -1.022 -1.716 NA -2.115 -1.902 -0.154 -0.151 0.832 NA -0.364 -1.330 -0.143 -1.873 0.293 -0.071 -1.311 -0.586 -1.831 -0.265 0.080 -0.981 -0.333 -1.386 -1.270 -1.275 -0.112 -0.207 -1.714 -1.281 -1.440 -1.777 -1.831 P-Histone-H3-Ser10 0.598 0.242 0.835 1.277 NA 2.429 0.480 0.941 1.282 1.411 NA 1.148 -0.100 2.270 1.809 1.536 2.008 0.746 0.854 0.494 1.450 0.778 1.387 1.105 1.803 0.508 0.782 1.825 2.174 0.397 0.132 0.279 1.049 1.326 P-IRS1-Tyr632 0.588 0.568 0.506 -0.002 NA 0.213 0.277 1.112 1.091 1.495 NA 1.630 -1.148 1.788 0.223 0.709 1.651 1.056 0.965 0.089 1.542 1.097 0.743 1.292 1.167 0.124 -0.206 0.434 0.733 -0.005 0.495 0.152 1.861 2.152 Histone-H3-Acetyl-K9 -0.919 -1.706 -0.196 -0.919 NA 0.661 -1.186 -1.477 -0.686 -0.469 NA -0.900 -2.403 0.714 -1.052 -0.294 -0.152 -1.200 -0.829 -0.974 -0.563 -0.760 -0.975 0.390 0.023 -1.549 -0.481 -0.272 0.308 -0.891 -2.055 -0.619 -1.221 -0.580 Histone-H3-trimethylated-K9 -0.773 -0.739 1.991 -1.726 NA -1.431 -1.248 -0.482 -0.020 0.140 NA 0.297 -2.395 -0.460 -1.440 -1.167 -0.981 -0.352 -0.794 -1.796 -0.011 -0.395 -0.430 -1.405 -1.242 -1.214 -1.541 -0.724 -1.600 -1.429 -1.192 -1.510 -0.214 -0.218 p27 Kip1 -1.286 -0.147 -2.617 -3.152 NA -1.978 -1.629 -3.212 0.715 0.107 NA -0.150 -0.833 -0.189 -1.012 -1.197 -0.613 0.013 -0.119 -0.586 -0.729 0.947 -1.172 -0.785 -1.232 -0.792 -1.574 -0.705 -1.803 -0.780 -0.838 -0.768 -0.570 -1.595 P-p27-KIP1-Thr198 0.735 0.906 -0.740 0.540 NA -0.196 0.023 1.284 2.056 1.158 NA 0.839 -0.200 1.506 0.636 0.576 1.280 1.075 0.637 0.197 1.335 1.457 0.974 0.489 0.550 0.309 0.133 0.668 0.269 -0.015 -0.298 0.102 0.323 0.371 P-PRAS40-Thr246 1.332 1.633 0.991 0.702 NA 1.651 0.869 2.088 1.815 0.655 NA 1.696 1.927 1.031 1.595 1.529 2.379 1.549 1.412 0.686 0.179 1.025 2.256 1.056 1.635 1.445 0.445 2.595 1.941 1.147 2.189 0.782 2.120 1.936 P-PDK1-Ser241 0.015 -0.028 -1.128 -0.367 NA -0.696 -0.742 1.037 1.351 -0.602 NA -0.067 -0.571 0.229 -0.329 -0.241 -0.280 0.200 -0.056 -0.842 0.796 0.700 0.355 -0.668 -0.704 -0.275 -0.864 -0.169 -0.989 -0.521 0.401 -1.057 -1.343 0.912 FANCD2 1.237 0.870 0.009 0.490 NA 0.742 0.442 1.245 2.158 1.823 NA 0.455 -0.546 3.692 0.389 1.754 2.052 0.355 0.895 1.654 1.826 1.049 0.247 1.116 0.945 0.466 0.619 1.303 2.203 0.002 0.072 1.256 1.810 2.149 Aurora-A 1.911 0.644 -0.603 0.669 NA 0.469 0.696 1.409 1.786 0.710 NA 0.889 0.803 2.081 1.078 2.672 2.407 1.058 1.015 1.459 2.084 1.234 1.187 0.395 1.383 1.163 0.444 1.144 1.662 0.225 1.000 1.358 1.655 2.546 P-Chk2-Thr68 0.114 0.376 0.019 -0.279 NA -0.137 -0.013 -1.693 0.838 -0.653 NA 0.215 0.059 0.380 -0.632 1.201 -0.081 0.242 0.977 -0.264 -0.007 -0.120 -0.255 -0.513 0.188 -0.515 -0.374 0.569 0.762 -0.452 0.194 0.267 -1.428 0.488 HIF-1-alpha -0.970 0.150 -0.139 -0.037 NA -0.684 -0.108 -1.206 0.878 -0.713 NA 0.499 0.674 0.415 -0.142 0.615 -1.106 0.423 0.901 0.030 -2.497 -0.232 0.139 -0.147 0.231 0.245 -0.690 0.785 1.061 -0.021 0.337 0.686 -0.470 0.755 Cdc25C 0.926 1.111 0.240 0.684 NA -0.248 -0.603 0.146 1.449 1.673 NA -0.192 0.239 1.464 0.298 0.848 1.087 1.056 1.792 -0.064 1.122 0.225 1.408 -0.018 1.047 0.718 0.017 1.153 1.354 0.215 0.046 0.401 1.506 0.563 Cdk2 0.293 0.980 -0.035 0.252 NA -0.256 -0.186 -0.659 1.238 0.760 NA 0.049 -0.497 1.885 -0.203 1.279 1.377 1.194 1.896 0.180 0.734 1.332 -0.255 -0.029 0.651 0.469 -0.182 1.207 0.900 0.569 -0.147 -0.070 1.292 0.845 PD-L1 -0.130 -0.204 0.014 -0.340 NA 0.076 0.001 -3.270 -0.101 -1.526 NA 1.185 0.278 0.126 0.505 -0.340 -0.846 -0.018 -0.350 0.141 -0.163 -0.482 -1.511 -0.438 0.055 0.399 0.336 -0.551 -0.468 -0.037 0.248 0.484 -3.085 0.183 c-Jun -0.014 0.754 0.117 -0.585 NA 1.922 0.180 0.228 1.318 0.312 NA 0.469 -1.328 0.326 -0.466 -0.100 1.041 0.919 -0.509 0.112 0.787 0.735 1.522 0.507 0.090 0.449 0.451 -0.107 0.730 -0.056 -0.023 -0.173 1.073 0.920 p21-Waf1-Cip1 0.475 -1.146 1.990 -0.365 NA 0.648 -1.990 -3.079 -0.170 -1.606 NA -0.021 -0.421 -0.921 -1.119 -1.308 -0.411 -0.736 -0.053 1.134 0.663 1.179 -0.026 -1.429 -0.343 0.653 -0.073 -0.179 -0.902 -0.891 1.206 0.739 0.706 -0.144 JunB -0.089 -0.036 0.208 -0.211 NA 0.639 -0.668 -0.121 0.083 0.694 NA 0.231 0.853 -0.686 0.115 0.425 -0.020 0.290 -0.198 -0.491 0.237 -0.479 0.493 -0.477 -0.090 -0.250 -0.174 1.502 1.088 -0.285 0.500 0.474 1.334 0.980 P-Rb-Ser807-811 1.496 0.849 0.484 1.473 NA 2.406 1.217 0.775 1.647 1.968 NA 0.945 1.457 1.460 2.094 0.768 0.385 0.454 0.731 2.261 2.099 0.920 1.222 1.047 1.468 0.862 1.650 1.286 1.360 3.138 0.594 1.441 1.305 1.182 Histone-H3R2me2s-symmetric 0.212 -0.355 -0.887 -0.918 NA 0.647 -1.074 -0.957 -0.213 0.650 NA -0.400 0.364 -0.057 -0.757 -0.353 0.029 -0.023 0.428 -0.996 0.767 0.035 -1.724 -0.779 0.091 -0.358 -0.087 -0.028 0.220 -0.103 -0.662 -0.411 0.819 0.252 P-MCM2-Ser108 0.671 0.183 -0.772 -0.037 NA 1.511 0.005 -0.412 0.451 1.293 NA 0.012 0.577 1.031 0.530 0.090 0.446 0.229 0.754 1.652 0.729 -0.011 -0.279 -0.087 0.536 0.274 0.703 0.193 0.548 1.373 -0.434 0.554 0.233 1.285 53BP1 0.172 0.008 0.138 0.871 NA 1.133 0.513 -0.240 -0.123 0.250 NA 0.302 1.854 0.210 -0.129 0.218 0.779 0.315 -0.418 2.199 0.583 1.113 0.456 0.315 0.361 1.487 0.536 0.459 0.949 1.713 2.125 1.240 0.534 1.933 RSPO2 -0.015 -0.134 -0.867 -0.715 NA 0.129 -0.606 -0.806 0.035 -0.696 NA -0.195 0.199 -0.149 -0.180 -0.417 -0.022 -0.120 0.013 1.302 -0.438 -0.482 -0.431 -0.668 0.147 -0.276 -0.164 -0.079 0.119 1.509 -0.407 0.016 -0.535 -0.200 BAD -0.189 -0.850 -0.479 -0.576 NA 0.798 -1.706 -2.402 -1.388 -1.704 NA -0.050 0.041 -0.567 -0.707 -0.782 -0.488 -1.084 -1.175 -0.669 -0.143 -0.974 -1.409 -1.615 -0.105 -0.255 -0.307 -0.627 -0.649 -0.497 -0.485 -1.495 -1.770 -0.362 Cdk1-Cdc2 -0.717 0.492 -1.337 -1.317 NA -1.143 -2.589 -0.164 -0.725 1.329 NA 0.393 0.493 -0.214 -0.417 -0.037 -0.207 0.440 0.162 -1.585 1.074 -0.514 0.927 -1.113 -0.434 -0.066 -0.527 -0.517 0.029 0.542 0.499 -0.247 1.030 -0.025 Ku80 0.721 0.560 0.046 1.772 NA -0.218 -0.308 -0.076 -0.632 1.584 NA -0.312 -0.017 -0.029 -0.234 0.539 0.031 -0.398 -0.145 1.577 0.918 0.782 0.105 0.062 0.415 0.009 0.575 0.123 0.307 1.056 -0.215 -0.315 0.004 0.922 CREB 0.114 -0.034 -0.395 0.165 NA -1.287 0.300 0.000 -0.078 -2.789 NA -0.168 -1.715 -0.352 -0.045 -1.985 -0.454 -0.585 -1.324 0.359 -1.288 0.010 -2.702 -0.536 -1.052 -1.835 -0.053 -0.485 -0.405 -0.768 -1.821 -0.840 -0.353 -0.406 P-MSK1-Ser360 -0.297 0.296 0.126 0.778 NA -2.376 0.402 0.871 -0.126 -3.482 NA -0.566 0.749 0.002 0.012 -0.507 -0.258 -0.076 0.206 0.763 -1.504 -0.210 -0.789 -0.230 0.029 -0.299 0.137 -0.069 -0.294 0.670 0.569 0.113 0.117 0.322 PDGFR-alpha -0.286 0.562 -0.091 -0.415 NA -1.832 0.694 0.865 -0.146 -3.541 NA 0.418 0.246 0.063 0.394 -0.706 0.069 -0.117 -0.221 -0.564 -1.246 0.245 -0.311 -0.439 0.187 -0.355 0.292 0.303 -0.385 0.165 0.434 -0.395 -1.308 -2.063 P-Shc-Tyr239-240 0.297 0.520 1.055 0.948 NA -1.122 1.032 0.958 0.325 -2.667 NA 0.584 -0.232 0.189 0.829 0.341 0.102 0.070 1.042 1.101 -1.209 -0.460 0.094 0.431 0.694 -0.021 0.386 0.579 1.041 0.395 0.778 0.759 0.030 2.721 P-Stat1-Tyr701 0.294 0.043 -0.251 0.667 NA -0.219 -2.387 0.273 0.528 0.009 NA 0.175 1.379 -0.336 0.395 -0.451 -0.002 0.105 -0.295 0.705 -0.173 -0.128 0.718 0.044 -0.015 0.098 0.676 -0.071 -0.193 0.675 0.036 0.087 0.329 0.010 SUV39H1 0.208 -0.088 0.480 1.786 NA 1.179 -0.020 0.931 1.119 -0.588 NA 0.505 1.234 -0.046 1.620 -0.637 1.345 1.105 -0.511 0.789 0.202 -0.002 0.671 0.165 0.236 1.093 0.191 0.436 0.056 1.354 0.065 0.203 0.864 0.145 P-4E-BP1-Thr70 0.037 0.240 -0.485 0.240 NA -0.824 0.554 -0.489 0.264 -0.637 NA -0.911 -1.640 -0.282 -0.076 -1.474 -0.302 -0.399 -2.188 0.730 -0.064 -0.005 -1.668 -0.820 -0.968 -1.476 -0.129 -0.372 -0.358 -0.733 -1.518 -0.691 -0.007 -0.663 P-PTEN-ser380-Thr382-383 0.226 0.619 0.829 1.227 NA -1.226 1.379 1.130 -0.097 -1.182 NA 0.439 -0.518 0.185 0.111 -0.449 0.558 0.148 0.500 1.182 -1.498 0.000 -1.691 -0.007 -0.062 -0.240 0.480 0.266 0.457 0.156 0.379 0.506 -0.138 -0.134 P-Rb-Thr356 1.513 0.941 1.423 2.169 NA 0.020 2.224 1.328 0.967 0.218 NA 0.466 1.385 1.427 1.668 0.330 0.442 0.147 1.370 1.706 0.154 0.414 0.407 0.814 1.337 0.674 1.363 1.251 1.262 1.982 0.193 1.164 1.072 0.217 Trf2 0.609 0.242 0.330 1.062 NA -0.204 0.101 0.535 0.088 -0.877 NA 0.173 0.612 0.186 0.513 -1.011 0.744 -0.116 -1.141 -0.026 -2.087 -0.072 -0.419 0.208 0.029 -0.404 0.551 0.348 -0.025 0.399 -0.165 0.075 -0.086 -0.701 ALDH 1A1 -0.601 -0.409 -0.425 0.561 NA -1.348 -0.960 -1.673 -1.954 -1.044 NA -1.260 -0.437 -0.062 -1.611 0.179 -0.252 -0.836 -0.879 0.288 -0.618 -2.060 -1.291 -1.859 -0.147 -2.093 -0.761 -0.370 -0.207 -1.752 -1.783 -0.081 -0.326 0.297 Chk1 -0.003 -0.285 -0.533 0.411 NA 0.621 0.317 -0.213 -0.662 -1.704 NA -0.230 0.078 -0.589 0.321 -1.176 1.145 -0.443 -0.607 0.068 -0.319 -0.794 -2.548 0.094 -0.242 0.195 0.115 -0.260 -1.118 0.357 0.119 -0.018 -2.171 -1.407 Chk2 -0.091 -0.163 -0.197 -0.175 NA 0.724 0.168 -2.188 -1.709 -1.884 NA -0.482 0.114 -0.355 -0.146 -0.700 0.721 -1.308 -0.413 -0.737 -0.618 -0.455 -1.460 -0.327 -0.274 -0.307 0.766 -0.600 -1.161 -0.215 -0.094 -0.272 -3.384 -2.469 BAP1 -0.691 -0.443 0.349 0.717 NA 1.100 1.481 1.145 -0.201 -0.480 NA -0.133 1.089 -0.085 0.863 -0.974 1.252 -0.278 0.571 0.226 -0.018 -0.333 -0.562 0.194 0.168 0.455 0.882 -0.118 -0.261 0.420 0.502 0.397 -1.587 -1.391 P-Fyn-Tyr528-Src-Tyr530 -0.591 -0.623 -0.386 0.587 NA 0.010 0.225 0.175 -0.745 -1.812 NA -1.244 1.078 -0.729 0.429 NA -0.050 -0.821 0.045 -0.129 -0.751 -0.877 -0.694 -0.471 -0.448 0.309 0.149 -0.240 -1.087 0.132 0.549 0.040 -0.747 -0.071 Trf1 0.258 -0.405 -0.446 0.218 NA -0.550 -0.595 -0.039 -0.700 -1.033 NA -0.382 -0.249 -0.595 -0.193 NA -0.805 -0.669 -0.694 -0.524 -0.131 -0.563 -1.986 -0.398 -0.463 -0.513 -0.382 0.053 -0.268 -0.424 -0.871 -0.108 -0.230 -0.851 Vimentin -1.388 -1.160 -1.489 -0.609 NA -0.726 2.437 -0.569 -1.344 2.131 NA 0.957 1.274 -1.773 0.127 NA 0.096 0.490 -1.819 -1.379 -1.363 -1.542 2.817 -1.542 -1.527 -1.467 -0.635 -1.399 -1.718 1.155 -1.711 -0.356 0.227 -1.787 XRCC1 0.468 -0.371 -0.656 -0.376 NA 0.401 0.527 -0.058 -0.628 -1.035 NA -0.858 0.820 -0.320 0.445 NA -0.286 -0.291 -0.281 -1.075 -0.779 -0.414 -0.884 -0.050 -0.093 0.371 1.292 -0.285 -0.557 1.065 0.767 0.720 0.087 -1.695 P-Cyclin-B1-Ser133 -0.474 -1.268 0.756 0.733 NA 0.364 -0.062 0.401 -0.909 -1.682 NA -1.991 0.265 -1.317 -0.204 NA -0.796 -1.455 -0.656 0.159 -0.668 -0.514 -0.089 -0.991 -0.550 -0.094 0.059 -0.170 -1.362 -0.048 0.103 -0.092 -0.895 -1.609 P-p38-MAPK-Thr180-Tyr182 -0.797 -1.097 -0.480 0.061 NA -0.464 0.099 -0.319 -0.323 -1.984 NA -0.881 0.069 -1.592 -0.844 NA -0.673 -1.551 -0.164 -0.725 -0.840 -0.890 -1.472 -0.838 -0.866 -0.832 -0.248 -0.723 -1.196 -0.360 -0.824 -0.768 -0.983 -1.264 FAK -0.841 -0.408 -0.794 0.848 NA 0.379 0.358 0.219 -0.491 0.080 NA -0.670 -0.125 -0.780 0.030 NA -0.036 -0.434 -0.816 0.047 -0.035 -0.044 0.226 -1.193 -0.458 -0.037 -0.166 -0.745 -0.509 0.362 0.365 -0.536 0.911 1.001 P-HER4-Tyr1162 0.169 0.652 -0.241 -0.959 0.399 0.941 -0.515 -1.011 -0.200 -0.642 NA 0.902 0.334 0.165 -0.264 0.225 0.388 0.407 0.182 0.288 0.329 0.209 0.201 0.283 1.039 -0.133 0.378 0.426 0.538 0.223 -0.364 0.216 0.710 4.969 HER4-ErbB4 -0.608 0.479 -0.968 -1.891 -0.391 0.222 -1.846 -1.312 0.583 -0.282 NA 0.365 -0.364 0.008 -1.184 0.077 0.265 0.239 0.835 -0.473 -0.937 1.154 -0.653 -0.211 -0.656 0.051 -0.519 0.415 0.348 -0.268 -0.103 0.790 0.562 0.042