Drugs	Alias	Targets	Targeted cellular function	Clinical status		Supplier	Reference
				In any tumor type	In HCC		
Sorafenib	BAY 43-9006	BRAF, KDR, FLT4, PDGFRB, KIT, FLT3, RET	Tyrosine kinases	Approved	Approved	Selleck Chemicals	S1040
Regorafenib	BAY 73-4506	VEGFR1/2/3, PDGFRB, KIT, RET, RAF1	Tyrosine kinases	Approved	Approved	Selleck Chemicals	S1178
Cabozantinib	XL184, BMS-907351	VEGFR2, c-MET	Tyrosine kinases	Approved	Approved	Selleck Chemicals	S1119
Lenvatinib	E7080	VEGFR2, VEGFR3, VEGFR1, PDGFR, FGFR1	Tyrosine kinases	Approved	Approved	Selleck Chemicals	S1164
Doxorubicin  	Adriamycin, NSC123127	DNA topoisomerase II	DNA replication	Approved	Approved	Selleck Chemicals	S1208
Tivantinib	ARQ197	Microtubule 	Mitosis	Phase 1, 2, 3	Phase 3	Selleck Chemicals	S2753
Selumetinib	AZD6244 	MEK1/2	MAPK/ERK signaling	Phase 1, 2 	Phase 2 	Selleck Chemicals	S1008
Trametinib	GSK1120212	MEK1/2	MAPK/ERK signaling	Approved	Phase 2 	Selleck Chemicals	S2673
Refametinib	BAY 86-9766 	MEK1/2	MAPK/ERK signaling	Phase 1, 2 	Phase 2 	Selleck Chemicals	S1089
Rapamycin	Sirolimus	mTOR (mTORC1/mTORC2)	PI3K-AKT-mTOR signaling	Phase 1, 2, 3	Phase 2 	Selleck Chemicals	S1039
PF-04691502	PF4691502	PI3K, mTOR	PI3K-AKT-mTOR signaling	Phase 1, 2		Selleck Chemicals	S2743
MK-2206		AKT1/2/3	PI3K-AKT-mTOR signaling	Phase 1, 2 	Phase 2 	Selleck Chemicals	S1078
Dasatinib	BMS-354825	SRC, ABL	Tyrosine kinases	Approved	Phase 2 	Selleck Chemicals	S1021
Nutlin-3		MDM2	P53 signaling	Phase 1		Selleck Chemicals	S1061
JNJ-38877605		c-MET	MET signaling	Phase 1		Selleck Chemicals	S1114
PHA-665752		c-MET	MET signaling	Preclinical		Selleck Chemicals	S1070
Brivanib	BMS-540215	VEGFR1, 2 and 3, FGFR1, 2 and 3	Tyrosine kinases	Phase 1, 2, 3	Phase 3	Selleck Chemicals	S1084
BLU-9931		FGFR4	FGFR4/FGF19 signaling	Preclinical		Gift from Blueprint	
Linsitinib	OSI-906	IGF-1R	Insulin growth factor signaling	Phase 1, 2	Phase 2 	Selleck Chemicals	S1091
ICG-001		CBP 	Wnt/_-catenin signaling	Phase 1		Selleck Chemicals	S2662
Tanespimycin	17-AAG	HSP90	Chaperone protein folding	Phase 1, 2		Sigma-Aldrich	A8476
Alvespimycin	17-DMAG	HSP90	Chaperone protein folding	Phase 1, 2		Sigma-Aldrich	D5193
Bortezomib	Velcade	Proteasome	Protein degradation	Approved	Phase 2 	Selleck Chemicals	S1013
Navitoclax	ABT-263	BCL-2	Apoptosis	Phase 1, 2		Selleck Chemicals	S1001
Paclitaxel 	Taxol, NSC125973	Microtubule stabilizer	Mitosis	Approved	Phase 2 	Selleck Chemicals	S1150
Vinblastine	NSC49842	Microtubule destabilizer	Mitosis	Approved		Selleck Chemicals	S1248
Alisertib	MLN8237	AURORA A, MYCN	Mitosis	Phase 1, 2, 3		Selleck Chemicals	S1133
CD532		AURORA A, MYCN	Mitosis	Preclinical		Calbiochem	532605
Decitabine	5-Aza-2_-deoxycytidine	DNA methyltransferase	DNA metylation	Approved		ApexBio Technology	A1906
Resminostat	RAS2410	HDAC1/3/6	Epigenetic erasers	Phase 1, 2	Phase 2 	Selleck Chemicals	S2693
Entinostat	MS-275	HDAC1/3	Epigenetic erasers	Phase 1, 2	Phase 1	Selleck Chemicals	S1053