Liver Cancer Cell Lines
Database

LCCL to predict drug response

Data files

Item Data Details
Cell lines LCCL_description
Description of liver cancer cell lines.
Cell lines Protein_expression
Expression of 126 proteins analyzed by RPPA in 34 liver cancer cell lines (log2-transformed).
Cell lines microRNAseq_RPM
microRNA expression in 34 liver cancer cell lines (RPM)
Cell lines microRNAseq_vsn
microRNA expression in 34 liver cancer cell lines (vsn)
Cell lines RNAseq_FPMK
RNA expression in 34 liver cancer cell lines (FPKM)
Cell lines RNAseq_vsn
RNA expression in 34 liver cancer cell lines (vsn)
Cell lines Drivers
List of the 252 cancer driver genes used to analyze association between drug sensitivity and genetic alterations in 34 liver cancer cell lines.
Cell lines HBV_fusions
HBV RNA fusions identified by RNA-sequencing among 34 liver cancer cell lines.
Cell lines Fusion_transcripts
Fusion transcripts identified in 34 liver cancer cell lines by RNA-sequencing.
Cell lines Somatic_alterations
List of putative somatic genomic alterations identified in 34 Liver Cancer Cell Lines by whole-exome sequencing.
Cell lines/Drugs AUC
Drug sensitivity in 34 liver cancer cell lines. Table of AUC values for each drug
Cell lines/Drugs GI50
Drug sensitivity in 34 liver cancer cell lines. Table of GI50 values for each drug
Drugs Screened_compounds
Description of screened compounds.
For further information please refer to:
S. Caruso*, A-L. Calatayud*, J. Pilet*, T. La Bella, S. Rekik, S. Imbeaud, E. Letouzé, L. Meunier, Q. Bayard, N. Rohr-Udilova, C. Péneau, B. Grasl-Kraupp, L. de Koning, B. Ouine, P. Bioulac-Sage, G. Couchy, J. Calderaro, J-C. Nault, J. Zucman-Rossi, S. Rebouissou.
"Analysis of Liver Cancer Cell Lines Identifies Agents With Likely Efficacy Against Hepatocellular Carcinoma and Markers of Response." Gastroenterology 2019. DOI: 10.1053/j.gastro.2019.05.001. PMID: 31063779
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