Liver Cancer Cell Lines Database

Cell line description

Cell line name	Synonyms	Cellosaurus ID	Tumor type	Reference	Supplier	Culture medium
HCC.1.1	3SP	CVCL_0C52	Hepatocellular Carcinoma	Sagmeister et al. Br J Cancer (2008) [PMID: 18594539]	Gift from Bettina Grasl-Kraupp (Austria)	DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

Age	Gender	Geographic Origin	Ethnicity	HBV	HCV
56	Male	Austria	European	No	Yes

Transcriptomic subgroup: CL3

Mutations and CNAs (227)

Gene nameFilter by Gene name	Alteration type	Variant class	Annotation transcript	gNomen	cNomen	pNomen	PPH prédiction
ARHGAP29	Mutation	In-Frame	ENST00000260526.6	g.94640194_94640199del g.94640194_94640199del	c.3012_3017del c.3012_3017del	p.Asn1004_Val1006delinsLys p.Asn1004_Val1006delinsLys	damaging damaging
C10orf90	Mutation	In-Frame	ENST00000284694.7	g.128192896_128192897insCGA g.128192896_128192897insCGA	c.872_873insTCG c.872_873insTCG	p.Ser291_Leu292insArg p.Ser291_Leu292insArg	damaging damaging
TRIM44	Mutation	In-Frame	ENST00000299413.5	g.35684956_35684973del g.35684956_35684973del	c.297_314del c.297_314del	p.Ser107_Glu112del p.Ser107_Glu112del	damaging damaging
RNF10	Mutation	In-Frame	ENST00000325954.4	g.120984355_120984356insGCA g.120984355_120984356insGCA	c.305_306insGCA c.305_306insGCA	p.Gly102_Ser103insHis p.Gly102_Ser103insHis	damaging damaging
ARNTL2	Mutation	In-Frame	ENST00000266503.5	g.27523083_27523084insCGTGGTGGT g.27523083_27523084insCGTGGTGGT	c.204_205insCGTGGTGGT c.204_205insCGTGGTGGT	p.Lys68_Val69insArgGlyGly p.Lys68_Val69insArgGlyGly	damaging damaging
CEP128	Mutation	In-Frame	ENST00000216517.6	g.81307094_81307096del g.81307094_81307096del	c.779_781del c.779_781del	p.Glu260del p.Glu260del	damaging damaging
DNMT1	Mutation	In-Frame	ENST00000340748.4	g.10251514_10251522del g.10251514_10251522del	c.3410_3418del c.3410_3418del	p.Pro1137_Leu1139del p.Pro1137_Leu1139del	damaging damaging
HNRNPCL1	Mutation	Missense	ENST00000317869.6	g.12907365C>T g.12907365C>T	c.778G>A c.778G>A	p.Glu260Lys p.Glu260Lys	possibly damaging possibly damaging
THBS3	Mutation	Missense	ENST00000368378.3	g.155167407A>C g.155167407A>C	c.2346T>G c.2346T>G	p.His782Gln p.His782Gln	probably damaging probably damaging
PEAR1	Mutation	Missense	ENST00000292357.7	g.156878523G>A g.156878523G>A	c.1192G>A c.1192G>A	p.Asp398Asn p.Asp398Asn	possibly damaging possibly damaging
LHX4	Mutation	Missense	ENST00000263726.2	g.180241084G>C g.180241084G>C	c.721G>C c.721G>C	p.Glu241Gln p.Glu241Gln	benign benign
ELF3	Mutation	Missense	ENST00000359651.3	g.201981475C>T g.201981475C>T	c.389C>T c.389C>T	p.Ser130Phe p.Ser130Phe	benign benign
MIA3	Mutation	Missense	ENST00000344441.6	g.222801973G>T g.222801973G>T	c.1411G>T c.1411G>T	p.Val471Phe p.Val471Phe	possibly damaging possibly damaging
OR2T33	Mutation	Missense	ENST00000318021.2	g.248436227C>T g.248436227C>T	c.890G>A c.890G>A	p.Gly297Glu p.Gly297Glu	benign benign
OR2T33	Mutation	Missense	ENST00000318021.2	g.248436245T>C g.248436245T>C	c.872A>G c.872A>G	p.Lys291Arg p.Lys291Arg	benign benign
ZCCHC17	Mutation	Missense	ENST00000344147.5	g.31819535G>T g.31819535G>T	c.366G>T c.366G>T	p.Lys122Asn p.Lys122Asn	possibly damaging possibly damaging
CSMD2	Mutation	Missense	ENST00000241312.4	g.33985512G>A g.33985512G>A	c.10204C>T c.10204C>T	p.Arg3546Cys p.Arg3546Cys	benign benign
EXO5	Mutation	Missense	ENST00000296380.4	g.40981256C>A g.40981256C>A	c.1040C>A c.1040C>A	p.Thr347Asn p.Thr347Asn	benign benign
ACOT7	Mutation	Missense	ENST00000361521.4	g.6453428G>T g.6453428G>T	c.32C>A c.32C>A	p.Pro11Gln p.Pro11Gln	benign benign
TCF7L2	Mutation	Missense	ENST00000349937.2	g.114711316C>G g.114711316C>G	c.331C>G c.331C>G	p.Leu111Val p.Leu111Val	benign benign
KIAA1598	Mutation	Missense	ENST00000260777.10	g.118728190C>T g.118728190C>T	c.145G>A c.145G>A	p.Val49Ile p.Val49Ile	benign benign
PRLHR	Mutation	Missense	ENST00000239032.2	g.120354591C>A g.120354591C>A	c.166G>T c.166G>T	p.Val56Leu p.Val56Leu	benign benign
FUT11	Mutation	Missense	ENST00000372841.3	g.75532458T>C g.75532458T>C	c.367T>C c.367T>C	p.Tyr123His p.Tyr123His	probably damaging probably damaging
SORBS1	Mutation	Missense	ENST00000361941.3	g.97111094C>G g.97111094C>G	c.2254G>C c.2254G>C	p.Glu752Gln p.Glu752Gln	probably damaging probably damaging
GRIA4	Mutation	Missense	ENST00000282499.5	g.105774602G>C g.105774602G>C	c.948G>C c.948G>C	p.Arg316Ser p.Arg316Ser	benign benign

Mutational Signature

Fusion transcripts (9)

Fusion Name	Gene (1)	Chr (1)	Genomic position hg19 (1)	Gene (2)	Chr (2)	Genomic position hg19 (2)	Supporting reads	Consistance fusion	Fusion type
AKAP2--PALM2-AKAP2	PALM2-AKAP2	chr9	112778265	AKAP2	chr9	112898406	64	straight	DEL
AXIN1--MPG	MPG	chr16	133254	AXIN1	chr16	380756	21	inverted	DEL
AXIN1--RHBDF1	AXIN1	chr16	396147	RHBDF1	chr16	115036	54	straight	DEL
CHSY1--LRRK1	LRRK1	chr15	101590983	CHSY1	chr15	101775286	10	inverted	DEL
DNAJB9--FOXP2	DNAJB9	chr7	108212384	FOXP2	chr7	114174669	13	straight	DEL
GALNT7--LOC101930370	LOC101930370	chr4	174090111	GALNT7	chr4	174213258	11	NA	DEL
LDB2--RP11-446J8.1	RP11-446J8.1	chr4	16428062	LDB2	chr4	16540506	14	inverted	DEL
PPP2R5C--TECPR2	TECPR2	chr14	102843274	PPP2R5C	chr14	102360841	28	straight	DUP
RP11-634B7.4--TRIM58	RP11-634B7.4	chr1	247803730	TRIM58	chr1	248023918	16	straight	DEL

HBV RNA fusions (0)

Breakpoint on human genome (hg19)	Affected gene	Breakpoint on HBV genome (X02763)	Nb of paired reads (HG19 HBV)
No records found.

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)

Drugs (35)

DrugFilter by Drug	AUC	GI50
Bortezomib	0.22	0.007
Vinblastine	0.27	0.005
Paclitaxel	0.36	0.021
Alvespimycin	0.47	0.081
Tivantinib	0.51	0.105
Tanespimycin	0.58	0.17
Alisertib	0.58	0.145
PF.04691502	0.63	0.375
Rapamycin	0.65	10.0
Doxorubicin	0.67	0.635
Trametinib	0.69	1.055
Sorafenib_Trametinib	0.73	0.72
Dasatinib	0.74	2.48
CD532	0.76	1.655
Sorafenib_MK.2206	0.77	2.844

Liver Cancer Cell Lines Database

Cell Line: HCC.1.1

Transcriptomic subgroup: CL3

Mutational Signature

Liver Cancer Cell Lines
Database