Liver Cancer Cell Lines
Database

LCCL to predict drug response

Cell Line: HCC.1.1


Cell line description
Cell line nameSynonymsCellosaurus IDTumor typeReferenceSupplierCulture medium
HCC.1.1 3SP CVCL_0C52 Hepatocellular Carcinoma Sagmeister et al. Br J Cancer (2008) [PMID: 18594539] Gift from Bettina Grasl-Kraupp (Austria) DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

AgeGenderGeographic OriginEthnicityHBVHCV
56 Male Austria European No Yes

Transcriptomic subgroup: CL3


Mutations and CNAs (227)
Gene nameAlteration typeVariant classAnnotation transcriptgNomencNomenpNomenPPH pr├ędiction
ARHGAP29MutationIn-FrameENST00000260526.6
g.94640194_94640199del
g.94640194_94640199del
c.3012_3017del
c.3012_3017del
p.Asn1004_Val1006delinsLys
p.Asn1004_Val1006delinsLys
damaging
damaging
C10orf90MutationIn-FrameENST00000284694.7
g.128192896_128192897insCGA
g.128192896_128192897insCGA
c.872_873insTCG
c.872_873insTCG
p.Ser291_Leu292insArg
p.Ser291_Leu292insArg
damaging
damaging
TRIM44MutationIn-FrameENST00000299413.5
g.35684956_35684973del
g.35684956_35684973del
c.297_314del
c.297_314del
p.Ser107_Glu112del
p.Ser107_Glu112del
damaging
damaging
RNF10MutationIn-FrameENST00000325954.4
g.120984355_120984356insGCA
g.120984355_120984356insGCA
c.305_306insGCA
c.305_306insGCA
p.Gly102_Ser103insHis
p.Gly102_Ser103insHis
damaging
damaging
ARNTL2MutationIn-FrameENST00000266503.5
g.27523083_27523084insCGTGGTGGT
g.27523083_27523084insCGTGGTGGT
c.204_205insCGTGGTGGT
c.204_205insCGTGGTGGT
p.Lys68_Val69insArgGlyGly
p.Lys68_Val69insArgGlyGly
damaging
damaging
CEP128MutationIn-FrameENST00000216517.6
g.81307094_81307096del
g.81307094_81307096del
c.779_781del
c.779_781del
p.Glu260del
p.Glu260del
damaging
damaging
DNMT1MutationIn-FrameENST00000340748.4
g.10251514_10251522del
g.10251514_10251522del
c.3410_3418del
c.3410_3418del
p.Pro1137_Leu1139del
p.Pro1137_Leu1139del
damaging
damaging
HNRNPCL1MutationMissenseENST00000317869.6
g.12907365C>T
g.12907365C>T
c.778G>A
c.778G>A
p.Glu260Lys
p.Glu260Lys
possibly damaging
possibly damaging
THBS3MutationMissenseENST00000368378.3
g.155167407A>C
g.155167407A>C
c.2346T>G
c.2346T>G
p.His782Gln
p.His782Gln
probably damaging
probably damaging
PEAR1MutationMissenseENST00000292357.7
g.156878523G>A
g.156878523G>A
c.1192G>A
c.1192G>A
p.Asp398Asn
p.Asp398Asn
possibly damaging
possibly damaging
LHX4MutationMissenseENST00000263726.2
g.180241084G>C
g.180241084G>C
c.721G>C
c.721G>C
p.Glu241Gln
p.Glu241Gln
benign
benign
ELF3MutationMissenseENST00000359651.3
g.201981475C>T
g.201981475C>T
c.389C>T
c.389C>T
p.Ser130Phe
p.Ser130Phe
benign
benign
MIA3MutationMissenseENST00000344441.6
g.222801973G>T
g.222801973G>T
c.1411G>T
c.1411G>T
p.Val471Phe
p.Val471Phe
possibly damaging
possibly damaging
OR2T33MutationMissenseENST00000318021.2
g.248436227C>T
g.248436227C>T
c.890G>A
c.890G>A
p.Gly297Glu
p.Gly297Glu
benign
benign
OR2T33MutationMissenseENST00000318021.2
g.248436245T>C
g.248436245T>C
c.872A>G
c.872A>G
p.Lys291Arg
p.Lys291Arg
benign
benign
ZCCHC17MutationMissenseENST00000344147.5
g.31819535G>T
g.31819535G>T
c.366G>T
c.366G>T
p.Lys122Asn
p.Lys122Asn
possibly damaging
possibly damaging
CSMD2MutationMissenseENST00000241312.4
g.33985512G>A
g.33985512G>A
c.10204C>T
c.10204C>T
p.Arg3546Cys
p.Arg3546Cys
benign
benign
EXO5MutationMissenseENST00000296380.4
g.40981256C>A
g.40981256C>A
c.1040C>A
c.1040C>A
p.Thr347Asn
p.Thr347Asn
benign
benign
ACOT7MutationMissenseENST00000361521.4
g.6453428G>T
g.6453428G>T
c.32C>A
c.32C>A
p.Pro11Gln
p.Pro11Gln
benign
benign
TCF7L2MutationMissenseENST00000349937.2
g.114711316C>G
g.114711316C>G
c.331C>G
c.331C>G
p.Leu111Val
p.Leu111Val
benign
benign
KIAA1598MutationMissenseENST00000260777.10
g.118728190C>T
g.118728190C>T
c.145G>A
c.145G>A
p.Val49Ile
p.Val49Ile
benign
benign
PRLHRMutationMissenseENST00000239032.2
g.120354591C>A
g.120354591C>A
c.166G>T
c.166G>T
p.Val56Leu
p.Val56Leu
benign
benign
FUT11MutationMissenseENST00000372841.3
g.75532458T>C
g.75532458T>C
c.367T>C
c.367T>C
p.Tyr123His
p.Tyr123His
probably damaging
probably damaging
SORBS1MutationMissenseENST00000361941.3
g.97111094C>G
g.97111094C>G
c.2254G>C
c.2254G>C
p.Glu752Gln
p.Glu752Gln
probably damaging
probably damaging
GRIA4MutationMissenseENST00000282499.5
g.105774602G>C
g.105774602G>C
c.948G>C
c.948G>C
p.Arg316Ser
p.Arg316Ser
benign
benign

Mutational Signature



Fusion transcripts (9)
Fusion NameGene (1)Chr (1)Genomic position hg19 (1)Gene (2)Chr (2)Genomic position hg19 (2)Supporting readsConsistance fusionFusion type
AKAP2--PALM2-AKAP2PALM2-AKAP2chr9112778265AKAP2chr911289840664straightDEL
AXIN1--MPGMPGchr16133254AXIN1chr1638075621invertedDEL
AXIN1--RHBDF1AXIN1chr16396147RHBDF1chr1611503654straightDEL
CHSY1--LRRK1LRRK1chr15101590983CHSY1chr1510177528610invertedDEL
DNAJB9--FOXP2DNAJB9chr7108212384FOXP2chr711417466913straightDEL
GALNT7--LOC101930370LOC101930370chr4174090111GALNT7chr417421325811NADEL
LDB2--RP11-446J8.1RP11-446J8.1chr416428062LDB2chr41654050614invertedDEL
PPP2R5C--TECPR2TECPR2chr14102843274PPP2R5Cchr1410236084128straightDUP
RP11-634B7.4--TRIM58RP11-634B7.4chr1247803730TRIM58chr124802391816straightDEL

HBV RNA fusions (0)
Breakpoint on human genome (hg19)Affected geneBreakpoint on HBV genome (X02763)Nb of paired reads (HG19 HBV)
No records found.

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)


Drugs (35)
DrugAUCGI50
Bortezomib0.220.007
Vinblastine0.270.005
Paclitaxel0.360.021
Alvespimycin0.470.081
Tivantinib0.510.105
Alisertib0.580.145
Tanespimycin0.580.17
PF.046915020.630.375
Rapamycin0.6510.0
Doxorubicin0.670.635
Trametinib0.691.055
Sorafenib_Trametinib0.730.72
Dasatinib0.742.48
CD5320.761.655
Sorafenib_MK.22060.772.844


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