Liver Cancer Cell Lines Database

Cell line description

Cell line name	Synonyms	Cellosaurus ID	Tumor type	Reference	Supplier	Culture medium
Huh1		CVCL_2956	Hepatocellular Carcinoma	Huh et al. Mutat Res (1982) [PMID: 6287253]	JCRB - Japan	DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

Age	Gender	Geographic Origin	Ethnicity	HBV	HCV
53	Male	Japan	Asian	Yes	NA

Transcriptomic subgroup: CL1

Mutations and CNAs (495)

Gene nameFilter by Gene name	Alteration type	Variant class	Annotation transcript	gNomen	cNomen	pNomen	PPH prédiction
ZBTB21	Mutation	In-Frame	ENST00000310826.5	g.43412989_43412990insGAT g.43412989_43412990insGAT	c.1215_1216insATC c.1215_1216insATC	p.His405_Arg406insIle p.His405_Arg406insIle	damaging damaging
UGT2B11	Mutation	In-Frame	ENST00000446444.1	g.70066307_70066475del g.70066307_70066475del	c.1311-38_1441del c.1311-38_1441del	p.L437_splice p.L437_splice	damaging damaging
PROB1	Mutation	In-Frame	ENST00000434752.2	g.138728094_138728096del g.138728094_138728096del	c.2675_2677del c.2675_2677del	p.Tyr892del p.Tyr892del	damaging damaging
ASCC3	Mutation	In-Frame	ENST00000369143.2	g.101307022_101307054del g.101307022_101307054del	c.266_298del c.266_298del	p.Arg89_Lys99del p.Arg89_Lys99del	damaging damaging
HLA-DRB1	Mutation	In-Frame	ENST00000360004.5	g.32552130_32552131ins21 g.32552130_32552131ins21	c.125_126insTTCTTGGAGTACTCTACGGGT c.125_126insTTCTTGGAGTACTCTACGGGT	p.Arg42delins8 p.Arg42delins8	damaging damaging
CRH	Mutation	In-Frame	ENST00000276571.3	g.67089559_67089560insGCG g.67089559_67089560insGCG	c.154_155insGCC c.154_155insGCC	p.Pro51_Gln52insArg p.Pro51_Gln52insArg	damaging damaging
COL11A1	Mutation	Missense	ENST00000370096.3	g.103444283G>A g.103444283G>A	c.2735C>T c.2735C>T	p.Pro912Leu p.Pro912Leu	possibly damaging possibly damaging
CELSR2	Mutation	Missense	ENST00000271332.3	g.109793822G>A g.109793822G>A	c.1121G>A c.1121G>A	p.Arg374Gln p.Arg374Gln	possibly damaging possibly damaging
ACP6	Mutation	Missense	ENST00000369238.6	g.147121997T>C g.147121997T>C	c.926A>G c.926A>G	p.Glu309Gly p.Glu309Gly	possibly damaging possibly damaging
ACP6	Mutation	Missense	ENST00000369238.6	g.147121998C>T g.147121998C>T	c.925G>A c.925G>A	p.Glu309Lys p.Glu309Lys	benign benign
FLG	Mutation	Missense	ENST00000368799.1	g.152281505C>A g.152281505C>A	c.5857G>T c.5857G>T	p.Gly1953Cys p.Gly1953Cys	possibly damaging possibly damaging
KRTCAP2	Mutation	Missense	ENST00000295682.4	g.155145751T>C g.155145751T>C	c.28A>G c.28A>G	p.Ser10Gly p.Ser10Gly	benign benign
CD5L	Mutation	Missense	ENST00000368174.4	g.157803177A>T g.157803177A>T	c.844T>A c.844T>A	p.Cys282Ser p.Cys282Ser	probably damaging probably damaging
PLEKHM2	Mutation	Missense	ENST00000375799.3	g.16053822G>A g.16053822G>A	c.1255G>A c.1255G>A	p.Gly419Arg p.Gly419Arg	probably damaging probably damaging
MAEL	Mutation	Missense	ENST00000367872.4	g.166959040A>G g.166959040A>G	c.199A>G c.199A>G	p.Lys67Glu p.Lys67Glu	benign benign
POU2F1	Mutation	Missense	ENST00000420254.3	g.167365538G>A g.167365538G>A	c.934G>A c.934G>A	p.Ala312Thr p.Ala312Thr	possibly damaging possibly damaging
NADK	Mutation	Missense	ENST00000344463.4	g.1691286A>C g.1691286A>C	c.319T>G c.319T>G	p.Ser107Ala p.Ser107Ala	benign benign
SCYL3	Mutation	Missense	ENST00000367770.1	g.169836049G>C g.169836049G>C	c.803C>G c.803C>G	p.Thr268Arg p.Thr268Arg	probably damaging probably damaging
KIAA1614	Mutation	Missense	ENST00000367588.4	g.180885782C>G g.180885782C>G	c.543C>G c.543C>G	p.Asn181Lys p.Asn181Lys	benign benign
BRINP3	Mutation	Missense	ENST00000367462.3	g.190068070C>T g.190068070C>T	c.1379G>A c.1379G>A	p.Cys460Tyr p.Cys460Tyr	probably damaging probably damaging
BRINP3	Mutation	Missense	ENST00000367462.3	g.190195412C>T g.190195412C>T	c.761G>A c.761G>A	p.Arg254His p.Arg254His	benign benign
CAPN8	Mutation	Missense	ENST00000366873.2	g.223807121G>A g.223807121G>A	c.1009C>T c.1009C>T	p.R337W p.R337W	probably damaging probably damaging
ITPKB	Mutation	Missense	ENST00000272117.3	g.226924630G>A g.226924630G>A	c.530C>T c.530C>T	p.Pro177Leu p.Pro177Leu	probably damaging probably damaging
RYR2	Mutation	Missense	ENST00000366574.2	g.237948091C>T g.237948091C>T	c.13079C>T c.13079C>T	p.Ser4360Phe p.Ser4360Phe	benign benign
OR1C1	Mutation	Missense	ENST00000408896.2	g.247921099C>T g.247921099C>T	c.610G>A c.610G>A	p.Gly204Ser p.Gly204Ser	benign benign

Mutational Signature

Fusion transcripts (18)

Fusion Name	Gene (1)	Chr (1)	Genomic position hg19 (1)	Gene (2)	Chr (2)	Genomic position hg19 (2)	Supporting reads	Consistance fusion	Fusion type
BAGE4--MIB1	MIB1	chr18	19359643	BAGE4	chr21	11039430	24	NA	TRANS
C11orf88--SIK2	SIK2	chr11	111491125	C11orf88	chr11	111404470	39	straight	DUP
CACNA1E--PCMTD1	PCMTD1	chr8	52744003	CACNA1E	chr1	181620473	11	straight	TRANS
CLPTM1L--PLEKHG4B	CLPTM1L	chr5	1330394	PLEKHG4B	chr5	113365	24	straight	INV
CSMD3--RNF139-AS1	CSMD3	chr8	113998603	RNF139-AS1	chr8	125486327	26	inverted	INV
DPY19L2P2--PMPCB	DPY19L2P2	chr7	102835514	PMPCB	chr7	102937904	12	inverted	DEL
EFR3A--FAM49B	FAM49B	chr8	130983188	EFR3A	chr8	132945681	13	inverted	DUP
EMG1--SLC4A8	EMG1	chr12	7084537	SLC4A8	chr12	51864173	24	straight	DEL
FAM49B--KCNQ3	FAM49B	chr8	130983188	KCNQ3	chr8	133222571	12	straight	DUP
FCRL4--METTL13	METTL13	chr1	171755217	FCRL4	chr1	157559247	19	straight	INV
FGFR1--NSD3	FGFR1	chr8	38314873	NSD3	chr8	38173559	134	NA	DEL
LIX1L--RALGPS2	RALGPS2	chr1	178694553	LIX1L	chr1	145487303	14	inverted	INV
LPCAT3--SLC4A8	LPCAT3	chr12	7086080	SLC4A8	chr12	51864174	37	inverted	DEL
LYN--NCOA2	NCOA2	chr8	71314398	LYN	chr8	56922465	445	straight	INV
MSC--PPP1R42	PPP1R42	chr8	67876568	MSC	chr8	72756656	60	inverted	INV
NTN1--SPECC1	SPECC1	chr17	20013874	NTN1	chr17	9124484	41	straight	DUP
PRPF3--RPRD2	PRPF3	chr1	150300924	RPRD2	chr1	150437002	10	straight	DEL
PRR16--RP11-574H6.1	RP11-574H6.1	chr5	119722621	PRR16	chr5	119952789	20	inverted	DEL

HBV RNA fusions (4)

Breakpoint on human genome (hg19)	Affected gene	Breakpoint on HBV genome (X02763)	Nb of paired reads (HG19 HBV)
chr1:83,856,484	intergenic	1,676	18
chr5:1,296,044	TERT (promoter)	1,105	20
chr5:1,296,559	TERT (promoter)	1,825	27
chr5:63,74	intergenic	1,826	5

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)

Drugs (35)

DrugFilter by Drug	AUC	GI50
Bortezomib	0.46	0.054
Paclitaxel	0.47	0.02
Alvespimycin	0.56	0.118
Vinblastine	0.58	0.067
Tanespimycin	0.62	0.21
CD532	0.64	0.36
PF.04691502	0.69	0.48
PHA.665752	0.77	5.136
Sorafenib_MK.2206	0.77	2.132
Doxorubicin	0.78	1.175
MK.2206	0.81	4.383
JNJ.38877605	0.81	10.0
Sorafenib_Resminostat	0.83	3.452
Linsitinib	0.83	5.615
Resminostat	0.84	3.407

Liver Cancer Cell Lines Database

Cell Line: Huh1

Transcriptomic subgroup: CL1

Mutational Signature

Liver Cancer Cell Lines
Database