Liver Cancer Cell Lines
Database

LCCL to predict drug response

Cell Line: Huh1


Cell line description
Cell line nameSynonymsCellosaurus IDTumor typeReferenceSupplierCulture medium
Huh1 CVCL_2956 Hepatocellular Carcinoma Huh et al. Mutat Res (1982) [PMID: 6287253] JCRB - Japan DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

AgeGenderGeographic OriginEthnicityHBVHCV
53 Male Japan Asian Yes NA

Transcriptomic subgroup: CL1


Mutations and CNAs (495)
Gene nameAlteration typeVariant classAnnotation transcriptgNomencNomenpNomenPPH pr├ędiction
ZBTB21MutationIn-FrameENST00000310826.5
g.43412989_43412990insGAT
g.43412989_43412990insGAT
c.1215_1216insATC
c.1215_1216insATC
p.His405_Arg406insIle
p.His405_Arg406insIle
damaging
damaging
UGT2B11MutationIn-FrameENST00000446444.1
g.70066307_70066475del
g.70066307_70066475del
c.1311-38_1441del
c.1311-38_1441del
p.L437_splice
p.L437_splice
damaging
damaging
PROB1MutationIn-FrameENST00000434752.2
g.138728094_138728096del
g.138728094_138728096del
c.2675_2677del
c.2675_2677del
p.Tyr892del
p.Tyr892del
damaging
damaging
ASCC3MutationIn-FrameENST00000369143.2
g.101307022_101307054del
g.101307022_101307054del
c.266_298del
c.266_298del
p.Arg89_Lys99del
p.Arg89_Lys99del
damaging
damaging
HLA-DRB1MutationIn-FrameENST00000360004.5
g.32552130_32552131ins21
g.32552130_32552131ins21
c.125_126insTTCTTGGAGTACTCTACGGGT
c.125_126insTTCTTGGAGTACTCTACGGGT
p.Arg42delins8
p.Arg42delins8
damaging
damaging
CRHMutationIn-FrameENST00000276571.3
g.67089559_67089560insGCG
g.67089559_67089560insGCG
c.154_155insGCC
c.154_155insGCC
p.Pro51_Gln52insArg
p.Pro51_Gln52insArg
damaging
damaging
COL11A1MutationMissenseENST00000370096.3
g.103444283G>A
g.103444283G>A
c.2735C>T
c.2735C>T
p.Pro912Leu
p.Pro912Leu
possibly damaging
possibly damaging
CELSR2MutationMissenseENST00000271332.3
g.109793822G>A
g.109793822G>A
c.1121G>A
c.1121G>A
p.Arg374Gln
p.Arg374Gln
possibly damaging
possibly damaging
ACP6MutationMissenseENST00000369238.6
g.147121997T>C
g.147121997T>C
c.926A>G
c.926A>G
p.Glu309Gly
p.Glu309Gly
possibly damaging
possibly damaging
ACP6MutationMissenseENST00000369238.6
g.147121998C>T
g.147121998C>T
c.925G>A
c.925G>A
p.Glu309Lys
p.Glu309Lys
benign
benign
FLGMutationMissenseENST00000368799.1
g.152281505C>A
g.152281505C>A
c.5857G>T
c.5857G>T
p.Gly1953Cys
p.Gly1953Cys
possibly damaging
possibly damaging
KRTCAP2MutationMissenseENST00000295682.4
g.155145751T>C
g.155145751T>C
c.28A>G
c.28A>G
p.Ser10Gly
p.Ser10Gly
benign
benign
CD5LMutationMissenseENST00000368174.4
g.157803177A>T
g.157803177A>T
c.844T>A
c.844T>A
p.Cys282Ser
p.Cys282Ser
probably damaging
probably damaging
PLEKHM2MutationMissenseENST00000375799.3
g.16053822G>A
g.16053822G>A
c.1255G>A
c.1255G>A
p.Gly419Arg
p.Gly419Arg
probably damaging
probably damaging
MAELMutationMissenseENST00000367872.4
g.166959040A>G
g.166959040A>G
c.199A>G
c.199A>G
p.Lys67Glu
p.Lys67Glu
benign
benign
POU2F1MutationMissenseENST00000420254.3
g.167365538G>A
g.167365538G>A
c.934G>A
c.934G>A
p.Ala312Thr
p.Ala312Thr
possibly damaging
possibly damaging
NADKMutationMissenseENST00000344463.4
g.1691286A>C
g.1691286A>C
c.319T>G
c.319T>G
p.Ser107Ala
p.Ser107Ala
benign
benign
SCYL3MutationMissenseENST00000367770.1
g.169836049G>C
g.169836049G>C
c.803C>G
c.803C>G
p.Thr268Arg
p.Thr268Arg
probably damaging
probably damaging
KIAA1614MutationMissenseENST00000367588.4
g.180885782C>G
g.180885782C>G
c.543C>G
c.543C>G
p.Asn181Lys
p.Asn181Lys
benign
benign
BRINP3MutationMissenseENST00000367462.3
g.190068070C>T
g.190068070C>T
c.1379G>A
c.1379G>A
p.Cys460Tyr
p.Cys460Tyr
probably damaging
probably damaging
BRINP3MutationMissenseENST00000367462.3
g.190195412C>T
g.190195412C>T
c.761G>A
c.761G>A
p.Arg254His
p.Arg254His
benign
benign
CAPN8MutationMissenseENST00000366873.2
g.223807121G>A
g.223807121G>A
c.1009C>T
c.1009C>T
p.R337W
p.R337W
probably damaging
probably damaging
ITPKBMutationMissenseENST00000272117.3
g.226924630G>A
g.226924630G>A
c.530C>T
c.530C>T
p.Pro177Leu
p.Pro177Leu
probably damaging
probably damaging
RYR2MutationMissenseENST00000366574.2
g.237948091C>T
g.237948091C>T
c.13079C>T
c.13079C>T
p.Ser4360Phe
p.Ser4360Phe
benign
benign
OR1C1MutationMissenseENST00000408896.2
g.247921099C>T
g.247921099C>T
c.610G>A
c.610G>A
p.Gly204Ser
p.Gly204Ser
benign
benign

Mutational Signature



Fusion transcripts (18)
Fusion NameGene (1)Chr (1)Genomic position hg19 (1)Gene (2)Chr (2)Genomic position hg19 (2)Supporting readsConsistance fusionFusion type
BAGE4--MIB1MIB1chr1819359643BAGE4chr211103943024NATRANS
C11orf88--SIK2SIK2chr11111491125C11orf88chr1111140447039straightDUP
CACNA1E--PCMTD1PCMTD1chr852744003CACNA1Echr118162047311straightTRANS
CLPTM1L--PLEKHG4BCLPTM1Lchr51330394PLEKHG4Bchr511336524straightINV
CSMD3--RNF139-AS1CSMD3chr8113998603RNF139-AS1chr812548632726invertedINV
DPY19L2P2--PMPCBDPY19L2P2chr7102835514PMPCBchr710293790412invertedDEL
EFR3A--FAM49BFAM49Bchr8130983188EFR3Achr813294568113invertedDUP
EMG1--SLC4A8EMG1chr127084537SLC4A8chr125186417324straightDEL
FAM49B--KCNQ3FAM49Bchr8130983188KCNQ3chr813322257112straightDUP
FCRL4--METTL13METTL13chr1171755217FCRL4chr115755924719straightINV
FGFR1--NSD3FGFR1chr838314873NSD3chr838173559134NADEL
LIX1L--RALGPS2RALGPS2chr1178694553LIX1Lchr114548730314invertedINV
LPCAT3--SLC4A8LPCAT3chr127086080SLC4A8chr125186417437invertedDEL
LYN--NCOA2NCOA2chr871314398LYNchr856922465445straightINV
MSC--PPP1R42PPP1R42chr867876568MSCchr87275665660invertedINV
NTN1--SPECC1SPECC1chr1720013874NTN1chr17912448441straightDUP
PRPF3--RPRD2PRPF3chr1150300924RPRD2chr115043700210straightDEL
PRR16--RP11-574H6.1RP11-574H6.1chr5119722621PRR16chr511995278920invertedDEL

HBV RNA fusions (4)
Breakpoint on human genome (hg19)Affected geneBreakpoint on HBV genome (X02763)Nb of paired reads (HG19 HBV)
chr1:83,856,484intergenic1,67618
chr5:1,296,044TERT (promoter)1,10520
chr5:1,296,559TERT (promoter)1,82527
chr5:63,74intergenic1,8265

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)


Drugs (35)
DrugAUCGI50
Bortezomib0.460.054
Paclitaxel0.470.02
Alvespimycin0.560.118
Vinblastine0.580.067
Tanespimycin0.620.21
CD5320.640.36
PF.046915020.690.48
Sorafenib_MK.22060.772.132
PHA.6657520.775.136
Doxorubicin0.781.175
JNJ.388776050.8110.0
MK.22060.814.383
Sorafenib_Resminostat0.833.452
Linsitinib0.835.615
Entinostat0.843.79


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