Liver Cancer Cell Lines Database

Cell line description

Cell line name	Synonyms	Cellosaurus ID	Tumor type	Reference	Supplier	Culture medium
Huh6		CVCL_4381	Hepatoblastoma	Doi et al. Gan (1976)	RIKEN BioResource Center - Japan	DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

Age	Gender	Geographic Origin	Ethnicity	HBV	HCV
1	Male	Japan	Asian	No	No

Transcriptomic subgroup: CL1

Mutations and CNAs (469)

Gene nameFilter by Gene name	Alteration type	Variant class	Annotation transcript	gNomen	cNomen	pNomen	PPH prédiction
NT5DC3	Mutation	In-Frame	ENST00000392876.3	g.104186946_104186948del g.104186946_104186948del	c.1013_1015del c.1013_1015del	p.Lys338del p.Lys338del	damaging damaging
FLII	Mutation	In-Frame	ENST00000327031.4	g.18150110_18150112del g.18150110_18150112del	c.2847_2849del c.2847_2849del	p.Glu950del p.Glu950del	damaging damaging
SUPT20HL1	Mutation	In-Frame	NM_001136234.1	g.24382519_24382536del g.24382519_24382536del	c.1642_1659del c.1642_1659del	p.Pro548_Ala553del p.Pro548_Ala553del	damaging damaging
SORBS2	Mutation	In-Frame	ENST00000284776.7	g.186533019_186533021del g.186533019_186533021del	c.2997_2999del c.2997_2999del	p.Lys999del p.Lys999del	damaging damaging
AMPD1	Mutation	Missense	ENST00000369538.3	g.115238109G>A g.115238109G>A	c.83C>T c.83C>T	p.Ser28Leu p.Ser28Leu	damaging damaging
NPPB	Mutation	Missense	ENST00000376468.3	g.11918421G>A g.11918421G>A	c.238C>T c.238C>T	p.Arg80Trp p.Arg80Trp	possibly damaging possibly damaging
MFN2	Mutation	Missense	ENST00000235329.5	g.12064980G>A g.12064980G>A	c.1491G>A c.1491G>A	p.Met497Ile p.Met497Ile	benign benign
SCNN1D	Mutation	Missense	ENST00000379101.4	g.1219428C>T g.1219428C>T	c.422C>T c.422C>T	p.Thr141Met p.Thr141Met	benign benign
GLTPD1	Mutation	Missense	ENST00000343938.4	g.1263017G>C g.1263017G>C	c.519G>C c.519G>C	p.Glu173Asp p.Glu173Asp	benign benign
PRAMEF1	Mutation	Missense	ENST00000332296.7	g.12854528T>C g.12854528T>C	c.752T>C c.752T>C	p.Leu251Pro p.Leu251Pro	possibly damaging possibly damaging
PRDM2	Mutation	Missense	ENST00000235372.7	g.14108437G>A g.14108437G>A	c.4147G>A c.4147G>A	p.Val1383Met p.Val1383Met	probably damaging probably damaging
POLR3C	Mutation	Missense	ENST00000334163.3	g.145597044G>A g.145597044G>A	c.1081C>T c.1081C>T	p.Arg361Cys p.Arg361Cys	probably damaging probably damaging
ANP32E	Mutation	Missense	ENST00000314136.8	g.150199042C>A g.150199042C>A	c.579G>T c.579G>T	p.Glu193Asp p.Glu193Asp	benign benign
NUP210L	Mutation	Missense	ENST00000271854.3	g.154026847C>T g.154026847C>T	c.3340G>A c.3340G>A	p.Val1114Ile p.Val1114Ile	benign benign
HAX1	Mutation	Missense	ENST00000328703.7	g.154247666C>T g.154247666C>T	c.593C>T c.593C>T	p.Pro198Leu p.Pro198Leu	possibly damaging possibly damaging
PKLR	Mutation	Missense	ENST00000392414.3	g.155270674T>C g.155270674T>C	c.5A>G c.5A>G	p.Glu2Gly (Splice) p.Glu2Gly (Splice)	benign benign
PRCC	Mutation	Missense	ENST00000271526.4	g.156737907C>T g.156737907C>T	c.344C>T c.344C>T	p.Pro115Leu p.Pro115Leu	benign benign
FHAD1	Mutation	Missense	ENST00000358897.4	g.15675557C>T g.15675557C>T	c.2300C>T c.2300C>T	p.Ala767Val p.Ala767Val	possibly damaging possibly damaging
SH2D2A	Mutation	Missense	ENST00000368199.3	g.156777059C>T g.156777059C>T	c.1081G>A c.1081G>A	p.Ala361Thr p.Ala361Thr	benign benign
VSIG8	Mutation	Missense	ENST00000368100.1	g.159827753C>T g.159827753C>T	c.434G>A c.434G>A	p.Arg145Gln p.Arg145Gln	probably damaging probably damaging
POGK	Mutation	Missense	ENST00000367875.1	g.166816764G>A g.166816764G>A	c.293G>A c.293G>A	p.Arg98His p.Arg98His	possibly damaging possibly damaging
DUSP27	Mutation	Missense	ENST00000271385.5	g.167096794C>T g.167096794C>T	c.2426C>T c.2426C>T	p.Ala809Val p.Ala809Val	benign benign
PADI3	Mutation	Missense	ENST00000375460.3	g.17586111G>C g.17586111G>C	c.131G>C c.131G>C	p.Gly44Ala p.Gly44Ala	probably damaging probably damaging
XPR1	Mutation	Missense	ENST00000367590.4	g.180849367G>A g.180849367G>A	c.1964G>A c.1964G>A	p.Arg655His p.Arg655His	probably damaging probably damaging
PLA2G4A	Mutation	Missense	ENST00000367466.3	g.186925434C>A g.186925434C>A	c.1537C>A c.1537C>A	p.Gln513Lys p.Gln513Lys	benign benign

Mutational Signature

Fusion transcripts (4)

Fusion Name	Gene (1)	Chr (1)	Genomic position hg19 (1)	Gene (2)	Chr (2)	Genomic position hg19 (2)	Supporting reads	Consistance fusion	Fusion type
GCN1--P2RX7	GCN1	chr12	120599683	P2RX7	chr12	121576100	26	NA	DUP
PHLDB2--PLCXD2	PLCXD2	chr3	111451549	PHLDB2	chr3	111632165	23	straight	DEL
PUDP--RP11-120D5.1	RP11-120D5.1	chrX	11074055	PUDP	chrX	7023878	13	NA	DEL
RNF5--RNF5P1	RNF5	chr6	32146568	RNF5P1	chr8	38458580	47	straight	TRANS

HBV RNA fusions (0)

Breakpoint on human genome (hg19)	Affected gene	Breakpoint on HBV genome (X02763)	Nb of paired reads (HG19 HBV)
No records found.

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)

Drugs (35)

DrugFilter by Drug	AUC	GI50
Paclitaxel	0.24	0.003
Vinblastine	0.35	0.006
Bortezomib	0.39	0.027
Dasatinib	0.59	5.025
Doxorubicin	0.6	0.152
Alvespimycin	0.61	0.378
PF.04691502	0.68	0.64
Tivantinib	0.7	0.545
Sorafenib_Trametinib	0.7	1.49
Sorafenib_Resminostat	0.78	1.66
Sorafenib_Refametinib	0.8	1.5
Rapamycin	0.8	10.0
BLU.9931	0.82	10.0
Tanespimycin	0.83	2.45
Entinostat	0.85	5.71

Liver Cancer Cell Lines Database

Cell Line: Huh6

Transcriptomic subgroup: CL1

Mutational Signature

Liver Cancer Cell Lines
Database