Liver Cancer Cell Lines
Database

LCCL to predict drug response

Cell Line: Huh6


Cell line description
Cell line nameSynonymsCellosaurus IDTumor typeReferenceSupplierCulture medium
Huh6 CVCL_4381 Hepatoblastoma Doi et al. Gan (1976) RIKEN BioResource Center - Japan DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

AgeGenderGeographic OriginEthnicityHBVHCV
1 Male Japan Asian No No

Transcriptomic subgroup: CL1


Mutations and CNAs (469)
Gene nameAlteration typeVariant classAnnotation transcriptgNomencNomenpNomenPPH pr├ędiction
NT5DC3MutationIn-FrameENST00000392876.3
g.104186946_104186948del
g.104186946_104186948del
c.1013_1015del
c.1013_1015del
p.Lys338del
p.Lys338del
damaging
damaging
FLIIMutationIn-FrameENST00000327031.4
g.18150110_18150112del
g.18150110_18150112del
c.2847_2849del
c.2847_2849del
p.Glu950del
p.Glu950del
damaging
damaging
SUPT20HL1MutationIn-FrameNM_001136234.1
g.24382519_24382536del
g.24382519_24382536del
c.1642_1659del
c.1642_1659del
p.Pro548_Ala553del
p.Pro548_Ala553del
damaging
damaging
SORBS2MutationIn-FrameENST00000284776.7
g.186533019_186533021del
g.186533019_186533021del
c.2997_2999del
c.2997_2999del
p.Lys999del
p.Lys999del
damaging
damaging
AMPD1MutationMissenseENST00000369538.3
g.115238109G>A
g.115238109G>A
c.83C>T
c.83C>T
p.Ser28Leu
p.Ser28Leu
damaging
damaging
NPPBMutationMissenseENST00000376468.3
g.11918421G>A
g.11918421G>A
c.238C>T
c.238C>T
p.Arg80Trp
p.Arg80Trp
possibly damaging
possibly damaging
MFN2MutationMissenseENST00000235329.5
g.12064980G>A
g.12064980G>A
c.1491G>A
c.1491G>A
p.Met497Ile
p.Met497Ile
benign
benign
SCNN1DMutationMissenseENST00000379101.4
g.1219428C>T
g.1219428C>T
c.422C>T
c.422C>T
p.Thr141Met
p.Thr141Met
benign
benign
GLTPD1MutationMissenseENST00000343938.4
g.1263017G>C
g.1263017G>C
c.519G>C
c.519G>C
p.Glu173Asp
p.Glu173Asp
benign
benign
PRAMEF1MutationMissenseENST00000332296.7
g.12854528T>C
g.12854528T>C
c.752T>C
c.752T>C
p.Leu251Pro
p.Leu251Pro
possibly damaging
possibly damaging
PRDM2MutationMissenseENST00000235372.7
g.14108437G>A
g.14108437G>A
c.4147G>A
c.4147G>A
p.Val1383Met
p.Val1383Met
probably damaging
probably damaging
POLR3CMutationMissenseENST00000334163.3
g.145597044G>A
g.145597044G>A
c.1081C>T
c.1081C>T
p.Arg361Cys
p.Arg361Cys
probably damaging
probably damaging
ANP32EMutationMissenseENST00000314136.8
g.150199042C>A
g.150199042C>A
c.579G>T
c.579G>T
p.Glu193Asp
p.Glu193Asp
benign
benign
NUP210LMutationMissenseENST00000271854.3
g.154026847C>T
g.154026847C>T
c.3340G>A
c.3340G>A
p.Val1114Ile
p.Val1114Ile
benign
benign
HAX1MutationMissenseENST00000328703.7
g.154247666C>T
g.154247666C>T
c.593C>T
c.593C>T
p.Pro198Leu
p.Pro198Leu
possibly damaging
possibly damaging
PKLRMutationMissenseENST00000392414.3
g.155270674T>C
g.155270674T>C
c.5A>G
c.5A>G
p.Glu2Gly (Splice)
p.Glu2Gly (Splice)
benign
benign
PRCCMutationMissenseENST00000271526.4
g.156737907C>T
g.156737907C>T
c.344C>T
c.344C>T
p.Pro115Leu
p.Pro115Leu
benign
benign
FHAD1MutationMissenseENST00000358897.4
g.15675557C>T
g.15675557C>T
c.2300C>T
c.2300C>T
p.Ala767Val
p.Ala767Val
possibly damaging
possibly damaging
SH2D2AMutationMissenseENST00000368199.3
g.156777059C>T
g.156777059C>T
c.1081G>A
c.1081G>A
p.Ala361Thr
p.Ala361Thr
benign
benign
VSIG8MutationMissenseENST00000368100.1
g.159827753C>T
g.159827753C>T
c.434G>A
c.434G>A
p.Arg145Gln
p.Arg145Gln
probably damaging
probably damaging
POGKMutationMissenseENST00000367875.1
g.166816764G>A
g.166816764G>A
c.293G>A
c.293G>A
p.Arg98His
p.Arg98His
possibly damaging
possibly damaging
DUSP27MutationMissenseENST00000271385.5
g.167096794C>T
g.167096794C>T
c.2426C>T
c.2426C>T
p.Ala809Val
p.Ala809Val
benign
benign
PADI3MutationMissenseENST00000375460.3
g.17586111G>C
g.17586111G>C
c.131G>C
c.131G>C
p.Gly44Ala
p.Gly44Ala
probably damaging
probably damaging
XPR1MutationMissenseENST00000367590.4
g.180849367G>A
g.180849367G>A
c.1964G>A
c.1964G>A
p.Arg655His
p.Arg655His
probably damaging
probably damaging
PLA2G4AMutationMissenseENST00000367466.3
g.186925434C>A
g.186925434C>A
c.1537C>A
c.1537C>A
p.Gln513Lys
p.Gln513Lys
benign
benign

Mutational Signature



Fusion transcripts (4)
Fusion NameGene (1)Chr (1)Genomic position hg19 (1)Gene (2)Chr (2)Genomic position hg19 (2)Supporting readsConsistance fusionFusion type
GCN1--P2RX7GCN1chr12120599683P2RX7chr1212157610026NADUP
PHLDB2--PLCXD2PLCXD2chr3111451549PHLDB2chr311163216523straightDEL
PUDP--RP11-120D5.1RP11-120D5.1chrX11074055PUDPchrX702387813NADEL
RNF5--RNF5P1RNF5chr632146568RNF5P1chr83845858047straightTRANS

HBV RNA fusions (0)
Breakpoint on human genome (hg19)Affected geneBreakpoint on HBV genome (X02763)Nb of paired reads (HG19 HBV)
No records found.

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)


Drugs (35)
DrugAUCGI50
Paclitaxel0.240.003
Vinblastine0.350.006
Bortezomib0.390.027
Dasatinib0.595.025
Doxorubicin0.60.152
Alvespimycin0.610.378
PF.046915020.680.64
Tivantinib0.70.545
Sorafenib_Trametinib0.71.49
Sorafenib_Resminostat0.781.66
Sorafenib_Refametinib0.81.5
Rapamycin0.810.0
BLU.99310.8210.0
Tanespimycin0.832.45
Trametinib0.8510.0


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