Liver Cancer Cell Lines
Database

LCCL to predict drug response

Cell Line: JHH2


Cell line description
Cell line nameSynonymsCellosaurus IDTumor typeReferenceSupplierCulture medium
JHH2 CVCL_2786 Hepatocellular Carcinoma Fujise K et al. Hepatogastroenterology (1990) [PMID: 1701409] JCRB - Japan DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

AgeGenderGeographic OriginEthnicityHBVHCV
57 Male Japan Asian No NA

Transcriptomic subgroup: CL2


Mutations and CNAs (421)
Gene nameAlteration typeVariant classAnnotation transcriptgNomencNomenpNomenPPH pr├ędiction
PHRF1MutationIn-FrameENST00000416188.2
g.607474_607476del
g.607474_607476del
c.2015_2017del
c.2015_2017del
p.Arg672del
p.Arg672del
damaging
damaging
ACSM3MutationIn-FrameENST00000289416.5
g.20808273_20808275del
g.20808273_20808275del
c.1740_1742del
c.1740_1742del
p.Lys581del
p.Lys581del
damaging
damaging
LRP2MutationIn-FrameENST00000263816.3
g.170063198_170063200del
g.170063198_170063200del
c.7030_7032del
c.7030_7032del
p.Asn2344del
p.Asn2344del
damaging
damaging
KPNA7MutationIn-FrameENST00000327442.6
g.98771410_98771412del
g.98771410_98771412del
c.1470_1472del
c.1470_1472del
p.Glu490del (Splice)
p.Glu490del (Splice)
damaging
damaging
CRHMutationIn-FrameENST00000276571.3
g.67089559_67089560insGCG
g.67089559_67089560insGCG
c.154_155insGCC
c.154_155insGCC
p.Pro51_Gln52insArg
p.Pro51_Gln52insArg
damaging
damaging
DBTMutationMissenseENST00000370131.3
g.100696450G>A
g.100696450G>A
c.272C>T
c.272C>T
p.Thr91Ile
p.Thr91Ile
benign
benign
EXTL2MutationMissenseENST00000370113.3
g.101339831G>C
g.101339831G>C
c.660C>G
c.660C>G
p.Ser220Arg
p.Ser220Arg
benign
benign
CELSR2MutationMissenseENST00000271332.3
g.109792780C>T
g.109792780C>T
c.79C>T
c.79C>T
p.Pro27Ser
p.Pro27Ser
benign
benign
TARDBPMutationMissenseENST00000240185.3
g.11080604T>A
g.11080604T>A
c.662T>A
c.662T>A
p.Phe221Tyr
p.Phe221Tyr
possibly damaging
possibly damaging
SLC16A4MutationMissenseENST00000369779.4
g.110921937G>C
g.110921937G>C
c.568C>G
c.568C>G
p.Pro190Ala
p.Pro190Ala
possibly damaging
possibly damaging
PHGDHMutationMissenseENST00000369409.4
g.120284468C>T
g.120284468C>T
c.1157C>T
c.1157C>T
p.Ala386Val
p.Ala386Val
benign
benign
MFN2MutationMissenseENST00000235329.5
g.12065963G>A
g.12065963G>A
c.1691G>A
c.1691G>A
p.Arg564Gln
p.Arg564Gln
possibly damaging
possibly damaging
PIP5K1AMutationMissenseENST00000368888.4
g.151204758A>C
g.151204758A>C
c.403A>C
c.403A>C
p.Asn135His
p.Asn135His
possibly damaging
possibly damaging
FLGMutationMissenseENST00000368799.1
g.152279617C>G
g.152279617C>G
c.7745G>C
c.7745G>C
p.Arg2582Thr
p.Arg2582Thr
benign
benign
FLG2MutationMissenseENST00000388718.5
g.152331326A>G
g.152331326A>G
c.35T>C
c.35T>C
p.Ile12Thr
p.Ile12Thr
possibly damaging
possibly damaging
KAZNMutationMissenseENST00000376030.2
g.15382719C>T
g.15382719C>T
c.859C>T
c.859C>T
p.Arg287Trp
p.Arg287Trp
probably damaging
probably damaging
CRTC2MutationMissenseENST00000368633.1
g.153925051T>G
g.153925051T>G
c.698A>C
c.698A>C
p.Lys233Thr
p.Lys233Thr
probably damaging
probably damaging
KCNN3MutationMissenseENST00000271915.4
g.154842210C>A
g.154842210C>A
c.231G>T
c.231G>T
p.Gln77His
p.Gln77His
benign
benign
UBQLN4MutationMissenseENST00000368309.3
g.156011760G>A
g.156011760G>A
c.1369C>T
c.1369C>T
p.Leu457Phe
p.Leu457Phe
probably damaging
probably damaging
ARHGEF19MutationMissenseENST00000270747.3
g.16525116C>T
g.16525116C>T
c.2375G>A
c.2375G>A
p.Ser792Asn
p.Ser792Asn
benign
benign
DUSP27MutationMissenseENST00000271385.5
g.167096794C>T
g.167096794C>T
c.2426C>T
c.2426C>T
p.Ala809Val
p.Ala809Val
benign
benign
ARHGEF10LMutationMissenseENST00000361221.3
g.18023630G>A
g.18023630G>A
c.3595G>A
c.3595G>A
p.Ala1199Thr
p.Ala1199Thr
benign
benign
HMCN1MutationMissenseENST00000271588.4
g.186057112C>G
g.186057112C>G
c.9412C>G
c.9412C>G
p.Arg3138Gly
p.Arg3138Gly
probably damaging
probably damaging
HMCN1MutationMissenseENST00000271588.4
g.186062340C>A
g.186062340C>A
c.9962C>A
c.9962C>A
p.Ala3321Asp
p.Ala3321Asp
probably damaging
probably damaging
IPO9MutationMissenseENST00000361565.4
g.201837847A>G
g.201837847A>G
c.1927A>G
c.1927A>G
p.Met643Val
p.Met643Val
benign
benign

Mutational Signature



Fusion transcripts (14)
Fusion NameGene (1)Chr (1)Genomic position hg19 (1)Gene (2)Chr (2)Genomic position hg19 (2)Supporting readsConsistance fusionFusion type
ARHGAP5--NUBPLARHGAP5chr1432563591NUBPLchr143231567669straightDUP
CCDC146--FBXL13FBXL13chr7102462486CCDC146chr77679692810straightINV
CTD-2277K2.1--FLJ22447CTD-2277K2.1chr1462394688FLJ22447chr146211767910NADUP
CYP1B1--PTPN1PTPN1chr2049127126CYP1B1chr23829845234straightTRANS
EIF3B--IQCEIQCEchr72617988EIF3Bchr72418323210straightDUP
FARP1--STK24FARP1chr1398811242STK24chr1399118499100invertedDEL
GAB2--ZFAND3ZFAND3chr637787791GAB2chr117799194617straightTRANS
KLHL20--SRGAP2KLHL20chr1173703424SRGAP2chr120662822311straightDEL
LOC101929371--RBL1RBL1chr2035635813LOC101929371chr20998716025NAINV
MBNL3--RAP2CMBNL3chrX131563840RAP2CchrX13135286426straightDEL
MKL1--TNRC6BTNRC6Bchr2240463928MKL1chr224091546715invertedDEL
NEO1--TUBGCP5TUBGCP5chr1522883157NEO1chr157347076671straightDUP
PATJ--SGIP1PATJchr162545237SGIP1chr16714280112NAINV
PDE4B--SGIP1PDE4Bchr166391890SGIP1chr16713253820straightDEL

HBV RNA fusions (0)
Breakpoint on human genome (hg19)Affected geneBreakpoint on HBV genome (X02763)Nb of paired reads (HG19 HBV)
No records found.

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)


Drugs (35)
DrugAUCGI50
Bortezomib0.550.095
Vinblastine0.560.098
Sorafenib_Trametinib0.610.16
Rapamycin0.6610.0
PF.046915020.690.465
Paclitaxel0.695.124
Doxorubicin0.730.77
Sorafenib_Refametinib0.741.23
Dasatinib0.8310.0
Sorafenib_Resminostat0.874.184
Sorafenib_MK.22060.896.216
Trametinib0.8910.0
Linsitinib0.9110.0
CD5320.914.781
MK.22060.9210.0


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