Liver Cancer Cell Lines Database

Cell line description

Cell line name	Synonyms	Cellosaurus ID	Tumor type	Reference	Supplier	Culture medium
JHH2		CVCL_2786	Hepatocellular Carcinoma	Fujise K et al. Hepatogastroenterology (1990) [PMID: 1701409]	JCRB - Japan	DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

Age	Gender	Geographic Origin	Ethnicity	HBV	HCV
57	Male	Japan	Asian	No	NA

Transcriptomic subgroup: CL2

Mutations and CNAs (421)

Gene nameFilter by Gene name	Alteration type	Variant class	Annotation transcript	gNomen	cNomen	pNomen	PPH prédiction
PHRF1	Mutation	In-Frame	ENST00000416188.2	g.607474_607476del g.607474_607476del	c.2015_2017del c.2015_2017del	p.Arg672del p.Arg672del	damaging damaging
ACSM3	Mutation	In-Frame	ENST00000289416.5	g.20808273_20808275del g.20808273_20808275del	c.1740_1742del c.1740_1742del	p.Lys581del p.Lys581del	damaging damaging
LRP2	Mutation	In-Frame	ENST00000263816.3	g.170063198_170063200del g.170063198_170063200del	c.7030_7032del c.7030_7032del	p.Asn2344del p.Asn2344del	damaging damaging
KPNA7	Mutation	In-Frame	ENST00000327442.6	g.98771410_98771412del g.98771410_98771412del	c.1470_1472del c.1470_1472del	p.Glu490del (Splice) p.Glu490del (Splice)	damaging damaging
CRH	Mutation	In-Frame	ENST00000276571.3	g.67089559_67089560insGCG g.67089559_67089560insGCG	c.154_155insGCC c.154_155insGCC	p.Pro51_Gln52insArg p.Pro51_Gln52insArg	damaging damaging
DBT	Mutation	Missense	ENST00000370131.3	g.100696450G>A g.100696450G>A	c.272C>T c.272C>T	p.Thr91Ile p.Thr91Ile	benign benign
EXTL2	Mutation	Missense	ENST00000370113.3	g.101339831G>C g.101339831G>C	c.660C>G c.660C>G	p.Ser220Arg p.Ser220Arg	benign benign
CELSR2	Mutation	Missense	ENST00000271332.3	g.109792780C>T g.109792780C>T	c.79C>T c.79C>T	p.Pro27Ser p.Pro27Ser	benign benign
TARDBP	Mutation	Missense	ENST00000240185.3	g.11080604T>A g.11080604T>A	c.662T>A c.662T>A	p.Phe221Tyr p.Phe221Tyr	possibly damaging possibly damaging
SLC16A4	Mutation	Missense	ENST00000369779.4	g.110921937G>C g.110921937G>C	c.568C>G c.568C>G	p.Pro190Ala p.Pro190Ala	possibly damaging possibly damaging
PHGDH	Mutation	Missense	ENST00000369409.4	g.120284468C>T g.120284468C>T	c.1157C>T c.1157C>T	p.Ala386Val p.Ala386Val	benign benign
MFN2	Mutation	Missense	ENST00000235329.5	g.12065963G>A g.12065963G>A	c.1691G>A c.1691G>A	p.Arg564Gln p.Arg564Gln	possibly damaging possibly damaging
PIP5K1A	Mutation	Missense	ENST00000368888.4	g.151204758A>C g.151204758A>C	c.403A>C c.403A>C	p.Asn135His p.Asn135His	possibly damaging possibly damaging
FLG	Mutation	Missense	ENST00000368799.1	g.152279617C>G g.152279617C>G	c.7745G>C c.7745G>C	p.Arg2582Thr p.Arg2582Thr	benign benign
FLG2	Mutation	Missense	ENST00000388718.5	g.152331326A>G g.152331326A>G	c.35T>C c.35T>C	p.Ile12Thr p.Ile12Thr	possibly damaging possibly damaging
KAZN	Mutation	Missense	ENST00000376030.2	g.15382719C>T g.15382719C>T	c.859C>T c.859C>T	p.Arg287Trp p.Arg287Trp	probably damaging probably damaging
CRTC2	Mutation	Missense	ENST00000368633.1	g.153925051T>G g.153925051T>G	c.698A>C c.698A>C	p.Lys233Thr p.Lys233Thr	probably damaging probably damaging
KCNN3	Mutation	Missense	ENST00000271915.4	g.154842210C>A g.154842210C>A	c.231G>T c.231G>T	p.Gln77His p.Gln77His	benign benign
UBQLN4	Mutation	Missense	ENST00000368309.3	g.156011760G>A g.156011760G>A	c.1369C>T c.1369C>T	p.Leu457Phe p.Leu457Phe	probably damaging probably damaging
ARHGEF19	Mutation	Missense	ENST00000270747.3	g.16525116C>T g.16525116C>T	c.2375G>A c.2375G>A	p.Ser792Asn p.Ser792Asn	benign benign
DUSP27	Mutation	Missense	ENST00000271385.5	g.167096794C>T g.167096794C>T	c.2426C>T c.2426C>T	p.Ala809Val p.Ala809Val	benign benign
ARHGEF10L	Mutation	Missense	ENST00000361221.3	g.18023630G>A g.18023630G>A	c.3595G>A c.3595G>A	p.Ala1199Thr p.Ala1199Thr	benign benign
HMCN1	Mutation	Missense	ENST00000271588.4	g.186057112C>G g.186057112C>G	c.9412C>G c.9412C>G	p.Arg3138Gly p.Arg3138Gly	probably damaging probably damaging
HMCN1	Mutation	Missense	ENST00000271588.4	g.186062340C>A g.186062340C>A	c.9962C>A c.9962C>A	p.Ala3321Asp p.Ala3321Asp	probably damaging probably damaging
IPO9	Mutation	Missense	ENST00000361565.4	g.201837847A>G g.201837847A>G	c.1927A>G c.1927A>G	p.Met643Val p.Met643Val	benign benign

Mutational Signature

Fusion transcripts (14)

Fusion Name	Gene (1)	Chr (1)	Genomic position hg19 (1)	Gene (2)	Chr (2)	Genomic position hg19 (2)	Supporting reads	Consistance fusion	Fusion type
ARHGAP5--NUBPL	ARHGAP5	chr14	32563591	NUBPL	chr14	32315676	69	straight	DUP
CCDC146--FBXL13	FBXL13	chr7	102462486	CCDC146	chr7	76796928	10	straight	INV
CTD-2277K2.1--FLJ22447	CTD-2277K2.1	chr14	62394688	FLJ22447	chr14	62117679	10	NA	DUP
CYP1B1--PTPN1	PTPN1	chr20	49127126	CYP1B1	chr2	38298452	34	straight	TRANS
EIF3B--IQCE	IQCE	chr7	2617988	EIF3B	chr7	2418323	210	straight	DUP
FARP1--STK24	FARP1	chr13	98811242	STK24	chr13	99118499	100	inverted	DEL
GAB2--ZFAND3	ZFAND3	chr6	37787791	GAB2	chr11	77991946	17	straight	TRANS
KLHL20--SRGAP2	KLHL20	chr1	173703424	SRGAP2	chr1	206628223	11	straight	DEL
LOC101929371--RBL1	RBL1	chr20	35635813	LOC101929371	chr20	9987160	25	NA	INV
MBNL3--RAP2C	MBNL3	chrX	131563840	RAP2C	chrX	131352864	26	straight	DEL
MKL1--TNRC6B	TNRC6B	chr22	40463928	MKL1	chr22	40915467	15	inverted	DEL
NEO1--TUBGCP5	TUBGCP5	chr15	22883157	NEO1	chr15	73470766	71	straight	DUP
PATJ--SGIP1	PATJ	chr1	62545237	SGIP1	chr1	67142801	12	NA	INV
PDE4B--SGIP1	PDE4B	chr1	66391890	SGIP1	chr1	67132538	20	straight	DEL

HBV RNA fusions (0)

Breakpoint on human genome (hg19)	Affected gene	Breakpoint on HBV genome (X02763)	Nb of paired reads (HG19 HBV)
No records found.

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)

Drugs (35)

DrugFilter by Drug	AUC	GI50
Bortezomib	0.55	0.095
Vinblastine	0.56	0.098
Sorafenib_Trametinib	0.61	0.16
Rapamycin	0.66	10.0
PF.04691502	0.69	0.465
Paclitaxel	0.69	5.124
Doxorubicin	0.73	0.77
Sorafenib_Refametinib	0.74	1.23
Dasatinib	0.83	10.0
Sorafenib_Resminostat	0.87	4.184
Sorafenib_MK.2206	0.89	6.216
Trametinib	0.89	10.0
Linsitinib	0.91	10.0
CD532	0.91	4.781
Resminostat	0.92	5.491

Liver Cancer Cell Lines Database

Cell Line: JHH2

Transcriptomic subgroup: CL2

Mutational Signature

Liver Cancer Cell Lines
Database