Liver Cancer Cell Lines
Database

LCCL to predict drug response

Cell Line: JHH6


Cell line description
Cell line nameSynonymsCellosaurus IDTumor typeReferenceSupplierCulture medium
JHH6 CVCL_2788 Hepatocellular Carcinoma Fujise K et al. Hepatogastroenterology (1990) [PMID: 1701409] JCRB - Japan Williams 'Medium E (#22551-022, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin + 1X glutamine

AgeGenderGeographic OriginEthnicityHBVHCV
57 Female Japan Asian No Yes

Transcriptomic subgroup: CL3


Mutations and CNAs (374)
Gene nameAlteration typeVariant classAnnotation transcriptgNomencNomenpNomenPPH pr├ędiction
AMER2MutationIn-FrameENST00000515384.1
g.25744837_25744838ins21
g.25744837_25744838ins21
c.920_921insAAGCCCCGGGCACCCCCCGAG
c.920_921insAAGCCCCGGGCACCCCCCGAG
p.Glu307_Pro308ins7
p.Glu307_Pro308ins7
damaging
damaging
UGGT2MutationIn-FrameENST00000376747.3
g.96555122_96555127del
g.96555122_96555127del
c.2483_2488del
c.2483_2488del
p.Ile828_Lys829del
p.Ile828_Lys829del
damaging
damaging
ZNF260MutationIn-FrameENST00000523638.1
g.37005316_37005321del
g.37005316_37005321del
c.820_825del
c.820_825del
p.Lys274_Pro275del
p.Lys274_Pro275del
damaging
damaging
MAST4MutationIn-FrameENST00000403625.2
g.66461184_66461186del
g.66461184_66461186del
c.6177_6179del
c.6177_6179del
p.Ser2060del
p.Ser2060del
damaging
damaging
DTNBP1MutationIn-FrameENST00000338950.5
g.15663043_15663047del
g.15663043_15663047del
c.54_56+2del
c.54_56+2del
p.Gly19del
p.Gly19del
damaging
damaging
OR6B1MutationIn-FrameENST00000408922.2
g.143701933_143701935del
g.143701933_143701935del
c.844_846del
c.844_846del
p.Ser282del
p.Ser282del
damaging
damaging
MTDHMutationIn-FrameENST00000336273.3
g.98657013_98657015del
g.98657013_98657015del
c.279_281del
c.279_281del
p.Ala94del
p.Ala94del
damaging
damaging
FRRS1MutationMissenseENST00000287474.5
g.100207773C>G
g.100207773C>G
c.390G>C
c.390G>C
p.Trp130Cys
p.Trp130Cys
probably damaging
probably damaging
COL11A1MutationMissenseENST00000370096.3
g.103444283G>A
g.103444283G>A
c.2735C>T
c.2735C>T
p.Pro912Leu
p.Pro912Leu
possibly damaging
possibly damaging
NBPF7MutationMissenseNM_001047980.2
g.120384206A>G
g.120384206A>G
c.356T>C
c.356T>C
p.Val119Ala
p.Val119Ala
benign
benign
LCE1CMutationMissenseENST00000368768.1
g.152777767C>T
g.152777767C>T
c.188G>A
c.188G>A
p.Ser63Asn
p.Ser63Asn
benign
benign
NPR1MutationMissenseENST00000368680.3
g.153651622G>T
g.153651622G>T
c.38G>T
c.38G>T
p.Arg13Leu
p.Arg13Leu
benign
benign
OR6K6MutationMissenseENST00000368144.2
g.158724723T>A
g.158724723T>A
c.118T>A
c.118T>A
p.Phe40Ile
p.Phe40Ile
possibly damaging
possibly damaging
LY9MutationMissenseENST00000263285.6
g.160784237C>T
g.160784237C>T
c.758C>T
c.758C>T
p.Thr253Met
p.Thr253Met
benign
benign
EPHA2MutationMissenseENST00000358432.5
g.16464614G>A
g.16464614G>A
c.1046C>T
c.1046C>T
p.Thr349Met
p.Thr349Met
possibly damaging
possibly damaging
RASAL2MutationMissenseENST00000462775.1
g.178421723G>A
g.178421723G>A
c.1501G>A
c.1501G>A
p.Asp501Asn
p.Asp501Asn
probably damaging
probably damaging
CEP350MutationMissenseENST00000367607.3
g.179989635A>C
g.179989635A>C
c.2726A>C
c.2726A>C
p.Asp909Ala
p.Asp909Ala
benign
benign
LHX4MutationMissenseENST00000263726.2
g.180240618C>G
g.180240618C>G
c.555C>G
c.555C>G
p.His185Gln
p.His185Gln
probably damaging
probably damaging
PIK3C2BMutationMissenseENST00000367187.3
g.204413520A>G
g.204413520A>G
c.2711T>C
c.2711T>C
p.Val904Ala
p.Val904Ala
probably damaging
probably damaging
HSPG2MutationMissenseENST00000374695.3
g.22155354C>A
g.22155354C>A
c.12211G>T
c.12211G>T
p.A4071S
p.A4071S
possibly damaging
possibly damaging
CCSAPMutationMissenseENST00000284617.2
g.229462631T>C
g.229462631T>C
c.490A>G
c.490A>G
p.Arg164Gly
p.Arg164Gly
probably damaging
probably damaging
NID1MutationMissenseENST00000264187.6
g.236143150T>G
g.236143150T>G
c.3481A>C
c.3481A>C
p.Lys1161Gln
p.Lys1161Gln
possibly damaging
possibly damaging
KIF26BMutationMissenseENST00000407071.2
g.245850456A>G
g.245850456A>G
c.4171A>G
c.4171A>G
p.Ile1391Val
p.Ile1391Val
benign
benign
SEPN1MutationMissenseENST00000361547.2
g.26140628T>C
g.26140628T>C
c.1561T>C
c.1561T>C
p.Phe521Leu
p.Phe521Leu
probably damaging
probably damaging
ZDHHC18MutationMissenseENST00000374142.4
g.27176861C>T
g.27176861C>T
c.716C>T
c.716C>T
p.Ala239Val
p.Ala239Val
probably damaging
probably damaging

Mutational Signature



Fusion transcripts (4)
Fusion NameGene (1)Chr (1)Genomic position hg19 (1)Gene (2)Chr (2)Genomic position hg19 (2)Supporting readsConsistance fusionFusion type
CCT3--TSACCCCT3chr1156303380TSACCchr115630802710invertedDUP
CDKN2A--CDKN2B-AS1CDKN2B-AS1chr922029592CDKN2Achr92196824040straightINV
LOC101928272--PHYHLOC101928272chr109320450PHYHchr101332568937NAINV
PRR16--RP11-574H6.1RP11-574H6.1chr5119722621PRR16chr511995278917invertedDEL

HBV RNA fusions (0)
Breakpoint on human genome (hg19)Affected geneBreakpoint on HBV genome (X02763)Nb of paired reads (HG19 HBV)
No records found.

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)


Drugs (35)
DrugAUCGI50
Paclitaxel0.40.006
Bortezomib0.520.076
Vinblastine0.550.061
CD5320.610.313
Doxorubicin0.690.367
Tivantinib0.70.755
PF.046915020.710.59
Alvespimycin0.720.47
Tanespimycin0.731.143
Alisertib0.86.241
Dasatinib0.8210.0
Sorafenib_MK.22060.823.55
Rapamycin0.838.485
Sorafenib_Resminostat0.885.65
PHA.6657520.884.137


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