Liver Cancer Cell Lines Database

Cell line description

Cell line name	Synonyms	Cellosaurus ID	Tumor type	Reference	Supplier	Culture medium
JHH6		CVCL_2788	Hepatocellular Carcinoma	Fujise K et al. Hepatogastroenterology (1990) [PMID: 1701409]	JCRB - Japan	Williams 'Medium E (#22551-022, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin + 1X glutamine

Age	Gender	Geographic Origin	Ethnicity	HBV	HCV
57	Female	Japan	Asian	No	Yes

Transcriptomic subgroup: CL3

Mutations and CNAs (374)

Gene nameFilter by Gene name	Alteration type	Variant class	Annotation transcript	gNomen	cNomen	pNomen	PPH prédiction
AMER2	Mutation	In-Frame	ENST00000515384.1	g.25744837_25744838ins21 g.25744837_25744838ins21	c.920_921insAAGCCCCGGGCACCCCCCGAG c.920_921insAAGCCCCGGGCACCCCCCGAG	p.Glu307_Pro308ins7 p.Glu307_Pro308ins7	damaging damaging
UGGT2	Mutation	In-Frame	ENST00000376747.3	g.96555122_96555127del g.96555122_96555127del	c.2483_2488del c.2483_2488del	p.Ile828_Lys829del p.Ile828_Lys829del	damaging damaging
ZNF260	Mutation	In-Frame	ENST00000523638.1	g.37005316_37005321del g.37005316_37005321del	c.820_825del c.820_825del	p.Lys274_Pro275del p.Lys274_Pro275del	damaging damaging
MAST4	Mutation	In-Frame	ENST00000403625.2	g.66461184_66461186del g.66461184_66461186del	c.6177_6179del c.6177_6179del	p.Ser2060del p.Ser2060del	damaging damaging
DTNBP1	Mutation	In-Frame	ENST00000338950.5	g.15663043_15663047del g.15663043_15663047del	c.54_56+2del c.54_56+2del	p.Gly19del p.Gly19del	damaging damaging
OR6B1	Mutation	In-Frame	ENST00000408922.2	g.143701933_143701935del g.143701933_143701935del	c.844_846del c.844_846del	p.Ser282del p.Ser282del	damaging damaging
MTDH	Mutation	In-Frame	ENST00000336273.3	g.98657013_98657015del g.98657013_98657015del	c.279_281del c.279_281del	p.Ala94del p.Ala94del	damaging damaging
FRRS1	Mutation	Missense	ENST00000287474.5	g.100207773C>G g.100207773C>G	c.390G>C c.390G>C	p.Trp130Cys p.Trp130Cys	probably damaging probably damaging
COL11A1	Mutation	Missense	ENST00000370096.3	g.103444283G>A g.103444283G>A	c.2735C>T c.2735C>T	p.Pro912Leu p.Pro912Leu	possibly damaging possibly damaging
NBPF7	Mutation	Missense	NM_001047980.2	g.120384206A>G g.120384206A>G	c.356T>C c.356T>C	p.Val119Ala p.Val119Ala	benign benign
LCE1C	Mutation	Missense	ENST00000368768.1	g.152777767C>T g.152777767C>T	c.188G>A c.188G>A	p.Ser63Asn p.Ser63Asn	benign benign
NPR1	Mutation	Missense	ENST00000368680.3	g.153651622G>T g.153651622G>T	c.38G>T c.38G>T	p.Arg13Leu p.Arg13Leu	benign benign
OR6K6	Mutation	Missense	ENST00000368144.2	g.158724723T>A g.158724723T>A	c.118T>A c.118T>A	p.Phe40Ile p.Phe40Ile	possibly damaging possibly damaging
LY9	Mutation	Missense	ENST00000263285.6	g.160784237C>T g.160784237C>T	c.758C>T c.758C>T	p.Thr253Met p.Thr253Met	benign benign
EPHA2	Mutation	Missense	ENST00000358432.5	g.16464614G>A g.16464614G>A	c.1046C>T c.1046C>T	p.Thr349Met p.Thr349Met	possibly damaging possibly damaging
RASAL2	Mutation	Missense	ENST00000462775.1	g.178421723G>A g.178421723G>A	c.1501G>A c.1501G>A	p.Asp501Asn p.Asp501Asn	probably damaging probably damaging
CEP350	Mutation	Missense	ENST00000367607.3	g.179989635A>C g.179989635A>C	c.2726A>C c.2726A>C	p.Asp909Ala p.Asp909Ala	benign benign
LHX4	Mutation	Missense	ENST00000263726.2	g.180240618C>G g.180240618C>G	c.555C>G c.555C>G	p.His185Gln p.His185Gln	probably damaging probably damaging
PIK3C2B	Mutation	Missense	ENST00000367187.3	g.204413520A>G g.204413520A>G	c.2711T>C c.2711T>C	p.Val904Ala p.Val904Ala	probably damaging probably damaging
HSPG2	Mutation	Missense	ENST00000374695.3	g.22155354C>A g.22155354C>A	c.12211G>T c.12211G>T	p.A4071S p.A4071S	possibly damaging possibly damaging
CCSAP	Mutation	Missense	ENST00000284617.2	g.229462631T>C g.229462631T>C	c.490A>G c.490A>G	p.Arg164Gly p.Arg164Gly	probably damaging probably damaging
NID1	Mutation	Missense	ENST00000264187.6	g.236143150T>G g.236143150T>G	c.3481A>C c.3481A>C	p.Lys1161Gln p.Lys1161Gln	possibly damaging possibly damaging
KIF26B	Mutation	Missense	ENST00000407071.2	g.245850456A>G g.245850456A>G	c.4171A>G c.4171A>G	p.Ile1391Val p.Ile1391Val	benign benign
SEPN1	Mutation	Missense	ENST00000361547.2	g.26140628T>C g.26140628T>C	c.1561T>C c.1561T>C	p.Phe521Leu p.Phe521Leu	probably damaging probably damaging
ZDHHC18	Mutation	Missense	ENST00000374142.4	g.27176861C>T g.27176861C>T	c.716C>T c.716C>T	p.Ala239Val p.Ala239Val	probably damaging probably damaging

Mutational Signature

Fusion transcripts (4)

Fusion Name	Gene (1)	Chr (1)	Genomic position hg19 (1)	Gene (2)	Chr (2)	Genomic position hg19 (2)	Supporting reads	Consistance fusion	Fusion type
CCT3--TSACC	CCT3	chr1	156303380	TSACC	chr1	156308027	10	inverted	DUP
CDKN2A--CDKN2B-AS1	CDKN2B-AS1	chr9	22029592	CDKN2A	chr9	21968240	40	straight	INV
LOC101928272--PHYH	LOC101928272	chr10	9320450	PHYH	chr10	13325689	37	NA	INV
PRR16--RP11-574H6.1	RP11-574H6.1	chr5	119722621	PRR16	chr5	119952789	17	inverted	DEL

HBV RNA fusions (0)

Breakpoint on human genome (hg19)	Affected gene	Breakpoint on HBV genome (X02763)	Nb of paired reads (HG19 HBV)
No records found.

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)

Drugs (35)

DrugFilter by Drug	AUC	GI50
Paclitaxel	0.4	0.006
Bortezomib	0.52	0.076
Vinblastine	0.55	0.061
CD532	0.61	0.313
Doxorubicin	0.69	0.367
Tivantinib	0.7	0.755
PF.04691502	0.71	0.59
Alvespimycin	0.72	0.47
Tanespimycin	0.73	1.143
Alisertib	0.8	6.241
Dasatinib	0.82	10.0
Sorafenib_MK.2206	0.82	3.55
Rapamycin	0.83	8.485
Sorafenib_Resminostat	0.88	5.65
MK.2206	0.88	4.25

Liver Cancer Cell Lines Database

Cell Line: JHH6

Transcriptomic subgroup: CL3

Mutational Signature

Liver Cancer Cell Lines
Database