Liver Cancer Cell Lines Database

Cell line description

Cell line name	Synonyms	Cellosaurus ID	Tumor type	Reference	Supplier	Culture medium
JHH7		CVCL_2805	Hepatocellular Carcinoma	Fujise K et al. Hepatogastroenterology (1990) [PMID: 1701409]	JCRB - Japan	DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

Age	Gender	Geographic Origin	Ethnicity	HBV	HCV
53	Male	Japan	Asian	Yes	NA

Transcriptomic subgroup: CL1

Mutations and CNAs (705)

Gene nameFilter by Gene name	Alteration type	Variant class	Annotation transcript	gNomen	cNomen	pNomen	PPH prédiction
SLC16A1	Mutation	In-Frame	ENST00000369626.3	g.113460320_113460322del g.113460320_113460322del	c.706_708del c.706_708del	p.Arg236del p.Arg236del	damaging damaging
ITPR2	Mutation	In-Frame	ENST00000381340.3	g.26709269_26709289del g.26709269_26709289del	c.4841_4861del c.4841_4861del	p.Glu1614_Met1621delinsVal p.Glu1614_Met1621delinsVal	damaging damaging
RP11-166B2.1	Mutation	In-Frame	ENST00000399147.4	g.12021341_12021342insTGG g.12021341_12021342insTGG	c.1082_1083insCCA c.1082_1083insCCA	p.361_361E>DQ p.361_361E>DQ	damaging damaging
AXIN1	Mutation	In-Frame	ENST00000262320.3	g.396700_396744del g.396700_396744del	c.282_326del c.282_326del	p.Asp94_Gln108del p.Asp94_Gln108del	damaging damaging
FABP2	Mutation	In-Frame	ENST00000274024.3	g.120240701_120240703del g.120240701_120240703del	c.336_338del c.336_338del	p.Asp112del p.Asp112del	damaging damaging
KIF1B	Mutation	Missense	ENST00000377081.1	g.10355737G>A g.10355737G>A	c.1690G>A c.1690G>A	p.Glu564Lys p.Glu564Lys	benign benign
ADORA3	Mutation	Missense	ENST00000241356.4	g.112045778G>T g.112045778G>T	c.199C>A c.199C>A	p.Pro67Thr p.Pro67Thr	probably damaging probably damaging
SLC16A1	Mutation	Missense	ENST00000369626.3	g.113460325C>G g.113460325C>G	c.703G>C c.703G>C	p.Gly235Arg p.Gly235Arg	possibly damaging possibly damaging
TNFRSF18	Mutation	Missense	ENST00000328596.6	g.1141926G>A g.1141926G>A	c.26C>T c.26C>T	p.Ala9Val p.Ala9Val	benign benign
HIPK1	Mutation	Missense	ENST00000369554.2	g.114499274G>A g.114499274G>A	c.1433G>A c.1433G>A	p.Gly478Glu p.Gly478Glu	probably damaging probably damaging
TTF2	Mutation	Missense	ENST00000369466.4	g.117635518A>G g.117635518A>G	c.2971A>G c.2971A>G	p.Thr991Ala p.Thr991Ala	possibly damaging possibly damaging
SPAG17	Mutation	Missense	ENST00000336338.5	g.118548200A>T g.118548200A>T	c.4613T>A c.4613T>A	p.Leu1538His p.Leu1538His	probably damaging probably damaging
BCL9	Mutation	Missense	ENST00000234739.3	g.147092314C>A g.147092314C>A	c.2353C>A c.2353C>A	p.Leu785Ile p.Leu785Ile	benign benign
ACP6	Mutation	Missense	ENST00000369238.6	g.147121998C>T g.147121998C>T	c.925G>A c.925G>A	p.Glu309Lys p.Glu309Lys	benign benign
FLG	Mutation	Missense	ENST00000368799.1	g.152280589C>T g.152280589C>T	c.6773G>A c.6773G>A	p.Arg2258Lys p.Arg2258Lys	possibly damaging possibly damaging
INTS3	Mutation	Missense	ENST00000318967.2	g.153742707A>G g.153742707A>G	c.2423A>G c.2423A>G	p.Tyr808Cys p.Tyr808Cys	probably damaging probably damaging
AQP10	Mutation	Missense	ENST00000324978.3	g.154296786G>A g.154296786G>A	c.736G>A c.736G>A	p.Val246Met p.Val246Met	possibly damaging possibly damaging
RAB25	Mutation	Missense	ENST00000361084.5	g.156038092G>A g.156038092G>A	c.271G>A c.271G>A	p.Val91Met p.Val91Met	probably damaging probably damaging
SLC35E2B	Mutation	Missense	ENST00000234800.6	g.1599887C>T g.1599887C>T	c.859G>A c.859G>A	p.Gly287Arg p.Gly287Arg	benign benign
DUSP12	Mutation	Missense	ENST00000367943.4	g.161726633T>C g.161726633T>C	c.919T>C c.919T>C	p.Cys307Arg p.Cys307Arg	probably damaging probably damaging
TNR	Mutation	Missense	ENST00000263525.2	g.175293532G>C g.175293532G>C	c.3917C>G c.3917C>G	p.Thr1306Ser p.Thr1306Ser	benign benign
ASTN1	Mutation	Missense	ENST00000361833.2	g.176998875C>A g.176998875C>A	c.1015G>T c.1015G>T	p.Gly339Cys (Splice) p.Gly339Cys (Splice)	probably damaging probably damaging
TPR	Mutation	Missense	ENST00000367478.4	g.186321206G>A g.186321206G>A	c.2371C>T c.2371C>T	p.Leu791Phe p.Leu791Phe	probably damaging probably damaging
CFH	Mutation	Missense	ENST00000359637.2	g.196654257G>A g.196654257G>A	c.662G>A c.662G>A	p.Arg221Lys p.Arg221Lys	probably damaging probably damaging
CFHR3	Mutation	Missense	ENST00000367425.4	g.196748355C>G g.196748355C>G	c.122C>G c.122C>G	p.Pro41Arg p.Pro41Arg	benign benign

Mutational Signature

Fusion transcripts (15)

Fusion Name	Gene (1)	Chr (1)	Genomic position hg19 (1)	Gene (2)	Chr (2)	Genomic position hg19 (2)	Supporting reads	Consistance fusion	Fusion type
AC018816.3--ITPR1	ITPR1	chr3	4562777	AC018816.3	chr3	4920034	51	inverted	DEL
AL121578.2--SYTL5	AL121578.2	chrX	37766092	SYTL5	chrX	37892786	25	straight	DEL
AP3D1--MKNK2	MKNK2	chr19	2041038	AP3D1	chr19	2102266	33	straight	DUP
C16orf70--CBFB	C16orf70	chr16	67178278	CBFB	chr16	67132612	170	straight	DUP
C22orf39--HIRA	C22orf39	chr22	19431534	HIRA	chr22	19319078	56	straight	DEL
CASS4--TMEM120B	TMEM120B	chr12	122150866	CASS4	chr20	54987389	15	straight	TRANS
CTSC--RAB38	CTSC	chr11	88033697	RAB38	chr11	87883122	36	straight	DEL
DEPDC1B--PDE4D	DEPDC1B	chr5	59934576	PDE4D	chr5	59284543	18	straight	DEL
DUSP6--POC1B	POC1B	chr12	89860546	DUSP6	chr12	89743337	10	straight	DEL
GNPNAT1--TXNDC16	GNPNAT1	chr14	53258145	TXNDC16	chr14	53011088	14	straight	DEL
LINC01508--RAPGEF1	LINC01508	chr9	93131094	RAPGEF1	chr9	134497182	170	NA	INV
LOC105371907--SEPT9	LOC105371907	chr17	75277635	set-09	chr17	75486823	117	NA	DEL
MYO6--SENP6	SENP6	chr6	76380435	MYO6	chr6	76527217	51	straight	DEL
PDE3A--SLCO1C1	PDE3A	chr12	20523177	SLCO1C1	chr12	20893117	39	straight	DEL
TVP23C--TVP23C-CDRT4	TVP23C	chr17	15449098	TVP23C-CDRT4	chr17	15341516	57	straight	DEL

HBV RNA fusions (0)

Breakpoint on human genome (hg19)	Affected gene	Breakpoint on HBV genome (X02763)	Nb of paired reads (HG19 HBV)
No records found.

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)

Drugs (35)

DrugFilter by Drug	AUC	GI50
Paclitaxel	0.3	0.005
Bortezomib	0.38	0.025
Vinblastine	0.39	0.008
Alvespimycin	0.56	0.092
Tanespimycin	0.59	0.19
Tivantinib	0.65	0.345
Rapamycin	0.66	10.0
Doxorubicin	0.67	0.55
PF.04691502	0.68	0.775
CD532	0.68	0.58
Sorafenib_Resminostat	0.71	1.074
Sorafenib_Trametinib	0.72	1.84
Alisertib	0.72	0.62
Sorafenib_MK.2206	0.74	1.312
Trametinib	0.76	7.52

Liver Cancer Cell Lines Database

Cell Line: JHH7

Transcriptomic subgroup: CL1

Mutational Signature

Liver Cancer Cell Lines
Database