Liver Cancer Cell Lines
Database

LCCL to predict drug response

Cell Line: JHH7


Cell line description
Cell line nameSynonymsCellosaurus IDTumor typeReferenceSupplierCulture medium
JHH7 CVCL_2805 Hepatocellular Carcinoma Fujise K et al. Hepatogastroenterology (1990) [PMID: 1701409] JCRB - Japan DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

AgeGenderGeographic OriginEthnicityHBVHCV
53 Male Japan Asian Yes NA

Transcriptomic subgroup: CL1


Mutations and CNAs (705)
Gene nameAlteration typeVariant classAnnotation transcriptgNomencNomenpNomenPPH pr├ędiction
SLC16A1MutationIn-FrameENST00000369626.3
g.113460320_113460322del
g.113460320_113460322del
c.706_708del
c.706_708del
p.Arg236del
p.Arg236del
damaging
damaging
ITPR2MutationIn-FrameENST00000381340.3
g.26709269_26709289del
g.26709269_26709289del
c.4841_4861del
c.4841_4861del
p.Glu1614_Met1621delinsVal
p.Glu1614_Met1621delinsVal
damaging
damaging
RP11-166B2.1MutationIn-FrameENST00000399147.4
g.12021341_12021342insTGG
g.12021341_12021342insTGG
c.1082_1083insCCA
c.1082_1083insCCA
p.361_361E>DQ
p.361_361E>DQ
damaging
damaging
AXIN1MutationIn-FrameENST00000262320.3
g.396700_396744del
g.396700_396744del
c.282_326del
c.282_326del
p.Asp94_Gln108del
p.Asp94_Gln108del
damaging
damaging
FABP2MutationIn-FrameENST00000274024.3
g.120240701_120240703del
g.120240701_120240703del
c.336_338del
c.336_338del
p.Asp112del
p.Asp112del
damaging
damaging
KIF1BMutationMissenseENST00000377081.1
g.10355737G>A
g.10355737G>A
c.1690G>A
c.1690G>A
p.Glu564Lys
p.Glu564Lys
benign
benign
ADORA3MutationMissenseENST00000241356.4
g.112045778G>T
g.112045778G>T
c.199C>A
c.199C>A
p.Pro67Thr
p.Pro67Thr
probably damaging
probably damaging
SLC16A1MutationMissenseENST00000369626.3
g.113460325C>G
g.113460325C>G
c.703G>C
c.703G>C
p.Gly235Arg
p.Gly235Arg
possibly damaging
possibly damaging
TNFRSF18MutationMissenseENST00000328596.6
g.1141926G>A
g.1141926G>A
c.26C>T
c.26C>T
p.Ala9Val
p.Ala9Val
benign
benign
HIPK1MutationMissenseENST00000369554.2
g.114499274G>A
g.114499274G>A
c.1433G>A
c.1433G>A
p.Gly478Glu
p.Gly478Glu
probably damaging
probably damaging
TTF2MutationMissenseENST00000369466.4
g.117635518A>G
g.117635518A>G
c.2971A>G
c.2971A>G
p.Thr991Ala
p.Thr991Ala
possibly damaging
possibly damaging
SPAG17MutationMissenseENST00000336338.5
g.118548200A>T
g.118548200A>T
c.4613T>A
c.4613T>A
p.Leu1538His
p.Leu1538His
probably damaging
probably damaging
BCL9MutationMissenseENST00000234739.3
g.147092314C>A
g.147092314C>A
c.2353C>A
c.2353C>A
p.Leu785Ile
p.Leu785Ile
benign
benign
ACP6MutationMissenseENST00000369238.6
g.147121998C>T
g.147121998C>T
c.925G>A
c.925G>A
p.Glu309Lys
p.Glu309Lys
benign
benign
FLGMutationMissenseENST00000368799.1
g.152280589C>T
g.152280589C>T
c.6773G>A
c.6773G>A
p.Arg2258Lys
p.Arg2258Lys
possibly damaging
possibly damaging
INTS3MutationMissenseENST00000318967.2
g.153742707A>G
g.153742707A>G
c.2423A>G
c.2423A>G
p.Tyr808Cys
p.Tyr808Cys
probably damaging
probably damaging
AQP10MutationMissenseENST00000324978.3
g.154296786G>A
g.154296786G>A
c.736G>A
c.736G>A
p.Val246Met
p.Val246Met
possibly damaging
possibly damaging
RAB25MutationMissenseENST00000361084.5
g.156038092G>A
g.156038092G>A
c.271G>A
c.271G>A
p.Val91Met
p.Val91Met
probably damaging
probably damaging
SLC35E2BMutationMissenseENST00000234800.6
g.1599887C>T
g.1599887C>T
c.859G>A
c.859G>A
p.Gly287Arg
p.Gly287Arg
benign
benign
DUSP12MutationMissenseENST00000367943.4
g.161726633T>C
g.161726633T>C
c.919T>C
c.919T>C
p.Cys307Arg
p.Cys307Arg
probably damaging
probably damaging
TNRMutationMissenseENST00000263525.2
g.175293532G>C
g.175293532G>C
c.3917C>G
c.3917C>G
p.Thr1306Ser
p.Thr1306Ser
benign
benign
ASTN1MutationMissenseENST00000361833.2
g.176998875C>A
g.176998875C>A
c.1015G>T
c.1015G>T
p.Gly339Cys (Splice)
p.Gly339Cys (Splice)
probably damaging
probably damaging
TPRMutationMissenseENST00000367478.4
g.186321206G>A
g.186321206G>A
c.2371C>T
c.2371C>T
p.Leu791Phe
p.Leu791Phe
probably damaging
probably damaging
CFHMutationMissenseENST00000359637.2
g.196654257G>A
g.196654257G>A
c.662G>A
c.662G>A
p.Arg221Lys
p.Arg221Lys
probably damaging
probably damaging
CFHR3MutationMissenseENST00000367425.4
g.196748355C>G
g.196748355C>G
c.122C>G
c.122C>G
p.Pro41Arg
p.Pro41Arg
benign
benign

Mutational Signature



Fusion transcripts (15)
Fusion NameGene (1)Chr (1)Genomic position hg19 (1)Gene (2)Chr (2)Genomic position hg19 (2)Supporting readsConsistance fusionFusion type
AC018816.3--ITPR1ITPR1chr34562777AC018816.3chr3492003451invertedDEL
AL121578.2--SYTL5AL121578.2chrX37766092SYTL5chrX3789278625straightDEL
AP3D1--MKNK2MKNK2chr192041038AP3D1chr19210226633straightDUP
C16orf70--CBFBC16orf70chr1667178278CBFBchr1667132612170straightDUP
C22orf39--HIRAC22orf39chr2219431534HIRAchr221931907856straightDEL
CASS4--TMEM120BTMEM120Bchr12122150866CASS4chr205498738915straightTRANS
CTSC--RAB38CTSCchr1188033697RAB38chr118788312236straightDEL
DEPDC1B--PDE4DDEPDC1Bchr559934576PDE4Dchr55928454318straightDEL
DUSP6--POC1BPOC1Bchr1289860546DUSP6chr128974333710straightDEL
GNPNAT1--TXNDC16GNPNAT1chr1453258145TXNDC16chr145301108814straightDEL
LINC01508--RAPGEF1LINC01508chr993131094RAPGEF1chr9134497182170NAINV
LOC105371907--SEPT9LOC105371907chr1775277635set-09chr1775486823117NADEL
MYO6--SENP6SENP6chr676380435MYO6chr67652721751straightDEL
PDE3A--SLCO1C1PDE3Achr1220523177SLCO1C1chr122089311739straightDEL
TVP23C--TVP23C-CDRT4TVP23Cchr1715449098TVP23C-CDRT4chr171534151657straightDEL

HBV RNA fusions (0)
Breakpoint on human genome (hg19)Affected geneBreakpoint on HBV genome (X02763)Nb of paired reads (HG19 HBV)
No records found.

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)


Drugs (35)
DrugAUCGI50
Paclitaxel0.30.005
Bortezomib0.380.025
Vinblastine0.390.008
Alvespimycin0.560.092
Tanespimycin0.590.19
Tivantinib0.650.345
Rapamycin0.6610.0
Doxorubicin0.670.55
CD5320.680.58
PF.046915020.680.775
Sorafenib_Resminostat0.711.074
Alisertib0.720.62
Sorafenib_Trametinib0.721.84
Sorafenib_MK.22060.741.312
Trametinib0.767.52


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