Liver Cancer Cell Lines Database

Cell line description

Cell line name	Synonyms	Cellosaurus ID	Tumor type	Reference	Supplier	Culture medium
Li7		CVCL_3840	Hepatocellular Carcinoma	Tanno, H. (Tohoku Univ., 1st Surg)	RIKEN BioResource Center - Japan	DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

Age	Gender	Geographic Origin	Ethnicity	HBV	HCV
45	Male	Japan	Asian	No	No

Transcriptomic subgroup: CL2

Mutations and CNAs (455)

Gene nameFilter by Gene name	Alteration type	Variant class	Annotation transcript	gNomen	cNomen	pNomen	PPH prédiction
ASPM	Mutation	In-Frame	ENST00000367409.4	g.197074046_197074047ins15 g.197074046_197074047ins15	c.4335_4336insCACAAGTAAAAGCTT c.4335_4336insCACAAGTAAAAGCTT	p.Thr1446_Tyr3477delinsHisLysX p.Thr1446_Tyr3477delinsHisLysX	damaging damaging
WSCD1	Mutation	In-Frame	ENST00000317744.5	g.6023703_6023726del g.6023703_6023726del	c.1450_1473del c.1450_1473del	p.Arg484_Glu491del p.Arg484_Glu491del	damaging damaging
HECW2	Mutation	In-Frame	ENST00000260983.3	g.197184102_197184122del g.197184102_197184122del	c.1492_1512del c.1492_1512del	p.Asp498_Ser504del p.Asp498_Ser504del	damaging damaging
WFDC9	Mutation	In-Frame	ENST00000326000.1	g.44237437_44237439del g.44237437_44237439del	c.102_104del c.102_104del	p.Met34del p.Met34del	damaging damaging
TFR2	Mutation	In-Frame	ENST00000223051.3	g.100225010_100225021del g.100225010_100225021del	c.1861_1872del c.1861_1872del	p.Ala621_Gln624del p.Ala621_Gln624del	damaging damaging
SIKE1	Mutation	Missense	ENST00000060969.5	g.115316919C>A g.115316919C>A	c.597G>T c.597G>T	p.Met199Ile p.Met199Ile	benign benign
TRIM45	Mutation	Missense	ENST00000256649.4	g.117658296C>G g.117658296C>G	c.1368G>C c.1368G>C	p.Met456Ile p.Met456Ile	benign benign
ADAM30	Mutation	Missense	ENST00000369400.1	g.120437395C>T g.120437395C>T	c.1565G>A c.1565G>A	p.Cys522Tyr p.Cys522Tyr	probably damaging probably damaging
TCHH	Mutation	Missense	ENST00000368804.1	g.152084726C>G g.152084726C>G	c.967G>C c.967G>C	p.Glu323Gln p.Glu323Gln	benign benign
IVL	Mutation	Missense	ENST00000368764.3	g.152883061T>C g.152883061T>C	c.788T>C c.788T>C	p.Leu263Pro p.Leu263Pro	probably damaging probably damaging
KCNN3	Mutation	Missense	ENST00000271915.4	g.154842202T>G g.154842202T>G	c.239A>C c.239A>C	p.Gln80Pro p.Gln80Pro	benign benign
GON4L	Mutation	Missense	ENST00000271883.5	g.155735240G>A g.155735240G>A	c.4024C>T c.4024C>T	p.Arg1342Cys p.Arg1342Cys	benign benign
TMEM79	Mutation	Missense	ENST00000295694.5	g.156255135G>A g.156255135G>A	c.118G>A c.118G>A	p.Glu40Lys p.Glu40Lys	possibly damaging possibly damaging
BCAN	Mutation	Missense	ENST00000329117.5	g.156626789T>C g.156626789T>C	c.2110T>C c.2110T>C	p.Ser704Pro p.Ser704Pro	benign benign
FHAD1	Mutation	Missense	ENST00000358897.4	g.15675578A>G g.15675578A>G	c.2321A>G c.2321A>G	p.Lys774Arg p.Lys774Arg	benign benign
OR6K2	Mutation	Missense	ENST00000359610.2	g.158670216G>T g.158670216G>T	c.227C>A c.227C>A	p.Ala76Asp p.Ala76Asp	possibly damaging possibly damaging
LAMC2	Mutation	Missense	ENST00000264144.4	g.183204775C>G g.183204775C>G	c.2366C>G c.2366C>G	p.Ala789Gly p.Ala789Gly	possibly damaging possibly damaging
SMG7	Mutation	Missense	ENST00000347615.2	g.183498585A>G g.183498585A>G	c.760A>G c.760A>G	p.Ile254Val p.Ile254Val	benign benign
RGS18	Mutation	Missense	ENST00000367460.3	g.192128438G>A g.192128438G>A	c.208G>A c.208G>A	p.Ala70Thr p.Ala70Thr	benign benign
LGR6	Mutation	Missense	ENST00000367278.3	g.202266680G>A g.202266680G>A	c.761G>A c.761G>A	p.Arg254Gln p.Arg254Gln	possibly damaging possibly damaging
KIF17	Mutation	Missense	ENST00000247986.2	g.21030995C>G g.21030995C>G	c.1068G>C c.1068G>C	p.Glu356Asp p.Glu356Asp	probably damaging probably damaging
WNT4	Mutation	Missense	ENST00000290167.6	g.22456307C>T g.22456307C>T	c.115G>A c.115G>A	p.Glu39Lys p.Glu39Lys	benign benign
DNAH14	Mutation	Missense	ENST00000430092.1	g.225534194T>C g.225534194T>C	c.10855T>C c.10855T>C	p.Cys3619Arg p.Cys3619Arg	probably damaging probably damaging
TMEM63A	Mutation	Missense	ENST00000366835.3	g.226044654A>G g.226044654A>G	c.1441T>C c.1441T>C	p.Ser481Pro p.Ser481Pro	benign benign
TRIM17	Mutation	Missense	ENST00000295033.3	g.228598783A>G g.228598783A>G	c.620T>C c.620T>C	p.Leu207Pro p.Leu207Pro	probably damaging probably damaging

Mutational Signature

Fusion transcripts (13)

Fusion Name	Gene (1)	Chr (1)	Genomic position hg19 (1)	Gene (2)	Chr (2)	Genomic position hg19 (2)	Supporting reads	Consistance fusion	Fusion type
AL121578.2--SYTL5	AL121578.2	chrX	37765403	SYTL5	chrX	37913465	26	straight	DEL
ANO1--PPFIA1	ANO1	chr11	69973582	PPFIA1	chr11	70117608	65	inverted	INV
ANO1-AS2--SHANK2	SHANK2	chr11	70505932	ANO1-AS2	chr11	69919044	11	straight	DEL
BPIFB4--SAMM50	SAMM50	chr22	44360430	BPIFB4	chr20	31688229	183	straight	TRANS
GALNT7--LOC101930370	LOC101930370	chr4	174090111	GALNT7	chr4	174213258	11	NA	DEL
IMMP2L--KMT2E	KMT2E	chr7	104707253	IMMP2L	chr7	110325040	34	inverted	DEL
MAP3K13--SENP2	MAP3K13	chr3	185184750	SENP2	chr3	185307901	19	straight	DEL
METTL24--WASF1	METTL24	chr6	110636544	WASF1	chr6	110448831	26	straight	DEL
MMP26--OR51B5	MMP26	chr11	4805542	OR51B5	chr11	5367002	10	inverted	DEL
PPFIA1--SHANK2	PPFIA1	chr11	70172923	SHANK2	chr11	70412728	49	straight	INV
PRH1--SMIM10L1	PRH1	chr12	11126319	SMIM10L1	chr12	11324020	37	NA	DEL
PRH1-PRR4--SMIM10L1	PRH1-PRR4	chr12	11001005	SMIM10L1	chr12	11324020	36	NA	DEL
SRGAP1--TMEM5	SRGAP1	chr12	64238662	TMEM5	chr12	64174798	142	straight	DUP

HBV RNA fusions (0)

Breakpoint on human genome (hg19)	Affected gene	Breakpoint on HBV genome (X02763)	Nb of paired reads (HG19 HBV)
No records found.

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)

Drugs (35)

DrugFilter by Drug	AUC	GI50
PF.04691502	0.44	0.195
Rapamycin	0.44	5.15
Alvespimycin	0.63	0.23
Bortezomib	0.64	0.195
Vinblastine	0.65	5.104
Paclitaxel	0.66	0.469
Dasatinib	0.66	0.73
Trametinib	0.66	0.51
Sorafenib_Resminostat	0.7	0.728
Navitoclax	0.7	0.79
Tanespimycin	0.7	0.75
CD532	0.71	0.605
Doxorubicin	0.71	0.75
Sorafenib_Trametinib	0.75	0.8
Sorafenib_Refametinib	0.83	1.23

Liver Cancer Cell Lines Database

Cell Line: Li7

Transcriptomic subgroup: CL2

Mutational Signature

Liver Cancer Cell Lines
Database