Liver Cancer Cell Lines
Database

LCCL to predict drug response

Cell Line: Li7


Cell line description
Cell line nameSynonymsCellosaurus IDTumor typeReferenceSupplierCulture medium
Li7 CVCL_3840 Hepatocellular Carcinoma Tanno, H. (Tohoku Univ., 1st Surg) RIKEN BioResource Center - Japan DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

AgeGenderGeographic OriginEthnicityHBVHCV
45 Male Japan Asian No No

Transcriptomic subgroup: CL2


Mutations and CNAs (455)
Gene nameAlteration typeVariant classAnnotation transcriptgNomencNomenpNomenPPH pr├ędiction
ASPMMutationIn-FrameENST00000367409.4
g.197074046_197074047ins15
g.197074046_197074047ins15
c.4335_4336insCACAAGTAAAAGCTT
c.4335_4336insCACAAGTAAAAGCTT
p.Thr1446_Tyr3477delinsHisLysX
p.Thr1446_Tyr3477delinsHisLysX
damaging
damaging
WSCD1MutationIn-FrameENST00000317744.5
g.6023703_6023726del
g.6023703_6023726del
c.1450_1473del
c.1450_1473del
p.Arg484_Glu491del
p.Arg484_Glu491del
damaging
damaging
HECW2MutationIn-FrameENST00000260983.3
g.197184102_197184122del
g.197184102_197184122del
c.1492_1512del
c.1492_1512del
p.Asp498_Ser504del
p.Asp498_Ser504del
damaging
damaging
WFDC9MutationIn-FrameENST00000326000.1
g.44237437_44237439del
g.44237437_44237439del
c.102_104del
c.102_104del
p.Met34del
p.Met34del
damaging
damaging
TFR2MutationIn-FrameENST00000223051.3
g.100225010_100225021del
g.100225010_100225021del
c.1861_1872del
c.1861_1872del
p.Ala621_Gln624del
p.Ala621_Gln624del
damaging
damaging
SIKE1MutationMissenseENST00000060969.5
g.115316919C>A
g.115316919C>A
c.597G>T
c.597G>T
p.Met199Ile
p.Met199Ile
benign
benign
TRIM45MutationMissenseENST00000256649.4
g.117658296C>G
g.117658296C>G
c.1368G>C
c.1368G>C
p.Met456Ile
p.Met456Ile
benign
benign
ADAM30MutationMissenseENST00000369400.1
g.120437395C>T
g.120437395C>T
c.1565G>A
c.1565G>A
p.Cys522Tyr
p.Cys522Tyr
probably damaging
probably damaging
TCHHMutationMissenseENST00000368804.1
g.152084726C>G
g.152084726C>G
c.967G>C
c.967G>C
p.Glu323Gln
p.Glu323Gln
benign
benign
IVLMutationMissenseENST00000368764.3
g.152883061T>C
g.152883061T>C
c.788T>C
c.788T>C
p.Leu263Pro
p.Leu263Pro
probably damaging
probably damaging
KCNN3MutationMissenseENST00000271915.4
g.154842202T>G
g.154842202T>G
c.239A>C
c.239A>C
p.Gln80Pro
p.Gln80Pro
benign
benign
GON4LMutationMissenseENST00000271883.5
g.155735240G>A
g.155735240G>A
c.4024C>T
c.4024C>T
p.Arg1342Cys
p.Arg1342Cys
benign
benign
TMEM79MutationMissenseENST00000295694.5
g.156255135G>A
g.156255135G>A
c.118G>A
c.118G>A
p.Glu40Lys
p.Glu40Lys
possibly damaging
possibly damaging
BCANMutationMissenseENST00000329117.5
g.156626789T>C
g.156626789T>C
c.2110T>C
c.2110T>C
p.Ser704Pro
p.Ser704Pro
benign
benign
FHAD1MutationMissenseENST00000358897.4
g.15675578A>G
g.15675578A>G
c.2321A>G
c.2321A>G
p.Lys774Arg
p.Lys774Arg
benign
benign
OR6K2MutationMissenseENST00000359610.2
g.158670216G>T
g.158670216G>T
c.227C>A
c.227C>A
p.Ala76Asp
p.Ala76Asp
possibly damaging
possibly damaging
LAMC2MutationMissenseENST00000264144.4
g.183204775C>G
g.183204775C>G
c.2366C>G
c.2366C>G
p.Ala789Gly
p.Ala789Gly
possibly damaging
possibly damaging
SMG7MutationMissenseENST00000347615.2
g.183498585A>G
g.183498585A>G
c.760A>G
c.760A>G
p.Ile254Val
p.Ile254Val
benign
benign
RGS18MutationMissenseENST00000367460.3
g.192128438G>A
g.192128438G>A
c.208G>A
c.208G>A
p.Ala70Thr
p.Ala70Thr
benign
benign
LGR6MutationMissenseENST00000367278.3
g.202266680G>A
g.202266680G>A
c.761G>A
c.761G>A
p.Arg254Gln
p.Arg254Gln
possibly damaging
possibly damaging
KIF17MutationMissenseENST00000247986.2
g.21030995C>G
g.21030995C>G
c.1068G>C
c.1068G>C
p.Glu356Asp
p.Glu356Asp
probably damaging
probably damaging
WNT4MutationMissenseENST00000290167.6
g.22456307C>T
g.22456307C>T
c.115G>A
c.115G>A
p.Glu39Lys
p.Glu39Lys
benign
benign
DNAH14MutationMissenseENST00000430092.1
g.225534194T>C
g.225534194T>C
c.10855T>C
c.10855T>C
p.Cys3619Arg
p.Cys3619Arg
probably damaging
probably damaging
TMEM63AMutationMissenseENST00000366835.3
g.226044654A>G
g.226044654A>G
c.1441T>C
c.1441T>C
p.Ser481Pro
p.Ser481Pro
benign
benign
TRIM17MutationMissenseENST00000295033.3
g.228598783A>G
g.228598783A>G
c.620T>C
c.620T>C
p.Leu207Pro
p.Leu207Pro
probably damaging
probably damaging

Mutational Signature



Fusion transcripts (13)
Fusion NameGene (1)Chr (1)Genomic position hg19 (1)Gene (2)Chr (2)Genomic position hg19 (2)Supporting readsConsistance fusionFusion type
AL121578.2--SYTL5AL121578.2chrX37765403SYTL5chrX3791346526straightDEL
ANO1--PPFIA1ANO1chr1169973582PPFIA1chr117011760865invertedINV
ANO1-AS2--SHANK2SHANK2chr1170505932ANO1-AS2chr116991904411straightDEL
BPIFB4--SAMM50SAMM50chr2244360430BPIFB4chr2031688229183straightTRANS
GALNT7--LOC101930370LOC101930370chr4174090111GALNT7chr417421325811NADEL
IMMP2L--KMT2EKMT2Echr7104707253IMMP2Lchr711032504034invertedDEL
MAP3K13--SENP2MAP3K13chr3185184750SENP2chr318530790119straightDEL
METTL24--WASF1METTL24chr6110636544WASF1chr611044883126straightDEL
MMP26--OR51B5MMP26chr114805542OR51B5chr11536700210invertedDEL
PPFIA1--SHANK2PPFIA1chr1170172923SHANK2chr117041272849straightINV
PRH1--SMIM10L1PRH1chr1211126319SMIM10L1chr121132402037NADEL
PRH1-PRR4--SMIM10L1PRH1-PRR4chr1211001005SMIM10L1chr121132402036NADEL
SRGAP1--TMEM5SRGAP1chr1264238662TMEM5chr1264174798142straightDUP

HBV RNA fusions (0)
Breakpoint on human genome (hg19)Affected geneBreakpoint on HBV genome (X02763)Nb of paired reads (HG19 HBV)
No records found.

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)


Drugs (35)
DrugAUCGI50
Rapamycin0.445.15
PF.046915020.440.195
Alvespimycin0.630.23
Bortezomib0.640.195
Vinblastine0.655.104
Dasatinib0.660.73
Trametinib0.660.51
Paclitaxel0.660.469
Tanespimycin0.70.75
Sorafenib_Resminostat0.70.728
Navitoclax0.70.79
CD5320.710.605
Doxorubicin0.710.75
Sorafenib_Trametinib0.750.8
Entinostat0.835.345


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