Liver Cancer Cell Lines
Database

LCCL to predict drug response

Cell Line: MHCC97H


Cell line description
Cell line nameSynonymsCellosaurus IDTumor typeReferenceSupplierCulture medium
MHCC97H CVCL_4972 Hepatocellular Carcinoma Woodland Pharmaceutical LLC - USA DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

AgeGenderGeographic OriginEthnicityHBVHCV
39 Male China Asian Yes NA

Transcriptomic subgroup: CL2


Mutations and CNAs (588)
Gene nameAlteration typeVariant classAnnotation transcriptgNomencNomenpNomenPPH pr├ędiction
KIAA0226LMutationIn-FrameENST00000378787.3
g.46936714_46936716del
g.46936714_46936716del
c.943_945del
c.943_945del
p.Asp315del
p.Asp315del
damaging
damaging
SETD1AMutationIn-FrameENST00000262519.8
g.30982874_30982879del
g.30982874_30982879del
c.3192_3197del
c.3192_3197del
p.Asp1064_Glu1065del
p.Asp1064_Glu1065del
damaging
damaging
PSMD7MutationIn-FrameENST00000219313.4
g.74339620_74339628del
g.74339620_74339628del
c.964_972del
c.964_972del
p.Glu322X
p.Glu322X
damaging
damaging
SLC6A16MutationIn-FrameENST00000335875.4
g.49796599_49796601del
g.49796599_49796601del
c.1657_1659del
c.1657_1659del
p.Phe553del
p.Phe553del
damaging
damaging
CTDSP1MutationIn-FrameENST00000273062.2
g.219268038_219268040dup
g.219268038_219268040dup
c.556_558dup
c.556_558dup
p.Gly186dup
p.Gly186dup
damaging
damaging
CTNNB1MutationIn-FrameENST00000349496.5
g.41266101_41266358del
g.41266101_41266358del
c.98_242-87del
c.98_242-87del
p.Ser33_Asp81delinsTyr
p.Ser33_Asp81delinsTyr
damaging
damaging
MAP3K4MutationIn-FrameENST00000348824.7
g.161508869_161508871del
g.161508869_161508871del
c.2706_2708del
c.2706_2708del
p.Leu903del
p.Leu903del
damaging
damaging
TNRC18MutationIn-FrameENST00000399537.4
g.5427943_5427944insGGT
g.5427943_5427944insGGT
c.1511_1512insACC
c.1511_1512insACC
p.Thr504_Gly505insPro
p.Thr504_Gly505insPro
damaging
damaging
RP1L1MutationIn-FrameENST00000382483.3
g.10467515_10467517del
g.10467515_10467517del
c.4091_4093del
c.4091_4093del
p.Gly1364del
p.Gly1364del
damaging
damaging
RBMXL3MutationIn-FrameENST00000424776.3
g.114425210_114425455del
g.114425210_114425455del
c.1206_1451del
c.1206_1451del
p.Arg404_Gly485del
p.Arg404_Gly485del
NA
NA
DFFAMutationMissenseENST00000377036.2
g.10532440T>G
g.10532440T>G
c.76A>C
c.76A>C
p.Asn26His
p.Asn26His
probably damaging
probably damaging
KCNA10MutationMissenseENST00000369771.2
g.111061270G>A
g.111061270G>A
c.140C>T
c.140C>T
p.Ser47Phe
p.Ser47Phe
possibly damaging
possibly damaging
MTORMutationMissenseENST00000361445.4
g.11303303T>C
g.11303303T>C
c.1280A>G
c.1280A>G
p.Glu427Gly
p.Glu427Gly
possibly damaging
possibly damaging
HSD3B2MutationMissenseENST00000369416.3
g.119962109G>A
g.119962109G>A
c.211G>A
c.211G>A
p.Ala71Thr
p.Ala71Thr
probably damaging
probably damaging
FLGMutationMissenseENST00000368799.1
g.152275687C>T
g.152275687C>T
c.11675G>A
c.11675G>A
p.Arg3892Gln
p.Arg3892Gln
benign
benign
KIRRELMutationMissenseENST00000359209.6
g.158059580T>C
g.158059580T>C
c.1244T>C
c.1244T>C
p.Ile415Thr
p.Ile415Thr
probably damaging
probably damaging
ADAMTS4MutationMissenseENST00000367995.3
g.161168167C>T
g.161168167C>T
c.251G>A
c.251G>A
p.Arg84His
p.Arg84His
probably damaging
probably damaging
NADKMutationMissenseENST00000342348.5
g.1689870G>A
g.1689870G>A
c.101C>T
c.101C>T
p.Pro34Leu
p.Pro34Leu
benign
benign
PADI3MutationMissenseENST00000375460.3
g.17601154C>T
g.17601154C>T
c.1180C>T
c.1180C>T
p.Arg394Trp
p.Arg394Trp
probably damaging
probably damaging
ASTN1MutationMissenseENST00000367654.3
g.176983967T>G
g.176983967T>G
c.1507A>C
c.1507A>C
p.Lys503Gln
p.Lys503Gln
probably damaging
probably damaging
CEP350MutationMissenseENST00000367607.3
g.179983594C>G
g.179983594C>G
c.2006C>G
c.2006C>G
p.Thr669Ser
p.Thr669Ser
benign
benign
ASPMMutationMissenseENST00000367409.4
g.197072781G>T
g.197072781G>T
c.5600C>A
c.5600C>A
p.Thr1867Lys
p.Thr1867Lys
benign
benign
CNTN2MutationMissenseENST00000331830.4
g.205035721C>T
g.205035721C>T
c.1969C>T
c.1969C>T
p.Arg657Trp
p.Arg657Trp
probably damaging
probably damaging
YOD1MutationMissenseENST00000315927.4
g.207224365G>A
g.207224365G>A
c.11C>T
c.11C>T
p.Pro4Leu
p.Pro4Leu
benign
benign
TRAF3IP3MutationMissenseENST00000010338.4
g.209933481C>T
g.209933481C>T
c.97C>T
c.97C>T
p.Arg33Cys
p.Arg33Cys
probably damaging
probably damaging

Mutational Signature



Fusion transcripts (8)
Fusion NameGene (1)Chr (1)Genomic position hg19 (1)Gene (2)Chr (2)Genomic position hg19 (2)Supporting readsConsistance fusionFusion type
APOH--PRKCAAPOHchr1764216253PRKCAchr176430224485invertedDUP
ASB7--DPH6-AS1DPH6-AS1chr1536144514ASB7chr1510114351736invertedINV
BCAS1--NDRG3NDRG3chr2035284899BCAS1chr205256153434straightDUP
CAV1--LINC01510CAV1chr7116166742LINC01510chr711620422133NAINV
CCDC146--FBXL13FBXL13chr7102462486CCDC146chr77679692814straightINV
CCL26--HIP1HIP1chr775368117CCL26chr77540157010straightDUP
CEP250--MROH8CEP250chr2034079168MROH8chr203575220428straightINV
NDRG3--PLCB1PLCB1chr208197433NDRG3chr203528480211invertedDEL

HBV RNA fusions (1)
Breakpoint on human genome (hg19)Affected geneBreakpoint on HBV genome (X02763)Nb of paired reads (HG19 HBV)
chr5:1,296,080TERT (promoter)184102

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)


Drugs (35)
DrugAUCGI50
Bortezomib0.50.024
Cabozantinib0.560.0772
Vinblastine0.570.06
JNJ.388776050.570.083
PHA.6657520.590.154
Paclitaxel0.590.079
Alvespimycin0.610.39
Trametinib0.7210.0
Tivantinib0.730.915
PF.046915020.740.66
Sorafenib_Trametinib0.752.37
Tanespimycin0.781.32
BLU.99310.797.5
Alisertib0.8310.0
Doxorubicin0.835.855


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