Liver Cancer Cell Lines Database

Cell line description

Cell line name	Synonyms	Cellosaurus ID	Tumor type	Reference	Supplier	Culture medium
MHCC97H		CVCL_4972	Hepatocellular Carcinoma		Woodland Pharmaceutical LLC - USA	DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

Age	Gender	Geographic Origin	Ethnicity	HBV	HCV
39	Male	China	Asian	Yes	NA

Transcriptomic subgroup: CL2

Mutations and CNAs (588)

Gene nameFilter by Gene name	Alteration type	Variant class	Annotation transcript	gNomen	cNomen	pNomen	PPH prédiction
KIAA0226L	Mutation	In-Frame	ENST00000378787.3	g.46936714_46936716del g.46936714_46936716del	c.943_945del c.943_945del	p.Asp315del p.Asp315del	damaging damaging
SETD1A	Mutation	In-Frame	ENST00000262519.8	g.30982874_30982879del g.30982874_30982879del	c.3192_3197del c.3192_3197del	p.Asp1064_Glu1065del p.Asp1064_Glu1065del	damaging damaging
PSMD7	Mutation	In-Frame	ENST00000219313.4	g.74339620_74339628del g.74339620_74339628del	c.964_972del c.964_972del	p.Glu322X p.Glu322X	damaging damaging
SLC6A16	Mutation	In-Frame	ENST00000335875.4	g.49796599_49796601del g.49796599_49796601del	c.1657_1659del c.1657_1659del	p.Phe553del p.Phe553del	damaging damaging
CTDSP1	Mutation	In-Frame	ENST00000273062.2	g.219268038_219268040dup g.219268038_219268040dup	c.556_558dup c.556_558dup	p.Gly186dup p.Gly186dup	damaging damaging
CTNNB1	Mutation	In-Frame	ENST00000349496.5	g.41266101_41266358del g.41266101_41266358del	c.98_242-87del c.98_242-87del	p.Ser33_Asp81delinsTyr p.Ser33_Asp81delinsTyr	damaging damaging
MAP3K4	Mutation	In-Frame	ENST00000348824.7	g.161508869_161508871del g.161508869_161508871del	c.2706_2708del c.2706_2708del	p.Leu903del p.Leu903del	damaging damaging
TNRC18	Mutation	In-Frame	ENST00000399537.4	g.5427943_5427944insGGT g.5427943_5427944insGGT	c.1511_1512insACC c.1511_1512insACC	p.Thr504_Gly505insPro p.Thr504_Gly505insPro	damaging damaging
RP1L1	Mutation	In-Frame	ENST00000382483.3	g.10467515_10467517del g.10467515_10467517del	c.4091_4093del c.4091_4093del	p.Gly1364del p.Gly1364del	damaging damaging
RBMXL3	Mutation	In-Frame	ENST00000424776.3	g.114425210_114425455del g.114425210_114425455del	c.1206_1451del c.1206_1451del	p.Arg404_Gly485del p.Arg404_Gly485del	NA NA
DFFA	Mutation	Missense	ENST00000377036.2	g.10532440T>G g.10532440T>G	c.76A>C c.76A>C	p.Asn26His p.Asn26His	probably damaging probably damaging
KCNA10	Mutation	Missense	ENST00000369771.2	g.111061270G>A g.111061270G>A	c.140C>T c.140C>T	p.Ser47Phe p.Ser47Phe	possibly damaging possibly damaging
MTOR	Mutation	Missense	ENST00000361445.4	g.11303303T>C g.11303303T>C	c.1280A>G c.1280A>G	p.Glu427Gly p.Glu427Gly	possibly damaging possibly damaging
HSD3B2	Mutation	Missense	ENST00000369416.3	g.119962109G>A g.119962109G>A	c.211G>A c.211G>A	p.Ala71Thr p.Ala71Thr	probably damaging probably damaging
FLG	Mutation	Missense	ENST00000368799.1	g.152275687C>T g.152275687C>T	c.11675G>A c.11675G>A	p.Arg3892Gln p.Arg3892Gln	benign benign
KIRREL	Mutation	Missense	ENST00000359209.6	g.158059580T>C g.158059580T>C	c.1244T>C c.1244T>C	p.Ile415Thr p.Ile415Thr	probably damaging probably damaging
ADAMTS4	Mutation	Missense	ENST00000367995.3	g.161168167C>T g.161168167C>T	c.251G>A c.251G>A	p.Arg84His p.Arg84His	probably damaging probably damaging
NADK	Mutation	Missense	ENST00000342348.5	g.1689870G>A g.1689870G>A	c.101C>T c.101C>T	p.Pro34Leu p.Pro34Leu	benign benign
PADI3	Mutation	Missense	ENST00000375460.3	g.17601154C>T g.17601154C>T	c.1180C>T c.1180C>T	p.Arg394Trp p.Arg394Trp	probably damaging probably damaging
ASTN1	Mutation	Missense	ENST00000367654.3	g.176983967T>G g.176983967T>G	c.1507A>C c.1507A>C	p.Lys503Gln p.Lys503Gln	probably damaging probably damaging
CEP350	Mutation	Missense	ENST00000367607.3	g.179983594C>G g.179983594C>G	c.2006C>G c.2006C>G	p.Thr669Ser p.Thr669Ser	benign benign
ASPM	Mutation	Missense	ENST00000367409.4	g.197072781G>T g.197072781G>T	c.5600C>A c.5600C>A	p.Thr1867Lys p.Thr1867Lys	benign benign
CNTN2	Mutation	Missense	ENST00000331830.4	g.205035721C>T g.205035721C>T	c.1969C>T c.1969C>T	p.Arg657Trp p.Arg657Trp	probably damaging probably damaging
YOD1	Mutation	Missense	ENST00000315927.4	g.207224365G>A g.207224365G>A	c.11C>T c.11C>T	p.Pro4Leu p.Pro4Leu	benign benign
TRAF3IP3	Mutation	Missense	ENST00000010338.4	g.209933481C>T g.209933481C>T	c.97C>T c.97C>T	p.Arg33Cys p.Arg33Cys	probably damaging probably damaging

Mutational Signature

Fusion transcripts (8)

Fusion Name	Gene (1)	Chr (1)	Genomic position hg19 (1)	Gene (2)	Chr (2)	Genomic position hg19 (2)	Supporting reads	Consistance fusion	Fusion type
APOH--PRKCA	APOH	chr17	64216253	PRKCA	chr17	64302244	85	inverted	DUP
ASB7--DPH6-AS1	DPH6-AS1	chr15	36144514	ASB7	chr15	101143517	36	inverted	INV
BCAS1--NDRG3	NDRG3	chr20	35284899	BCAS1	chr20	52561534	34	straight	DUP
CAV1--LINC01510	CAV1	chr7	116166742	LINC01510	chr7	116204221	33	NA	INV
CCDC146--FBXL13	FBXL13	chr7	102462486	CCDC146	chr7	76796928	14	straight	INV
CCL26--HIP1	HIP1	chr7	75368117	CCL26	chr7	75401570	10	straight	DUP
CEP250--MROH8	CEP250	chr20	34079168	MROH8	chr20	35752204	28	straight	INV
NDRG3--PLCB1	PLCB1	chr20	8197433	NDRG3	chr20	35284802	11	inverted	DEL

HBV RNA fusions (1)

Breakpoint on human genome (hg19)	Affected gene	Breakpoint on HBV genome (X02763)	Nb of paired reads (HG19 HBV)
chr5:1,296,080	TERT (promoter)	184	102

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)

Drugs (35)

DrugFilter by Drug	AUC	GI50
Bortezomib	0.5	0.024
Cabozantinib	0.56	0.0772
Vinblastine	0.57	0.06
JNJ.38877605	0.57	0.083
Paclitaxel	0.59	0.079
PHA.665752	0.59	0.154
Alvespimycin	0.61	0.39
Trametinib	0.72	10.0
Tivantinib	0.73	0.915
PF.04691502	0.74	0.66
Sorafenib_Trametinib	0.75	2.37
Tanespimycin	0.78	1.32
BLU.9931	0.79	7.5
Alisertib	0.83	10.0
Doxorubicin	0.83	5.855

Liver Cancer Cell Lines Database

Cell Line: MHCC97H

Transcriptomic subgroup: CL2

Mutational Signature

Liver Cancer Cell Lines
Database