Liver Cancer Cell Lines Database

Cell line description

Cell line name	Synonyms	Cellosaurus ID	Tumor type	Reference	Supplier	Culture medium
Mahlavu		CVCL_0405	Hepatocellular Carcinoma	Prozesky et al. (1973)	ATCC - USA	DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

Age	Gender	Geographic Origin	Ethnicity	HBV	HCV
NA	Female	South Africa	African	Yes	NA

Transcriptomic subgroup: CL3

Mutations and CNAs (685)

Gene nameFilter by Gene name	Alteration type	Variant class	Annotation transcript	gNomen	cNomen	pNomen	PPH prédiction
NUFIP1	Mutation	In-Frame	ENST00000379161.4	g.45517711_45517722del g.45517711_45517722del	c.1226_1237del c.1226_1237del	p.Lys409_Val412del p.Lys409_Val412del	damaging damaging
VSX2	Mutation	In-Frame	ENST00000261980.2	g.74727548_74727549insGAG g.74727548_74727549insGAG	c.1012_1013insGAG c.1012_1013insGAG	p.Pro337_Glu338insGly p.Pro337_Glu338insGly	damaging damaging
USP31	Mutation	In-Frame	ENST00000219689.7	g.23080146_23080151del g.23080146_23080151del	c.3275_3280del c.3275_3280del	p.Pro1092_Ala1093del p.Pro1092_Ala1093del	damaging damaging
CREBBP	Mutation	In-Frame	ENST00000262367.5	g.3779071_3779079del g.3779071_3779079del	c.5969_5977del c.5969_5977del	p.Thr1990_Gly1992del p.Thr1990_Gly1992del	damaging damaging
NANOS3	Mutation	In-Frame	ENST00000339133.5	g.13988559_13988560insGAG g.13988559_13988560insGAG	c.497_498insGAG c.497_498insGAG	p.Arg166dup p.Arg166dup	damaging damaging
DNAJC28	Mutation	In-Frame	ENST00000314399.3	g.34860534_34860602del g.34860534_34860602del	c.1099_1167del c.1099_1167del	p.Pro367_Phe388delinsCysLeuLeuSer p.Pro367_Phe388delinsCysLeuLeuSer	damaging damaging
GRIK2	Mutation	In-Frame	ENST00000318991.6	g.102124573_102124575del g.102124573_102124575del	c.617_619del c.617_619del	p.Ala206del p.Ala206del	damaging damaging
HOXA3	Mutation	In-Frame	ENST00000317201.2	g.27150179_27150181del g.27150179_27150181del	c.79_81del c.79_81del	p.Asn27del p.Asn27del	damaging damaging
UNC5D	Mutation	In-Frame	ENST00000404895.2	g.35631863_35631868del g.35631863_35631868del	c.2525_2530del c.2525_2530del	p.Phe842_Ala844delinsSer p.Phe842_Ala844delinsSer	damaging damaging
RP11-706O15.1	Mutation	In-Frame	ENST00000425492.2	g.3736507_3736509delCTT g.3736507_3736509delCTT	c.204_206del c.204_206del	p.68_69RR>R p.68_69RR>R	damaging damaging
RNPC3	Mutation	Missense	ENST00000423855.2	g.104076367A>G g.104076367A>G	c.247A>G c.247A>G	p.Thr83Ala p.Thr83Ala	benign benign
FAM19A3	Mutation	Missense	ENST00000369630.3	g.113266684G>A g.113266684G>A	c.383G>A c.383G>A	p.Arg128Gln p.Arg128Gln	benign benign
MAGI3	Mutation	Missense	ENST00000307546.9	g.114128215G>T g.114128215G>T	c.760G>T c.760G>T	p.Ala254Ser p.Ala254Ser	benign benign
TRIM45	Mutation	Missense	ENST00000256649.4	g.117663633A>T g.117663633A>T	c.191T>A c.191T>A	p.Ile64Asn p.Ile64Asn	benign benign
C1orf167	Mutation	Missense	ENST00000433342.1	g.11836524G>A g.11836524G>A	c.2240G>A c.2240G>A	p.R747H p.R747H	benign benign
PLOD1	Mutation	Missense	ENST00000196061.4	g.12017933G>A g.12017933G>A	c.776G>A c.776G>A	p.Arg259His p.Arg259His	benign benign
HNRNPCL1	Mutation	Missense	ENST00000317869.6	g.12907689T>A g.12907689T>A	c.454A>T c.454A>T	p.Thr152Ser p.Thr152Ser	benign benign
FMO5	Mutation	Missense	ENST00000254090.4	g.146672802A>T g.146672802A>T	c.1115T>A c.1115T>A	p.Ile372Asn p.Ile372Asn	probably damaging probably damaging
GJA8	Mutation	Missense	ENST00000240986.4	g.147380104G>A g.147380104G>A	c.22G>A c.22G>A	p.Gly8Arg p.Gly8Arg	probably damaging probably damaging
PRPF3	Mutation	Missense	ENST00000324862.6	g.150305538C>T g.150305538C>T	c.596C>T c.596C>T	p.Ala199Val p.Ala199Val	possibly damaging possibly damaging
TCHH	Mutation	Missense	ENST00000368804.1	g.152080928G>T g.152080928G>T	c.4765C>A c.4765C>A	p.Arg1589Ser p.Arg1589Ser	possibly damaging possibly damaging
FLG	Mutation	Missense	ENST00000368799.1	g.152282882C>A g.152282882C>A	c.4480G>T c.4480G>T	p.Gly1494Trp p.Gly1494Trp	probably damaging probably damaging
ETV3	Mutation	Missense	ENST00000368192.4	g.157094812T>A g.157094812T>A	c.1360A>T c.1360A>T	p.Arg454Trp p.Arg454Trp	possibly damaging possibly damaging
SLAMF8	Mutation	Missense	ENST00000289707.5	g.159802824C>G g.159802824C>G	c.526C>G c.526C>G	p.Pro176Ala p.Pro176Ala	benign benign
TNR	Mutation	Missense	ENST00000263525.2	g.175331892T>C g.175331892T>C	c.2761A>G c.2761A>G	p.Thr921Ala p.Thr921Ala	benign benign

Mutational Signature

Fusion transcripts (12)

Fusion Name	Gene (1)	Chr (1)	Genomic position hg19 (1)	Gene (2)	Chr (2)	Genomic position hg19 (2)	Supporting reads	Consistance fusion	Fusion type
C12orf40--RP11-542G1.1	RP11-542G1.1	chr4	76233336	C12orf40	chr12	40258563	18	straight	TRANS
DEPDC1B--PDE4D	DEPDC1B	chr5	59934576	PDE4D	chr5	59284543	19	straight	DEL
EFNA5--TUB	EFNA5	chr5	107006189	TUB	chr11	8111156	32	straight	TRANS
FBXW8--ISCU	ISCU	chr12	108962778	FBXW8	chr12	117449252	47	inverted	INV
GALNT7--LOC101930370	LOC101930370	chr4	174090111	GALNT7	chr4	174213258	15	NA	DEL
GCC2--LIMS1	GCC2	chr2	109068921	LIMS1	chr2	109300340	272	straight	DEL
HKR1--ZNF540	HKR1	chr19	37815166	ZNF540	chr19	38102413	25	straight	DEL
IFI35--NBR1	IFI35	chr17	41158984	NBR1	chr17	41348497	85	straight	DEL
IRAK4--ZCRB1	ZCRB1	chr12	42717820	IRAK4	chr12	44159377	70	inverted	DUP
PAWR--SYT1	SYT1	chr12	79787704	PAWR	chr12	79988108	24	inverted	DEL
PLPP1--SKIV2L2	SKIV2L2	chr5	54711959	PLPP1	chr5	54826351	13	NA	DEL
PTPRO--RERG	RERG	chr12	15274052	PTPRO	chr12	15490310	14	inverted	DEL

HBV RNA fusions (0)

Breakpoint on human genome (hg19)	Affected gene	Breakpoint on HBV genome (X02763)	Nb of paired reads (HG19 HBV)
No records found.

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)

Drugs (35)

DrugFilter by Drug	AUC	GI50
Bortezomib	0.14	0.003
Paclitaxel	0.3	0.008
Vinblastine	0.41	0.028
Doxorubicin	0.66	0.335
Alvespimycin	0.67	0.285
PF.04691502	0.67	0.415
CD532	0.71	0.516
Rapamycin	0.72	10.0
Dasatinib	0.77	6.41
Tanespimycin	0.78	1.535
Alisertib	0.8	1.881
MK.2206	0.8	5.608
Tivantinib	0.82	2.77
Sorafenib_Trametinib	0.85	6.56
Selumetinib	0.88	10.0

Liver Cancer Cell Lines Database

Cell Line: Mahlavu

Transcriptomic subgroup: CL3

Mutational Signature

Liver Cancer Cell Lines
Database