Liver Cancer Cell Lines
Database

LCCL to predict drug response

Cell Line: Mahlavu


Cell line description
Cell line nameSynonymsCellosaurus IDTumor typeReferenceSupplierCulture medium
Mahlavu CVCL_0405 Hepatocellular Carcinoma Prozesky et al. (1973) ATCC - USA DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

AgeGenderGeographic OriginEthnicityHBVHCV
NA Female South Africa African Yes NA

Transcriptomic subgroup: CL3


Mutations and CNAs (685)
Gene nameAlteration typeVariant classAnnotation transcriptgNomencNomenpNomenPPH pr├ędiction
NUFIP1MutationIn-FrameENST00000379161.4
g.45517711_45517722del
g.45517711_45517722del
c.1226_1237del
c.1226_1237del
p.Lys409_Val412del
p.Lys409_Val412del
damaging
damaging
VSX2MutationIn-FrameENST00000261980.2
g.74727548_74727549insGAG
g.74727548_74727549insGAG
c.1012_1013insGAG
c.1012_1013insGAG
p.Pro337_Glu338insGly
p.Pro337_Glu338insGly
damaging
damaging
USP31MutationIn-FrameENST00000219689.7
g.23080146_23080151del
g.23080146_23080151del
c.3275_3280del
c.3275_3280del
p.Pro1092_Ala1093del
p.Pro1092_Ala1093del
damaging
damaging
CREBBPMutationIn-FrameENST00000262367.5
g.3779071_3779079del
g.3779071_3779079del
c.5969_5977del
c.5969_5977del
p.Thr1990_Gly1992del
p.Thr1990_Gly1992del
damaging
damaging
NANOS3MutationIn-FrameENST00000339133.5
g.13988559_13988560insGAG
g.13988559_13988560insGAG
c.497_498insGAG
c.497_498insGAG
p.Arg166dup
p.Arg166dup
damaging
damaging
DNAJC28MutationIn-FrameENST00000314399.3
g.34860534_34860602del
g.34860534_34860602del
c.1099_1167del
c.1099_1167del
p.Pro367_Phe388delinsCysLeuLeuSer
p.Pro367_Phe388delinsCysLeuLeuSer
damaging
damaging
GRIK2MutationIn-FrameENST00000318991.6
g.102124573_102124575del
g.102124573_102124575del
c.617_619del
c.617_619del
p.Ala206del
p.Ala206del
damaging
damaging
HOXA3MutationIn-FrameENST00000317201.2
g.27150179_27150181del
g.27150179_27150181del
c.79_81del
c.79_81del
p.Asn27del
p.Asn27del
damaging
damaging
UNC5DMutationIn-FrameENST00000404895.2
g.35631863_35631868del
g.35631863_35631868del
c.2525_2530del
c.2525_2530del
p.Phe842_Ala844delinsSer
p.Phe842_Ala844delinsSer
damaging
damaging
RP11-706O15.1MutationIn-FrameENST00000425492.2
g.3736507_3736509delCTT
g.3736507_3736509delCTT
c.204_206del
c.204_206del
p.68_69RR>R
p.68_69RR>R
damaging
damaging
RNPC3MutationMissenseENST00000423855.2
g.104076367A>G
g.104076367A>G
c.247A>G
c.247A>G
p.Thr83Ala
p.Thr83Ala
benign
benign
FAM19A3MutationMissenseENST00000369630.3
g.113266684G>A
g.113266684G>A
c.383G>A
c.383G>A
p.Arg128Gln
p.Arg128Gln
benign
benign
MAGI3MutationMissenseENST00000307546.9
g.114128215G>T
g.114128215G>T
c.760G>T
c.760G>T
p.Ala254Ser
p.Ala254Ser
benign
benign
TRIM45MutationMissenseENST00000256649.4
g.117663633A>T
g.117663633A>T
c.191T>A
c.191T>A
p.Ile64Asn
p.Ile64Asn
benign
benign
C1orf167MutationMissenseENST00000433342.1
g.11836524G>A
g.11836524G>A
c.2240G>A
c.2240G>A
p.R747H
p.R747H
            benign
benign
PLOD1MutationMissenseENST00000196061.4
g.12017933G>A
g.12017933G>A
c.776G>A
c.776G>A
p.Arg259His
p.Arg259His
benign
benign
HNRNPCL1MutationMissenseENST00000317869.6
g.12907689T>A
g.12907689T>A
c.454A>T
c.454A>T
p.Thr152Ser
p.Thr152Ser
benign
benign
FMO5MutationMissenseENST00000254090.4
g.146672802A>T
g.146672802A>T
c.1115T>A
c.1115T>A
p.Ile372Asn
p.Ile372Asn
probably damaging
probably damaging
GJA8MutationMissenseENST00000240986.4
g.147380104G>A
g.147380104G>A
c.22G>A
c.22G>A
p.Gly8Arg
p.Gly8Arg
probably damaging
probably damaging
PRPF3MutationMissenseENST00000324862.6
g.150305538C>T
g.150305538C>T
c.596C>T
c.596C>T
p.Ala199Val
p.Ala199Val
possibly damaging
possibly damaging
TCHHMutationMissenseENST00000368804.1
g.152080928G>T
g.152080928G>T
c.4765C>A
c.4765C>A
p.Arg1589Ser
p.Arg1589Ser
possibly damaging
possibly damaging
FLGMutationMissenseENST00000368799.1
g.152282882C>A
g.152282882C>A
c.4480G>T
c.4480G>T
p.Gly1494Trp
p.Gly1494Trp
probably damaging
probably damaging
ETV3MutationMissenseENST00000368192.4
g.157094812T>A
g.157094812T>A
c.1360A>T
c.1360A>T
p.Arg454Trp
p.Arg454Trp
possibly damaging
possibly damaging
SLAMF8MutationMissenseENST00000289707.5
g.159802824C>G
g.159802824C>G
c.526C>G
c.526C>G
p.Pro176Ala
p.Pro176Ala
benign
benign
TNRMutationMissenseENST00000263525.2
g.175331892T>C
g.175331892T>C
c.2761A>G
c.2761A>G
p.Thr921Ala
p.Thr921Ala
benign
benign

Mutational Signature



Fusion transcripts (12)
Fusion NameGene (1)Chr (1)Genomic position hg19 (1)Gene (2)Chr (2)Genomic position hg19 (2)Supporting readsConsistance fusionFusion type
C12orf40--RP11-542G1.1RP11-542G1.1chr476233336C12orf40chr124025856318straightTRANS
DEPDC1B--PDE4DDEPDC1Bchr559934576PDE4Dchr55928454319straightDEL
EFNA5--TUBEFNA5chr5107006189TUBchr11811115632straightTRANS
FBXW8--ISCUISCUchr12108962778FBXW8chr1211744925247invertedINV
GALNT7--LOC101930370LOC101930370chr4174090111GALNT7chr417421325815NADEL
GCC2--LIMS1GCC2chr2109068921LIMS1chr2109300340272straightDEL
HKR1--ZNF540HKR1chr1937815166ZNF540chr193810241325straightDEL
IFI35--NBR1IFI35chr1741158984NBR1chr174134849785straightDEL
IRAK4--ZCRB1ZCRB1chr1242717820IRAK4chr124415937770invertedDUP
PAWR--SYT1SYT1chr1279787704PAWRchr127998810824invertedDEL
PLPP1--SKIV2L2SKIV2L2chr554711959PLPP1chr55482635113NADEL
PTPRO--RERGRERGchr1215274052PTPROchr121549031014invertedDEL

HBV RNA fusions (0)
Breakpoint on human genome (hg19)Affected geneBreakpoint on HBV genome (X02763)Nb of paired reads (HG19 HBV)
No records found.

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)


Drugs (35)
DrugAUCGI50
Bortezomib0.140.003
Paclitaxel0.30.008
Vinblastine0.410.028
Doxorubicin0.660.335
Alvespimycin0.670.285
PF.046915020.670.415
CD5320.710.516
Rapamycin0.7210.0
Dasatinib0.776.41
Tanespimycin0.781.535
Alisertib0.81.881
MK.22060.85.608
Tivantinib0.822.77
Sorafenib_Trametinib0.856.56
Sorafenib_Resminostat0.883.775


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