Liver Cancer Cell Lines
Database

LCCL to predict drug response

Cell Line: PLC.PRF5


Cell line description
Cell line nameSynonymsCellosaurus IDTumor typeReferenceSupplierCulture medium
PLC.PRF5 CVCL_0485 Hepatocellular Carcinoma Alexander et al. S Afr Med J (1976) [PMID: 63998] ATCC - USA DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

AgeGenderGeographic OriginEthnicityHBVHCV
24 Male South Africa African Yes No

Transcriptomic subgroup: CL1


Mutations and CNAs (901)
Gene nameAlteration typeVariant classAnnotation transcriptgNomencNomenpNomenPPH pr├ędiction
PRG4MutationIn-FrameENST00000445192.2
g.186273966_186273971del
g.186273966_186273971del
c.510_515del
c.510_515del
p.Ser176_Ser177del
p.Ser176_Ser177del
damaging
damaging
GBF1MutationIn-FrameENST00000369983.3
g.104118330_104118332del
g.104118330_104118332del
c.855_857del
c.855_857del
p.Val286del
p.Val286del
damaging
damaging
MKI67MutationIn-FrameENST00000368654.3
g.129905754_129905755insGCTGGG
g.129905754_129905755insGCTGGG
c.4349_4350insCCCAGC
c.4349_4350insCCCAGC
p.Gly1450_Ser1451insProAla
p.Gly1450_Ser1451insProAla
damaging
damaging
TMEM200CMutationIn-FrameENST00000383490.2
g.5891376_5891417del
g.5891376_5891417del
c.646_687del
c.646_687del
p.Lys216_Ala229del
p.Lys216_Ala229del
damaging
damaging
ARID1AMutationIn-FrameENST00000324856.7
g.27023020_27023022dup
g.27023020_27023022dup
c.126_128dup
c.126_128dup
p.Ala45dup
p.Ala45dup
damaging
damaging
KCNA10MutationMissenseENST00000369771.2
g.111059991C>A
g.111059991C>A
c.1419G>T
c.1419G>T
p.Lys473Asn
p.Lys473Asn
possibly damaging
possibly damaging
TTLL10MutationMissenseENST00000379289.1
g.1132937G>C
g.1132937G>C
c.1732G>C
c.1732G>C
p.Gly578Arg
p.Gly578Arg
benign
benign
PTCHD2MutationMissenseENST00000294484.6
g.11589913C>A
g.11589913C>A
c.2999C>A
c.2999C>A
p.Ala1000Glu
p.Ala1000Glu
probably damaging
probably damaging
CGNMutationMissenseENST00000271636.7
g.151497337G>T
g.151497337G>T
c.1589G>T
c.1589G>T
p.Arg530Leu
p.Arg530Leu
probably damaging
probably damaging
TUFT1MutationMissenseENST00000368849.3
g.151537026G>T
g.151537026G>T
c.350G>T
c.350G>T
p.Arg117Leu
p.Arg117Leu
probably damaging
probably damaging
FLGMutationMissenseENST00000368799.1
g.152286256G>T
g.152286256G>T
c.1106C>A
c.1106C>A
p.Thr369Asn
p.Thr369Asn
probably damaging
probably damaging
TRIM46MutationMissenseENST00000334634.4
g.155149501C>A
g.155149501C>A
c.763C>A
c.763C>A
p.His255Asn
p.His255Asn
probably damaging
probably damaging
IQGAP3MutationMissenseENST00000361170.2
g.156536317C>A
g.156536317C>A
c.147G>T
c.147G>T
p.Lys49Asn
p.Lys49Asn
benign
benign
TTC24MutationMissenseENST00000368236.3
g.156555756C>T
g.156555756C>T
c.1586C>T
c.1586C>T
p.Ala529Val
p.Ala529Val
benign
benign
INSRRMutationMissenseENST00000368195.3
g.156810796G>T
g.156810796G>T
c.3763C>A
c.3763C>A
p.Arg1255Ser
p.Arg1255Ser
benign
benign
KIRRELMutationMissenseENST00000359209.6
g.158045942C>T
g.158045942C>T
c.92C>T
c.92C>T
p.Thr31Met
p.Thr31Met
possibly damaging
possibly damaging
KIRRELMutationMissenseENST00000359209.6
g.158063206G>A
g.158063206G>A
c.1549G>A
c.1549G>A
p.Val517Ile
p.Val517Ile
benign
benign
CD1CMutationMissenseENST00000368170.3
g.158262151G>T
g.158262151G>T
c.606G>T
c.606G>T
p.Arg202Ser
p.Arg202Ser
probably damaging
probably damaging
CD1EMutationMissenseENST00000368155.3
g.158324221G>A
g.158324221G>A
c.113G>A
c.113G>A
p.Arg38His
p.Arg38His
benign
benign
OR6Y1MutationMissenseENST00000302617.3
g.158517145T>A
g.158517145T>A
c.751A>T
c.751A>T
p.Thr251Ser
p.Thr251Ser
benign
benign
OR6Y1MutationMissenseENST00000302617.3
g.158517490G>A
g.158517490G>A
c.406C>T
c.406C>T
p.Arg136Cys
p.Arg136Cys
probably damaging
probably damaging
OR6P1MutationMissenseENST00000334632.1
g.158532502T>G
g.158532502T>G
c.893A>C
c.893A>C
p.Lys298Thr
p.Lys298Thr
probably damaging
probably damaging
OR10X1MutationMissenseENST00000368150.1
g.158549273G>T
g.158549273G>T
c.417C>A
c.417C>A
p.Phe139Leu
p.Phe139Leu
probably damaging
probably damaging
SPTA1MutationMissenseENST00000368147.4
g.158612244A>T
g.158612244A>T
c.4694T>A
c.4694T>A
p.Leu1565Gln
p.Leu1565Gln
probably damaging
probably damaging
SPTA1MutationMissenseENST00000368147.4
g.158612618C>G
g.158612618C>G
c.4591G>C
c.4591G>C
p.Ala1531Pro
p.Ala1531Pro
benign
benign

Mutational Signature



Fusion transcripts (8)
Fusion NameGene (1)Chr (1)Genomic position hg19 (1)Gene (2)Chr (2)Genomic position hg19 (2)Supporting readsConsistance fusionFusion type
ARMC6--SUGP2SUGP2chr1919129917ARMC6chr1919153519259straightINV
ATF1--KRT80ATF1chr1251174020KRT80chr125258130315invertedDEL
ATF1--LINC00592ATF1chr1251174020LINC00592chr125261722954straightDEL
GATAD2A--ZNF675GATAD2Achr1919496946ZNF675chr192373088883invertedDEL
HNF1A--POP5POP5chr12121017725HNF1Achr1212141844640invertedDEL
INSL6--JAK2JAK2chr94992273INSL6chr9516417814invertedDEL
LDB2--RP11-446J8.1RP11-446J8.1chr416428062LDB2chr41654748519invertedDEL
TVP23C--TVP23C-CDRT4TVP23Cchr1715449098TVP23C-CDRT4chr171534151615straightDEL

HBV RNA fusions (8)
Breakpoint on human genome (hg19)Affected geneBreakpoint on HBV genome (X02763)Nb of paired reads (HG19 HBV)
chr2:21,235,076APOB (exon 26)3313
chr3:131,171,968intergenic1,41750
chr11:64,808,415SAC3D1 (5' UTR)230 (+ inserted seq)186
chr12:110,012,612MVK (intron 1)456311
chr13:33,662,698intergenic2,134136
chr13:33,662,260intergenic230 (+ inserted seq)55
chr17:80,059,744CCDC57 (intron 16)45624
chr17:80,065,502CCDC57 (intron 16)2,048 (+12pb)10

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)


Drugs (35)
DrugAUCGI50
Paclitaxel0.370.012
Bortezomib0.420.038
Alvespimycin0.440.033
Vinblastine0.490.035
Tanespimycin0.530.078
Rapamycin0.5910.0
PF.046915020.60.195
Doxorubicin0.730.795
Trametinib0.7910.0
Tivantinib0.793.34
Dasatinib0.8110.0
Selumetinib0.8210.0
CD5320.832.128
Sorafenib_MK.22060.854.9
Sorafenib_Trametinib0.869.09


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