Liver Cancer Cell Lines
Database

LCCL to predict drug response

Cell Line: SNU354


Cell line description
Cell line nameSynonymsCellosaurus IDTumor typeReferenceSupplierCulture medium
SNU354 CVCL_3947 Hepatocellular Carcinoma Park et al. Int J Cancer (1995) [PMID: 7543080] KCLB - Korea DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

AgeGenderGeographic OriginEthnicityHBVHCV
52 Male Korea Asian Yes NA

Transcriptomic subgroup: CL2


Mutations and CNAs (355)
Gene nameAlteration typeVariant classAnnotation transcriptgNomencNomenpNomenPPH pr├ędiction
SLC38A2MutationIn-FrameENST00000256689.5
g.46764574_46764576del
g.46764574_46764576del
c.181_183del
c.181_183del
p.Lys61del
p.Lys61del
damaging
damaging
TSNAXIP1MutationIn-FrameENST00000388833.3
g.67859917_67859919del
g.67859917_67859919del
c.920_922del
c.920_922del
p.Phe307del
p.Phe307del
damaging
damaging
TNFSF9MutationIn-FrameENST00000245817.3
g.6531236_6531265del
g.6531236_6531265del
c.189_218del
c.189_218del
p.Ser64_Gly73del
p.Ser64_Gly73del
damaging
damaging
AK9MutationIn-FrameENST00000285397.5
g.109980446_109980454del
g.109980446_109980454del
c.607_615del
c.607_615del
p.Glu203_Glu205del
p.Glu203_Glu205del
damaging
damaging
DPH5MutationMissenseENST00000342173.7
g.101458207C>T
g.101458207C>T
c.620G>A
c.620G>A
p.Arg207Gln
p.Arg207Gln
benign
benign
CELSR2MutationMissenseENST00000271332.3
g.109816144C>T
g.109816144C>T
c.8596C>T
c.8596C>T
p.Arg2866Trp
p.Arg2866Trp
probably damaging
probably damaging
KCNC4MutationMissenseENST00000369787.3
g.110768699C>G
g.110768699C>G
c.1718C>G
c.1718C>G
p.Ala573Gly
p.Ala573Gly
benign
benign
IVLMutationMissenseENST00000368764.3
g.152882758A>G
g.152882758A>G
c.485A>G
c.485A>G
p.His162Arg
p.His162Arg
possibly damaging
possibly damaging
ATP8B2MutationMissenseENST00000368489.3
g.154321416C>A
g.154321416C>A
c.3494C>A
c.3494C>A
p.Ser1165Tyr
p.Ser1165Tyr
probably damaging
probably damaging
C1orf195MutationMissenseENST00000376005.3
g.15495061T>G
g.15495061T>G
c.311A>C
c.311A>C
p.Gln104Pro
p.Gln104Pro
benign
benign
CD1AMutationMissenseENST00000289429.5
g.158225962T>C
g.158225962T>C
c.494T>C
c.494T>C
p.Leu165Pro
p.Leu165Pro
probably damaging
probably damaging
OR10Z1MutationMissenseENST00000361284.1
g.158576989G>A
g.158576989G>A
c.761G>A
c.761G>A
p.Cys254Tyr
p.Cys254Tyr
probably damaging
probably damaging
COPAMutationMissenseENST00000241704.7
g.160262284T>G
g.160262284T>G
c.2950A>C
c.2950A>C
p.Asn984His
p.Asn984His
benign
benign
ITLN1MutationMissenseENST00000326245.3
g.160850417C>A
g.160850417C>A
c.646G>T
c.646G>T
p.Ala216Ser
p.Ala216Ser
possibly damaging
possibly damaging
EIF4G3MutationMissenseENST00000264211.8
g.21268083C>T
g.21268083C>T
c.1396G>A
c.1396G>A
p.Ala466Thr
p.Ala466Thr
benign
benign
CAPN9MutationMissenseENST00000271971.2
g.230883297G>A
g.230883297G>A
c.55G>A
c.55G>A
p.Ala19Thr
p.Ala19Thr
possibly damaging
possibly damaging
LYSTMutationMissenseENST00000389793.2
g.235973403T>G
g.235973403T>G
c.715A>C
c.715A>C
p.Ser239Arg
p.Ser239Arg
benign
benign
PANK4MutationMissenseENST00000378466.3
g.2452561A>T
g.2452561A>T
c.401T>A
c.401T>A
p.Ile134Asn
p.Ile134Asn
probably damaging
probably damaging
OR2T4MutationMissenseENST00000366475.1
g.248524992A>G
g.248524992A>G
c.110A>G
c.110A>G
p.Asn37Ser
p.Asn37Ser
benign
benign
OR8G2MutationMissenseNM_001007249.1
g.124095422A>T
g.124095422A>T
c.25A>T
c.25A>T
p.Thr9Ser
p.Thr9Ser
benign
benign
COL16A1MutationMissenseENST00000373668.3
g.32150444T>C
g.32150444T>C
c.2030A>G
c.2030A>G
p.Glu677Gly
p.Glu677Gly
possibly damaging
possibly damaging
OSCP1MutationMissenseENST00000315643.9
g.36904361T>C
g.36904361T>C
c.293A>G
c.293A>G
p.Asp98Gly
p.Asp98Gly
possibly damaging
possibly damaging
HIVEP3MutationMissenseENST00000247584.5
g.42049603C>T
g.42049603C>T
c.866G>A
c.866G>A
p.Ser289Asn
p.Ser289Asn
benign
benign
LRRC7MutationMissenseENST00000035383.5
g.70504295G>A
g.70504295G>A
c.2674G>A
c.2674G>A
p.Val892Ile
p.Val892Ile
benign
benign
BCL10MutationMissenseENST00000370580.1
g.85733414C>T
g.85733414C>T
c.598G>A
c.598G>A
p.Ala200Thr
p.Ala200Thr
probably damaging
probably damaging

Mutational Signature



Fusion transcripts (3)
Fusion NameGene (1)Chr (1)Genomic position hg19 (1)Gene (2)Chr (2)Genomic position hg19 (2)Supporting readsConsistance fusionFusion type
BNC2--C9orf92BNC2chr916410943C9orf92chr91621589670straightDEL
HSPE1-MOB4--SF3B1SF3B1chr2198281464HSPE1-MOB4chr219837577067invertedDUP
KLF13--LINC02352KLF13chr1531665746LINC02352chr153151595519NADUP

HBV RNA fusions (0)
Breakpoint on human genome (hg19)Affected geneBreakpoint on HBV genome (X02763)Nb of paired reads (HG19 HBV)
No records found.

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)


Drugs (35)
DrugAUCGI50
Bortezomib0.270.01
Paclitaxel0.520.226
Vinblastine0.63.371
Alvespimycin0.650.425
PF.046915020.670.49
Dasatinib0.77.025
Tanespimycin0.71.005
Sorafenib_Resminostat0.730.515
Tivantinib0.750.605
Rapamycin0.7510.0
Sorafenib_Trametinib0.781.06
Navitoclax0.833.56
Trametinib0.848.49
Sorafenib_Refametinib0.842.02
Doxorubicin0.874.53


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