Liver Cancer Cell Lines Database

Cell line description

Cell line name	Synonyms	Cellosaurus ID	Tumor type	Reference	Supplier	Culture medium
SNU354		CVCL_3947	Hepatocellular Carcinoma	Park et al. Int J Cancer (1995) [PMID: 7543080]	KCLB - Korea	DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

Age	Gender	Geographic Origin	Ethnicity	HBV	HCV
52	Male	Korea	Asian	Yes	NA

Transcriptomic subgroup: CL2

Mutations and CNAs (355)

Gene nameFilter by Gene name	Alteration type	Variant class	Annotation transcript	gNomen	cNomen	pNomen	PPH prédiction
SLC38A2	Mutation	In-Frame	ENST00000256689.5	g.46764574_46764576del g.46764574_46764576del	c.181_183del c.181_183del	p.Lys61del p.Lys61del	damaging damaging
TSNAXIP1	Mutation	In-Frame	ENST00000388833.3	g.67859917_67859919del g.67859917_67859919del	c.920_922del c.920_922del	p.Phe307del p.Phe307del	damaging damaging
TNFSF9	Mutation	In-Frame	ENST00000245817.3	g.6531236_6531265del g.6531236_6531265del	c.189_218del c.189_218del	p.Ser64_Gly73del p.Ser64_Gly73del	damaging damaging
AK9	Mutation	In-Frame	ENST00000285397.5	g.109980446_109980454del g.109980446_109980454del	c.607_615del c.607_615del	p.Glu203_Glu205del p.Glu203_Glu205del	damaging damaging
DPH5	Mutation	Missense	ENST00000342173.7	g.101458207C>T g.101458207C>T	c.620G>A c.620G>A	p.Arg207Gln p.Arg207Gln	benign benign
CELSR2	Mutation	Missense	ENST00000271332.3	g.109816144C>T g.109816144C>T	c.8596C>T c.8596C>T	p.Arg2866Trp p.Arg2866Trp	probably damaging probably damaging
KCNC4	Mutation	Missense	ENST00000369787.3	g.110768699C>G g.110768699C>G	c.1718C>G c.1718C>G	p.Ala573Gly p.Ala573Gly	benign benign
IVL	Mutation	Missense	ENST00000368764.3	g.152882758A>G g.152882758A>G	c.485A>G c.485A>G	p.His162Arg p.His162Arg	possibly damaging possibly damaging
ATP8B2	Mutation	Missense	ENST00000368489.3	g.154321416C>A g.154321416C>A	c.3494C>A c.3494C>A	p.Ser1165Tyr p.Ser1165Tyr	probably damaging probably damaging
C1orf195	Mutation	Missense	ENST00000376005.3	g.15495061T>G g.15495061T>G	c.311A>C c.311A>C	p.Gln104Pro p.Gln104Pro	benign benign
CD1A	Mutation	Missense	ENST00000289429.5	g.158225962T>C g.158225962T>C	c.494T>C c.494T>C	p.Leu165Pro p.Leu165Pro	probably damaging probably damaging
OR10Z1	Mutation	Missense	ENST00000361284.1	g.158576989G>A g.158576989G>A	c.761G>A c.761G>A	p.Cys254Tyr p.Cys254Tyr	probably damaging probably damaging
COPA	Mutation	Missense	ENST00000241704.7	g.160262284T>G g.160262284T>G	c.2950A>C c.2950A>C	p.Asn984His p.Asn984His	benign benign
ITLN1	Mutation	Missense	ENST00000326245.3	g.160850417C>A g.160850417C>A	c.646G>T c.646G>T	p.Ala216Ser p.Ala216Ser	possibly damaging possibly damaging
EIF4G3	Mutation	Missense	ENST00000264211.8	g.21268083C>T g.21268083C>T	c.1396G>A c.1396G>A	p.Ala466Thr p.Ala466Thr	benign benign
CAPN9	Mutation	Missense	ENST00000271971.2	g.230883297G>A g.230883297G>A	c.55G>A c.55G>A	p.Ala19Thr p.Ala19Thr	possibly damaging possibly damaging
LYST	Mutation	Missense	ENST00000389793.2	g.235973403T>G g.235973403T>G	c.715A>C c.715A>C	p.Ser239Arg p.Ser239Arg	benign benign
PANK4	Mutation	Missense	ENST00000378466.3	g.2452561A>T g.2452561A>T	c.401T>A c.401T>A	p.Ile134Asn p.Ile134Asn	probably damaging probably damaging
OR2T4	Mutation	Missense	ENST00000366475.1	g.248524992A>G g.248524992A>G	c.110A>G c.110A>G	p.Asn37Ser p.Asn37Ser	benign benign
OR8G2	Mutation	Missense	NM_001007249.1	g.124095422A>T g.124095422A>T	c.25A>T c.25A>T	p.Thr9Ser p.Thr9Ser	benign benign
COL16A1	Mutation	Missense	ENST00000373668.3	g.32150444T>C g.32150444T>C	c.2030A>G c.2030A>G	p.Glu677Gly p.Glu677Gly	possibly damaging possibly damaging
OSCP1	Mutation	Missense	ENST00000315643.9	g.36904361T>C g.36904361T>C	c.293A>G c.293A>G	p.Asp98Gly p.Asp98Gly	possibly damaging possibly damaging
HIVEP3	Mutation	Missense	ENST00000247584.5	g.42049603C>T g.42049603C>T	c.866G>A c.866G>A	p.Ser289Asn p.Ser289Asn	benign benign
LRRC7	Mutation	Missense	ENST00000035383.5	g.70504295G>A g.70504295G>A	c.2674G>A c.2674G>A	p.Val892Ile p.Val892Ile	benign benign
BCL10	Mutation	Missense	ENST00000370580.1	g.85733414C>T g.85733414C>T	c.598G>A c.598G>A	p.Ala200Thr p.Ala200Thr	probably damaging probably damaging

Mutational Signature

Fusion transcripts (3)

Fusion Name	Gene (1)	Chr (1)	Genomic position hg19 (1)	Gene (2)	Chr (2)	Genomic position hg19 (2)	Supporting reads	Consistance fusion	Fusion type
BNC2--C9orf92	BNC2	chr9	16410943	C9orf92	chr9	16215896	70	straight	DEL
HSPE1-MOB4--SF3B1	SF3B1	chr2	198281464	HSPE1-MOB4	chr2	198375770	67	inverted	DUP
KLF13--LINC02352	KLF13	chr15	31665746	LINC02352	chr15	31515955	19	NA	DUP

HBV RNA fusions (0)

Breakpoint on human genome (hg19)	Affected gene	Breakpoint on HBV genome (X02763)	Nb of paired reads (HG19 HBV)
No records found.

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)

Drugs (35)

DrugFilter by Drug	AUC	GI50
Bortezomib	0.27	0.01
Paclitaxel	0.52	0.226
Vinblastine	0.6	3.371
Alvespimycin	0.65	0.425
PF.04691502	0.67	0.49
Tanespimycin	0.7	1.005
Dasatinib	0.7	7.025
Sorafenib_Resminostat	0.73	0.515
Rapamycin	0.75	10.0
Tivantinib	0.75	0.605
Sorafenib_Trametinib	0.78	1.06
Navitoclax	0.83	3.56
Sorafenib_Refametinib	0.84	2.02
Trametinib	0.84	8.49
Doxorubicin	0.87	4.53

Liver Cancer Cell Lines Database

Cell Line: SNU354

Transcriptomic subgroup: CL2

Mutational Signature

Liver Cancer Cell Lines
Database