Liver Cancer Cell Lines
Database

LCCL to predict drug response

Cell Line: SNU423


Cell line description
Cell line nameSynonymsCellosaurus IDTumor typeReferenceSupplierCulture medium
SNU423 CVCL_0366 Hepatocellular Carcinoma Park et al. Int J Cancer (1995) [PMID: 7543080] ATCC - USA DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

AgeGenderGeographic OriginEthnicityHBVHCV
40 Male Korea Asian Yes No

Transcriptomic subgroup: CL3


Mutations and CNAs (312)
Gene nameAlteration typeVariant classAnnotation transcriptgNomencNomenpNomenPPH pr├ędiction
RP11-166B2.1MutationIn-FrameENST00000399147.4
g.12021341_12021342insTGG
g.12021341_12021342insTGG
c.1082_1083insCCA
c.1082_1083insCCA
p.361_361E>DQ
p.361_361E>DQ
damaging
damaging
PABPN1LMutationIn-FrameENST00000378358.4
g.88932010_88932012del
g.88932010_88932012del
c.418_420del
c.418_420del
p.Glu140del
p.Glu140del
damaging
damaging
DIAPH1MutationIn-FrameENST00000253811.6
g.140953351_140953353del
g.140953351_140953353del
c.2064_2066del
c.2064_2066del
p.Pro693del
p.Pro693del
damaging
damaging
KIF1BMutationMissenseENST00000263934.6
g.10406001C>T
g.10406001C>T
c.3649C>T
c.3649C>T
p.Pro1217Ser
p.Pro1217Ser
benign
benign
VAV3MutationMissenseENST00000370056.4
g.108507344G>A
g.108507344G>A
c.148C>T
c.148C>T
p.Leu50Phe
p.Leu50Phe
probably damaging
probably damaging
SYT6MutationMissenseENST00000369547.1
g.114680458C>T
g.114680458C>T
c.475G>A
c.475G>A
p.Glu159Lys
p.Glu159Lys
probably damaging
probably damaging
MIIPMutationMissenseENST00000235332.4
g.12082333A>G
g.12082333A>G
c.296A>G
c.296A>G
p.Lys99Arg
p.Lys99Arg
benign
benign
DHRS3MutationMissenseENST00000376223.2
g.12638962C>T
g.12638962C>T
c.482G>A
c.482G>A
p.Arg161His
p.Arg161His
probably damaging
probably damaging
HRNRMutationMissenseENST00000368801.2
g.152191577C>T
g.152191577C>T
c.2528G>A
c.2528G>A
p.Arg843Gln
p.Arg843Gln
benign
benign
SMG5MutationMissenseENST00000361813.5
g.156233263C>T
g.156233263C>T
c.1954G>A
c.1954G>A
p.Glu652Lys
p.Glu652Lys
probably damaging
probably damaging
CD1BMutationMissenseENST00000368168.3
g.158299670A>T
g.158299670A>T
c.579T>A
c.579T>A
p.Asn193Lys
p.Asn193Lys
benign
benign
OR10K2MutationMissenseENST00000314902.2
g.158390224C>A
g.158390224C>A
c.433G>T
c.433G>T
p.Val145Leu
p.Val145Leu
possibly damaging
possibly damaging
ATP13A2MutationMissenseENST00000326735.8
g.17318244C>T
g.17318244C>T
c.2236G>A
c.2236G>A
p.Ala746Thr
p.Ala746Thr
benign
benign
PADI2MutationMissenseENST00000375486.4
g.17402215C>G
g.17402215C>G
c.1414G>C
c.1414G>C
p.Val472Leu
p.Val472Leu
benign
benign
PADI1MutationMissenseENST00000375471.4
g.17555507C>T
g.17555507C>T
c.890C>T
c.890C>T
p.Thr297Met
p.Thr297Met
probably damaging
probably damaging
CFHMutationMissenseENST00000359637.2
g.196643017C>T
g.196643017C>T
c.275C>T
c.275C>T
p.Pro92Leu
p.Pro92Leu
benign
benign
HSPG2MutationMissenseENST00000374695.3
g.22176542G>A
g.22176542G>A
c.7438C>T
c.7438C>T
p.R2480W
p.R2480W
probably damaging
probably damaging
EPHX1MutationMissenseENST00000272167.5
g.226016507C>G
g.226016507C>G
c.77C>G
c.77C>G
p.Thr26Ser
p.Thr26Ser
benign
benign
MAP3K6MutationMissenseENST00000357582.2
g.27684048T>A
g.27684048T>A
c.3101A>T
c.3101A>T
p.Asn1034Ile
p.Asn1034Ile
benign
benign
PRDM16MutationMissenseENST00000270722.5
g.3347605G>A
g.3347605G>A
c.3454G>A
c.3454G>A
p.Ala1152Thr
p.Ala1152Thr
benign
benign
WDR65MutationMissenseENST00000372492.4
g.43675482G>A
g.43675482G>A
c.1824G>A
c.1824G>A
p.Met608Ile
p.Met608Ile
possibly damaging
possibly damaging
LPHN2MutationMissenseENST00000271029.4
g.82408784C>T
g.82408784C>T
c.529C>T
c.529C>T
p.Pro177Ser
p.Pro177Ser
probably damaging
probably damaging
SYDE2MutationMissenseENST00000341460.5
g.85630373G>A
g.85630373G>A
c.2921C>T
c.2921C>T
p.Thr974Met
p.Thr974Met
probably damaging
probably damaging
SVILMutationMissenseENST00000355867.4
g.29839748A>G
g.29839748A>G
c.605T>C
c.605T>C
p.Ile202Thr
p.Ile202Thr
benign
benign
ANKRD30AMutationMissenseENST00000361713.1
g.37431129C>T
g.37431129C>T
c.1136C>T
c.1136C>T
p.Thr379Ile
p.Thr379Ile
possibly damaging
possibly damaging

Mutational Signature



Fusion transcripts (2)
Fusion NameGene (1)Chr (1)Genomic position hg19 (1)Gene (2)Chr (2)Genomic position hg19 (2)Supporting readsConsistance fusionFusion type
ABCA12--LOC101928103LOC101928103chr2215698828ABCA12chr221582653311NADEL
ACTR3--SAGACTR3chr2114674584SAGchr2234225347160invertedINV

HBV RNA fusions (0)
Breakpoint on human genome (hg19)Affected geneBreakpoint on HBV genome (X02763)Nb of paired reads (HG19 HBV)
No records found.

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)


Drugs (35)
DrugAUCGI50
Paclitaxel0.310.004
Bortezomib0.410.029
Vinblastine0.430.021
Doxorubicin0.570.128
PF.046915020.650.41
Dasatinib0.710.0
Tivantinib0.711.11
Sorafenib_Trametinib0.723.14
Rapamycin0.7210.0
CD5320.750.729
Alvespimycin0.760.965
Alisertib0.7810.0
Trametinib0.8210.0
Navitoclax0.824.44
Sorafenib_Resminostat0.843.371


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