Liver Cancer Cell Lines Database

Cell line description

Cell line name	Synonyms	Cellosaurus ID	Tumor type	Reference	Supplier	Culture medium
SNU423		CVCL_0366	Hepatocellular Carcinoma	Park et al. Int J Cancer (1995) [PMID: 7543080]	ATCC - USA	DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

Age	Gender	Geographic Origin	Ethnicity	HBV	HCV
40	Male	Korea	Asian	Yes	No

Transcriptomic subgroup: CL3

Mutations and CNAs (312)

Gene nameFilter by Gene name	Alteration type	Variant class	Annotation transcript	gNomen	cNomen	pNomen	PPH prédiction
RP11-166B2.1	Mutation	In-Frame	ENST00000399147.4	g.12021341_12021342insTGG g.12021341_12021342insTGG	c.1082_1083insCCA c.1082_1083insCCA	p.361_361E>DQ p.361_361E>DQ	damaging damaging
PABPN1L	Mutation	In-Frame	ENST00000378358.4	g.88932010_88932012del g.88932010_88932012del	c.418_420del c.418_420del	p.Glu140del p.Glu140del	damaging damaging
DIAPH1	Mutation	In-Frame	ENST00000253811.6	g.140953351_140953353del g.140953351_140953353del	c.2064_2066del c.2064_2066del	p.Pro693del p.Pro693del	damaging damaging
KIF1B	Mutation	Missense	ENST00000263934.6	g.10406001C>T g.10406001C>T	c.3649C>T c.3649C>T	p.Pro1217Ser p.Pro1217Ser	benign benign
VAV3	Mutation	Missense	ENST00000370056.4	g.108507344G>A g.108507344G>A	c.148C>T c.148C>T	p.Leu50Phe p.Leu50Phe	probably damaging probably damaging
SYT6	Mutation	Missense	ENST00000369547.1	g.114680458C>T g.114680458C>T	c.475G>A c.475G>A	p.Glu159Lys p.Glu159Lys	probably damaging probably damaging
MIIP	Mutation	Missense	ENST00000235332.4	g.12082333A>G g.12082333A>G	c.296A>G c.296A>G	p.Lys99Arg p.Lys99Arg	benign benign
DHRS3	Mutation	Missense	ENST00000376223.2	g.12638962C>T g.12638962C>T	c.482G>A c.482G>A	p.Arg161His p.Arg161His	probably damaging probably damaging
HRNR	Mutation	Missense	ENST00000368801.2	g.152191577C>T g.152191577C>T	c.2528G>A c.2528G>A	p.Arg843Gln p.Arg843Gln	benign benign
SMG5	Mutation	Missense	ENST00000361813.5	g.156233263C>T g.156233263C>T	c.1954G>A c.1954G>A	p.Glu652Lys p.Glu652Lys	probably damaging probably damaging
CD1B	Mutation	Missense	ENST00000368168.3	g.158299670A>T g.158299670A>T	c.579T>A c.579T>A	p.Asn193Lys p.Asn193Lys	benign benign
OR10K2	Mutation	Missense	ENST00000314902.2	g.158390224C>A g.158390224C>A	c.433G>T c.433G>T	p.Val145Leu p.Val145Leu	possibly damaging possibly damaging
ATP13A2	Mutation	Missense	ENST00000326735.8	g.17318244C>T g.17318244C>T	c.2236G>A c.2236G>A	p.Ala746Thr p.Ala746Thr	benign benign
PADI2	Mutation	Missense	ENST00000375486.4	g.17402215C>G g.17402215C>G	c.1414G>C c.1414G>C	p.Val472Leu p.Val472Leu	benign benign
PADI1	Mutation	Missense	ENST00000375471.4	g.17555507C>T g.17555507C>T	c.890C>T c.890C>T	p.Thr297Met p.Thr297Met	probably damaging probably damaging
CFH	Mutation	Missense	ENST00000359637.2	g.196643017C>T g.196643017C>T	c.275C>T c.275C>T	p.Pro92Leu p.Pro92Leu	benign benign
HSPG2	Mutation	Missense	ENST00000374695.3	g.22176542G>A g.22176542G>A	c.7438C>T c.7438C>T	p.R2480W p.R2480W	probably damaging probably damaging
EPHX1	Mutation	Missense	ENST00000272167.5	g.226016507C>G g.226016507C>G	c.77C>G c.77C>G	p.Thr26Ser p.Thr26Ser	benign benign
MAP3K6	Mutation	Missense	ENST00000357582.2	g.27684048T>A g.27684048T>A	c.3101A>T c.3101A>T	p.Asn1034Ile p.Asn1034Ile	benign benign
PRDM16	Mutation	Missense	ENST00000270722.5	g.3347605G>A g.3347605G>A	c.3454G>A c.3454G>A	p.Ala1152Thr p.Ala1152Thr	benign benign
WDR65	Mutation	Missense	ENST00000372492.4	g.43675482G>A g.43675482G>A	c.1824G>A c.1824G>A	p.Met608Ile p.Met608Ile	possibly damaging possibly damaging
LPHN2	Mutation	Missense	ENST00000271029.4	g.82408784C>T g.82408784C>T	c.529C>T c.529C>T	p.Pro177Ser p.Pro177Ser	probably damaging probably damaging
SYDE2	Mutation	Missense	ENST00000341460.5	g.85630373G>A g.85630373G>A	c.2921C>T c.2921C>T	p.Thr974Met p.Thr974Met	probably damaging probably damaging
SVIL	Mutation	Missense	ENST00000355867.4	g.29839748A>G g.29839748A>G	c.605T>C c.605T>C	p.Ile202Thr p.Ile202Thr	benign benign
ANKRD30A	Mutation	Missense	ENST00000361713.1	g.37431129C>T g.37431129C>T	c.1136C>T c.1136C>T	p.Thr379Ile p.Thr379Ile	possibly damaging possibly damaging

Mutational Signature

Fusion transcripts (2)

Fusion Name	Gene (1)	Chr (1)	Genomic position hg19 (1)	Gene (2)	Chr (2)	Genomic position hg19 (2)	Supporting reads	Consistance fusion	Fusion type
ABCA12--LOC101928103	LOC101928103	chr2	215698828	ABCA12	chr2	215826533	11	NA	DEL
ACTR3--SAG	ACTR3	chr2	114674584	SAG	chr2	234225347	160	inverted	INV

HBV RNA fusions (0)

Breakpoint on human genome (hg19)	Affected gene	Breakpoint on HBV genome (X02763)	Nb of paired reads (HG19 HBV)
No records found.

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)

Drugs (35)

DrugFilter by Drug	AUC	GI50
Paclitaxel	0.31	0.004
Bortezomib	0.41	0.029
Vinblastine	0.43	0.021
Doxorubicin	0.57	0.128
PF.04691502	0.65	0.41
Dasatinib	0.7	10.0
Tivantinib	0.71	1.11
Sorafenib_Trametinib	0.72	3.14
Rapamycin	0.72	10.0
CD532	0.75	0.729
Alvespimycin	0.76	0.965
Alisertib	0.78	10.0
Trametinib	0.82	10.0
Navitoclax	0.82	4.44
Sorafenib_Resminostat	0.84	3.371

Liver Cancer Cell Lines Database

Cell Line: SNU423

Transcriptomic subgroup: CL3

Mutational Signature

Liver Cancer Cell Lines
Database