Liver Cancer Cell Lines
Database

LCCL to predict drug response

Cell Line: SNU739


Cell line description
Cell line nameSynonymsCellosaurus IDTumor typeReferenceSupplierCulture medium
SNU739 CVCL_5088 Hepatocellular Carcinoma Lee et al. World J Gastroenterol (1999) [PMID: 11819450] KCLB - Korea DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

AgeGenderGeographic OriginEthnicityHBVHCV
52 Male Korea Asian Yes NA

Transcriptomic subgroup: CL3


Mutations and CNAs (518)
Gene nameAlteration typeVariant classAnnotation transcriptgNomencNomenpNomenPPH pr├ędiction
SIGLEC6MutationIn-FrameENST00000343300.4
g.52034110_52034115del
g.52034110_52034115del
c.526_531del
c.526_531del
p.Thr176_Pro177del
p.Thr176_Pro177del
damaging
damaging
CEP19MutationIn-FrameENST00000409690.3
g.196434521_196434523del
g.196434521_196434523del
c.403_405del
c.403_405del
p.Lys135del
p.Lys135del
damaging
damaging
CITED2MutationIn-FrameENST00000367651.2
g.139694491_139694502del
g.139694491_139694502del
c.580_591del
c.580_591del
p.Gly194_Gly197del
p.Gly194_Gly197del
damaging
damaging
AP4B1MutationMissenseENST00000256658.4
g.114442556C>A
g.114442556C>A
c.1084G>T
c.1084G>T
p.Asp362Tyr
p.Asp362Tyr
probably damaging
probably damaging
SLC22A15MutationMissenseENST00000369503.4
g.116579932G>A
g.116579932G>A
c.1094G>A
c.1094G>A
p.Arg365Gln
p.Arg365Gln
probably damaging
probably damaging
MTHFRMutationMissenseENST00000376590.3
g.11863022C>T
g.11863022C>T
c.152G>A
c.152G>A
p.Arg51Gln
p.Arg51Gln
probably damaging
probably damaging
DVL1MutationMissenseENST00000378891.5
g.1271557C>T
g.1271557C>T
c.1978G>A
c.1978G>A
p.Gly660Arg
p.Gly660Arg
probably damaging
probably damaging
C1orf51MutationMissenseENST00000290363.5
g.150259184A>T
g.150259184A>T
c.976A>T
c.976A>T
p.Met326Leu
p.Met326Leu
benign
benign
BNIPLMutationMissenseENST00000368931.3
g.151010995G>C
g.151010995G>C
c.153G>C
c.153G>C
p.Glu51Asp
p.Glu51Asp
probably damaging
probably damaging
IVLMutationMissenseENST00000368764.3
g.152882410A>G
g.152882410A>G
c.137A>G
c.137A>G
p.Lys46Arg
p.Lys46Arg
probably damaging
probably damaging
NPR1MutationMissenseENST00000368680.3
g.153651622G>T
g.153651622G>T
c.38G>T
c.38G>T
p.Arg13Leu
p.Arg13Leu
benign
benign
MIB2MutationMissenseENST00000357210.4
g.1560479G>A
g.1560479G>A
c.809G>A
c.809G>A
p.Arg270His
p.Arg270His
probably damaging
probably damaging
SPENMutationMissenseENST00000375759.3
g.16235857G>C
g.16235857G>C
c.923G>C
c.923G>C
p.Arg308Pro
p.Arg308Pro
probably damaging
probably damaging
DCAF6MutationMissenseENST00000312263.6
g.167944183C>G
g.167944183C>G
c.368C>G
c.368C>G
p.Thr123Ser
p.Thr123Ser
probably damaging
probably damaging
ALDH4A1MutationMissenseENST00000290597.5
g.19209807G>A
g.19209807G>A
c.569C>T
c.569C>T
p.Pro190Leu
p.Pro190Leu
benign
benign
IGFN1MutationMissenseENST00000335211.4
g.201186421C>T
g.201186421C>T
c.9602C>T
c.9602C>T
p.Pro3201Leu
p.Pro3201Leu
probably damaging
probably damaging
PLEKHA6MutationMissenseENST00000272203.3
g.204199666T>A
g.204199666T>A
c.2458A>T
c.2458A>T
p.Ser820Cys
p.Ser820Cys
probably damaging
probably damaging
HSPG2MutationMissenseENST00000374695.3
g.22158206C>T
g.22158206C>T
c.11291G>A
c.11291G>A
p.Arg3764His
p.Arg3764His
probably damaging
probably damaging
CDC42BPAMutationMissenseENST00000366769.3
g.227182658C>T
g.227182658C>T
c.4894G>A
c.4894G>A
p.Ala1632Thr
p.Ala1632Thr
probably damaging
probably damaging
OR2T4MutationMissenseENST00000366475.1
g.248524992A>G
g.248524992A>G
c.110A>G
c.110A>G
p.Asn37Ser
p.Asn37Ser
benign
benign
AUNIPMutationMissenseENST00000374298.3
g.26161924C>T
g.26161924C>T
c.634G>A
c.634G>A
p.Glu212Lys
p.Glu212Lys
benign
benign
PTPRUMutationMissenseENST00000323874.8
g.29581862A>T
g.29581862A>T
c.149A>T
c.149A>T
p.Gln50Leu
p.Gln50Leu
possibly damaging
possibly damaging
TRIM62MutationMissenseENST00000291416.5
g.33625445G>A
g.33625445G>A
c.605C>T
c.605C>T
p.Ala202Val
p.Ala202Val
benign
benign
MEGF6MutationMissenseENST00000356575.4
g.3511910C>T
g.3511910C>T
c.368G>A
c.368G>A
p.Cys123Tyr
p.Cys123Tyr
probably damaging
probably damaging
YIPF1MutationMissenseENST00000072644.1
g.54332570G>A
g.54332570G>A
c.509C>T
c.509C>T
p.Ala170Val
p.Ala170Val
benign
benign

Mutational Signature



Fusion transcripts (10)
Fusion NameGene (1)Chr (1)Genomic position hg19 (1)Gene (2)Chr (2)Genomic position hg19 (2)Supporting readsConsistance fusionFusion type
AKAP2--PALM2-AKAP2PALM2-AKAP2chr9112778265AKAP2chr911289840678straightDEL
CDX2--UBA6UBA6chr468543328CDX2chr132853915111straightTRANS
CNR1--RP11-459O1.2RP11-459O1.2chr689033718CNR1chr68885505517straightDEL
GNE--SIPA1GNEchr936227244SIPA1chr116541242528straightTRANS
GNE--XRRA1XRRA1chr1174562132GNEchr93622745422straightTRANS
LINC01237--LINC01881LINC01881chr2243037177LINC01237chr224299621716NADUP
LOXL2--PLCXD2LOXL2chr823261466PLCXD2chr311145146542straightTRANS
LRCH1--RP11-189B4.7RP11-189B4.7chr1347067094LRCH1chr134722433512NADEL
OSBPL8--SYT1SYT1chr1279693331OSBPL8chr127677232828straightINV
PREX1--RP5-906C1.1RP5-906C1.1chr2047465971PREX1chr204736441649NADEL

HBV RNA fusions (2)
Breakpoint on human genome (hg19)Affected geneBreakpoint on HBV genome (X02763)Nb of paired reads (HG19 HBV)
chr4:25,187,521LOC285540 (intron 1)1,82479
chr13:28,611,427FTL3 (intron 9)2,45310

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)


Drugs (35)
DrugAUCGI50
Bortezomib0.260.008
Paclitaxel0.290.004
Vinblastine0.470.047
Alisertib0.640.547
Alvespimycin0.690.44
CD5320.70.593
Tivantinib0.70.595
Dasatinib0.7110.0
Rapamycin0.7910.0
PF.046915020.791.205
Sorafenib_Resminostat0.812.881
Doxorubicin0.822.907
Linsitinib0.8310.0
Trametinib0.8610.0
PHA.6657520.884.777


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