Liver Cancer Cell Lines Database

Cell line description

Cell line name	Synonyms	Cellosaurus ID	Tumor type	Reference	Supplier	Culture medium
SNU739		CVCL_5088	Hepatocellular Carcinoma	Lee et al. World J Gastroenterol (1999) [PMID: 11819450]	KCLB - Korea	DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

Age	Gender	Geographic Origin	Ethnicity	HBV	HCV
52	Male	Korea	Asian	Yes	NA

Transcriptomic subgroup: CL3

Mutations and CNAs (518)

Gene nameFilter by Gene name	Alteration type	Variant class	Annotation transcript	gNomen	cNomen	pNomen	PPH prédiction
SIGLEC6	Mutation	In-Frame	ENST00000343300.4	g.52034110_52034115del g.52034110_52034115del	c.526_531del c.526_531del	p.Thr176_Pro177del p.Thr176_Pro177del	damaging damaging
CEP19	Mutation	In-Frame	ENST00000409690.3	g.196434521_196434523del g.196434521_196434523del	c.403_405del c.403_405del	p.Lys135del p.Lys135del	damaging damaging
CITED2	Mutation	In-Frame	ENST00000367651.2	g.139694491_139694502del g.139694491_139694502del	c.580_591del c.580_591del	p.Gly194_Gly197del p.Gly194_Gly197del	damaging damaging
AP4B1	Mutation	Missense	ENST00000256658.4	g.114442556C>A g.114442556C>A	c.1084G>T c.1084G>T	p.Asp362Tyr p.Asp362Tyr	probably damaging probably damaging
SLC22A15	Mutation	Missense	ENST00000369503.4	g.116579932G>A g.116579932G>A	c.1094G>A c.1094G>A	p.Arg365Gln p.Arg365Gln	probably damaging probably damaging
MTHFR	Mutation	Missense	ENST00000376590.3	g.11863022C>T g.11863022C>T	c.152G>A c.152G>A	p.Arg51Gln p.Arg51Gln	probably damaging probably damaging
DVL1	Mutation	Missense	ENST00000378891.5	g.1271557C>T g.1271557C>T	c.1978G>A c.1978G>A	p.Gly660Arg p.Gly660Arg	probably damaging probably damaging
C1orf51	Mutation	Missense	ENST00000290363.5	g.150259184A>T g.150259184A>T	c.976A>T c.976A>T	p.Met326Leu p.Met326Leu	benign benign
BNIPL	Mutation	Missense	ENST00000368931.3	g.151010995G>C g.151010995G>C	c.153G>C c.153G>C	p.Glu51Asp p.Glu51Asp	probably damaging probably damaging
IVL	Mutation	Missense	ENST00000368764.3	g.152882410A>G g.152882410A>G	c.137A>G c.137A>G	p.Lys46Arg p.Lys46Arg	probably damaging probably damaging
NPR1	Mutation	Missense	ENST00000368680.3	g.153651622G>T g.153651622G>T	c.38G>T c.38G>T	p.Arg13Leu p.Arg13Leu	benign benign
MIB2	Mutation	Missense	ENST00000357210.4	g.1560479G>A g.1560479G>A	c.809G>A c.809G>A	p.Arg270His p.Arg270His	probably damaging probably damaging
SPEN	Mutation	Missense	ENST00000375759.3	g.16235857G>C g.16235857G>C	c.923G>C c.923G>C	p.Arg308Pro p.Arg308Pro	probably damaging probably damaging
DCAF6	Mutation	Missense	ENST00000312263.6	g.167944183C>G g.167944183C>G	c.368C>G c.368C>G	p.Thr123Ser p.Thr123Ser	probably damaging probably damaging
ALDH4A1	Mutation	Missense	ENST00000290597.5	g.19209807G>A g.19209807G>A	c.569C>T c.569C>T	p.Pro190Leu p.Pro190Leu	benign benign
IGFN1	Mutation	Missense	ENST00000335211.4	g.201186421C>T g.201186421C>T	c.9602C>T c.9602C>T	p.Pro3201Leu p.Pro3201Leu	probably damaging probably damaging
PLEKHA6	Mutation	Missense	ENST00000272203.3	g.204199666T>A g.204199666T>A	c.2458A>T c.2458A>T	p.Ser820Cys p.Ser820Cys	probably damaging probably damaging
HSPG2	Mutation	Missense	ENST00000374695.3	g.22158206C>T g.22158206C>T	c.11291G>A c.11291G>A	p.Arg3764His p.Arg3764His	probably damaging probably damaging
CDC42BPA	Mutation	Missense	ENST00000366769.3	g.227182658C>T g.227182658C>T	c.4894G>A c.4894G>A	p.Ala1632Thr p.Ala1632Thr	probably damaging probably damaging
OR2T4	Mutation	Missense	ENST00000366475.1	g.248524992A>G g.248524992A>G	c.110A>G c.110A>G	p.Asn37Ser p.Asn37Ser	benign benign
AUNIP	Mutation	Missense	ENST00000374298.3	g.26161924C>T g.26161924C>T	c.634G>A c.634G>A	p.Glu212Lys p.Glu212Lys	benign benign
PTPRU	Mutation	Missense	ENST00000323874.8	g.29581862A>T g.29581862A>T	c.149A>T c.149A>T	p.Gln50Leu p.Gln50Leu	possibly damaging possibly damaging
TRIM62	Mutation	Missense	ENST00000291416.5	g.33625445G>A g.33625445G>A	c.605C>T c.605C>T	p.Ala202Val p.Ala202Val	benign benign
MEGF6	Mutation	Missense	ENST00000356575.4	g.3511910C>T g.3511910C>T	c.368G>A c.368G>A	p.Cys123Tyr p.Cys123Tyr	probably damaging probably damaging
YIPF1	Mutation	Missense	ENST00000072644.1	g.54332570G>A g.54332570G>A	c.509C>T c.509C>T	p.Ala170Val p.Ala170Val	benign benign

Mutational Signature

Fusion transcripts (10)

Fusion Name	Gene (1)	Chr (1)	Genomic position hg19 (1)	Gene (2)	Chr (2)	Genomic position hg19 (2)	Supporting reads	Consistance fusion	Fusion type
AKAP2--PALM2-AKAP2	PALM2-AKAP2	chr9	112778265	AKAP2	chr9	112898406	78	straight	DEL
CDX2--UBA6	UBA6	chr4	68543328	CDX2	chr13	28539151	11	straight	TRANS
CNR1--RP11-459O1.2	RP11-459O1.2	chr6	89033718	CNR1	chr6	88855055	17	straight	DEL
GNE--SIPA1	GNE	chr9	36227244	SIPA1	chr11	65412425	28	straight	TRANS
GNE--XRRA1	XRRA1	chr11	74562132	GNE	chr9	36227454	22	straight	TRANS
LINC01237--LINC01881	LINC01881	chr2	243037177	LINC01237	chr2	242996217	16	NA	DUP
LOXL2--PLCXD2	LOXL2	chr8	23261466	PLCXD2	chr3	111451465	42	straight	TRANS
LRCH1--RP11-189B4.7	RP11-189B4.7	chr13	47067094	LRCH1	chr13	47224335	12	NA	DEL
OSBPL8--SYT1	SYT1	chr12	79693331	OSBPL8	chr12	76772328	28	straight	INV
PREX1--RP5-906C1.1	RP5-906C1.1	chr20	47465971	PREX1	chr20	47364416	49	NA	DEL

HBV RNA fusions (2)

Breakpoint on human genome (hg19)	Affected gene	Breakpoint on HBV genome (X02763)	Nb of paired reads (HG19 HBV)
chr4:25,187,521	LOC285540 (intron 1)	1,824	79
chr13:28,611,427	FTL3 (intron 9)	2,453	10

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)

Drugs (35)

DrugFilter by Drug	AUC	GI50
Bortezomib	0.26	0.008
Paclitaxel	0.29	0.004
Vinblastine	0.47	0.047
Alisertib	0.64	0.547
Alvespimycin	0.69	0.44
CD532	0.7	0.593
Tivantinib	0.7	0.595
Dasatinib	0.71	10.0
PF.04691502	0.79	1.205
Rapamycin	0.79	10.0
Sorafenib_Resminostat	0.81	2.881
Doxorubicin	0.82	2.907
Linsitinib	0.83	10.0
Trametinib	0.86	10.0
PHA.665752	0.88	4.777

Liver Cancer Cell Lines Database

Cell Line: SNU739

Transcriptomic subgroup: CL3

Mutational Signature

Liver Cancer Cell Lines
Database