Liver Cancer Cell Lines Database

Cell line description

Cell line name	Synonyms	Cellosaurus ID	Tumor type	Reference	Supplier	Culture medium
SNU761		CVCL_5089	Hepatocellular Carcinoma	Lee et al. World J Gastroenterol (1999) [PMID: 11819450]	KCLB - Korea	Williams' Medium E (#22551-022, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin + 1X glutamine

Age	Gender	Geographic Origin	Ethnicity	HBV	HCV
49	Male	Korea	Asian	Yes	NA

Transcriptomic subgroup: CL2

Mutations and CNAs (454)

Gene nameFilter by Gene name	Alteration type	Variant class	Annotation transcript	gNomen	cNomen	pNomen	PPH prédiction
DCLRE1C	Mutation	In-Frame	ENST00000378278.2	g.14951099_14951101del g.14951099_14951101del	c.1385_1387del c.1385_1387del	p.Glu462del p.Glu462del	damaging damaging
ZWINT	Mutation	In-Frame	ENST00000361148.6	g.58120977_58120982del g.58120977_58120982del	c.16_21del c.16_21del	p.Thr6_Glu7del p.Thr6_Glu7del	damaging damaging
RPS27L	Mutation	In-Frame	ENST00000330964.5	g.63448682_63448687del g.63448682_63448687del	c.40_45del c.40_45del	p.Glu14_Glu15del p.Glu14_Glu15del	damaging damaging
AKAP13	Mutation	In-Frame	NM_001270546.1	g.86262400_86262438del g.86262400_86262438del	c.1958_1996del c.1958_1996del	p.Gln653_Glu665del p.Gln653_Glu665del	damaging damaging
PLIN4	Mutation	In-Frame	ENST00000301286.3	g.4511731_4511732ins24 g.4511731_4511732ins24	c.2198_2199insGTCCAGGGGGGCCTGGACACTACA c.2198_2199insGTCCAGGGGGGCCTGGACACTACA	p.Ala733_Ile734ins8 p.Ala733_Ile734ins8	damaging damaging
BMP6	Mutation	In-Frame	ENST00000283147.6	g.7727523_7727524insAGC g.7727523_7727524insAGC	c.335_336insAGC c.335_336insAGC	p.Glu112_Gln113insAla p.Glu112_Gln113insAla	damaging damaging
DENND2D	Mutation	Missense	ENST00000357640.4	g.111740585T>C g.111740585T>C	c.383A>G c.383A>G	p.Asn128Ser p.Asn128Ser	probably damaging probably damaging
DENND2C	Mutation	Missense	ENST00000393274.1	g.115168586C>T g.115168586C>T	c.20G>A c.20G>A	p.Arg7His p.Arg7His	probably damaging probably damaging
VPS13D	Mutation	Missense	ENST00000356315.4	g.12333136A>G g.12333136A>G	c.2180A>G c.2180A>G	p.Lys727Arg p.Lys727Arg	possibly damaging possibly damaging
FLG	Mutation	Missense	ENST00000368799.1	g.152282956C>T g.152282956C>T	c.4406G>A c.4406G>A	p.Arg1469His p.Arg1469His	benign benign
NUP210L	Mutation	Missense	ENST00000368559.3	g.153974300T>C g.153974300T>C	c.5092A>G c.5092A>G	p.Ile1698Val p.Ile1698Val	benign benign
DAP3	Mutation	Missense	ENST00000343043.3	g.155695231A>G g.155695231A>G	c.329A>G c.329A>G	p.His110Arg p.His110Arg	benign benign
CELA2B	Mutation	Missense	ENST00000375910.3	g.15813785C>G g.15813785C>G	c.645C>G c.645C>G	p.Asp215Glu p.Asp215Glu	probably damaging probably damaging
ADCY10	Mutation	Missense	ENST00000367851.4	g.167817638C>T g.167817638C>T	c.2398G>A c.2398G>A	p.Val800Ile p.Val800Ile	probably damaging probably damaging
LAMC1	Mutation	Missense	ENST00000258341.4	g.183106855G>A g.183106855G>A	c.4366G>A c.4366G>A	p.Asp1456Asn p.Asp1456Asn	benign benign
ZNF281	Mutation	Missense	ENST00000294740.3	g.200376462T>C g.200376462T>C	c.2372A>G c.2372A>G	p.Gln791Arg p.Gln791Arg	benign benign
CSRP1	Mutation	Missense	ENST00000340006.2	g.201459355G>A g.201459355G>A	c.230C>T c.230C>T	p.Ala77Val p.Ala77Val	probably damaging probably damaging
LGR6	Mutation	Missense	ENST00000439764.2	g.202183337G>T g.202183337G>T	c.55G>T c.55G>T	p.Ala19Ser p.Ala19Ser	benign benign
FCAMR	Mutation	Missense	ENST00000324852.4	g.207131914A>T g.207131914A>T	c.1681T>A c.1681T>A	p.Ser561Thr p.Ser561Thr	possibly damaging possibly damaging
ANGEL2	Mutation	Missense	ENST00000366962.3	g.213186671T>C g.213186671T>C	c.149A>G c.149A>G	p.His50Arg p.His50Arg	possibly damaging possibly damaging
RAB3GAP2	Mutation	Missense	ENST00000358951.2	g.220445634C>T g.220445634C>T	c.46G>A c.46G>A	p.Ala16Thr p.Ala16Thr	benign benign
C1orf65	Mutation	Missense	ENST00000366875.3	g.223568031G>T g.223568031G>T	c.1214G>T c.1214G>T	p.Cys405Phe p.Cys405Phe	probably damaging probably damaging
TRIM17	Mutation	Missense	ENST00000295033.3	g.228602394T>A g.228602394T>A	c.380A>T c.380A>T	p.His127Leu p.His127Leu	probably damaging probably damaging
URB2	Mutation	Missense	ENST00000258243.2	g.229770731G>A g.229770731G>A	c.371G>A c.371G>A	p.Arg124Gln p.Arg124Gln	benign benign
GNPAT	Mutation	Missense	ENST00000366647.4	g.231401825A>G g.231401825A>G	c.838A>G c.838A>G	p.Ile280Val p.Ile280Val	benign benign

Mutational Signature

Fusion transcripts (8)

Fusion Name	Gene (1)	Chr (1)	Genomic position hg19 (1)	Gene (2)	Chr (2)	Genomic position hg19 (2)	Supporting reads	Consistance fusion	Fusion type
AL121578.2--SYTL5	AL121578.2	chrX	37765403	SYTL5	chrX	37913465	10	straight	DEL
BIRC6--TTC27	BIRC6	chr2	32836648	TTC27	chr2	33002948	27	straight	DEL
CCDC7--ITGB1	CCDC7	chr10	33039665	ITGB1	chr10	33197295	17	inverted	DEL
FGFR1--FSIP1	FGFR1	chr8	38314873	FSIP1	chr15	40005781	54	straight	TRANS
MBNL3--RAP2C	MBNL3	chrX	131563840	RAP2C	chrX	131352864	23	straight	DEL
MYBL1--STAU2	STAU2	chr8	74439924	MYBL1	chr8	67488608	16	straight	DEL
OLFML2A--TAOK1	TAOK1	chr17	27718041	OLFML2A	chr9	127549253	24	straight	TRANS
RP11-351I24.1--SBF2	RP11-351I24.1	chr11	10324842	SBF2	chr11	10215533	11	straight	DEL

HBV RNA fusions (5)

Breakpoint on human genome (hg19)	Affected gene	Breakpoint on HBV genome (X02763)	Nb of paired reads (HG19 HBV)
chr11:81,645,273	intergenic	1,667	199
chr14:29,813,179	intergenic	2,305	28
chr5:1,192,175	intergenic	1,811	18
chr5:1,297,813	TERT (promoter)	1,703	864
chr9:77,914,823	intergenic	1,825	183

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)

Drugs (35)

DrugFilter by Drug	AUC	GI50
Bortezomib	0.46	0.052
Sorafenib_Trametinib	0.62	0.12
Trametinib	0.64	0.305
Rapamycin	0.75	10.0
Doxorubicin	0.75	1.51
PF.04691502	0.76	0.9
Alvespimycin	0.79	2.61
Sorafenib_Resminostat	0.8	3.05
Tivantinib	0.83	10.0
Sorafenib_Refametinib	0.83	1.31
Tanespimycin	0.88	10.0
Resminostat	0.89	7.507
Sorafenib_MK.2206	0.9	4.604
Vinblastine	0.9	10.0
Entinostat	0.92	10.0

Liver Cancer Cell Lines Database

Cell Line: SNU761

Transcriptomic subgroup: CL2

Mutational Signature

Liver Cancer Cell Lines
Database