Liver Cancer Cell Lines
Database

LCCL to predict drug response

Cell Line: SNU761


Cell line description
Cell line nameSynonymsCellosaurus IDTumor typeReferenceSupplierCulture medium
SNU761 CVCL_5089 Hepatocellular Carcinoma Lee et al. World J Gastroenterol (1999) [PMID: 11819450] KCLB - Korea Williams' Medium E (#22551-022, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin + 1X glutamine

AgeGenderGeographic OriginEthnicityHBVHCV
49 Male Korea Asian Yes NA

Transcriptomic subgroup: CL2


Mutations and CNAs (454)
Gene nameAlteration typeVariant classAnnotation transcriptgNomencNomenpNomenPPH pr├ędiction
DCLRE1CMutationIn-FrameENST00000378278.2
g.14951099_14951101del
g.14951099_14951101del
c.1385_1387del
c.1385_1387del
p.Glu462del
p.Glu462del
damaging
damaging
ZWINTMutationIn-FrameENST00000361148.6
g.58120977_58120982del
g.58120977_58120982del
c.16_21del
c.16_21del
p.Thr6_Glu7del
p.Thr6_Glu7del
damaging
damaging
RPS27LMutationIn-FrameENST00000330964.5
g.63448682_63448687del
g.63448682_63448687del
c.40_45del
c.40_45del
p.Glu14_Glu15del
p.Glu14_Glu15del
damaging
damaging
AKAP13MutationIn-FrameNM_001270546.1
g.86262400_86262438del
g.86262400_86262438del
c.1958_1996del
c.1958_1996del
p.Gln653_Glu665del
p.Gln653_Glu665del
damaging
damaging
PLIN4MutationIn-FrameENST00000301286.3
g.4511731_4511732ins24
g.4511731_4511732ins24
c.2198_2199insGTCCAGGGGGGCCTGGACACTACA
c.2198_2199insGTCCAGGGGGGCCTGGACACTACA
p.Ala733_Ile734ins8
p.Ala733_Ile734ins8
damaging
damaging
BMP6MutationIn-FrameENST00000283147.6
g.7727523_7727524insAGC
g.7727523_7727524insAGC
c.335_336insAGC
c.335_336insAGC
p.Glu112_Gln113insAla
p.Glu112_Gln113insAla
damaging
damaging
DENND2DMutationMissenseENST00000357640.4
g.111740585T>C
g.111740585T>C
c.383A>G
c.383A>G
p.Asn128Ser
p.Asn128Ser
probably damaging
probably damaging
DENND2CMutationMissenseENST00000393274.1
g.115168586C>T
g.115168586C>T
c.20G>A
c.20G>A
p.Arg7His
p.Arg7His
probably damaging
probably damaging
VPS13DMutationMissenseENST00000356315.4
g.12333136A>G
g.12333136A>G
c.2180A>G
c.2180A>G
p.Lys727Arg
p.Lys727Arg
possibly damaging
possibly damaging
FLGMutationMissenseENST00000368799.1
g.152282956C>T
g.152282956C>T
c.4406G>A
c.4406G>A
p.Arg1469His
p.Arg1469His
benign
benign
NUP210LMutationMissenseENST00000368559.3
g.153974300T>C
g.153974300T>C
c.5092A>G
c.5092A>G
p.Ile1698Val
p.Ile1698Val
benign
benign
DAP3MutationMissenseENST00000343043.3
g.155695231A>G
g.155695231A>G
c.329A>G
c.329A>G
p.His110Arg
p.His110Arg
benign
benign
CELA2BMutationMissenseENST00000375910.3
g.15813785C>G
g.15813785C>G
c.645C>G
c.645C>G
p.Asp215Glu
p.Asp215Glu
probably damaging
probably damaging
ADCY10MutationMissenseENST00000367851.4
g.167817638C>T
g.167817638C>T
c.2398G>A
c.2398G>A
p.Val800Ile
p.Val800Ile
probably damaging
probably damaging
LAMC1MutationMissenseENST00000258341.4
g.183106855G>A
g.183106855G>A
c.4366G>A
c.4366G>A
p.Asp1456Asn
p.Asp1456Asn
benign
benign
ZNF281MutationMissenseENST00000294740.3
g.200376462T>C
g.200376462T>C
c.2372A>G
c.2372A>G
p.Gln791Arg
p.Gln791Arg
benign
benign
CSRP1MutationMissenseENST00000340006.2
g.201459355G>A
g.201459355G>A
c.230C>T
c.230C>T
p.Ala77Val
p.Ala77Val
probably damaging
probably damaging
LGR6MutationMissenseENST00000439764.2
g.202183337G>T
g.202183337G>T
c.55G>T
c.55G>T
p.Ala19Ser
p.Ala19Ser
benign
benign
FCAMRMutationMissenseENST00000324852.4
g.207131914A>T
g.207131914A>T
c.1681T>A
c.1681T>A
p.Ser561Thr
p.Ser561Thr
possibly damaging
possibly damaging
ANGEL2MutationMissenseENST00000366962.3
g.213186671T>C
g.213186671T>C
c.149A>G
c.149A>G
p.His50Arg
p.His50Arg
possibly damaging
possibly damaging
RAB3GAP2MutationMissenseENST00000358951.2
g.220445634C>T
g.220445634C>T
c.46G>A
c.46G>A
p.Ala16Thr
p.Ala16Thr
benign
benign
C1orf65MutationMissenseENST00000366875.3
g.223568031G>T
g.223568031G>T
c.1214G>T
c.1214G>T
p.Cys405Phe
p.Cys405Phe
probably damaging
probably damaging
TRIM17MutationMissenseENST00000295033.3
g.228602394T>A
g.228602394T>A
c.380A>T
c.380A>T
p.His127Leu
p.His127Leu
probably damaging
probably damaging
URB2MutationMissenseENST00000258243.2
g.229770731G>A
g.229770731G>A
c.371G>A
c.371G>A
p.Arg124Gln
p.Arg124Gln
benign
benign
GNPATMutationMissenseENST00000366647.4
g.231401825A>G
g.231401825A>G
c.838A>G
c.838A>G
p.Ile280Val
p.Ile280Val
benign
benign

Mutational Signature



Fusion transcripts (8)
Fusion NameGene (1)Chr (1)Genomic position hg19 (1)Gene (2)Chr (2)Genomic position hg19 (2)Supporting readsConsistance fusionFusion type
AL121578.2--SYTL5AL121578.2chrX37765403SYTL5chrX3791346510straightDEL
BIRC6--TTC27BIRC6chr232836648TTC27chr23300294827straightDEL
CCDC7--ITGB1CCDC7chr1033039665ITGB1chr103319729517invertedDEL
FGFR1--FSIP1FGFR1chr838314873FSIP1chr154000578154straightTRANS
MBNL3--RAP2CMBNL3chrX131563840RAP2CchrX13135286423straightDEL
MYBL1--STAU2STAU2chr874439924MYBL1chr86748860816straightDEL
OLFML2A--TAOK1TAOK1chr1727718041OLFML2Achr912754925324straightTRANS
RP11-351I24.1--SBF2RP11-351I24.1chr1110324842SBF2chr111021553311straightDEL

HBV RNA fusions (5)
Breakpoint on human genome (hg19)Affected geneBreakpoint on HBV genome (X02763)Nb of paired reads (HG19 HBV)
chr11:81,645,273intergenic1,667199
chr14:29,813,179intergenic2,30528
chr5:1,192,175intergenic1,81118
chr5:1,297,813TERT (promoter)1,703864
chr9:77,914,823intergenic1,825183

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)


Drugs (35)
DrugAUCGI50
Bortezomib0.460.052
Sorafenib_Trametinib0.620.12
Trametinib0.640.305
Doxorubicin0.751.51
Rapamycin0.7510.0
PF.046915020.760.9
Alvespimycin0.792.61
Sorafenib_Resminostat0.83.05
Tivantinib0.8310.0
Sorafenib_Refametinib0.831.31
Tanespimycin0.8810.0
Resminostat0.897.507
Vinblastine0.910.0
Sorafenib_MK.22060.94.604
Entinostat0.9210.0


Codebase Soc. Coop.
info@codebase.it