Liver Cancer Cell Lines
Database

LCCL to predict drug response

Cell Line: SNU878


Cell line description
Cell line nameSynonymsCellosaurus IDTumor typeReferenceSupplierCulture medium
SNU878 CVCL_5102 Hepatocellular Carcinoma Lee et al. World J Gastroenterol (1999) [PMID: 11819450] KCLB - Korea DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

AgeGenderGeographic OriginEthnicityHBVHCV
54 Female Korea Asian Yes NA

Transcriptomic subgroup: CL2


Mutations and CNAs (404)
Gene nameAlteration typeVariant classAnnotation transcriptgNomencNomenpNomenPPH pr├ędiction
ZRANB2MutationIn-FrameENST00000254821.6
g.71536548_71536550del
g.71536548_71536550del
c.643_645del
c.643_645del
p.Ser215del
p.Ser215del
damaging
damaging
CATSPER2MutationIn-FrameENST00000321596.5
g.43924553_43924554insCCA
g.43924553_43924554insCCA
c.1404_1405insTGG
c.1404_1405insTGG
p.Leu468_Asp469insTrp
p.Leu468_Asp469insTrp
damaging
damaging
FOXF2MutationIn-FrameENST00000259806.1
g.1391086_1391087insGGC
g.1391086_1391087insGGC
c.905_906insGCG
c.905_906insGCG
p.Gly302_Gly303insArg
p.Gly302_Gly303insArg
damaging
damaging
SETDB1MutationMissenseENST00000271640.5
g.150923536G>T
g.150923536G>T
c.2183G>T
c.2183G>T
p.Gly728Val
p.Gly728Val
probably damaging
probably damaging
PGLYRP4MutationMissenseENST00000359650.5
g.153317814C>T
g.153317814C>T
c.184G>A
c.184G>A
p.Gly62Arg
p.Gly62Arg
probably damaging
probably damaging
NTRK1MutationMissenseENST00000358660.3
g.156843527A>G
g.156843527A>G
c.953A>G
c.953A>G
p.Asn318Ser
p.Asn318Ser
probably damaging
probably damaging
PEAR1MutationMissenseENST00000292357.7
g.156880496T>C
g.156880496T>C
c.1912T>C
c.1912T>C
p.Tyr638His
p.Tyr638His
benign
benign
RSC1A1MutationMissenseENST00000345034.1
g.15986559T>C
g.15986559T>C
c.196T>C
c.196T>C
p.Ser66Pro
p.Ser66Pro
benign
benign
ARHGAP30MutationMissenseENST00000368013.3
g.161022098A>T
g.161022098A>T
c.996T>A
c.996T>A
p.Ser332Arg
p.Ser332Arg
probably damaging
probably damaging
F5MutationMissenseENST00000367797.3
g.169511985A>C
g.169511985A>C
c.2343T>G
c.2343T>G
p.Ser781Arg
p.Ser781Arg
benign
benign
PRDX6MutationMissenseENST00000340385.5
g.173446558G>A
g.173446558G>A
c.22G>A
c.22G>A
p.Gly8Arg
p.Gly8Arg
possibly damaging
possibly damaging
RGSL1MutationMissenseENST00000294854.8
g.182522650G>A
g.182522650G>A
c.3104G>A
c.3104G>A
p.Arg1035Gln
p.Arg1035Gln
probably damaging
probably damaging
IFFO2MutationMissenseENST00000455833.2
g.19282714C>G
g.19282714C>G
c.113G>C
c.113G>C
p.Gly38Ala
p.Gly38Ala
benign
benign
IL19MutationMissenseENST00000270218.6
g.207013261C>T
g.207013261C>T
c.277C>T
c.277C>T
p.His93Tyr
p.His93Tyr
probably damaging
probably damaging
DNAH14MutationMissenseENST00000430092.1
g.225239246G>A
g.225239246G>A
c.2173G>A
c.2173G>A
p.Ala725Thr
p.Ala725Thr
probably damaging
probably damaging
DNAH14MutationMissenseENST00000430092.1
g.225380540A>G
g.225380540A>G
c.5747A>G
c.5747A>G
p.Tyr1916Cys
p.Tyr1916Cys
benign
benign
EPHA8MutationMissenseENST00000166244.3
g.22903017G>A
g.22903017G>A
c.467G>A
c.467G>A
p.Gly156Asp
p.Gly156Asp
probably damaging
probably damaging
SYF2MutationMissenseENST00000236273.4
g.25551565T>C
g.25551565T>C
c.494A>G
c.494A>G
p.Asn165Ser
p.Asn165Ser
benign
benign
MACF1MutationMissenseENST00000317713.7
g.39847651G>T
g.39847651G>T
c.7489G>T
c.7489G>T
p.Val2497Phe
p.Val2497Phe
benign
benign
HIVEP3MutationMissenseENST00000247584.5
g.42050411G>A
g.42050411G>A
c.58C>T
c.58C>T
p.Arg20Trp
p.Arg20Trp
probably damaging
probably damaging
SZT2MutationMissenseENST00000562955.1
g.43900974G>T
g.43900974G>T
c.5837G>T
c.5837G>T
p.Arg1946Leu
p.Arg1946Leu
probably damaging
probably damaging
DAB1MutationMissenseENST00000371234.4
g.57480898G>C
g.57480898G>C
c.1102C>G
c.1102C>G
p.Pro368Ala
p.Pro368Ala
probably damaging
probably damaging
SEC31BMutationMissenseENST00000370329.5
g.102269198C>T
g.102269198C>T
c.274G>A
c.274G>A
p.Gly92Arg
p.Gly92Arg
probably damaging
probably damaging
FAM178AMutationMissenseENST00000238961.4
g.102684518A>T
g.102684518A>T
c.1760A>T
c.1760A>T
p.Asn587Ile
p.Asn587Ile
possibly damaging
possibly damaging
GPR26MutationMissenseENST00000284674.1
g.125426366G>T
g.125426366G>T
c.443G>T
c.443G>T
p.Gly148Val
p.Gly148Val
probably damaging
probably damaging

Mutational Signature



Fusion transcripts (6)
Fusion NameGene (1)Chr (1)Genomic position hg19 (1)Gene (2)Chr (2)Genomic position hg19 (2)Supporting readsConsistance fusionFusion type
ALDH3B1--UNC93B1ALDH3B1chr1167782928UNC93B1chr116776714962straightINV
ASPH--RP11-705O24.1ASPHchr862555446RP11-705O24.1chr86271841911invertedDUP
AXIN1--LUC7LAXIN1chr16380490LUC7Lchr1625818613straightDEL
CDH7--RP11-775G23.1RP11-775G23.1chr1863310004CDH7chr186342988223straightDEL
LINC01116--OLA1LINC01116chr2177502189OLA1chr217500672730NADEL
LMO3--MGST1MGST1chr1216520398LMO3chr121674246110invertedDEL

HBV RNA fusions (1)
Breakpoint on human genome (hg19)Affected geneBreakpoint on HBV genome (X02763)Nb of paired reads (HG19 HBV)
chr13:67,275,475PCDH9 (intron 2/3)1,78119

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)


Drugs (35)
DrugAUCGI50
Sorafenib_Trametinib
Bortezomib0.370.03
Vinblastine0.420.01
Trametinib0.450.08
Paclitaxel0.460.03
Tivantinib0.560.086
Navitoclax0.560.21
PF.046915020.580.165
Rapamycin0.6310.0
Tanespimycin0.670.623
Dasatinib0.710.0
Alisertib0.720.473
Selumetinib0.756.727
Alvespimycin0.761.21
Doxorubicin0.781.0


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