Liver Cancer Cell Lines Database

Cell line description

Cell line name	Synonyms	Cellosaurus ID	Tumor type	Reference	Supplier	Culture medium
SNU878		CVCL_5102	Hepatocellular Carcinoma	Lee et al. World J Gastroenterol (1999) [PMID: 11819450]	KCLB - Korea	DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

Age	Gender	Geographic Origin	Ethnicity	HBV	HCV
54	Female	Korea	Asian	Yes	NA

Transcriptomic subgroup: CL2

Mutations and CNAs (404)

Gene nameFilter by Gene name	Alteration type	Variant class	Annotation transcript	gNomen	cNomen	pNomen	PPH prédiction
ZRANB2	Mutation	In-Frame	ENST00000254821.6	g.71536548_71536550del g.71536548_71536550del	c.643_645del c.643_645del	p.Ser215del p.Ser215del	damaging damaging
CATSPER2	Mutation	In-Frame	ENST00000321596.5	g.43924553_43924554insCCA g.43924553_43924554insCCA	c.1404_1405insTGG c.1404_1405insTGG	p.Leu468_Asp469insTrp p.Leu468_Asp469insTrp	damaging damaging
FOXF2	Mutation	In-Frame	ENST00000259806.1	g.1391086_1391087insGGC g.1391086_1391087insGGC	c.905_906insGCG c.905_906insGCG	p.Gly302_Gly303insArg p.Gly302_Gly303insArg	damaging damaging
SETDB1	Mutation	Missense	ENST00000271640.5	g.150923536G>T g.150923536G>T	c.2183G>T c.2183G>T	p.Gly728Val p.Gly728Val	probably damaging probably damaging
PGLYRP4	Mutation	Missense	ENST00000359650.5	g.153317814C>T g.153317814C>T	c.184G>A c.184G>A	p.Gly62Arg p.Gly62Arg	probably damaging probably damaging
NTRK1	Mutation	Missense	ENST00000358660.3	g.156843527A>G g.156843527A>G	c.953A>G c.953A>G	p.Asn318Ser p.Asn318Ser	probably damaging probably damaging
PEAR1	Mutation	Missense	ENST00000292357.7	g.156880496T>C g.156880496T>C	c.1912T>C c.1912T>C	p.Tyr638His p.Tyr638His	benign benign
RSC1A1	Mutation	Missense	ENST00000345034.1	g.15986559T>C g.15986559T>C	c.196T>C c.196T>C	p.Ser66Pro p.Ser66Pro	benign benign
ARHGAP30	Mutation	Missense	ENST00000368013.3	g.161022098A>T g.161022098A>T	c.996T>A c.996T>A	p.Ser332Arg p.Ser332Arg	probably damaging probably damaging
F5	Mutation	Missense	ENST00000367797.3	g.169511985A>C g.169511985A>C	c.2343T>G c.2343T>G	p.Ser781Arg p.Ser781Arg	benign benign
PRDX6	Mutation	Missense	ENST00000340385.5	g.173446558G>A g.173446558G>A	c.22G>A c.22G>A	p.Gly8Arg p.Gly8Arg	possibly damaging possibly damaging
RGSL1	Mutation	Missense	ENST00000294854.8	g.182522650G>A g.182522650G>A	c.3104G>A c.3104G>A	p.Arg1035Gln p.Arg1035Gln	probably damaging probably damaging
IFFO2	Mutation	Missense	ENST00000455833.2	g.19282714C>G g.19282714C>G	c.113G>C c.113G>C	p.Gly38Ala p.Gly38Ala	benign benign
IL19	Mutation	Missense	ENST00000270218.6	g.207013261C>T g.207013261C>T	c.277C>T c.277C>T	p.His93Tyr p.His93Tyr	probably damaging probably damaging
DNAH14	Mutation	Missense	ENST00000430092.1	g.225239246G>A g.225239246G>A	c.2173G>A c.2173G>A	p.Ala725Thr p.Ala725Thr	probably damaging probably damaging
DNAH14	Mutation	Missense	ENST00000430092.1	g.225380540A>G g.225380540A>G	c.5747A>G c.5747A>G	p.Tyr1916Cys p.Tyr1916Cys	benign benign
EPHA8	Mutation	Missense	ENST00000166244.3	g.22903017G>A g.22903017G>A	c.467G>A c.467G>A	p.Gly156Asp p.Gly156Asp	probably damaging probably damaging
SYF2	Mutation	Missense	ENST00000236273.4	g.25551565T>C g.25551565T>C	c.494A>G c.494A>G	p.Asn165Ser p.Asn165Ser	benign benign
MACF1	Mutation	Missense	ENST00000317713.7	g.39847651G>T g.39847651G>T	c.7489G>T c.7489G>T	p.Val2497Phe p.Val2497Phe	benign benign
HIVEP3	Mutation	Missense	ENST00000247584.5	g.42050411G>A g.42050411G>A	c.58C>T c.58C>T	p.Arg20Trp p.Arg20Trp	probably damaging probably damaging
SZT2	Mutation	Missense	ENST00000562955.1	g.43900974G>T g.43900974G>T	c.5837G>T c.5837G>T	p.Arg1946Leu p.Arg1946Leu	probably damaging probably damaging
DAB1	Mutation	Missense	ENST00000371234.4	g.57480898G>C g.57480898G>C	c.1102C>G c.1102C>G	p.Pro368Ala p.Pro368Ala	probably damaging probably damaging
SEC31B	Mutation	Missense	ENST00000370329.5	g.102269198C>T g.102269198C>T	c.274G>A c.274G>A	p.Gly92Arg p.Gly92Arg	probably damaging probably damaging
FAM178A	Mutation	Missense	ENST00000238961.4	g.102684518A>T g.102684518A>T	c.1760A>T c.1760A>T	p.Asn587Ile p.Asn587Ile	possibly damaging possibly damaging
GPR26	Mutation	Missense	ENST00000284674.1	g.125426366G>T g.125426366G>T	c.443G>T c.443G>T	p.Gly148Val p.Gly148Val	probably damaging probably damaging

Mutational Signature

Fusion transcripts (6)

Fusion Name	Gene (1)	Chr (1)	Genomic position hg19 (1)	Gene (2)	Chr (2)	Genomic position hg19 (2)	Supporting reads	Consistance fusion	Fusion type
ALDH3B1--UNC93B1	ALDH3B1	chr11	67782928	UNC93B1	chr11	67767149	62	straight	INV
ASPH--RP11-705O24.1	ASPH	chr8	62555446	RP11-705O24.1	chr8	62718419	11	inverted	DUP
AXIN1--LUC7L	AXIN1	chr16	380490	LUC7L	chr16	258186	13	straight	DEL
CDH7--RP11-775G23.1	RP11-775G23.1	chr18	63310004	CDH7	chr18	63429882	23	straight	DEL
LINC01116--OLA1	LINC01116	chr2	177502189	OLA1	chr2	175006727	30	NA	DEL
LMO3--MGST1	MGST1	chr12	16520398	LMO3	chr12	16742461	10	inverted	DEL

HBV RNA fusions (1)

Breakpoint on human genome (hg19)	Affected gene	Breakpoint on HBV genome (X02763)	Nb of paired reads (HG19 HBV)
chr13:67,275,475	PCDH9 (intron 2/3)	1,781	19

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)

Drugs (35)

DrugFilter by Drug	AUC	GI50
Sorafenib_Trametinib
Bortezomib	0.37	0.03
Vinblastine	0.42	0.01
Trametinib	0.45	0.08
Paclitaxel	0.46	0.03
Navitoclax	0.56	0.21
Tivantinib	0.56	0.086
PF.04691502	0.58	0.165
Rapamycin	0.63	10.0
Tanespimycin	0.67	0.623
Dasatinib	0.7	10.0
Alisertib	0.72	0.473
Selumetinib	0.75	6.727
Alvespimycin	0.76	1.21
Doxorubicin	0.78	1.0

Liver Cancer Cell Lines Database

Cell Line: SNU878

Transcriptomic subgroup: CL2

Mutational Signature

Liver Cancer Cell Lines
Database