Liver Cancer Cell Lines
Database

LCCL to predict drug response

Cell Line: SNU886


Cell line description
Cell line nameSynonymsCellosaurus IDTumor typeReferenceSupplierCulture medium
SNU886 CVCL_5103 Hepatocellular Carcinoma Lee et al. World J Gastroenterol (1999) [PMID: 11819450] KCLB - Korea DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

AgeGenderGeographic OriginEthnicityHBVHCV
57 Male Korea Asian Yes NA

Transcriptomic subgroup: CL2


Mutations and CNAs (408)
Gene nameAlteration typeVariant classAnnotation transcriptgNomencNomenpNomenPPH pr├ędiction
RNF111MutationIn-FrameENST00000348370.4
g.59323502_59323504del
g.59323502_59323504del
c.481_483del
c.481_483del
p.Val161del
p.Val161del
damaging
damaging
CYP2A13MutationIn-FrameENST00000330436.3
g.41596006_41596007insCCA
g.41596006_41596007insCCA
c.399_400insCAC
c.399_400insCAC
p.Ala133_Thr134insHis
p.Ala133_Thr134insHis
damaging
damaging
ARHGEF26MutationIn-FrameENST00000356448.4
g.153840202_153840207del
g.153840202_153840207del
c.421_426del
c.421_426del
p.Pro141_Pro142del
p.Pro141_Pro142del
damaging
damaging
ARRDC1MutationIn-FrameENST00000371421.4
g.140509174_140509179del
g.140509174_140509179del
c.959_964del
c.959_964del
p.Glu320_Ala321del
p.Glu320_Ala321del
damaging
damaging
GPR88MutationMissenseENST00000315033.4
g.101004613C>A
g.101004613C>A
c.91C>A
c.91C>A
p.Arg31Ser
p.Arg31Ser
probably damaging
probably damaging
C1orf159MutationMissenseENST00000294576.5
g.1021387G>C
g.1021387G>C
c.316C>G
c.316C>G
p.Pro106Ala
p.Pro106Ala
probably damaging
probably damaging
VAV3MutationMissenseENST00000370056.4
g.108185345A>G
g.108185345A>G
c.1810T>C
c.1810T>C
p.Ser604Pro
p.Ser604Pro
benign
benign
CELSR2MutationMissenseENST00000271332.3
g.109814294C>T
g.109814294C>T
c.7876C>T
c.7876C>T
p.Arg2626Cys
p.Arg2626Cys
probably damaging
probably damaging
WNT2BMutationMissenseENST00000369684.4
g.113059924G>A
g.113059924G>A
c.863G>A
c.863G>A
p.Arg288His
p.Arg288His
benign
benign
SETDB1MutationMissenseENST00000271640.5
g.150935609A>G
g.150935609A>G
c.3451A>G
c.3451A>G
p.Met1151Val
p.Met1151Val
benign
benign
LCE2BMutationMissenseENST00000368780.3
g.152659498C>G
g.152659498C>G
c.179C>G
c.179C>G
p.Ser60Cys
p.Ser60Cys
probably damaging
probably damaging
S100A16MutationMissenseENST00000368703.2
g.153580513G>C
g.153580513G>C
c.115C>G
c.115C>G
p.Arg39Gly
p.Arg39Gly
benign
benign
CRTC2MutationMissenseENST00000368633.1
g.153921613A>T
g.153921613A>T
c.1652T>A
c.1652T>A
p.Met551Lys
p.Met551Lys
benign
benign
GBAMutationMissenseENST00000327247.5
g.155204815T>C
g.155204815T>C
c.1582A>G
c.1582A>G
p.Ile528Val
p.Ile528Val
possibly damaging
possibly damaging
RAB25MutationMissenseENST00000361084.5
g.156035875C>T
g.156035875C>T
c.217C>T
c.217C>T
p.Arg73Trp
p.Arg73Trp
probably damaging
probably damaging
NESMutationMissenseENST00000368223.3
g.156642838C>T
g.156642838C>T
c.1142G>A
c.1142G>A
p.Arg381His
p.Arg381His
benign
benign
INSRRMutationMissenseENST00000368195.3
g.156811545G>A
g.156811545G>A
c.3439C>T
c.3439C>T
p.Arg1147Cys
p.Arg1147Cys
probably damaging
probably damaging
CASP9MutationMissenseENST00000333868.5
g.15844776C>A
g.15844776C>A
c.247G>T
c.247G>T
p.Asp83Tyr
p.Asp83Tyr
benign
benign
OR6P1MutationMissenseENST00000334632.1
g.158532668C>T
g.158532668C>T
c.727G>A
c.727G>A
p.Ala243Thr
p.Ala243Thr
benign
benign
IFI16MutationMissenseENST00000295809.7
g.158986327G>C
g.158986327G>C
c.386G>C
c.386G>C
p.Arg129Thr
p.Arg129Thr
possibly damaging
possibly damaging
EPHA2MutationMissenseENST00000358432.5
g.16460396C>T
g.16460396C>T
c.1697G>A
c.1697G>A
p.Arg566His
p.Arg566His
benign
benign
MYOCMutationMissenseENST00000037502.6
g.171607843G>C
g.171607843G>C
c.624C>G
c.624C>G
p.Asp208Glu
p.Asp208Glu
benign
benign
SUCOMutationMissenseENST00000263688.3
g.172579359T>C
g.172579359T>C
c.3725T>C
c.3725T>C
p.Val1242Ala
p.Val1242Ala
probably damaging
probably damaging
TNRMutationMissenseENST00000263525.2
g.175293533T>A
g.175293533T>A
c.3916A>T
c.3916A>T
p.Thr1306Ser
p.Thr1306Ser
benign
benign
IVNS1ABPMutationMissenseENST00000367498.3
g.185268931A>C
g.185268931A>C
c.1586T>G
c.1586T>G
p.Val529Gly
p.Val529Gly
probably damaging
probably damaging

Mutational Signature



Fusion transcripts (5)
Fusion NameGene (1)Chr (1)Genomic position hg19 (1)Gene (2)Chr (2)Genomic position hg19 (2)Supporting readsConsistance fusionFusion type
ABCD4--LINC02274ABCD4chr1474766250LINC02274chr147429019413NADEL
BMPER--NPSR1-AS1BMPERchr734125703NPSR1-AS1chr734664346499invertedDEL
BNC2--C9orf92BNC2chr916410943C9orf92chr91621589628straightDEL
GALNT7--LOC101930370LOC101930370chr4174090111GALNT7chr417421325812NADEL
IGHMBP2--RP11-757G1.5IGHMBP2chr1168707237RP11-757G1.5chr116870945011straightINV

HBV RNA fusions (5)
Breakpoint on human genome (hg19)Affected geneBreakpoint on HBV genome (X02763)Nb of paired reads (HG19 HBV)
chr9:43,355,553 / chr9:44,514,466intergenic1,946167
chr11:69,554,589intergenic (FGF19/FGF4 locus)1,62928
chr11:69,065,983MYEOV (downstream)1,83122
chr11:69,156,276intergenic34513
chr12:122,833,604CLIP1 (intron 8)1,82620

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)


Drugs (35)
DrugAUCGI50
Vinblastine0.340.013
Paclitaxel0.360.02
Bortezomib0.390.025
Sorafenib_Trametinib0.430.04
PF.046915020.530.135
Rapamycin0.559.025
Alvespimycin0.610.21
Tivantinib0.640.5
Doxorubicin0.650.8
Dasatinib0.740.78
Trametinib0.742.49
Sorafenib_Refametinib0.750.54
CD5320.771.39
Tanespimycin0.781.033
Navitoclax0.82.525


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