Liver Cancer Cell Lines Database

Cell line description

Cell line name	Synonyms	Cellosaurus ID	Tumor type	Reference	Supplier	Culture medium
SNU886		CVCL_5103	Hepatocellular Carcinoma	Lee et al. World J Gastroenterol (1999) [PMID: 11819450]	KCLB - Korea	DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

Age	Gender	Geographic Origin	Ethnicity	HBV	HCV
57	Male	Korea	Asian	Yes	NA

Transcriptomic subgroup: CL2

Mutations and CNAs (408)

Gene nameFilter by Gene name	Alteration type	Variant class	Annotation transcript	gNomen	cNomen	pNomen	PPH prédiction
RNF111	Mutation	In-Frame	ENST00000348370.4	g.59323502_59323504del g.59323502_59323504del	c.481_483del c.481_483del	p.Val161del p.Val161del	damaging damaging
CYP2A13	Mutation	In-Frame	ENST00000330436.3	g.41596006_41596007insCCA g.41596006_41596007insCCA	c.399_400insCAC c.399_400insCAC	p.Ala133_Thr134insHis p.Ala133_Thr134insHis	damaging damaging
ARHGEF26	Mutation	In-Frame	ENST00000356448.4	g.153840202_153840207del g.153840202_153840207del	c.421_426del c.421_426del	p.Pro141_Pro142del p.Pro141_Pro142del	damaging damaging
ARRDC1	Mutation	In-Frame	ENST00000371421.4	g.140509174_140509179del g.140509174_140509179del	c.959_964del c.959_964del	p.Glu320_Ala321del p.Glu320_Ala321del	damaging damaging
GPR88	Mutation	Missense	ENST00000315033.4	g.101004613C>A g.101004613C>A	c.91C>A c.91C>A	p.Arg31Ser p.Arg31Ser	probably damaging probably damaging
C1orf159	Mutation	Missense	ENST00000294576.5	g.1021387G>C g.1021387G>C	c.316C>G c.316C>G	p.Pro106Ala p.Pro106Ala	probably damaging probably damaging
VAV3	Mutation	Missense	ENST00000370056.4	g.108185345A>G g.108185345A>G	c.1810T>C c.1810T>C	p.Ser604Pro p.Ser604Pro	benign benign
CELSR2	Mutation	Missense	ENST00000271332.3	g.109814294C>T g.109814294C>T	c.7876C>T c.7876C>T	p.Arg2626Cys p.Arg2626Cys	probably damaging probably damaging
WNT2B	Mutation	Missense	ENST00000369684.4	g.113059924G>A g.113059924G>A	c.863G>A c.863G>A	p.Arg288His p.Arg288His	benign benign
SETDB1	Mutation	Missense	ENST00000271640.5	g.150935609A>G g.150935609A>G	c.3451A>G c.3451A>G	p.Met1151Val p.Met1151Val	benign benign
LCE2B	Mutation	Missense	ENST00000368780.3	g.152659498C>G g.152659498C>G	c.179C>G c.179C>G	p.Ser60Cys p.Ser60Cys	probably damaging probably damaging
S100A16	Mutation	Missense	ENST00000368703.2	g.153580513G>C g.153580513G>C	c.115C>G c.115C>G	p.Arg39Gly p.Arg39Gly	benign benign
CRTC2	Mutation	Missense	ENST00000368633.1	g.153921613A>T g.153921613A>T	c.1652T>A c.1652T>A	p.Met551Lys p.Met551Lys	benign benign
GBA	Mutation	Missense	ENST00000327247.5	g.155204815T>C g.155204815T>C	c.1582A>G c.1582A>G	p.Ile528Val p.Ile528Val	possibly damaging possibly damaging
RAB25	Mutation	Missense	ENST00000361084.5	g.156035875C>T g.156035875C>T	c.217C>T c.217C>T	p.Arg73Trp p.Arg73Trp	probably damaging probably damaging
NES	Mutation	Missense	ENST00000368223.3	g.156642838C>T g.156642838C>T	c.1142G>A c.1142G>A	p.Arg381His p.Arg381His	benign benign
INSRR	Mutation	Missense	ENST00000368195.3	g.156811545G>A g.156811545G>A	c.3439C>T c.3439C>T	p.Arg1147Cys p.Arg1147Cys	probably damaging probably damaging
CASP9	Mutation	Missense	ENST00000333868.5	g.15844776C>A g.15844776C>A	c.247G>T c.247G>T	p.Asp83Tyr p.Asp83Tyr	benign benign
OR6P1	Mutation	Missense	ENST00000334632.1	g.158532668C>T g.158532668C>T	c.727G>A c.727G>A	p.Ala243Thr p.Ala243Thr	benign benign
IFI16	Mutation	Missense	ENST00000295809.7	g.158986327G>C g.158986327G>C	c.386G>C c.386G>C	p.Arg129Thr p.Arg129Thr	possibly damaging possibly damaging
EPHA2	Mutation	Missense	ENST00000358432.5	g.16460396C>T g.16460396C>T	c.1697G>A c.1697G>A	p.Arg566His p.Arg566His	benign benign
MYOC	Mutation	Missense	ENST00000037502.6	g.171607843G>C g.171607843G>C	c.624C>G c.624C>G	p.Asp208Glu p.Asp208Glu	benign benign
SUCO	Mutation	Missense	ENST00000263688.3	g.172579359T>C g.172579359T>C	c.3725T>C c.3725T>C	p.Val1242Ala p.Val1242Ala	probably damaging probably damaging
TNR	Mutation	Missense	ENST00000263525.2	g.175293533T>A g.175293533T>A	c.3916A>T c.3916A>T	p.Thr1306Ser p.Thr1306Ser	benign benign
IVNS1ABP	Mutation	Missense	ENST00000367498.3	g.185268931A>C g.185268931A>C	c.1586T>G c.1586T>G	p.Val529Gly p.Val529Gly	probably damaging probably damaging

Mutational Signature

Fusion transcripts (5)

Fusion Name	Gene (1)	Chr (1)	Genomic position hg19 (1)	Gene (2)	Chr (2)	Genomic position hg19 (2)	Supporting reads	Consistance fusion	Fusion type
ABCD4--LINC02274	ABCD4	chr14	74766250	LINC02274	chr14	74290194	13	NA	DEL
BMPER--NPSR1-AS1	BMPER	chr7	34125703	NPSR1-AS1	chr7	34664346	499	inverted	DEL
BNC2--C9orf92	BNC2	chr9	16410943	C9orf92	chr9	16215896	28	straight	DEL
GALNT7--LOC101930370	LOC101930370	chr4	174090111	GALNT7	chr4	174213258	12	NA	DEL
IGHMBP2--RP11-757G1.5	IGHMBP2	chr11	68707237	RP11-757G1.5	chr11	68709450	11	straight	INV

HBV RNA fusions (5)

Breakpoint on human genome (hg19)	Affected gene	Breakpoint on HBV genome (X02763)	Nb of paired reads (HG19 HBV)
chr9:43,355,553 / chr9:44,514,466	intergenic	1,946	167
chr11:69,554,589	intergenic (FGF19/FGF4 locus)	1,629	28
chr11:69,065,983	MYEOV (downstream)	1,831	22
chr11:69,156,276	intergenic	345	13
chr12:122,833,604	CLIP1 (intron 8)	1,826	20

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)

Drugs (35)

DrugFilter by Drug	AUC	GI50
Vinblastine	0.34	0.013
Paclitaxel	0.36	0.02
Bortezomib	0.39	0.025
Sorafenib_Trametinib	0.43	0.04
PF.04691502	0.53	0.135
Rapamycin	0.55	9.025
Alvespimycin	0.61	0.21
Tivantinib	0.64	0.5
Doxorubicin	0.65	0.8
Dasatinib	0.74	0.78
Trametinib	0.74	2.49
Sorafenib_Refametinib	0.75	0.54
CD532	0.77	1.39
Tanespimycin	0.78	1.033
Navitoclax	0.8	2.525

Liver Cancer Cell Lines Database

Cell Line: SNU886

Transcriptomic subgroup: CL2

Mutational Signature

Liver Cancer Cell Lines
Database