Liver Cancer Cell Lines
Database

LCCL to predict drug response

Cell Line: B1


Cell line description
Cell line nameSynonymsCellosaurus IDTumor typeReferenceSupplierCulture medium
B1 CVCL_A1AS Hepatocellular Carcinoma Gift from Bettina Grasl-Kraupp (Austria) DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

AgeGenderGeographic OriginEthnicityHBVHCV
NA NA Austria European NA NA

Transcriptomic subgroup: CL1


Mutations and CNAs (240)
Gene nameAlteration typeVariant classAnnotation transcriptgNomencNomenpNomenPPH pr├ędiction
RAB44MutationIn-FrameNM_001257357.1
g.36689831_36689832insGGTGCA
g.36689831_36689832insGGTGCA
c.1921_1922insGTGCAG
c.1921_1922insGTGCAG
p.Ala640_Val641insGlyAla
p.Ala640_Val641insGlyAla
damaging
damaging
TRMT13MutationMissenseENST00000370141.2
g.100598759G>T
g.100598759G>T
c.35G>T
c.35G>T
p.Gly12Val
p.Gly12Val
benign
benign
GNAT2MutationMissenseENST00000351050.3
g.110146010A>G
g.110146010A>G
c.1031T>C
c.1031T>C
p.Ile344Thr
p.Ile344Thr
probably damaging
probably damaging
DDX20MutationMissenseENST00000369702.4
g.112309199A>T
g.112309199A>T
c.2153A>T
c.2153A>T
p.Gln718Leu
p.Gln718Leu
benign
benign
SCNN1DMutationMissenseENST00000379101.4
g.1216859C>T
g.1216859C>T
c.146C>T
c.146C>T
p.Thr49Ile
p.Thr49Ile
unknown
unknown
VPS45MutationMissenseENST00000369130.3
g.150040693A>G
g.150040693A>G
c.100A>G
c.100A>G
p.Ile34Val
p.Ile34Val
benign
benign
CCDC19MutationMissenseENST00000368099.4
g.159854305G>A
g.159854305G>A
c.818C>T
c.818C>T
p.Ser273Leu
p.Ser273Leu
benign
benign
PADI1MutationMissenseENST00000375471.4
g.17567192C>G
g.17567192C>G
c.1695C>G
c.1695C>G
p.Ile565Met
p.Ile565Met
probably damaging
probably damaging
SMG7MutationMissenseENST00000507469.1
g.183516381C>G
g.183516381C>G
c.2748C>G
c.2748C>G
p.Ser916Arg
p.Ser916Arg
damaging
damaging
IGFN1MutationMissenseENST00000335211.4
g.201178199G>C
g.201178199G>C
c.4178G>C
c.4178G>C
p.Arg1393Thr
p.Arg1393Thr
unknown
unknown
EIF2DMutationMissenseENST00000271764.2
g.206767021A>C
g.206767021A>C
c.1631T>G
c.1631T>G
p.Leu544Arg
p.Leu544Arg
benign
benign
TP53MutationMissenseENST00000269305.4
g.7578475G>A
g.7578475G>A
c.455C>T
c.455C>T
p.Pro152Leu
p.Pro152Leu
probably damaging
probably damaging
KCNK1MutationMissenseENST00000366621.3
g.233807068G>A
g.233807068G>A
c.803G>A
c.803G>A
p.Cys268Tyr
p.Cys268Tyr
probably damaging
probably damaging
ASAP3MutationMissenseENST00000336689.3
g.23759654C>T
g.23759654C>T
c.2239G>A
c.2239G>A
p.Glu747Lys
p.Glu747Lys
benign
benign
CNR2MutationMissenseENST00000374472.4
g.24202064T>C
g.24202064T>C
c.44A>G
c.44A>G
p.Asp15Gly
p.Asp15Gly
benign
benign
ST3GAL3MutationMissenseENST00000262915.3
g.44202013C>T
g.44202013C>T
c.80C>T
c.80C>T
p.Ala27Val
p.Ala27Val
probably damaging
probably damaging
PTCH2MutationMissenseENST00000372192.3
g.45292425G>A
g.45292425G>A
c.2711C>T
c.2711C>T
p.Pro904Leu
p.Pro904Leu
probably damaging
probably damaging
MAST2MutationMissenseENST00000361297.2
g.46500798C>G
g.46500798C>G
c.4457C>G
c.4457C>G
p.Ala1486Gly
p.Ala1486Gly
possibly damaging
possibly damaging
NRD1MutationMissenseENST00000354831.7
g.52303211T>C
g.52303211T>C
c.712A>G
c.712A>G
p.Thr238Ala
p.Thr238Ala
benign
benign
EVI5MutationMissenseENST00000370331.1
g.93202045G>A
g.93202045G>A
c.191C>T
c.191C>T
p.Thr64Ile
p.Thr64Ile
possibly damaging
possibly damaging
CALHM1MutationMissenseENST00000329905.5
g.105218334C>T
g.105218334C>T
c.175G>A
c.175G>A
p.Ala59Thr
p.Ala59Thr
benign
benign
NEURL1MutationMissenseENST00000369780.4
g.105331513C>T
g.105331513C>T
c.583C>T
c.583C>T
p.Arg195Cys
p.Arg195Cys
probably damaging
probably damaging
MALRD1MutationMissenseENST00000454679.2
g.19493250C>G
g.19493250C>G
c.6C>G
c.6C>G
p.F2L
p.F2L
NA
NA
KIAA1217MutationMissenseENST00000376454.3
g.24790355A>G
g.24790355A>G
c.1882A>G
c.1882A>G
p.Thr628Ala
p.Thr628Ala
benign
benign
ADAMTS14MutationMissenseENST00000373207.1
g.72511968C>A
g.72511968C>A
c.2714C>A
c.2714C>A
p.Pro905Gln
p.Pro905Gln
benign
benign

Mutational Signature



Fusion transcripts (3)
Fusion NameGene (1)Chr (1)Genomic position hg19 (1)Gene (2)Chr (2)Genomic position hg19 (2)Supporting readsConsistance fusionFusion type
CARD18--RP11-94P11.4RP11-94P11.4chr11105130368CARD18chr1110500980411straightDEL
FBXO33--GNG2FBXO33chr1439900767GNG2chr145236415630invertedDUP
PUDP--STSPUDPchrX7065642STSchrX717123622NADEL

HBV RNA fusions (0)
Breakpoint on human genome (hg19)Affected geneBreakpoint on HBV genome (X02763)Nb of paired reads (HG19 HBV)
No records found.

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)


Drugs (35)
DrugAUCGI50
Bortezomib0.160.003
Sorafenib_Trametinib0.30.02
Paclitaxel0.330.008
Rapamycin0.510.52
Vinblastine0.520.035
Linsitinib0.570.14
PF.046915020.60.164
Entinostat0.663.78
Alisertib0.680.678
Sorafenib_Resminostat0.680.7
Sorafenib_MK.22060.680.5
Dasatinib0.695.49
Alvespimycin0.70.785
Navitoclax0.710.825
Cabozantinib0.710.6266


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