Liver Cancer Cell Lines Database

Cell line description

Cell line name	Synonyms	Cellosaurus ID	Tumor type	Reference	Supplier	Culture medium
B1		CVCL_A1AS	Hepatocellular Carcinoma		Gift from Bettina Grasl-Kraupp (Austria)	DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

Age	Gender	Geographic Origin	Ethnicity	HBV	HCV
NA	NA	Austria	European	NA	NA

Transcriptomic subgroup: CL1

Mutations and CNAs (240)

Gene nameFilter by Gene name	Alteration type	Variant class	Annotation transcript	gNomen	cNomen	pNomen	PPH prédiction
RAB44	Mutation	In-Frame	NM_001257357.1	g.36689831_36689832insGGTGCA g.36689831_36689832insGGTGCA	c.1921_1922insGTGCAG c.1921_1922insGTGCAG	p.Ala640_Val641insGlyAla p.Ala640_Val641insGlyAla	damaging damaging
TRMT13	Mutation	Missense	ENST00000370141.2	g.100598759G>T g.100598759G>T	c.35G>T c.35G>T	p.Gly12Val p.Gly12Val	benign benign
GNAT2	Mutation	Missense	ENST00000351050.3	g.110146010A>G g.110146010A>G	c.1031T>C c.1031T>C	p.Ile344Thr p.Ile344Thr	probably damaging probably damaging
DDX20	Mutation	Missense	ENST00000369702.4	g.112309199A>T g.112309199A>T	c.2153A>T c.2153A>T	p.Gln718Leu p.Gln718Leu	benign benign
SCNN1D	Mutation	Missense	ENST00000379101.4	g.1216859C>T g.1216859C>T	c.146C>T c.146C>T	p.Thr49Ile p.Thr49Ile	unknown unknown
VPS45	Mutation	Missense	ENST00000369130.3	g.150040693A>G g.150040693A>G	c.100A>G c.100A>G	p.Ile34Val p.Ile34Val	benign benign
CCDC19	Mutation	Missense	ENST00000368099.4	g.159854305G>A g.159854305G>A	c.818C>T c.818C>T	p.Ser273Leu p.Ser273Leu	benign benign
PADI1	Mutation	Missense	ENST00000375471.4	g.17567192C>G g.17567192C>G	c.1695C>G c.1695C>G	p.Ile565Met p.Ile565Met	probably damaging probably damaging
SMG7	Mutation	Missense	ENST00000507469.1	g.183516381C>G g.183516381C>G	c.2748C>G c.2748C>G	p.Ser916Arg p.Ser916Arg	damaging damaging
IGFN1	Mutation	Missense	ENST00000335211.4	g.201178199G>C g.201178199G>C	c.4178G>C c.4178G>C	p.Arg1393Thr p.Arg1393Thr	unknown unknown
EIF2D	Mutation	Missense	ENST00000271764.2	g.206767021A>C g.206767021A>C	c.1631T>G c.1631T>G	p.Leu544Arg p.Leu544Arg	benign benign
TP53	Mutation	Missense	ENST00000269305.4	g.7578475G>A g.7578475G>A	c.455C>T c.455C>T	p.Pro152Leu p.Pro152Leu	probably damaging probably damaging
KCNK1	Mutation	Missense	ENST00000366621.3	g.233807068G>A g.233807068G>A	c.803G>A c.803G>A	p.Cys268Tyr p.Cys268Tyr	probably damaging probably damaging
ASAP3	Mutation	Missense	ENST00000336689.3	g.23759654C>T g.23759654C>T	c.2239G>A c.2239G>A	p.Glu747Lys p.Glu747Lys	benign benign
CNR2	Mutation	Missense	ENST00000374472.4	g.24202064T>C g.24202064T>C	c.44A>G c.44A>G	p.Asp15Gly p.Asp15Gly	benign benign
ST3GAL3	Mutation	Missense	ENST00000262915.3	g.44202013C>T g.44202013C>T	c.80C>T c.80C>T	p.Ala27Val p.Ala27Val	probably damaging probably damaging
PTCH2	Mutation	Missense	ENST00000372192.3	g.45292425G>A g.45292425G>A	c.2711C>T c.2711C>T	p.Pro904Leu p.Pro904Leu	probably damaging probably damaging
MAST2	Mutation	Missense	ENST00000361297.2	g.46500798C>G g.46500798C>G	c.4457C>G c.4457C>G	p.Ala1486Gly p.Ala1486Gly	possibly damaging possibly damaging
NRD1	Mutation	Missense	ENST00000354831.7	g.52303211T>C g.52303211T>C	c.712A>G c.712A>G	p.Thr238Ala p.Thr238Ala	benign benign
EVI5	Mutation	Missense	ENST00000370331.1	g.93202045G>A g.93202045G>A	c.191C>T c.191C>T	p.Thr64Ile p.Thr64Ile	possibly damaging possibly damaging
CALHM1	Mutation	Missense	ENST00000329905.5	g.105218334C>T g.105218334C>T	c.175G>A c.175G>A	p.Ala59Thr p.Ala59Thr	benign benign
NEURL1	Mutation	Missense	ENST00000369780.4	g.105331513C>T g.105331513C>T	c.583C>T c.583C>T	p.Arg195Cys p.Arg195Cys	probably damaging probably damaging
MALRD1	Mutation	Missense	ENST00000454679.2	g.19493250C>G g.19493250C>G	c.6C>G c.6C>G	p.F2L p.F2L	NA NA
KIAA1217	Mutation	Missense	ENST00000376454.3	g.24790355A>G g.24790355A>G	c.1882A>G c.1882A>G	p.Thr628Ala p.Thr628Ala	benign benign
ADAMTS14	Mutation	Missense	ENST00000373207.1	g.72511968C>A g.72511968C>A	c.2714C>A c.2714C>A	p.Pro905Gln p.Pro905Gln	benign benign

Mutational Signature

Fusion transcripts (3)

Fusion Name	Gene (1)	Chr (1)	Genomic position hg19 (1)	Gene (2)	Chr (2)	Genomic position hg19 (2)	Supporting reads	Consistance fusion	Fusion type
CARD18--RP11-94P11.4	RP11-94P11.4	chr11	105130368	CARD18	chr11	105009804	11	straight	DEL
FBXO33--GNG2	FBXO33	chr14	39900767	GNG2	chr14	52364156	30	inverted	DUP
PUDP--STS	PUDP	chrX	7065642	STS	chrX	7171236	22	NA	DEL

HBV RNA fusions (0)

Breakpoint on human genome (hg19)	Affected gene	Breakpoint on HBV genome (X02763)	Nb of paired reads (HG19 HBV)
No records found.

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)

Drugs (35)

DrugFilter by Drug	AUC	GI50
Bortezomib	0.16	0.003
Sorafenib_Trametinib	0.3	0.02
Paclitaxel	0.33	0.008
Rapamycin	0.51	0.52
Vinblastine	0.52	0.035
Linsitinib	0.57	0.14
PF.04691502	0.6	0.164
Entinostat	0.66	3.78
Sorafenib_MK.2206	0.68	0.5
Sorafenib_Resminostat	0.68	0.7
Alisertib	0.68	0.678
Dasatinib	0.69	5.49
Alvespimycin	0.7	0.785
Cabozantinib	0.71	0.6266
Navitoclax	0.71	0.825

Liver Cancer Cell Lines Database

Cell Line: B1

Transcriptomic subgroup: CL1

Mutational Signature

Liver Cancer Cell Lines
Database