Liver Cancer Cell Lines
Database

LCCL to predict drug response

Cell Line: HCC.3


Cell line description
Cell line nameSynonymsCellosaurus IDTumor typeReferenceSupplierCulture medium
HCC.3 AKH13 CVCL_0C57 Hepatocellular Carcinoma Sagmeister et al. Br J Cancer (2008) [PMID: 18594539] Gift from Bettina Grasl-Kraupp (Austria) DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

AgeGenderGeographic OriginEthnicityHBVHCV
50 Male Austria European No Yes

Transcriptomic subgroup: CL1


Mutations and CNAs (204)
Gene nameAlteration typeVariant classAnnotation transcriptgNomencNomenpNomenPPH pr├ędiction
ASCC1MutationIn-FrameENST00000342444.4
g.73862691_73862692ins33
g.73862691_73862692ins33
c.1075_1076insGCAAAAAAAAGGAAAAAAAAACATAGTATCTAT
c.1075_1076insGCAAAAAAAAGGAAAAAAAAACATAGTATCTAT
p.Asp359_Ser400delins8X
p.Asp359_Ser400delins8X
damaging
damaging
RERGLMutationIn-FrameENST00000229002.2
g.18234192_18234193ins153
g.18234192_18234193ins153
c.550_551insTGACATGGAGACATAGAATGTTACTGCTAGACCAGACACTCCAAATGAAAGAAGTGCTGCCATAACTGCAGCCCCAGAATTTGGCAATCTCTGGTATCTCAGTCAGGTCAATGATAGGATGACAACAGAGGAAAGAGAACAATTCCCCACAGG
c.550_551insTGACATGGAGACATAGAATGTTACTGCTAGACCAGACACTCCAAATGAAAGAAGTGCTGCCATAACTGCAGCCCCAGAATTTGGCAATCTCTGGTATCTCAGTCAGGTCAATGATAGGATGACAACAGAGGAAAGAGAACAATTCCCCACAGG
p.Pro184_Val205delins21X
p.Pro184_Val205delins21X
damaging
damaging
CYFIP1MutationIn-FrameENST00000313077.7
g.22954235_22954240del
g.22954235_22954240del
c.1385_1390del
c.1385_1390del
p.Gln462_Val463del
p.Gln462_Val463del
damaging
damaging
GZF1MutationIn-FrameENST00000338121.5
g.23345961_23345963del
g.23345961_23345963del
c.941_943del
c.941_943del
p.Lys314del
p.Lys314del
damaging
damaging
SFI1MutationIn-FrameENST00000400288.2
g.32014362_32014363insCTG
g.32014362_32014363insCTG
c.3687_3688insCTG
c.3687_3688insCTG
p.Ala1229_Cys1230insLeu
p.Ala1229_Cys1230insLeu
damaging
damaging
ALDOBMutationIn-FrameENST00000374855.4
g.104192168_104192170del
g.104192168_104192170del
c.191_193del
c.191_193del
p.Phe64del
p.Phe64del
damaging
damaging
TSC1MutationIn-FrameENST00000298552.3
g.135771988_135771989insGCT
g.135771988_135771989insGCT
c.3128_3129insAGC
c.3128_3129insAGC
p.Ser1043delinsArgAla
p.Ser1043delinsArgAla
damaging
damaging
DDX20MutationMissenseENST00000369702.4
g.112303425G>A
g.112303425G>A
c.778G>A
c.778G>A
p.Asp260Asn
p.Asp260Asn
benign
benign
DENND2CMutationMissenseENST00000393276.3
g.115143469T>C
g.115143469T>C
c.1757A>G
c.1757A>G
p.Lys643Arg
p.Lys643Arg
benign
benign
IGSF3MutationMissenseENST00000318837.6
g.117150851C>T
g.117150851C>T
c.935G>A
c.935G>A
p.Arg312His
p.Arg312His
probably damaging
probably damaging
POGZMutationMissenseENST00000271715.2
g.151378683T>C
g.151378683T>C
c.2828A>G
c.2828A>G
p.Asp943Gly
p.Asp943Gly
benign
benign
SPTA1MutationMissenseENST00000368147.4
g.158607931C>T
g.158607931C>T
c.5081G>A
c.5081G>A
p.Arg1694His
p.Arg1694His
probably damaging
probably damaging
ADAMTS4MutationMissenseENST00000367995.3
g.161168120A>G
g.161168120A>G
c.298T>C
c.298T>C
p.Ser100Pro
p.Ser100Pro
benign
benign
MIR205HGMutationMissenseNM_001104548.1
g.209603789A>T
g.209603789A>T
c.131A>T
c.131A>T
p.Tyr44Phe
p.Tyr44Phe
NA
NA
PTPRCMutationMissenseENST00000367376.2
g.198676028C>A
g.198676028C>A
c.845C>A
c.845C>A
p.Ser282Tyr
p.Ser282Tyr
benign
benign
GPATCH2MutationMissenseENST00000366934.3
g.217793189G>T
g.217793189G>T
c.709C>A
c.709C>A
p.Gln237Lys
p.Gln237Lys
benign
benign
OBSCNMutationMissenseENST00000570156.2
g.228461096A>T
g.228461096A>T
c.6110A>T
c.6110A>T
p.D2037V
p.D2037V
NA
NA
PEX10MutationMissenseENST00000288774.3
g.2339977C>A
g.2339977C>A
c.514G>T
c.514G>T
p.Ala172Ser
p.Ala172Ser
benign
benign
HCRTR1MutationMissenseENST00000373705.1
g.32090716A>G
g.32090716A>G
c.1084A>G
c.1084A>G
p.Ser362Gly
p.Ser362Gly
probably damaging
probably damaging
CYP4B1MutationMissenseENST00000271153.4
g.47280765T>G
g.47280765T>G
c.899T>G
c.899T>G
p.Leu300Arg
p.Leu300Arg
probably damaging
probably damaging
SLC35D1MutationMissenseENST00000235345.5
g.67518477G>A
g.67518477G>A
c.301C>T
c.301C>T
p.Leu101Phe
p.Leu101Phe
benign
benign
COL24A1MutationMissenseENST00000370571.2
g.86334514T>C
g.86334514T>C
c.3143A>G
c.3143A>G
p.Glu1048Gly
p.Glu1048Gly
probably damaging
probably damaging
SEP15MutationMissenseENST00000331835.5
g.87369110A>T
g.87369110A>T
c.97T>A
c.97T>A
p.F33I
p.F33I
benign
benign
NOC2LMutationMissenseENST00000327044.6
g.880159G>C
g.880159G>C
c.2165C>G
c.2165C>G
p.Ala722Gly
p.Ala722Gly
possibly damaging
possibly damaging
COL17A1MutationMissenseENST00000353479.5
g.105797412C>T
g.105797412C>T
c.3190G>A
c.3190G>A
p.Val1064Ile
p.Val1064Ile
probably damaging
probably damaging

Mutational Signature



Fusion transcripts (12)
Fusion NameGene (1)Chr (1)Genomic position hg19 (1)Gene (2)Chr (2)Genomic position hg19 (2)Supporting readsConsistance fusionFusion type
ATF2--CHN1ATF2chr2175945387CHN1chr217581692912straightDEL
CDH7--RP11-775G23.1RP11-775G23.1chr1863310004CDH7chr186342988251straightDEL
DYNLT3--RPS6KA3RPS6KA3chrX20252875DYNLT3chrX37701157696straightDUP
ESPNP--RCC2ESPNPchr117022376RCC2chr117735559289invertedINV
GOLGA5--RIN3GOLGA5chr1493286180RIN3chr149314281915straightDUP
KRT28--PTGES3L-AARSD1PTGES3L-AARSD1chr1741116122KRT28chr1738955208180straightDEL
LINC01226--LOC101927895LOC101927895chr119537052LINC01226chr13198762518NADEL
LINC02027--LINC02050LINC02050chr380820105LINC02027chr38114426233NADEL
LSAMP--RP11-384F7.2RP11-384F7.2chr3117716028LSAMPchr311580540229straightDEL
LUC7L--SDHBSDHBchr117380442LUC7Lchr16258186152straightTRANS
PREX1--RP5-906C1.1RP5-906C1.1chr2047465971PREX1chr204736441634NADEL
SBF2--SWAP70SBF2chr119917489SWAP70chr11971569226straightINV

HBV RNA fusions (0)
Breakpoint on human genome (hg19)Affected geneBreakpoint on HBV genome (X02763)Nb of paired reads (HG19 HBV)
No records found.

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)


Drugs (35)
DrugAUCGI50
Bortezomib0.270.009
Doxorubicin0.550.13
PF.046915020.610.165
Alvespimycin0.660.75
Cabozantinib0.680.5439
Paclitaxel0.680.423
Sorafenib_Trametinib0.692.22
Rapamycin0.75.72
Vinblastine0.731.034
Tivantinib0.770.9
Sorafenib_MK.22060.771.45
PHA.6657520.771.158
Navitoclax0.781.575
CD5320.781.228
Linsitinib0.792.465


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