Liver Cancer Cell Lines Database

Cell line description

Cell line name	Synonyms	Cellosaurus ID	Tumor type	Reference	Supplier	Culture medium
HLE		CVCL_1281	Hepatocellular Carcinoma	Doi et al. Gan (1975)	HSRRB - Japan	DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

Age	Gender	Geographic Origin	Ethnicity	HBV	HCV
68	Male	Japan	Asian	No	No

Transcriptomic subgroup: CL3

Mutations and CNAs (394)

Gene nameFilter by Gene name	Alteration type	Variant class	Annotation transcript	gNomen	cNomen	pNomen	PPH prédiction
SALL2	Mutation	In-Frame	ENST00000327430.3	g.21991334_21991335insGGT g.21991334_21991335insGGT	c.2527_2528insACC c.2527_2528insACC	p.Pro842_Pro843insHis p.Pro842_Pro843insHis	damaging damaging
MYH4	Mutation	In-Frame	ENST00000255381.2	g.10359135_10359140del g.10359135_10359140del	c.2047_2052del c.2047_2052del	p.Lys683_Thr684del p.Lys683_Thr684del	damaging damaging
KRTAP13-1	Mutation	In-Frame	ENST00000355459.2	g.31768478_31768480del g.31768478_31768480del	c.74_76del c.74_76del	p.Ser25del p.Ser25del	damaging damaging
CENPM	Mutation	In-Frame	ENST00000215980.5	g.42343029_42343031del g.42343029_42343031del	c.50_52del c.50_52del	p.Thr17del p.Thr17del	damaging damaging
C3orf62	Mutation	In-Frame	ENST00000343010.3	g.49314137_49314139del g.49314137_49314139del	c.167_169del c.167_169del	p.Phe56del p.Phe56del	damaging damaging
FAM189A2	Mutation	In-Frame	ENST00000257515.8	g.72003322_72003324del g.72003322_72003324del	c.1105_1107del c.1105_1107del	p.Glu369del p.Glu369del	damaging damaging
COL11A1	Mutation	Missense	ENST00000370096.3	g.103488388T>A g.103488388T>A	c.1155A>T c.1155A>T	p.Glu385Asp p.Glu385Asp	benign benign
LRIG2	Mutation	Missense	ENST00000361127.5	g.113657444A>G g.113657444A>G	c.2476A>G c.2476A>G	p.Ile826Val p.Ile826Val	benign benign
IVL	Mutation	Missense	ENST00000368764.3	g.152883501G>A g.152883501G>A	c.1228G>A c.1228G>A	p.Glu410Lys p.Glu410Lys	benign benign
ADAR	Mutation	Missense	ENST00000368474.4	g.154573823A>T g.154573823A>T	c.1295T>A c.1295T>A	p.Leu432Gln p.Leu432Gln	possibly damaging possibly damaging
GBA	Mutation	Missense	ENST00000327247.5	g.155205599T>A g.155205599T>A	c.1261A>T c.1261A>T	p.Asn421Tyr p.Asn421Tyr	probably damaging probably damaging
RAB25	Mutation	Missense	ENST00000361084.5	g.156038092G>A g.156038092G>A	c.271G>A c.271G>A	p.Val91Met p.Val91Met	probably damaging probably damaging
CD84	Mutation	Missense	ENST00000311224.4	g.160535251T>C g.160535251T>C	c.331A>G c.331A>G	p.Ile111Val p.Ile111Val	possibly damaging possibly damaging
LAMC2	Mutation	Missense	ENST00000264144.4	g.183200111C>T g.183200111C>T	c.1730C>T c.1730C>T	p.Pro577Leu p.Pro577Leu	probably damaging probably damaging
LGR6	Mutation	Missense	ENST00000367278.3	g.202287956G>A g.202287956G>A	c.2525G>A c.2525G>A	p.Arg842Gln p.Arg842Gln	possibly damaging possibly damaging
OBSCN	Mutation	Missense	ENST00000284548.11	g.228468098C>T g.228468098C>T	c.7882C>T c.7882C>T	p.Arg2628Cys p.Arg2628Cys	benign benign
KDM1A	Mutation	Missense	ENST00000356634.3	g.23346231G>T g.23346231G>T	c.142G>T c.142G>T	p.Ala48Ser p.Ala48Ser	benign benign
MAN1C1	Mutation	Missense	ENST00000374332.4	g.26098153G>A g.26098153G>A	c.1147G>A c.1147G>A	p.Val383Ile p.Val383Ile	benign benign
ZSCAN20	Mutation	Missense	ENST00000361328.3	g.33957092C>T g.33957092C>T	c.1234C>T c.1234C>T	p.Arg412Trp p.Arg412Trp	probably damaging probably damaging
MACF1	Mutation	Missense	ENST00000317713.7	g.39818694G>A g.39818694G>A	c.5029G>A c.5029G>A	p.Glu1677Lys p.Glu1677Lys	probably damaging probably damaging
SZT2	Mutation	Missense	ENST00000562955.1	g.43897471G>A g.43897471G>A	c.5002G>A c.5002G>A	p.Ala1668Thr p.Ala1668Thr	benign benign
FAM151A	Mutation	Missense	ENST00000302250.2	g.55078184T>G g.55078184T>G	c.775A>C c.775A>C	p.Ser259Arg p.Ser259Arg	probably damaging probably damaging
TNNI3K	Mutation	Missense	ENST00000326637.3	g.74905204A>T g.74905204A>T	c.1909A>T c.1909A>T	p.Thr738Ser p.Thr738Ser	benign benign
KIAA1107	Mutation	Missense	ENST00000370378.4	g.92649681G>A g.92649681G>A	c.3859G>A c.3859G>A	p.Ala1287Thr p.Ala1287Thr	probably damaging probably damaging
AGRN	Mutation	Missense	ENST00000379370.2	g.976885C>A g.976885C>A	c.980C>A c.980C>A	p.Pro327Gln p.Pro327Gln	benign benign

Mutational Signature

Fusion transcripts (21)

Fusion Name	Gene (1)	Chr (1)	Genomic position hg19 (1)	Gene (2)	Chr (2)	Genomic position hg19 (2)	Supporting reads	Consistance fusion	Fusion type
AANAT--TBCD	TBCD	chr17	80828255	AANAT	chr17	74458397	22	straight	DUP
ALG1--PARD3B	ALG1	chr16	5117334	PARD3B	chr2	205830045	16	inverted	TRANS
ANKS1B--IKBIP	ANKS1B	chr12	99446934	IKBIP	chr12	99028190	10	straight	DEL
CCDC3--OPTN	CCDC3	chr10	13137214	OPTN	chr10	13154634	10	inverted	DUP
CTD-2334D19.1--PRR16	PRR16	chr5	119800339	CTD-2334D19.1	chr5	120125648	10	straight	DEL
ERC1--WNK1	WNK1	chr12	863489	ERC1	chr12	1553727	772	straight	DEL
GAB2--NARS2	NARS2	chr11	78270584	GAB2	chr11	77991946	27	straight	DEL
GALNT7--LOC101930370	LOC101930370	chr4	174090111	GALNT7	chr4	174213258	16	NA	DEL
KATNB1--VAC14	KATNB1	chr16	57778422	VAC14	chr16	70820267	19	straight	INV
LDB2--RP11-446J8.1	RP11-446J8.1	chr4	16428062	LDB2	chr4	16547485	11	inverted	DEL
LINC01478--LINC01601	LINC01478	chr18	41906446	LINC01601	chr18	42129442	52	NA	DEL
LINC01572--SEPT9	LINC01572	chr16	72556451	set-09	chr17	75398140	16	NA	TRANS
LLGL2--SNHG16	SNHG16	chr17	74553938	LLGL2	chr17	73569094	825	straight	DUP
LOC100506083--WWP2	WWP2	chr16	69833197	LOC100506083	chr16	70376001	10	NA	INV
MINOS1-NBL1--RPS14	RPS14	chr5	149826442	MINOS1-NBL1	chr1	19934902	60	straight	TRANS
OGFOD3--SEPT9	OGFOD3	chr17	80373273	set-09	chr17	75478225	110	straight	INV
PTPRO--RERG	RERG	chr12	15274052	PTPRO	chr12	15490310	30	inverted	DEL
RB1--RCBTB2	RB1	chr13	48955578	RCBTB2	chr13	49070722	150	inverted	DEL
RP11-634B7.4--TRIM58	RP11-634B7.4	chr1	247803730	TRIM58	chr1	248023918	16	straight	DEL
RPLP2--SLC35F2	RPLP2	chr11	812586	SLC35F2	chr11	107779403	65	inverted	DEL
SEPT9--VAC14	VAC14	chr16	70744521	set-09	chr17	75398784	39	inverted	TRANS

HBV RNA fusions (0)

Breakpoint on human genome (hg19)	Affected gene	Breakpoint on HBV genome (X02763)	Nb of paired reads (HG19 HBV)
No records found.

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)

Drugs (35)

DrugFilter by Drug	AUC	GI50
Bortezomib	0.24	0.006
Vinblastine	0.39	0.024
Paclitaxel	0.42	0.024
Alvespimycin	0.57	0.094
Tivantinib	0.61	0.21
CD532	0.62	0.282
Tanespimycin	0.65	0.25
PF.04691502	0.68	0.575
Alisertib	0.68	0.461
Doxorubicin	0.73	0.635
Rapamycin	0.73	10.0
Sorafenib_Resminostat	0.81	2.7
Sorafenib_MK.2206	0.81	3.9
Sorafenib	0.86	3.65
Resminostat	0.87	5.3

Liver Cancer Cell Lines Database

Cell Line: HLE

Transcriptomic subgroup: CL3

Mutational Signature

Liver Cancer Cell Lines
Database