Liver Cancer Cell Lines
Database

LCCL to predict drug response

Cell Line: HLE


Cell line description
Cell line nameSynonymsCellosaurus IDTumor typeReferenceSupplierCulture medium
HLE CVCL_1281 Hepatocellular Carcinoma Doi et al. Gan (1975) HSRRB - Japan DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

AgeGenderGeographic OriginEthnicityHBVHCV
68 Male Japan Asian No No

Transcriptomic subgroup: CL3


Mutations and CNAs (394)
Gene nameAlteration typeVariant classAnnotation transcriptgNomencNomenpNomenPPH pr├ędiction
SALL2MutationIn-FrameENST00000327430.3
g.21991334_21991335insGGT
g.21991334_21991335insGGT
c.2527_2528insACC
c.2527_2528insACC
p.Pro842_Pro843insHis
p.Pro842_Pro843insHis
damaging
damaging
MYH4MutationIn-FrameENST00000255381.2
g.10359135_10359140del
g.10359135_10359140del
c.2047_2052del
c.2047_2052del
p.Lys683_Thr684del
p.Lys683_Thr684del
damaging
damaging
KRTAP13-1MutationIn-FrameENST00000355459.2
g.31768478_31768480del
g.31768478_31768480del
c.74_76del
c.74_76del
p.Ser25del
p.Ser25del
damaging
damaging
CENPMMutationIn-FrameENST00000215980.5
g.42343029_42343031del
g.42343029_42343031del
c.50_52del
c.50_52del
p.Thr17del
p.Thr17del
damaging
damaging
C3orf62MutationIn-FrameENST00000343010.3
g.49314137_49314139del
g.49314137_49314139del
c.167_169del
c.167_169del
p.Phe56del
p.Phe56del
damaging
damaging
FAM189A2MutationIn-FrameENST00000257515.8
g.72003322_72003324del
g.72003322_72003324del
c.1105_1107del
c.1105_1107del
p.Glu369del
p.Glu369del
damaging
damaging
COL11A1MutationMissenseENST00000370096.3
g.103488388T>A
g.103488388T>A
c.1155A>T
c.1155A>T
p.Glu385Asp
p.Glu385Asp
benign
benign
LRIG2MutationMissenseENST00000361127.5
g.113657444A>G
g.113657444A>G
c.2476A>G
c.2476A>G
p.Ile826Val
p.Ile826Val
benign
benign
IVLMutationMissenseENST00000368764.3
g.152883501G>A
g.152883501G>A
c.1228G>A
c.1228G>A
p.Glu410Lys
p.Glu410Lys
benign
benign
ADARMutationMissenseENST00000368474.4
g.154573823A>T
g.154573823A>T
c.1295T>A
c.1295T>A
p.Leu432Gln
p.Leu432Gln
possibly damaging
possibly damaging
GBAMutationMissenseENST00000327247.5
g.155205599T>A
g.155205599T>A
c.1261A>T
c.1261A>T
p.Asn421Tyr
p.Asn421Tyr
probably damaging
probably damaging
RAB25MutationMissenseENST00000361084.5
g.156038092G>A
g.156038092G>A
c.271G>A
c.271G>A
p.Val91Met
p.Val91Met
probably damaging
probably damaging
CD84MutationMissenseENST00000311224.4
g.160535251T>C
g.160535251T>C
c.331A>G
c.331A>G
p.Ile111Val
p.Ile111Val
possibly damaging
possibly damaging
LAMC2MutationMissenseENST00000264144.4
g.183200111C>T
g.183200111C>T
c.1730C>T
c.1730C>T
p.Pro577Leu
p.Pro577Leu
probably damaging
probably damaging
LGR6MutationMissenseENST00000367278.3
g.202287956G>A
g.202287956G>A
c.2525G>A
c.2525G>A
p.Arg842Gln
p.Arg842Gln
possibly damaging
possibly damaging
OBSCNMutationMissenseENST00000284548.11
g.228468098C>T
g.228468098C>T
c.7882C>T
c.7882C>T
p.Arg2628Cys
p.Arg2628Cys
benign
benign
KDM1AMutationMissenseENST00000356634.3
g.23346231G>T
g.23346231G>T
c.142G>T
c.142G>T
p.Ala48Ser
p.Ala48Ser
benign
benign
MAN1C1MutationMissenseENST00000374332.4
g.26098153G>A
g.26098153G>A
c.1147G>A
c.1147G>A
p.Val383Ile
p.Val383Ile
benign
benign
ZSCAN20MutationMissenseENST00000361328.3
g.33957092C>T
g.33957092C>T
c.1234C>T
c.1234C>T
p.Arg412Trp
p.Arg412Trp
probably damaging
probably damaging
MACF1MutationMissenseENST00000317713.7
g.39818694G>A
g.39818694G>A
c.5029G>A
c.5029G>A
p.Glu1677Lys
p.Glu1677Lys
probably damaging
probably damaging
SZT2MutationMissenseENST00000562955.1
g.43897471G>A
g.43897471G>A
c.5002G>A
c.5002G>A
p.Ala1668Thr
p.Ala1668Thr
benign
benign
FAM151AMutationMissenseENST00000302250.2
g.55078184T>G
g.55078184T>G
c.775A>C
c.775A>C
p.Ser259Arg
p.Ser259Arg
probably damaging
probably damaging
TNNI3KMutationMissenseENST00000326637.3
g.74905204A>T
g.74905204A>T
c.1909A>T
c.1909A>T
p.Thr738Ser
p.Thr738Ser
benign
benign
KIAA1107MutationMissenseENST00000370378.4
g.92649681G>A
g.92649681G>A
c.3859G>A
c.3859G>A
p.Ala1287Thr
p.Ala1287Thr
probably damaging
probably damaging
AGRNMutationMissenseENST00000379370.2
g.976885C>A
g.976885C>A
c.980C>A
c.980C>A
p.Pro327Gln
p.Pro327Gln
benign
benign

Mutational Signature



Fusion transcripts (21)
Fusion NameGene (1)Chr (1)Genomic position hg19 (1)Gene (2)Chr (2)Genomic position hg19 (2)Supporting readsConsistance fusionFusion type
AANAT--TBCDTBCDchr1780828255AANATchr177445839722straightDUP
ALG1--PARD3BALG1chr165117334PARD3Bchr220583004516invertedTRANS
ANKS1B--IKBIPANKS1Bchr1299446934IKBIPchr129902819010straightDEL
CCDC3--OPTNCCDC3chr1013137214OPTNchr101315463410invertedDUP
CTD-2334D19.1--PRR16PRR16chr5119800339CTD-2334D19.1chr512012564810straightDEL
ERC1--WNK1WNK1chr12863489ERC1chr121553727772straightDEL
GAB2--NARS2NARS2chr1178270584GAB2chr117799194627straightDEL
GALNT7--LOC101930370LOC101930370chr4174090111GALNT7chr417421325816NADEL
KATNB1--VAC14KATNB1chr1657778422VAC14chr167082026719straightINV
LDB2--RP11-446J8.1RP11-446J8.1chr416428062LDB2chr41654748511invertedDEL
LINC01478--LINC01601LINC01478chr1841906446LINC01601chr184212944252NADEL
LINC01572--SEPT9LINC01572chr1672556451set-09chr177539814016NATRANS
LLGL2--SNHG16SNHG16chr1774553938LLGL2chr1773569094825straightDUP
LOC100506083--WWP2WWP2chr1669833197LOC100506083chr167037600110NAINV
MINOS1-NBL1--RPS14RPS14chr5149826442MINOS1-NBL1chr11993490260straightTRANS
OGFOD3--SEPT9OGFOD3chr1780373273set-09chr1775478225110straightINV
PTPRO--RERGRERGchr1215274052PTPROchr121549031030invertedDEL
RB1--RCBTB2RB1chr1348955578RCBTB2chr1349070722150invertedDEL
RP11-634B7.4--TRIM58RP11-634B7.4chr1247803730TRIM58chr124802391816straightDEL
RPLP2--SLC35F2RPLP2chr11812586SLC35F2chr1110777940365invertedDEL
SEPT9--VAC14VAC14chr1670744521set-09chr177539878439invertedTRANS

HBV RNA fusions (0)
Breakpoint on human genome (hg19)Affected geneBreakpoint on HBV genome (X02763)Nb of paired reads (HG19 HBV)
No records found.

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)


Drugs (35)
DrugAUCGI50
Bortezomib0.240.006
Vinblastine0.390.024
Paclitaxel0.420.024
Alvespimycin0.570.094
Tivantinib0.610.21
CD5320.620.282
Tanespimycin0.650.25
PF.046915020.680.575
Alisertib0.680.461
Doxorubicin0.730.635
Rapamycin0.7310.0
Sorafenib_Resminostat0.812.7
Sorafenib_MK.22060.813.9
Sorafenib0.863.65
Resminostat0.875.3


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