Liver Cancer Cell Lines Database

Cell line description

Cell line name	Synonyms	Cellosaurus ID	Tumor type	Reference	Supplier	Culture medium
HLF		CVCL_2947	Hepatocellular Carcinoma	Doi et al. Gan (1975)	HSRRB - Japan	DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

Age	Gender	Geographic Origin	Ethnicity	HBV	HCV
68	Male	Japan	Asian	No	No

Transcriptomic subgroup: CL3

Mutations and CNAs (358)

Gene nameFilter by Gene name	Alteration type	Variant class	Annotation transcript	gNomen	cNomen	pNomen	PPH prédiction
SALL2	Mutation	In-Frame	ENST00000327430.3	g.21991334_21991335insGGT g.21991334_21991335insGGT	c.2527_2528insACC c.2527_2528insACC	p.Pro842_Pro843insHis p.Pro842_Pro843insHis	damaging damaging
PHF23	Mutation	In-Frame	ENST00000320316.3	g.7139476_7139484del g.7139476_7139484del	c.762_770del c.762_770del	p.Glu259_Glu261del p.Glu259_Glu261del	damaging damaging
CENPM	Mutation	In-Frame	ENST00000215980.5	g.42343029_42343031del g.42343029_42343031del	c.50_52del c.50_52del	p.Thr17del p.Thr17del	damaging damaging
C3orf62	Mutation	In-Frame	ENST00000343010.3	g.49314137_49314139del g.49314137_49314139del	c.167_169del c.167_169del	p.Phe56del p.Phe56del	damaging damaging
FAM189A2	Mutation	In-Frame	ENST00000257515.8	g.72003322_72003324del g.72003322_72003324del	c.1105_1107del c.1105_1107del	p.Glu369del p.Glu369del	damaging damaging
COL11A1	Mutation	Missense	ENST00000370096.3	g.103488388T>A g.103488388T>A	c.1155A>T c.1155A>T	p.Glu385Asp p.Glu385Asp	benign benign
LRIG2	Mutation	Missense	ENST00000361127.5	g.113657444A>G g.113657444A>G	c.2476A>G c.2476A>G	p.Ile826Val p.Ile826Val	benign benign
IVL	Mutation	Missense	ENST00000368764.3	g.152883501G>A g.152883501G>A	c.1228G>A c.1228G>A	p.Glu410Lys p.Glu410Lys	benign benign
ADAR	Mutation	Missense	ENST00000368474.4	g.154573823A>T g.154573823A>T	c.1295T>A c.1295T>A	p.Leu432Gln p.Leu432Gln	possibly damaging possibly damaging
GBA	Mutation	Missense	ENST00000327247.5	g.155205599T>A g.155205599T>A	c.1261A>T c.1261A>T	p.Asn421Tyr p.Asn421Tyr	probably damaging probably damaging
RAB25	Mutation	Missense	ENST00000361084.5	g.156038092G>A g.156038092G>A	c.271G>A c.271G>A	p.Val91Met p.Val91Met	probably damaging probably damaging
ARHGEF11	Mutation	Missense	ENST00000361409.2	g.156950243C>T g.156950243C>T	c.259G>A c.259G>A	p.Asp87Asn p.Asp87Asn	probably damaging probably damaging
CD84	Mutation	Missense	ENST00000311224.4	g.160535251T>C g.160535251T>C	c.331A>G c.331A>G	p.Ile111Val p.Ile111Val	possibly damaging possibly damaging
PAPPA2	Mutation	Missense	ENST00000367661.3	g.176659492C>A g.176659492C>A	c.2357C>A c.2357C>A	p.Pro786Gln p.Pro786Gln	probably damaging probably damaging
LAMC2	Mutation	Missense	ENST00000264144.4	g.183200111C>T g.183200111C>T	c.1730C>T c.1730C>T	p.Pro577Leu p.Pro577Leu	probably damaging probably damaging
LGR6	Mutation	Missense	ENST00000367278.3	g.202287956G>A g.202287956G>A	c.2525G>A c.2525G>A	p.Arg842Gln p.Arg842Gln	possibly damaging possibly damaging
CENPF	Mutation	Missense	ENST00000366955.3	g.214817975C>A g.214817975C>A	c.5062C>A c.5062C>A	p.His1688Asn p.His1688Asn	benign benign
RAB3GAP2	Mutation	Missense	ENST00000358951.2	g.220338086T>C g.220338086T>C	c.3143A>G c.3143A>G	p.His1048Arg p.His1048Arg	possibly damaging possibly damaging
FBXO28	Mutation	Missense	ENST00000366862.5	g.224340949A>G g.224340949A>G	c.622A>G c.622A>G	p.Met208Val p.Met208Val	possibly damaging possibly damaging
SNAP47	Mutation	Missense	ENST00000315781.5	g.227946865T>C g.227946865T>C	c.802T>C c.802T>C	p.Ser268Pro p.Ser268Pro	probably damaging probably damaging
OBSCN	Mutation	Missense	ENST00000284548.11	g.228468098C>T g.228468098C>T	c.7882C>T c.7882C>T	p.Arg2628Cys p.Arg2628Cys	benign benign
MAN1C1	Mutation	Missense	ENST00000374332.4	g.26098153G>A g.26098153G>A	c.1147G>A c.1147G>A	p.Val383Ile p.Val383Ile	benign benign
ZSCAN20	Mutation	Missense	ENST00000361328.3	g.33957092C>T g.33957092C>T	c.1234C>T c.1234C>T	p.Arg412Trp p.Arg412Trp	probably damaging probably damaging
MACF1	Mutation	Missense	ENST00000317713.7	g.39818694G>A g.39818694G>A	c.5029G>A c.5029G>A	p.Glu1677Lys p.Glu1677Lys	probably damaging probably damaging
SZT2	Mutation	Missense	ENST00000562955.1	g.43897471G>A g.43897471G>A	c.5002G>A c.5002G>A	p.Ala1668Thr p.Ala1668Thr	benign benign

Mutational Signature

Fusion transcripts (6)

Fusion Name	Gene (1)	Chr (1)	Genomic position hg19 (1)	Gene (2)	Chr (2)	Genomic position hg19 (2)	Supporting reads	Consistance fusion	Fusion type
CCDC157--RP3-438O4.4	RP3-438O4.4	chr22	30602973	CCDC157	chr22	30753120	18	inverted	DUP
GALNT7--LOC101930370	LOC101930370	chr4	174090111	GALNT7	chr4	174213258	15	NA	DEL
JMJD1C--NRBF2	NRBF2	chr10	64897409	JMJD1C	chr10	65140077	76	inverted	DEL
RB1--RCBTB2	RB1	chr13	48955578	RCBTB2	chr13	49070722	217	inverted	DEL
RP11-307P5.1--SASH1	RP11-307P5.1	chr6	147981954	SASH1	chr6	148711269	39	straight	DEL
RP11-634B7.4--TRIM58	RP11-634B7.4	chr1	247803730	TRIM58	chr1	248023918	16	straight	DEL

HBV RNA fusions (0)

Breakpoint on human genome (hg19)	Affected gene	Breakpoint on HBV genome (X02763)	Nb of paired reads (HG19 HBV)
No records found.

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)

Drugs (35)

DrugFilter by Drug	AUC	GI50
Bortezomib	0.3	0.013
Paclitaxel	0.39	0.024
Vinblastine	0.41	0.022
Alvespimycin	0.55	0.083
Tanespimycin	0.63	0.285
CD532	0.71	0.612
Alisertib	0.73	0.466
Doxorubicin	0.73	0.765
Tivantinib	0.74	0.805
PF.04691502	0.84	6.195
Sorafenib_Resminostat	0.84	3.843
Rapamycin	0.86	10.0
Resminostat	0.89	5.145
Sorafenib_MK.2206	0.9	5.235
Dasatinib	0.93	10.0

Liver Cancer Cell Lines Database

Cell Line: HLF

Transcriptomic subgroup: CL3

Mutational Signature

Liver Cancer Cell Lines
Database