Liver Cancer Cell Lines
Database

LCCL to predict drug response

Cell Line: HLF


Cell line description
Cell line nameSynonymsCellosaurus IDTumor typeReferenceSupplierCulture medium
HLF CVCL_2947 Hepatocellular Carcinoma Doi et al. Gan (1975) HSRRB - Japan DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

AgeGenderGeographic OriginEthnicityHBVHCV
68 Male Japan Asian No No

Transcriptomic subgroup: CL3


Mutations and CNAs (358)
Gene nameAlteration typeVariant classAnnotation transcriptgNomencNomenpNomenPPH pr├ędiction
SALL2MutationIn-FrameENST00000327430.3
g.21991334_21991335insGGT
g.21991334_21991335insGGT
c.2527_2528insACC
c.2527_2528insACC
p.Pro842_Pro843insHis
p.Pro842_Pro843insHis
damaging
damaging
PHF23MutationIn-FrameENST00000320316.3
g.7139476_7139484del
g.7139476_7139484del
c.762_770del
c.762_770del
p.Glu259_Glu261del
p.Glu259_Glu261del
damaging
damaging
CENPMMutationIn-FrameENST00000215980.5
g.42343029_42343031del
g.42343029_42343031del
c.50_52del
c.50_52del
p.Thr17del
p.Thr17del
damaging
damaging
C3orf62MutationIn-FrameENST00000343010.3
g.49314137_49314139del
g.49314137_49314139del
c.167_169del
c.167_169del
p.Phe56del
p.Phe56del
damaging
damaging
FAM189A2MutationIn-FrameENST00000257515.8
g.72003322_72003324del
g.72003322_72003324del
c.1105_1107del
c.1105_1107del
p.Glu369del
p.Glu369del
damaging
damaging
COL11A1MutationMissenseENST00000370096.3
g.103488388T>A
g.103488388T>A
c.1155A>T
c.1155A>T
p.Glu385Asp
p.Glu385Asp
benign
benign
LRIG2MutationMissenseENST00000361127.5
g.113657444A>G
g.113657444A>G
c.2476A>G
c.2476A>G
p.Ile826Val
p.Ile826Val
benign
benign
IVLMutationMissenseENST00000368764.3
g.152883501G>A
g.152883501G>A
c.1228G>A
c.1228G>A
p.Glu410Lys
p.Glu410Lys
benign
benign
ADARMutationMissenseENST00000368474.4
g.154573823A>T
g.154573823A>T
c.1295T>A
c.1295T>A
p.Leu432Gln
p.Leu432Gln
possibly damaging
possibly damaging
GBAMutationMissenseENST00000327247.5
g.155205599T>A
g.155205599T>A
c.1261A>T
c.1261A>T
p.Asn421Tyr
p.Asn421Tyr
probably damaging
probably damaging
RAB25MutationMissenseENST00000361084.5
g.156038092G>A
g.156038092G>A
c.271G>A
c.271G>A
p.Val91Met
p.Val91Met
probably damaging
probably damaging
ARHGEF11MutationMissenseENST00000361409.2
g.156950243C>T
g.156950243C>T
c.259G>A
c.259G>A
p.Asp87Asn
p.Asp87Asn
probably damaging
probably damaging
CD84MutationMissenseENST00000311224.4
g.160535251T>C
g.160535251T>C
c.331A>G
c.331A>G
p.Ile111Val
p.Ile111Val
possibly damaging
possibly damaging
PAPPA2MutationMissenseENST00000367661.3
g.176659492C>A
g.176659492C>A
c.2357C>A
c.2357C>A
p.Pro786Gln
p.Pro786Gln
probably damaging
probably damaging
LAMC2MutationMissenseENST00000264144.4
g.183200111C>T
g.183200111C>T
c.1730C>T
c.1730C>T
p.Pro577Leu
p.Pro577Leu
probably damaging
probably damaging
LGR6MutationMissenseENST00000367278.3
g.202287956G>A
g.202287956G>A
c.2525G>A
c.2525G>A
p.Arg842Gln
p.Arg842Gln
possibly damaging
possibly damaging
CENPFMutationMissenseENST00000366955.3
g.214817975C>A
g.214817975C>A
c.5062C>A
c.5062C>A
p.His1688Asn
p.His1688Asn
benign
benign
RAB3GAP2MutationMissenseENST00000358951.2
g.220338086T>C
g.220338086T>C
c.3143A>G
c.3143A>G
p.His1048Arg
p.His1048Arg
possibly damaging
possibly damaging
FBXO28MutationMissenseENST00000366862.5
g.224340949A>G
g.224340949A>G
c.622A>G
c.622A>G
p.Met208Val
p.Met208Val
possibly damaging
possibly damaging
SNAP47MutationMissenseENST00000315781.5
g.227946865T>C
g.227946865T>C
c.802T>C
c.802T>C
p.Ser268Pro
p.Ser268Pro
probably damaging
probably damaging
OBSCNMutationMissenseENST00000284548.11
g.228468098C>T
g.228468098C>T
c.7882C>T
c.7882C>T
p.Arg2628Cys
p.Arg2628Cys
benign
benign
MAN1C1MutationMissenseENST00000374332.4
g.26098153G>A
g.26098153G>A
c.1147G>A
c.1147G>A
p.Val383Ile
p.Val383Ile
benign
benign
ZSCAN20MutationMissenseENST00000361328.3
g.33957092C>T
g.33957092C>T
c.1234C>T
c.1234C>T
p.Arg412Trp
p.Arg412Trp
probably damaging
probably damaging
MACF1MutationMissenseENST00000317713.7
g.39818694G>A
g.39818694G>A
c.5029G>A
c.5029G>A
p.Glu1677Lys
p.Glu1677Lys
probably damaging
probably damaging
SZT2MutationMissenseENST00000562955.1
g.43897471G>A
g.43897471G>A
c.5002G>A
c.5002G>A
p.Ala1668Thr
p.Ala1668Thr
benign
benign

Mutational Signature



Fusion transcripts (6)
Fusion NameGene (1)Chr (1)Genomic position hg19 (1)Gene (2)Chr (2)Genomic position hg19 (2)Supporting readsConsistance fusionFusion type
CCDC157--RP3-438O4.4RP3-438O4.4chr2230602973CCDC157chr223075312018invertedDUP
GALNT7--LOC101930370LOC101930370chr4174090111GALNT7chr417421325815NADEL
JMJD1C--NRBF2NRBF2chr1064897409JMJD1Cchr106514007776invertedDEL
RB1--RCBTB2RB1chr1348955578RCBTB2chr1349070722217invertedDEL
RP11-307P5.1--SASH1RP11-307P5.1chr6147981954SASH1chr614871126939straightDEL
RP11-634B7.4--TRIM58RP11-634B7.4chr1247803730TRIM58chr124802391816straightDEL

HBV RNA fusions (0)
Breakpoint on human genome (hg19)Affected geneBreakpoint on HBV genome (X02763)Nb of paired reads (HG19 HBV)
No records found.

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)


Drugs (35)
DrugAUCGI50
Bortezomib0.30.013
Paclitaxel0.390.024
Vinblastine0.410.022
Alvespimycin0.550.083
Tanespimycin0.630.285
CD5320.710.612
Alisertib0.730.466
Doxorubicin0.730.765
Tivantinib0.740.805
PF.046915020.846.195
Sorafenib_Resminostat0.843.843
Rapamycin0.8610.0
Resminostat0.895.145
Sorafenib_MK.22060.95.235
Dasatinib0.9310.0


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