Liver Cancer Cell Lines Database

Cell line description

Cell line name	Synonyms	Cellosaurus ID	Tumor type	Reference	Supplier	Culture medium
Hep3B		CVCL_0326	Hepatocellular Carcinoma	Aden et al. Nature (1979) [PMID: 233137]	ATCC - USA	DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

Age	Gender	Geographic Origin	Ethnicity	HBV	HCV
8	Male	USA	African-American	Yes	No

Transcriptomic subgroup: CL1

Mutations and CNAs (409)

Gene nameFilter by Gene name	Alteration type	Variant class	Annotation transcript	gNomen	cNomen	pNomen	PPH prédiction
TRIM64C	Mutation	In-Frame	ENST00000530230.1	g.49080591_49080592insGGGTCTATG g.49080591_49080592insGGGTCTATG	c.74_75insATAGACCCC c.74_75insATAGACCCC	p.Val26X p.Val26X	damaging damaging
RCE1	Mutation	In-Frame	ENST00000309657.3	g.66610978_66610986del g.66610978_66610986del	c.52_60del c.52_60del	p.Glu18_Pro20del p.Glu18_Pro20del	damaging damaging
DUOX2	Mutation	In-Frame	ENST00000389039.6	g.45394038_45394058del g.45394038_45394058del	c.2784_2804del c.2784_2804del	p.Asp930_Arg936del p.Asp930_Arg936del	damaging damaging
TSHZ2	Mutation	In-Frame	ENST00000371497.5	g.51870084_51870086del g.51870084_51870086del	c.87_89del c.87_89del	p.Glu34del p.Glu34del	damaging damaging
IL17RC	Mutation	In-Frame	ENST00000295981.3	g.9959222_9959223insTCTGGTCTT g.9959222_9959223insTCTGGTCTT	c.223_224insTCTGGTCTT c.223_224insTCTGGTCTT	p.Leu74_Ser75insPheTrpSer p.Leu74_Ser75insPheTrpSer	damaging damaging
MPDZ	Mutation	In-Frame	ENST00000319217.7	g.13196173_13196175del g.13196173_13196175del	c.1601_1603del c.1601_1603del	p.Glu534del p.Glu534del	damaging damaging
TAS1R3	Mutation	Missense	ENST00000339381.5	g.1267608C>T g.1267608C>T	c.697C>T c.697C>T	p.Arg233Cys p.Arg233Cys	probably damaging probably damaging
TAS1R3	Mutation	Missense	ENST00000339381.5	g.1268747C>T g.1268747C>T	c.1588C>T c.1588C>T	p.Arg530Trp p.Arg530Trp	benign benign
MXRA8	Mutation	Missense	ENST00000309212.6	g.1290506C>A g.1290506C>A	c.505G>T c.505G>T	p.Gly169Cys p.Gly169Cys	probably damaging probably damaging
BOLA1	Mutation	Missense	ENST00000369150.1	g.149871738G>C g.149871738G>C	c.126G>C c.126G>C	p.Glu42Asp p.Glu42Asp	benign benign
FLG	Mutation	Missense	ENST00000368799.1	g.152282882C>A g.152282882C>A	c.4480G>T c.4480G>T	p.Gly1494Trp p.Gly1494Trp	probably damaging probably damaging
SLC50A1	Mutation	Missense	NM_001287592.1	g.155108066A>G g.155108066A>G	c.4A>G c.4A>G	p.Ile2Val p.Ile2Val	NA NA
OR10K2	Mutation	Missense	ENST00000314902.2	g.158389960C>G g.158389960C>G	c.697G>C c.697G>C	p.Gly233Arg p.Gly233Arg	probably damaging probably damaging
SLAMF9	Mutation	Missense	ENST00000368093.3	g.159921481C>A g.159921481C>A	c.840G>T c.840G>T	p.Lys280Asn p.Lys280Asn	possibly damaging possibly damaging
FCRLB	Mutation	Missense	ENST00000336830.5	g.161693280C>T g.161693280C>T	c.176C>T c.176C>T	p.Thr59Ile p.Thr59Ile	possibly damaging possibly damaging
CDK11A	Mutation	Missense	ENST00000357760.2	g.1650844C>T g.1650844C>T	c.278G>A c.278G>A	p.Arg93Gln p.Arg93Gln	probably damaging probably damaging
IGFN1	Mutation	Missense	ENST00000335211.4	g.201163380G>A g.201163380G>A	c.106G>A c.106G>A	p.Val36Ile p.Val36Ile	benign benign
OPTC	Mutation	Missense	ENST00000367222.2	g.203465241G>C g.203465241G>C	c.108G>C c.108G>C	p.Arg36Ser p.Arg36Ser	benign benign
CDC42BPA	Mutation	Missense	ENST00000334218.5	g.227257549C>G g.227257549C>G	c.2833G>C c.2833G>C	p.Glu945Gln p.Glu945Gln	benign benign
OBSCN	Mutation	Missense	ENST00000284548.11	g.228548329C>T g.228548329C>T	c.19736C>T c.19736C>T	p.Ala6579Val p.Ala6579Val	benign benign
URB2	Mutation	Missense	ENST00000258243.2	g.229770779C>T g.229770779C>T	c.419C>T c.419C>T	p.Thr140Met p.Thr140Met	probably damaging probably damaging
RYR2	Mutation	Missense	ENST00000366574.2	g.237949311A>G g.237949311A>G	c.13303A>G c.13303A>G	p.Thr4435Ala p.Thr4435Ala	benign benign
CHML	Mutation	Missense	ENST00000366553.1	g.241798739C>G g.241798739C>G	c.330G>C c.330G>C	p.Glu110Asp p.Glu110Asp	benign benign
SH3D21	Mutation	Missense	ENST00000426732.2	g.36773415C>T g.36773415C>T	c.133C>T c.133C>T	p.Arg45Trp p.Arg45Trp	probably damaging probably damaging
GLIS1	Mutation	Missense	ENST00000312233.2	g.53980338G>T g.53980338G>T	c.1318C>A c.1318C>A	p.His440Asn p.His440Asn	probably damaging probably damaging

Mutational Signature

Fusion transcripts (6)

Fusion Name	Gene (1)	Chr (1)	Genomic position hg19 (1)	Gene (2)	Chr (2)	Genomic position hg19 (2)	Supporting reads	Consistance fusion	Fusion type
AURKA--CSTF1	AURKA	chr20	54966034	CSTF1	chr20	54974412	23	inverted	DUP
DPYD--GDAP2	DPYD	chr1	98361295	GDAP2	chr1	118438160	71	inverted	INV
HORMAD2--NF2	NF2	chr22	30054252	HORMAD2	chr22	30572051	42	straight	DEL
IGF2BP2--TFEB	IGF2BP2	chr3	185540940	TFEB	chr6	41658972	130	straight	TRANS
LOC101927870--PHF21A	PHF21A	chr11	45957289	LOC101927870	chr7	103151297	71	NA	TRANS
TVP23C--TVP23C-CDRT4	TVP23C	chr17	15449098	TVP23C-CDRT4	chr17	15341516	10	straight	DEL

HBV RNA fusions (1)

Breakpoint on human genome (hg19)	Affected gene	Breakpoint on HBV genome (X02763)	Nb of paired reads (HG19 HBV)
chr4:73,690,401	intergenic	1,792	267

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)

Drugs (35)

DrugFilter by Drug	AUC	GI50
Bortezomib	0.31	0.013
Trametinib	0.5	0.077
Paclitaxel	0.52	0.032
Doxorubicin	0.55	0.26
Sorafenib_Trametinib	0.59	0.08
PF.04691502	0.6	0.42
Alvespimycin	0.61	0.29
Vinblastine	0.67	6.679
CD532	0.7	0.4
Rapamycin	0.74	10.0
Alisertib	0.75	5.328
BLU.9931	0.78	10.0
Tanespimycin	0.78	2.055
Sorafenib_Refametinib	0.8	0.77
Navitoclax	0.81	4.34

Liver Cancer Cell Lines Database

Cell Line: Hep3B

Transcriptomic subgroup: CL1

Mutational Signature

Liver Cancer Cell Lines
Database