Liver Cancer Cell Lines
Database

LCCL to predict drug response

Cell Line: Hep3B


Cell line description
Cell line nameSynonymsCellosaurus IDTumor typeReferenceSupplierCulture medium
Hep3B CVCL_0326 Hepatocellular Carcinoma Aden et al. Nature (1979) [PMID: 233137] ATCC - USA DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

AgeGenderGeographic OriginEthnicityHBVHCV
8 Male USA African-American Yes No

Transcriptomic subgroup: CL1


Mutations and CNAs (409)
Gene nameAlteration typeVariant classAnnotation transcriptgNomencNomenpNomenPPH pr├ędiction
TRIM64CMutationIn-FrameENST00000530230.1
g.49080591_49080592insGGGTCTATG
g.49080591_49080592insGGGTCTATG
c.74_75insATAGACCCC
c.74_75insATAGACCCC
p.Val26X
p.Val26X
damaging
damaging
RCE1MutationIn-FrameENST00000309657.3
g.66610978_66610986del
g.66610978_66610986del
c.52_60del
c.52_60del
p.Glu18_Pro20del
p.Glu18_Pro20del
damaging
damaging
DUOX2MutationIn-FrameENST00000389039.6
g.45394038_45394058del
g.45394038_45394058del
c.2784_2804del
c.2784_2804del
p.Asp930_Arg936del
p.Asp930_Arg936del
damaging
damaging
TSHZ2MutationIn-FrameENST00000371497.5
g.51870084_51870086del
g.51870084_51870086del
c.87_89del
c.87_89del
p.Glu34del
p.Glu34del
damaging
damaging
IL17RCMutationIn-FrameENST00000295981.3
g.9959222_9959223insTCTGGTCTT
g.9959222_9959223insTCTGGTCTT
c.223_224insTCTGGTCTT
c.223_224insTCTGGTCTT
p.Leu74_Ser75insPheTrpSer
p.Leu74_Ser75insPheTrpSer
damaging
damaging
MPDZMutationIn-FrameENST00000319217.7
g.13196173_13196175del
g.13196173_13196175del
c.1601_1603del
c.1601_1603del
p.Glu534del
p.Glu534del
damaging
damaging
TAS1R3MutationMissenseENST00000339381.5
g.1267608C>T
g.1267608C>T
c.697C>T
c.697C>T
p.Arg233Cys
p.Arg233Cys
probably damaging
probably damaging
TAS1R3MutationMissenseENST00000339381.5
g.1268747C>T
g.1268747C>T
c.1588C>T
c.1588C>T
p.Arg530Trp
p.Arg530Trp
benign
benign
MXRA8MutationMissenseENST00000309212.6
g.1290506C>A
g.1290506C>A
c.505G>T
c.505G>T
p.Gly169Cys
p.Gly169Cys
probably damaging
probably damaging
BOLA1MutationMissenseENST00000369150.1
g.149871738G>C
g.149871738G>C
c.126G>C
c.126G>C
p.Glu42Asp
p.Glu42Asp
benign
benign
FLGMutationMissenseENST00000368799.1
g.152282882C>A
g.152282882C>A
c.4480G>T
c.4480G>T
p.Gly1494Trp
p.Gly1494Trp
probably damaging
probably damaging
SLC50A1MutationMissenseNM_001287592.1
g.155108066A>G
g.155108066A>G
c.4A>G
c.4A>G
p.Ile2Val
p.Ile2Val
NA
NA
OR10K2MutationMissenseENST00000314902.2
g.158389960C>G
g.158389960C>G
c.697G>C
c.697G>C
p.Gly233Arg
p.Gly233Arg
probably damaging
probably damaging
SLAMF9MutationMissenseENST00000368093.3
g.159921481C>A
g.159921481C>A
c.840G>T
c.840G>T
p.Lys280Asn
p.Lys280Asn
possibly damaging
possibly damaging
FCRLBMutationMissenseENST00000336830.5
g.161693280C>T
g.161693280C>T
c.176C>T
c.176C>T
p.Thr59Ile
p.Thr59Ile
possibly damaging
possibly damaging
CDK11AMutationMissenseENST00000357760.2
g.1650844C>T
g.1650844C>T
c.278G>A
c.278G>A
p.Arg93Gln
p.Arg93Gln
probably damaging
probably damaging
IGFN1MutationMissenseENST00000335211.4
g.201163380G>A
g.201163380G>A
c.106G>A
c.106G>A
p.Val36Ile
p.Val36Ile
benign
benign
OPTCMutationMissenseENST00000367222.2
g.203465241G>C
g.203465241G>C
c.108G>C
c.108G>C
p.Arg36Ser
p.Arg36Ser
benign
benign
CDC42BPAMutationMissenseENST00000334218.5
g.227257549C>G
g.227257549C>G
c.2833G>C
c.2833G>C
p.Glu945Gln
p.Glu945Gln
benign
benign
OBSCNMutationMissenseENST00000284548.11
g.228548329C>T
g.228548329C>T
c.19736C>T
c.19736C>T
p.Ala6579Val
p.Ala6579Val
benign
benign
URB2MutationMissenseENST00000258243.2
g.229770779C>T
g.229770779C>T
c.419C>T
c.419C>T
p.Thr140Met
p.Thr140Met
probably damaging
probably damaging
RYR2MutationMissenseENST00000366574.2
g.237949311A>G
g.237949311A>G
c.13303A>G
c.13303A>G
p.Thr4435Ala
p.Thr4435Ala
benign
benign
CHMLMutationMissenseENST00000366553.1
g.241798739C>G
g.241798739C>G
c.330G>C
c.330G>C
p.Glu110Asp
p.Glu110Asp
benign
benign
SH3D21MutationMissenseENST00000426732.2
g.36773415C>T
g.36773415C>T
c.133C>T
c.133C>T
p.Arg45Trp
p.Arg45Trp
probably damaging
probably damaging
GLIS1MutationMissenseENST00000312233.2
g.53980338G>T
g.53980338G>T
c.1318C>A
c.1318C>A
p.His440Asn
p.His440Asn
probably damaging
probably damaging

Mutational Signature



Fusion transcripts (6)
Fusion NameGene (1)Chr (1)Genomic position hg19 (1)Gene (2)Chr (2)Genomic position hg19 (2)Supporting readsConsistance fusionFusion type
AURKA--CSTF1AURKAchr2054966034CSTF1chr205497441223invertedDUP
DPYD--GDAP2DPYDchr198361295GDAP2chr111843816071invertedINV
HORMAD2--NF2NF2chr2230054252HORMAD2chr223057205142straightDEL
IGF2BP2--TFEBIGF2BP2chr3185540940TFEBchr641658972130straightTRANS
LOC101927870--PHF21APHF21Achr1145957289LOC101927870chr710315129771NATRANS
TVP23C--TVP23C-CDRT4TVP23Cchr1715449098TVP23C-CDRT4chr171534151610straightDEL

HBV RNA fusions (1)
Breakpoint on human genome (hg19)Affected geneBreakpoint on HBV genome (X02763)Nb of paired reads (HG19 HBV)
chr4:73,690,401intergenic1,792267

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)


Drugs (35)
DrugAUCGI50
Bortezomib0.310.013
Trametinib0.50.077
Paclitaxel0.520.032
Doxorubicin0.550.26
Sorafenib_Trametinib0.590.08
PF.046915020.60.42
Alvespimycin0.610.29
Vinblastine0.676.679
CD5320.70.4
Rapamycin0.7410.0
Alisertib0.755.328
BLU.99310.7810.0
Tanespimycin0.782.055
Sorafenib_Refametinib0.80.77
Navitoclax0.814.34


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