Liver Cancer Cell Lines
Database

LCCL to predict drug response

Cell Line: HepG2


Cell line description
Cell line nameSynonymsCellosaurus IDTumor typeReferenceSupplierCulture medium
HepG2 CVCL_0027 Hepatoblastoma Aden et al. Nature (1979) [PMID: 233137] ATCC - USA DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

AgeGenderGeographic OriginEthnicityHBVHCV
15 Male USA European No No

Transcriptomic subgroup: CL1


Mutations and CNAs (299)
Gene nameAlteration typeVariant classAnnotation transcriptgNomencNomenpNomenPPH pr├ędiction
CTNNB1MutationIn-FrameENST00000349496.5
g.41265568_41266630del
g.41265568_41266630del
c.9_427del
c.9_427del
p.Ala5_Gln143del
p.Ala5_Gln143del
damaging
damaging
EME2MutationIn-FrameENST00000568449.1
g.1825822_1825824delCTC
g.1825822_1825824delCTC
c.806_808del
c.806_808del
p.Ser269del
p.Ser269del
damaging
damaging
SLC26A11MutationIn-FrameENST00000361193.3
g.78196560_78196562del
g.78196560_78196562del
c.341_343del
c.341_343del
p.Phe114del
p.Phe114del
damaging
damaging
BPIMutationIn-FrameENST00000262865.4
g.36936015_36936016insCAA
g.36936015_36936016insCAA
c.189_190insCAA
c.189_190insCAA
p.Ile63_Lys64insGln
p.Ile63_Lys64insGln
damaging
damaging
GTF3C5MutationIn-FrameENST00000372097.5
g.135933304_135933306del
g.135933304_135933306del
c.1497_1499del
c.1497_1499del
p.Glu499del
p.Glu499del
damaging
damaging
CHIAMutationMissenseENST00000343320.6
g.111857987T>C
g.111857987T>C
c.410T>C
c.410T>C
p.Phe137Ser
p.Phe137Ser
probably damaging
probably damaging
AP4B1MutationMissenseENST00000256658.4
g.114442837T>C
g.114442837T>C
c.803A>G
c.803A>G
p.His268Arg
p.His268Arg
benign
benign
NRASMutationMissenseENST00000369535.4
g.115256529T>A
g.115256529T>A
c.182A>T
c.182A>T
p.Gln61Leu
p.Gln61Leu
probably damaging
probably damaging
DVL1MutationMissenseENST00000378888.5
g.1284367G>A
g.1284367G>A
c.79C>T
c.79C>T
p.Arg27Cys
p.Arg27Cys
probably damaging
probably damaging
HNRNPCL1MutationMissenseENST00000317869.6
g.12907794G>A
g.12907794G>A
c.349C>T
c.349C>T
p.Arg117Trp
p.Arg117Trp
probably damaging
probably damaging
SEMA6CMutationMissenseENST00000341697.3
g.151105616G>A
g.151105616G>A
c.2137C>T
c.2137C>T
p.Arg713Cys
p.Arg713Cys
probably damaging
probably damaging
PSMB4MutationMissenseENST00000290541.6
g.151372091G>A
g.151372091G>A
c.28G>A
c.28G>A
p.Gly10Arg
p.Gly10Arg
benign
benign
FLGMutationMissenseENST00000368799.1
g.152275598A>T
g.152275598A>T
c.11764T>A
c.11764T>A
p.Ser3922Thr
p.Ser3922Thr
possibly damaging
possibly damaging
KAZNMutationMissenseENST00000376030.2
g.15386706G>C
g.15386706G>C
c.955G>C
c.955G>C
p.Val319Leu
p.Val319Leu
benign
benign
INSRRMutationMissenseENST00000368195.3
g.156823861G>A
g.156823861G>A
c.320C>T
c.320C>T
p.Thr107Met
p.Thr107Met
possibly damaging
possibly damaging
KCNT2MutationMissenseENST00000294725.9
g.196295883T>G
g.196295883T>G
c.2240A>C
c.2240A>C
p.Lys747Thr
p.Lys747Thr
benign
benign
KDM5BMutationMissenseENST00000367265.3
g.202698963A>G
g.202698963A>G
c.4369T>C
c.4369T>C
p.Tyr1457His
p.Tyr1457His
benign
benign
C1orf65MutationMissenseENST00000366875.3
g.223566909T>C
g.223566909T>C
c.92T>C
c.92T>C
p.Leu31Pro
p.Leu31Pro
benign
benign
TAF5LMutationMissenseENST00000258281.2
g.229737995G>A
g.229737995G>A
c.919C>T
c.919C>T
p.His307Tyr
p.His307Tyr
probably damaging
probably damaging
RYR2MutationMissenseENST00000366574.2
g.237660048G>C
g.237660048G>C
c.2199G>C
c.2199G>C
p.Trp733Cys
p.Trp733Cys
probably damaging
probably damaging
KIF26BMutationMissenseENST00000407071.2
g.245772763C>T
g.245772763C>T
c.1847C>T
c.1847C>T
p.Thr616Met
p.Thr616Met
probably damaging
probably damaging
BAI2MutationMissenseENST00000257070.4
g.32203866G>A
g.32203866G>A
c.2707C>T
c.2707C>T
p.His903Tyr
p.His903Tyr
probably damaging
probably damaging
KIAA1522MutationMissenseENST00000373480.1
g.33236360G>A
g.33236360G>A
c.1403G>A
c.1403G>A
p.Arg468His
p.Arg468His
probably damaging
probably damaging
MUTYHMutationMissenseENST00000372098.3
g.45797519G>C
g.45797519G>C
c.991C>G
c.991C>G
p.Pro331Ala (Splice)
p.Pro331Ala (Splice)
benign
benign
PLEKHG5MutationMissenseENST00000400915.3
g.6556600G>C
g.6556600G>C
c.34C>G
c.34C>G
p.Leu12Val
p.Leu12Val
possibly damaging
possibly damaging

Mutational Signature



Fusion transcripts (3)
Fusion NameGene (1)Chr (1)Genomic position hg19 (1)Gene (2)Chr (2)Genomic position hg19 (2)Supporting readsConsistance fusionFusion type
LMO7--UCHL3LMO7chr1376210861UCHL3chr137617890419straightDUP
LOC407835--MAP2K2MAP2K2chr194110356LOC407835chr712876701817NATRANS
NFS1--PHF20NFS1chr2034278332PHF20chr203438926820invertedDUP

HBV RNA fusions (0)
Breakpoint on human genome (hg19)Affected geneBreakpoint on HBV genome (X02763)Nb of paired reads (HG19 HBV)
No records found.

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)


Drugs (35)
DrugAUCGI50
Alvespimycin0.360.025
Sorafenib_Trametinib0.370.001
Tanespimycin0.450.047
Bortezomib0.470.054
Trametinib0.50.008
Sorafenib_Refametinib0.530.09
Paclitaxel0.560.098
Refametinib0.5710.0
CD5320.650.025
Selumetinib0.7510.0
Vinblastine0.7610.0
Dasatinib0.7610.0
Rapamycin0.7910.0
Doxorubicin0.810.83
Linsitinib0.8510.0


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