Liver Cancer Cell Lines Database

Cell line description

Cell line name	Synonyms	Cellosaurus ID	Tumor type	Reference	Supplier	Culture medium
HepG2		CVCL_0027	Hepatoblastoma	Aden et al. Nature (1979) [PMID: 233137]	ATCC - USA	DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

Age	Gender	Geographic Origin	Ethnicity	HBV	HCV
15	Male	USA	European	No	No

Transcriptomic subgroup: CL1

Mutations and CNAs (299)

Gene nameFilter by Gene name	Alteration type	Variant class	Annotation transcript	gNomen	cNomen	pNomen	PPH prédiction
CTNNB1	Mutation	In-Frame	ENST00000349496.5	g.41265568_41266630del g.41265568_41266630del	c.9_427del c.9_427del	p.Ala5_Gln143del p.Ala5_Gln143del	damaging damaging
EME2	Mutation	In-Frame	ENST00000568449.1	g.1825822_1825824delCTC g.1825822_1825824delCTC	c.806_808del c.806_808del	p.Ser269del p.Ser269del	damaging damaging
SLC26A11	Mutation	In-Frame	ENST00000361193.3	g.78196560_78196562del g.78196560_78196562del	c.341_343del c.341_343del	p.Phe114del p.Phe114del	damaging damaging
BPI	Mutation	In-Frame	ENST00000262865.4	g.36936015_36936016insCAA g.36936015_36936016insCAA	c.189_190insCAA c.189_190insCAA	p.Ile63_Lys64insGln p.Ile63_Lys64insGln	damaging damaging
GTF3C5	Mutation	In-Frame	ENST00000372097.5	g.135933304_135933306del g.135933304_135933306del	c.1497_1499del c.1497_1499del	p.Glu499del p.Glu499del	damaging damaging
CHIA	Mutation	Missense	ENST00000343320.6	g.111857987T>C g.111857987T>C	c.410T>C c.410T>C	p.Phe137Ser p.Phe137Ser	probably damaging probably damaging
AP4B1	Mutation	Missense	ENST00000256658.4	g.114442837T>C g.114442837T>C	c.803A>G c.803A>G	p.His268Arg p.His268Arg	benign benign
NRAS	Mutation	Missense	ENST00000369535.4	g.115256529T>A g.115256529T>A	c.182A>T c.182A>T	p.Gln61Leu p.Gln61Leu	probably damaging probably damaging
DVL1	Mutation	Missense	ENST00000378888.5	g.1284367G>A g.1284367G>A	c.79C>T c.79C>T	p.Arg27Cys p.Arg27Cys	probably damaging probably damaging
HNRNPCL1	Mutation	Missense	ENST00000317869.6	g.12907794G>A g.12907794G>A	c.349C>T c.349C>T	p.Arg117Trp p.Arg117Trp	probably damaging probably damaging
SEMA6C	Mutation	Missense	ENST00000341697.3	g.151105616G>A g.151105616G>A	c.2137C>T c.2137C>T	p.Arg713Cys p.Arg713Cys	probably damaging probably damaging
PSMB4	Mutation	Missense	ENST00000290541.6	g.151372091G>A g.151372091G>A	c.28G>A c.28G>A	p.Gly10Arg p.Gly10Arg	benign benign
FLG	Mutation	Missense	ENST00000368799.1	g.152275598A>T g.152275598A>T	c.11764T>A c.11764T>A	p.Ser3922Thr p.Ser3922Thr	possibly damaging possibly damaging
KAZN	Mutation	Missense	ENST00000376030.2	g.15386706G>C g.15386706G>C	c.955G>C c.955G>C	p.Val319Leu p.Val319Leu	benign benign
INSRR	Mutation	Missense	ENST00000368195.3	g.156823861G>A g.156823861G>A	c.320C>T c.320C>T	p.Thr107Met p.Thr107Met	possibly damaging possibly damaging
KCNT2	Mutation	Missense	ENST00000294725.9	g.196295883T>G g.196295883T>G	c.2240A>C c.2240A>C	p.Lys747Thr p.Lys747Thr	benign benign
KDM5B	Mutation	Missense	ENST00000367265.3	g.202698963A>G g.202698963A>G	c.4369T>C c.4369T>C	p.Tyr1457His p.Tyr1457His	benign benign
C1orf65	Mutation	Missense	ENST00000366875.3	g.223566909T>C g.223566909T>C	c.92T>C c.92T>C	p.Leu31Pro p.Leu31Pro	benign benign
TAF5L	Mutation	Missense	ENST00000258281.2	g.229737995G>A g.229737995G>A	c.919C>T c.919C>T	p.His307Tyr p.His307Tyr	probably damaging probably damaging
RYR2	Mutation	Missense	ENST00000366574.2	g.237660048G>C g.237660048G>C	c.2199G>C c.2199G>C	p.Trp733Cys p.Trp733Cys	probably damaging probably damaging
KIF26B	Mutation	Missense	ENST00000407071.2	g.245772763C>T g.245772763C>T	c.1847C>T c.1847C>T	p.Thr616Met p.Thr616Met	probably damaging probably damaging
BAI2	Mutation	Missense	ENST00000257070.4	g.32203866G>A g.32203866G>A	c.2707C>T c.2707C>T	p.His903Tyr p.His903Tyr	probably damaging probably damaging
KIAA1522	Mutation	Missense	ENST00000373480.1	g.33236360G>A g.33236360G>A	c.1403G>A c.1403G>A	p.Arg468His p.Arg468His	probably damaging probably damaging
MUTYH	Mutation	Missense	ENST00000372098.3	g.45797519G>C g.45797519G>C	c.991C>G c.991C>G	p.Pro331Ala (Splice) p.Pro331Ala (Splice)	benign benign
PLEKHG5	Mutation	Missense	ENST00000400915.3	g.6556600G>C g.6556600G>C	c.34C>G c.34C>G	p.Leu12Val p.Leu12Val	possibly damaging possibly damaging

Mutational Signature

Fusion transcripts (3)

Fusion Name	Gene (1)	Chr (1)	Genomic position hg19 (1)	Gene (2)	Chr (2)	Genomic position hg19 (2)	Supporting reads	Consistance fusion	Fusion type
LMO7--UCHL3	LMO7	chr13	76210861	UCHL3	chr13	76178904	19	straight	DUP
LOC407835--MAP2K2	MAP2K2	chr19	4110356	LOC407835	chr7	128767018	17	NA	TRANS
NFS1--PHF20	NFS1	chr20	34278332	PHF20	chr20	34389268	20	inverted	DUP

HBV RNA fusions (0)

Breakpoint on human genome (hg19)	Affected gene	Breakpoint on HBV genome (X02763)	Nb of paired reads (HG19 HBV)
No records found.

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)

Drugs (35)

DrugFilter by Drug	AUC	GI50
Alvespimycin	0.36	0.025
Sorafenib_Trametinib	0.37	0.001
Tanespimycin	0.45	0.047
Bortezomib	0.47	0.054
Trametinib	0.5	0.008
Sorafenib_Refametinib	0.53	0.09
Paclitaxel	0.56	0.098
Refametinib	0.57	10.0
CD532	0.65	0.025
Selumetinib	0.75	10.0
Vinblastine	0.76	10.0
Dasatinib	0.76	10.0
Rapamycin	0.79	10.0
Doxorubicin	0.81	0.83
Linsitinib	0.85	10.0

Liver Cancer Cell Lines Database

Cell Line: HepG2

Transcriptomic subgroup: CL1

Mutational Signature

Liver Cancer Cell Lines
Database