Liver Cancer Cell Lines Database

Cell line description

Cell line name	Synonyms	Cellosaurus ID	Tumor type	Reference	Supplier	Culture medium
HepaRG		CVCL_9720	Hepatocellular Carcinoma	Gripon et al. PNAS (2002) [PMID: 12432097]	Gift from Philippe Merle and Fabien Zoulim (Inserm U1052, France)	DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

Age	Gender	Geographic Origin	Ethnicity	HBV	HCV
NA	Female	France	European	No	Yes

Transcriptomic subgroup: CL2

Mutations and CNAs (270)

Gene nameFilter by Gene name	Alteration type	Variant class	Annotation transcript	gNomen	cNomen	pNomen	PPH prédiction
NUDT17	Mutation	In-Frame	ENST00000334513.5	g.145586670_145586675del g.145586670_145586675del	c.901_906del c.901_906del	p.Lys301_Ser302del p.Lys301_Ser302del	damaging damaging
HIST1H3A	Mutation	In-Frame	ENST00000357647.3	g.26020735_26020740del g.26020735_26020740del	c.18_23del c.18_23del	p.Gln6_Ala8delinsHis p.Gln6_Ala8delinsHis	damaging damaging
CDKN1A	Mutation	In-Frame	ENST00000244741.5	g.36652015_36652029del g.36652015_36652029del	c.137_151del c.137_151del	p.Arg46_Phe51delinsLeu p.Arg46_Phe51delinsLeu	damaging damaging
NTNG1	Mutation	Missense	ENST00000370065.1	g.107973489G>T g.107973489G>T	c.1205G>T c.1205G>T	p.Gly402Val p.Gly402Val	possibly damaging possibly damaging
CELSR2	Mutation	Missense	ENST00000271332.3	g.109794206C>T g.109794206C>T	c.1505C>T c.1505C>T	p.Ala502Val p.Ala502Val	possibly damaging possibly damaging
MAGI3	Mutation	Missense	ENST00000307546.9	g.114225717A>T g.114225717A>T	c.3527A>T c.3527A>T	p.Glu1176Val p.Glu1176Val	possibly damaging possibly damaging
VPS13D	Mutation	Missense	ENST00000356315.4	g.12379644G>A g.12379644G>A	c.7505G>A c.7505G>A	p.Arg2502Gln p.Arg2502Gln	benign benign
RPRD2	Mutation	Missense	ENST00000369068.4	g.150443417T>C g.150443417T>C	c.1993T>C c.1993T>C	p.Ser665Pro p.Ser665Pro	probably damaging probably damaging
MCL1	Mutation	Missense	ENST00000307940.3	g.150551552T>C g.150551552T>C	c.455A>G c.455A>G	p.Asn152Ser p.Asn152Ser	benign benign
SLC27A3	Mutation	Missense	ENST00000368661.3	g.153748286C>T g.153748286C>T	c.454C>T c.454C>T	p.Arg152Cys p.Arg152Cys	benign benign
YY1AP1	Mutation	Missense	ENST00000295566.4	g.155630008C>A g.155630008C>A	c.1831G>T c.1831G>T	p.Val611Leu p.Val611Leu	possibly damaging possibly damaging
SLC25A34	Mutation	Missense	ENST00000294454.5	g.16063144C>T g.16063144C>T	c.164C>T c.164C>T	p.Ala55Val p.Ala55Val	benign benign
POGK	Mutation	Missense	ENST00000367875.1	g.166818803G>C g.166818803G>C	c.987G>C c.987G>C	p.Gln329His p.Gln329His	probably damaging probably damaging
MDM4	Mutation	Missense	ENST00000367182.3	g.204518437C>T g.204518437C>T	c.1100C>T c.1100C>T	p.Ser367Leu p.Ser367Leu	probably damaging probably damaging
VWA5B1	Mutation	Missense	ENST00000289815.8	g.20672051G>A g.20672051G>A	c.2729G>A c.2729G>A	p.Arg910Gln p.Arg910Gln	benign benign
ADCK3	Mutation	Missense	ENST00000366777.3	g.227172295T>A g.227172295T>A	c.1445T>A c.1445T>A	p.Phe482Tyr p.Phe482Tyr	possibly damaging possibly damaging
EXO1	Mutation	Missense	ENST00000348581.5	g.242020670T>A g.242020670T>A	c.429T>A c.429T>A	p.Asp143Glu p.Asp143Glu	probably damaging probably damaging
KIF26B	Mutation	Missense	ENST00000407071.2	g.245847603C>T g.245847603C>T	c.2327C>T c.2327C>T	p.Ala776Val p.Ala776Val	probably damaging probably damaging
OR1C1	Mutation	Missense	ENST00000408896.2	g.247920895T>C g.247920895T>C	c.814A>G c.814A>G	p.Thr272Ala p.Thr272Ala	benign benign
SLC9A1	Mutation	Missense	ENST00000263980.3	g.27426875T>C g.27426875T>C	c.2371A>G c.2371A>G	p.Ile791Val p.Ile791Val	benign benign
IFI6	Mutation	Missense	ENST00000339145.4	g.27995753C>T g.27995753C>T	c.73G>A c.73G>A	p.Glu25Lys p.Glu25Lys	benign benign
SPOCD1	Mutation	Missense	ENST00000360482.2	g.32279899C>T g.32279899C>T	c.1036G>A c.1036G>A	p.Val346Ile p.Val346Ile	benign benign
PRDM16	Mutation	Missense	ENST00000270722.5	g.3328547A>C g.3328547A>C	c.1786A>C c.1786A>C	p.Ser596Arg p.Ser596Arg	possibly damaging possibly damaging
EPHA10	Mutation	Missense	ENST00000373048.4	g.38184480G>A g.38184480G>A	c.2765C>T c.2765C>T	p.Thr922Ile p.Thr922Ile	benign benign
POMGNT1	Mutation	Missense	ENST00000371984.3	g.46658618C>T g.46658618C>T	c.1165G>A c.1165G>A	p.Ala389Thr p.Ala389Thr	benign benign

Mutational Signature

Fusion transcripts (5)

Fusion Name	Gene (1)	Chr (1)	Genomic position hg19 (1)	Gene (2)	Chr (2)	Genomic position hg19 (2)	Supporting reads	Consistance fusion	Fusion type
AL121578.2--SYTL5	AL121578.2	chrX	37808657	SYTL5	chrX	37913465	10	straight	DEL
BCL7B--TBL2	BCL7B	chr7	72957876	TBL2	chr7	72988841	12	straight	DUP
FPGS--PIP5KL1	FPGS	chr9	130575557	PIP5KL1	chr9	130684459	100	inverted	DEL
LOC407835--MAP2K2	MAP2K2	chr19	4110356	LOC407835	chr7	128767018	40	NA	TRANS
PAWR--SYT1	SYT1	chr12	79787704	PAWR	chr12	79986390	15	inverted	DEL

HBV RNA fusions (0)

Breakpoint on human genome (hg19)	Affected gene	Breakpoint on HBV genome (X02763)	Nb of paired reads (HG19 HBV)
No records found.

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)

Drugs (35)

DrugFilter by Drug	AUC	GI50
Bortezomib	0.25	0.005
Trametinib	0.29	0.016
Paclitaxel	0.3	0.007
Sorafenib_Trametinib	0.35	0.02
Vinblastine	0.46	0.037
Dasatinib	0.49	0.06
Doxorubicin	0.56	0.22
Navitoclax	0.56	0.089
Tivantinib	0.59	0.305
Sorafenib_Refametinib	0.61	0.29
PF.04691502	0.63	0.325
Alvespimycin	0.71	0.56
Selumetinib	0.73	10.0
CD532	0.73	1.119
Refametinib	0.74	1.8

Liver Cancer Cell Lines Database

Cell Line: HepaRG

Transcriptomic subgroup: CL2

Mutational Signature

Liver Cancer Cell Lines
Database