Liver Cancer Cell Lines
Database

LCCL to predict drug response

Cell Line: HepaRG


Cell line description
Cell line nameSynonymsCellosaurus IDTumor typeReferenceSupplierCulture medium
HepaRG CVCL_9720 Hepatocellular Carcinoma Gripon et al. PNAS (2002) [PMID: 12432097] Gift from Philippe Merle and Fabien Zoulim (Inserm U1052, France) DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

AgeGenderGeographic OriginEthnicityHBVHCV
NA Female France European No Yes

Transcriptomic subgroup: CL2


Mutations and CNAs (270)
Gene nameAlteration typeVariant classAnnotation transcriptgNomencNomenpNomenPPH pr├ędiction
NUDT17MutationIn-FrameENST00000334513.5
g.145586670_145586675del
g.145586670_145586675del
c.901_906del
c.901_906del
p.Lys301_Ser302del
p.Lys301_Ser302del
damaging
damaging
HIST1H3AMutationIn-FrameENST00000357647.3
g.26020735_26020740del
g.26020735_26020740del
c.18_23del
c.18_23del
p.Gln6_Ala8delinsHis
p.Gln6_Ala8delinsHis
damaging
damaging
CDKN1AMutationIn-FrameENST00000244741.5
g.36652015_36652029del
g.36652015_36652029del
c.137_151del
c.137_151del
p.Arg46_Phe51delinsLeu
p.Arg46_Phe51delinsLeu
damaging
damaging
NTNG1MutationMissenseENST00000370065.1
g.107973489G>T
g.107973489G>T
c.1205G>T
c.1205G>T
p.Gly402Val
p.Gly402Val
possibly damaging
possibly damaging
CELSR2MutationMissenseENST00000271332.3
g.109794206C>T
g.109794206C>T
c.1505C>T
c.1505C>T
p.Ala502Val
p.Ala502Val
possibly damaging
possibly damaging
MAGI3MutationMissenseENST00000307546.9
g.114225717A>T
g.114225717A>T
c.3527A>T
c.3527A>T
p.Glu1176Val
p.Glu1176Val
possibly damaging
possibly damaging
VPS13DMutationMissenseENST00000356315.4
g.12379644G>A
g.12379644G>A
c.7505G>A
c.7505G>A
p.Arg2502Gln
p.Arg2502Gln
benign
benign
RPRD2MutationMissenseENST00000369068.4
g.150443417T>C
g.150443417T>C
c.1993T>C
c.1993T>C
p.Ser665Pro
p.Ser665Pro
probably damaging
probably damaging
MCL1MutationMissenseENST00000307940.3
g.150551552T>C
g.150551552T>C
c.455A>G
c.455A>G
p.Asn152Ser
p.Asn152Ser
benign
benign
SLC27A3MutationMissenseENST00000368661.3
g.153748286C>T
g.153748286C>T
c.454C>T
c.454C>T
p.Arg152Cys
p.Arg152Cys
benign
benign
YY1AP1MutationMissenseENST00000295566.4
g.155630008C>A
g.155630008C>A
c.1831G>T
c.1831G>T
p.Val611Leu
p.Val611Leu
possibly damaging
possibly damaging
SLC25A34MutationMissenseENST00000294454.5
g.16063144C>T
g.16063144C>T
c.164C>T
c.164C>T
p.Ala55Val
p.Ala55Val
benign
benign
POGKMutationMissenseENST00000367875.1
g.166818803G>C
g.166818803G>C
c.987G>C
c.987G>C
p.Gln329His
p.Gln329His
probably damaging
probably damaging
MDM4MutationMissenseENST00000367182.3
g.204518437C>T
g.204518437C>T
c.1100C>T
c.1100C>T
p.Ser367Leu
p.Ser367Leu
probably damaging
probably damaging
VWA5B1MutationMissenseENST00000289815.8
g.20672051G>A
g.20672051G>A
c.2729G>A
c.2729G>A
p.Arg910Gln
p.Arg910Gln
benign
benign
ADCK3MutationMissenseENST00000366777.3
g.227172295T>A
g.227172295T>A
c.1445T>A
c.1445T>A
p.Phe482Tyr
p.Phe482Tyr
possibly damaging
possibly damaging
EXO1MutationMissenseENST00000348581.5
g.242020670T>A
g.242020670T>A
c.429T>A
c.429T>A
p.Asp143Glu
p.Asp143Glu
probably damaging
probably damaging
KIF26BMutationMissenseENST00000407071.2
g.245847603C>T
g.245847603C>T
c.2327C>T
c.2327C>T
p.Ala776Val
p.Ala776Val
probably damaging
probably damaging
OR1C1MutationMissenseENST00000408896.2
g.247920895T>C
g.247920895T>C
c.814A>G
c.814A>G
p.Thr272Ala
p.Thr272Ala
benign
benign
SLC9A1MutationMissenseENST00000263980.3
g.27426875T>C
g.27426875T>C
c.2371A>G
c.2371A>G
p.Ile791Val
p.Ile791Val
benign
benign
IFI6MutationMissenseENST00000339145.4
g.27995753C>T
g.27995753C>T
c.73G>A
c.73G>A
p.Glu25Lys
p.Glu25Lys
benign
benign
SPOCD1MutationMissenseENST00000360482.2
g.32279899C>T
g.32279899C>T
c.1036G>A
c.1036G>A
p.Val346Ile
p.Val346Ile
benign
benign
PRDM16MutationMissenseENST00000270722.5
g.3328547A>C
g.3328547A>C
c.1786A>C
c.1786A>C
p.Ser596Arg
p.Ser596Arg
possibly damaging
possibly damaging
EPHA10MutationMissenseENST00000373048.4
g.38184480G>A
g.38184480G>A
c.2765C>T
c.2765C>T
p.Thr922Ile
p.Thr922Ile
benign
benign
POMGNT1MutationMissenseENST00000371984.3
g.46658618C>T
g.46658618C>T
c.1165G>A
c.1165G>A
p.Ala389Thr
p.Ala389Thr
benign
benign

Mutational Signature



Fusion transcripts (5)
Fusion NameGene (1)Chr (1)Genomic position hg19 (1)Gene (2)Chr (2)Genomic position hg19 (2)Supporting readsConsistance fusionFusion type
AL121578.2--SYTL5AL121578.2chrX37808657SYTL5chrX3791346510straightDEL
BCL7B--TBL2BCL7Bchr772957876TBL2chr77298884112straightDUP
FPGS--PIP5KL1FPGSchr9130575557PIP5KL1chr9130684459100invertedDEL
LOC407835--MAP2K2MAP2K2chr194110356LOC407835chr712876701840NATRANS
PAWR--SYT1SYT1chr1279787704PAWRchr127998639015invertedDEL

HBV RNA fusions (0)
Breakpoint on human genome (hg19)Affected geneBreakpoint on HBV genome (X02763)Nb of paired reads (HG19 HBV)
No records found.

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)


Drugs (35)
DrugAUCGI50
Bortezomib0.250.005
Trametinib0.290.016
Paclitaxel0.30.007
Sorafenib_Trametinib0.350.02
Vinblastine0.460.037
Dasatinib0.490.06
Doxorubicin0.560.22
Navitoclax0.560.089
Tivantinib0.590.305
Sorafenib_Refametinib0.610.29
PF.046915020.630.325
Alvespimycin0.710.56
Selumetinib0.7310.0
CD5320.731.119
Refametinib0.741.8


Codebase Soc. Coop.
info@codebase.it