Liver Cancer Cell Lines
Database

LCCL to predict drug response

Cell Line: Huh7


Cell line description
Cell line nameSynonymsCellosaurus IDTumor typeReferenceSupplierCulture medium
Huh7 CVCL_0336 Hepatocellular Carcinoma Nakabayashi et al Cancer Res (1982) [PMID: 6286115] ATCC - USA DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

AgeGenderGeographic OriginEthnicityHBVHCV
57 Male Japan Asian No No

Transcriptomic subgroup: CL1


Mutations and CNAs (690)
Gene nameAlteration typeVariant classAnnotation transcriptgNomencNomenpNomenPPH pr├ędiction
DNAH17MutationIn-FrameNM_173628.3
g.76506522_76506527del
g.76506522_76506527del
c.4175_4180del
c.4175_4180del
p.Ser1392_Glu1394delinsLys
p.Ser1392_Glu1394delinsLys
damaging
damaging
PTPN23MutationIn-FrameENST00000265562.4
g.47452858_47452859insTCT
g.47452858_47452859insTCT
c.3570_3571insTCT
c.3570_3571insTCT
p.Ala1190_Leu1191insSer
p.Ala1190_Leu1191insSer
damaging
damaging
PABPC4LMutationIn-FrameENST00000529122.2
g.135122031_135122054del
g.135122031_135122054del
c.295_318del
c.295_318del
p.Ile99_Arg106del
p.Ile99_Arg106del
damaging
damaging
HFEMutationIn-FrameENST00000309234.6
g.26092987_26092989del
g.26092987_26092989del
c.691_693del
c.691_693del
p.Tyr231del
p.Tyr231del
damaging
damaging
GAL3ST4MutationIn-FrameENST00000360039.4
g.99758490_99758501del
g.99758490_99758501del
c.511_522del
c.511_522del
p.Tyr171_Ser174del
p.Tyr171_Ser174del
damaging
damaging
PEX14MutationMissenseENST00000356607.4
g.10687391T>G
g.10687391T>G
c.648T>G
c.648T>G
p.Ile216Met
p.Ile216Met
probably damaging
probably damaging
C1orf167MutationMissenseENST00000433342.1
g.11844522G>C
g.11844522G>C
c.3369G>C
c.3369G>C
p.Q1123H
p.Q1123H
            benign
benign
VPS13DMutationMissenseENST00000356315.4
g.12342810A>T
g.12342810A>T
c.4651A>T
c.4651A>T
p.Asn1551Tyr
p.Asn1551Tyr
possibly damaging
possibly damaging
TAS1R3MutationMissenseENST00000339381.5
g.1267155T>C
g.1267155T>C
c.329T>C
c.329T>C
p.Met110Thr
p.Met110Thr
probably damaging
probably damaging
GJA8MutationMissenseENST00000240986.4
g.147380433G>C
g.147380433G>C
c.351G>C
c.351G>C
p.Gln117His
p.Gln117His
probably damaging
probably damaging
RUSC1MutationMissenseENST00000368352.5
g.155291839A>T
g.155291839A>T
c.275A>T
c.275A>T
p.Glu92Val
p.Glu92Val
probably damaging
probably damaging
TOR1AIP2MutationMissenseENST00000367612.3
g.179816728A>C
g.179816728A>C
c.597T>G
c.597T>G
p.Ile199Met
p.Ile199Met
benign
benign
AIM1LMutationMissenseENST00000475866.2
g.26672776G>A
g.26672776G>A
c.373C>T
c.373C>T
p.Arg125Cys
p.Arg125Cys
unknown
unknown
PTPRCMutationMissenseENST00000367376.2
g.198704298C>T
g.198704298C>T
c.2314C>T
c.2314C>T
p.Arg772Trp
p.Arg772Trp
probably damaging
probably damaging
PTPRCMutationMissenseENST00000367376.2
g.198711052C>A
g.198711052C>A
c.2452C>A
c.2452C>A
p.Pro818Thr
p.Pro818Thr
probably damaging
probably damaging
ZNF281MutationMissenseENST00000294740.3
g.200377768T>A
g.200377768T>A
c.1066A>T
c.1066A>T
p.Arg356Trp
p.Arg356Trp
probably damaging
probably damaging
IPO9MutationMissenseENST00000361565.4
g.201816692A>G
g.201816692A>G
c.238A>G
c.238A>G
p.Ile80Val
p.Ile80Val
benign
benign
ETNK2MutationMissenseENST00000367202.4
g.204101331G>A
g.204101331G>A
c.1142C>T
c.1142C>T
p.Ala381Val
p.Ala381Val
possibly damaging
possibly damaging
CR2MutationMissenseENST00000367057.3
g.207641953G>T
g.207641953G>T
c.527G>T
c.527G>T
p.Gly176Val
p.Gly176Val
probably damaging
probably damaging
JMJD4MutationMissenseENST00000366758.3
g.227923054A>T
g.227923054A>T
c.59T>A
c.59T>A
p.Leu20His
p.Leu20His
benign
benign
SNAP47MutationMissenseENST00000315781.5
g.227935610A>G
g.227935610A>G
c.308A>G
c.308A>G
p.Lys103Arg
p.Lys103Arg
probably damaging
probably damaging
OBSCNMutationMissenseENST00000284548.11
g.228494090C>T
g.228494090C>T
c.11677C>T
c.11677C>T
p.Arg3893Trp
p.Arg3893Trp
probably damaging
probably damaging
KIF26BMutationMissenseENST00000407071.2
g.245772666A>C
g.245772666A>C
c.1750A>C
c.1750A>C
p.Lys584Gln
p.Lys584Gln
probably damaging
probably damaging
OR2T4MutationMissenseENST00000366475.1
g.248525381C>G
g.248525381C>G
c.499C>G
c.499C>G
p.Leu167Val
p.Leu167Val
probably damaging
probably damaging
BAI2MutationMissenseENST00000257070.4
g.32205768C>G
g.32205768C>G
c.2001G>C
c.2001G>C
p.Gln667His
p.Gln667His
possibly damaging
possibly damaging

Mutational Signature



Fusion transcripts (25)
Fusion NameGene (1)Chr (1)Genomic position hg19 (1)Gene (2)Chr (2)Genomic position hg19 (2)Supporting readsConsistance fusionFusion type
ABL1--MBLAC2MBLAC2chr589767563ABL1chr913371091119invertedTRANS
ANAPC5--ATP6V0A2ANAPC5chr12121747503ATP6V0A2chr1212421904920invertedDUP
ANKIB1--PTPRN2ANKIB1chr791991586PTPRN2chr715814978334straightINV
ANO3--SLC5A12ANO3chr1126587442SLC5A12chr112670530393invertedDEL
APAF1--MED13LMED13Lchr12116714864APAF1chr1299080525170straightINV
ATP6V0D1--RBM19ATP6V0D1chr1667514859RBM19chr1211429670018straightTRANS
CARD18--RP11-94P11.4RP11-94P11.4chr11105130368CARD18chr1110500980437straightDEL
CCSER1--SNCACCSER1chr491048981SNCAchr49075684218straightINV
CMB9-22P13.2--TRMT10CTRMT10Cchr3101280847CMB9-22P13.2chr1165255089521NATRANS
CNN2--WDR18CNN2chr191036244WDR18chr1998976151straightDUP
CYB5R3--KDELC2KDELC2chr11108344081CYB5R3chr224301539219invertedTRANS
DTX2P1-UPK3BP1-PMS2P11--PIEZO2PIEZO2chr1811026244DTX2P1-UPK3BP1-PMS2P11chr77661729821invertedTRANS
FIP1L1--RP11-25H12.1FIP1L1chr454266005RP11-25H12.1chr46689121659straightDEL
GAREM1--SDHAF3GAREM1chr1829890155SDHAF3chr796810323105NATRANS
IGFBP7--PCAT4IGFBP7chr457976066PCAT4chr48078244410straightINV
LMNTD1--USP34USP34chr261515811LMNTD1chr122570247916NATRANS
LTN1--USP16LTN1chr2130337085USP16chr213041534884invertedDUP
MBLAC2--PHF20PHF20chr2034519365MBLAC2chr58976756333invertedTRANS
PACS1--RTN3RTN3chr1163449249PACS1chr116596095638straightDEL
PHF24--SDHAF3SDHAF3chr796747208PHF24chr93497129114NATRANS
PLOD2--PLSCR4PLOD2chr3145820541PLSCR4chr314592454718straightDUP
RC3H1--SERPINC1SERPINC1chr1173883690RC3H1chr117390800814straightDUP
SORD--TERB2SORDchr1545315546TERB2chr154524909354NADUP
TMEM132E--ZNF274TMEM132Echr1732920768ZNF274chr1958698408227invertedTRANS
TVP23C--TVP23C-CDRT4TVP23Cchr1715449098TVP23C-CDRT4chr171534151618straightDEL

HBV RNA fusions (0)
Breakpoint on human genome (hg19)Affected geneBreakpoint on HBV genome (X02763)Nb of paired reads (HG19 HBV)
No records found.

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)


Drugs (35)
DrugAUCGI50
Sorafenib_Refametinib
Paclitaxel0.320.005
Vinblastine0.440.009
Alvespimycin0.510.053
Rapamycin0.552.677
Bortezomib0.550.07
Tanespimycin0.570.106
PF.046915020.60.177
Alisertib0.610.11
Doxorubicin0.630.413
CD5320.630.351
Tivantinib0.690.55
Sorafenib_Trametinib0.70.42
BLU.99310.741.4
Sorafenib_MK.22060.792.8


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