Liver Cancer Cell Lines Database

Cell line description

Cell line name	Synonyms	Cellosaurus ID	Tumor type	Reference	Supplier	Culture medium
Huh7		CVCL_0336	Hepatocellular Carcinoma	Nakabayashi et al Cancer Res (1982) [PMID: 6286115]	ATCC - USA	DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

Age	Gender	Geographic Origin	Ethnicity	HBV	HCV
57	Male	Japan	Asian	No	No

Transcriptomic subgroup: CL1

Mutations and CNAs (690)

Gene nameFilter by Gene name	Alteration type	Variant class	Annotation transcript	gNomen	cNomen	pNomen	PPH prédiction
DNAH17	Mutation	In-Frame	NM_173628.3	g.76506522_76506527del g.76506522_76506527del	c.4175_4180del c.4175_4180del	p.Ser1392_Glu1394delinsLys p.Ser1392_Glu1394delinsLys	damaging damaging
PTPN23	Mutation	In-Frame	ENST00000265562.4	g.47452858_47452859insTCT g.47452858_47452859insTCT	c.3570_3571insTCT c.3570_3571insTCT	p.Ala1190_Leu1191insSer p.Ala1190_Leu1191insSer	damaging damaging
PABPC4L	Mutation	In-Frame	ENST00000529122.2	g.135122031_135122054del g.135122031_135122054del	c.295_318del c.295_318del	p.Ile99_Arg106del p.Ile99_Arg106del	damaging damaging
HFE	Mutation	In-Frame	ENST00000309234.6	g.26092987_26092989del g.26092987_26092989del	c.691_693del c.691_693del	p.Tyr231del p.Tyr231del	damaging damaging
GAL3ST4	Mutation	In-Frame	ENST00000360039.4	g.99758490_99758501del g.99758490_99758501del	c.511_522del c.511_522del	p.Tyr171_Ser174del p.Tyr171_Ser174del	damaging damaging
PEX14	Mutation	Missense	ENST00000356607.4	g.10687391T>G g.10687391T>G	c.648T>G c.648T>G	p.Ile216Met p.Ile216Met	probably damaging probably damaging
C1orf167	Mutation	Missense	ENST00000433342.1	g.11844522G>C g.11844522G>C	c.3369G>C c.3369G>C	p.Q1123H p.Q1123H	benign benign
VPS13D	Mutation	Missense	ENST00000356315.4	g.12342810A>T g.12342810A>T	c.4651A>T c.4651A>T	p.Asn1551Tyr p.Asn1551Tyr	possibly damaging possibly damaging
TAS1R3	Mutation	Missense	ENST00000339381.5	g.1267155T>C g.1267155T>C	c.329T>C c.329T>C	p.Met110Thr p.Met110Thr	probably damaging probably damaging
GJA8	Mutation	Missense	ENST00000240986.4	g.147380433G>C g.147380433G>C	c.351G>C c.351G>C	p.Gln117His p.Gln117His	probably damaging probably damaging
RUSC1	Mutation	Missense	ENST00000368352.5	g.155291839A>T g.155291839A>T	c.275A>T c.275A>T	p.Glu92Val p.Glu92Val	probably damaging probably damaging
TOR1AIP2	Mutation	Missense	ENST00000367612.3	g.179816728A>C g.179816728A>C	c.597T>G c.597T>G	p.Ile199Met p.Ile199Met	benign benign
AIM1L	Mutation	Missense	ENST00000475866.2	g.26672776G>A g.26672776G>A	c.373C>T c.373C>T	p.Arg125Cys p.Arg125Cys	unknown unknown
PTPRC	Mutation	Missense	ENST00000367376.2	g.198704298C>T g.198704298C>T	c.2314C>T c.2314C>T	p.Arg772Trp p.Arg772Trp	probably damaging probably damaging
PTPRC	Mutation	Missense	ENST00000367376.2	g.198711052C>A g.198711052C>A	c.2452C>A c.2452C>A	p.Pro818Thr p.Pro818Thr	probably damaging probably damaging
ZNF281	Mutation	Missense	ENST00000294740.3	g.200377768T>A g.200377768T>A	c.1066A>T c.1066A>T	p.Arg356Trp p.Arg356Trp	probably damaging probably damaging
IPO9	Mutation	Missense	ENST00000361565.4	g.201816692A>G g.201816692A>G	c.238A>G c.238A>G	p.Ile80Val p.Ile80Val	benign benign
ETNK2	Mutation	Missense	ENST00000367202.4	g.204101331G>A g.204101331G>A	c.1142C>T c.1142C>T	p.Ala381Val p.Ala381Val	possibly damaging possibly damaging
CR2	Mutation	Missense	ENST00000367057.3	g.207641953G>T g.207641953G>T	c.527G>T c.527G>T	p.Gly176Val p.Gly176Val	probably damaging probably damaging
JMJD4	Mutation	Missense	ENST00000366758.3	g.227923054A>T g.227923054A>T	c.59T>A c.59T>A	p.Leu20His p.Leu20His	benign benign
SNAP47	Mutation	Missense	ENST00000315781.5	g.227935610A>G g.227935610A>G	c.308A>G c.308A>G	p.Lys103Arg p.Lys103Arg	probably damaging probably damaging
OBSCN	Mutation	Missense	ENST00000284548.11	g.228494090C>T g.228494090C>T	c.11677C>T c.11677C>T	p.Arg3893Trp p.Arg3893Trp	probably damaging probably damaging
KIF26B	Mutation	Missense	ENST00000407071.2	g.245772666A>C g.245772666A>C	c.1750A>C c.1750A>C	p.Lys584Gln p.Lys584Gln	probably damaging probably damaging
OR2T4	Mutation	Missense	ENST00000366475.1	g.248525381C>G g.248525381C>G	c.499C>G c.499C>G	p.Leu167Val p.Leu167Val	probably damaging probably damaging
BAI2	Mutation	Missense	ENST00000257070.4	g.32205768C>G g.32205768C>G	c.2001G>C c.2001G>C	p.Gln667His p.Gln667His	possibly damaging possibly damaging

Mutational Signature

Fusion transcripts (25)

Fusion Name	Gene (1)	Chr (1)	Genomic position hg19 (1)	Gene (2)	Chr (2)	Genomic position hg19 (2)	Supporting reads	Consistance fusion	Fusion type
ABL1--MBLAC2	MBLAC2	chr5	89767563	ABL1	chr9	133710911	19	inverted	TRANS
ANAPC5--ATP6V0A2	ANAPC5	chr12	121747503	ATP6V0A2	chr12	124219049	20	inverted	DUP
ANKIB1--PTPRN2	ANKIB1	chr7	91991586	PTPRN2	chr7	158149783	34	straight	INV
ANO3--SLC5A12	ANO3	chr11	26587442	SLC5A12	chr11	26705303	93	inverted	DEL
APAF1--MED13L	MED13L	chr12	116714864	APAF1	chr12	99080525	170	straight	INV
ATP6V0D1--RBM19	ATP6V0D1	chr16	67514859	RBM19	chr12	114296700	18	straight	TRANS
CARD18--RP11-94P11.4	RP11-94P11.4	chr11	105130368	CARD18	chr11	105009804	37	straight	DEL
CCSER1--SNCA	CCSER1	chr4	91048981	SNCA	chr4	90756842	18	straight	INV
CMB9-22P13.2--TRMT10C	TRMT10C	chr3	101280847	CMB9-22P13.2	chr11	65255089	521	NA	TRANS
CNN2--WDR18	CNN2	chr19	1036244	WDR18	chr19	989761	51	straight	DUP
CYB5R3--KDELC2	KDELC2	chr11	108344081	CYB5R3	chr22	43015392	19	inverted	TRANS
DTX2P1-UPK3BP1-PMS2P11--PIEZO2	PIEZO2	chr18	11026244	DTX2P1-UPK3BP1-PMS2P11	chr7	76617298	21	inverted	TRANS
FIP1L1--RP11-25H12.1	FIP1L1	chr4	54266005	RP11-25H12.1	chr4	66891216	59	straight	DEL
GAREM1--SDHAF3	GAREM1	chr18	29890155	SDHAF3	chr7	96810323	105	NA	TRANS
IGFBP7--PCAT4	IGFBP7	chr4	57976066	PCAT4	chr4	80782444	10	straight	INV
LMNTD1--USP34	USP34	chr2	61515811	LMNTD1	chr12	25702479	16	NA	TRANS
LTN1--USP16	LTN1	chr21	30337085	USP16	chr21	30415348	84	inverted	DUP
MBLAC2--PHF20	PHF20	chr20	34519365	MBLAC2	chr5	89767563	33	inverted	TRANS
PACS1--RTN3	RTN3	chr11	63449249	PACS1	chr11	65960956	38	straight	DEL
PHF24--SDHAF3	SDHAF3	chr7	96747208	PHF24	chr9	34971291	14	NA	TRANS
PLOD2--PLSCR4	PLOD2	chr3	145820541	PLSCR4	chr3	145924547	18	straight	DUP
RC3H1--SERPINC1	SERPINC1	chr1	173883690	RC3H1	chr1	173908008	14	straight	DUP
SORD--TERB2	SORD	chr15	45315546	TERB2	chr15	45249093	54	NA	DUP
TMEM132E--ZNF274	TMEM132E	chr17	32920768	ZNF274	chr19	58698408	227	inverted	TRANS
TVP23C--TVP23C-CDRT4	TVP23C	chr17	15449098	TVP23C-CDRT4	chr17	15341516	18	straight	DEL

HBV RNA fusions (0)

Breakpoint on human genome (hg19)	Affected gene	Breakpoint on HBV genome (X02763)	Nb of paired reads (HG19 HBV)
No records found.

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)

Drugs (35)

DrugFilter by Drug	AUC	GI50
Sorafenib_Refametinib
Paclitaxel	0.32	0.005
Vinblastine	0.44	0.009
Alvespimycin	0.51	0.053
Bortezomib	0.55	0.07
Rapamycin	0.55	2.677
Tanespimycin	0.57	0.106
PF.04691502	0.6	0.177
Alisertib	0.61	0.11
Doxorubicin	0.63	0.413
CD532	0.63	0.351
Tivantinib	0.69	0.55
Sorafenib_Trametinib	0.7	0.42
BLU.9931	0.74	1.4
Sorafenib_MK.2206	0.79	2.8

Liver Cancer Cell Lines Database

Cell Line: Huh7

Transcriptomic subgroup: CL1

Mutational Signature

Liver Cancer Cell Lines
Database