Liver Cancer Cell Lines Database

Cell line description

Cell line name	Synonyms	Cellosaurus ID	Tumor type	Reference	Supplier	Culture medium
JHH1		CVCL_2785	Hepatocellular Carcinoma	Fujise K et al. Hepatogastroenterology (1990) [PMID: 1701409]	JCRB - Japan	DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

Age	Gender	Geographic Origin	Ethnicity	HBV	HCV
50	Male	Japan	Asian	No	Yes

Transcriptomic subgroup: Unclassified

Mutations and CNAs (303)

Gene nameFilter by Gene name	Alteration type	Variant class	Annotation transcript	gNomen	cNomen	pNomen	PPH prédiction
PRDM2	Mutation	In-Frame	ENST00000235372.7	g.14105137_14105138insGAT g.14105137_14105138insGAT	c.847_848insGAT c.847_848insGAT	p.Asp283delinsGlyTyr p.Asp283delinsGlyTyr	damaging damaging
LDHAL6B	Mutation	In-Frame	ENST00000307144.4	g.59499770_59499772del g.59499770_59499772del	c.631_633del c.631_633del	p.Gly211del p.Gly211del	damaging damaging
AATF	Mutation	In-Frame	ENST00000225402.5	g.35307591_35307592ins63 g.35307591_35307592ins63	c.169_170insACACACAGCAGAAAACACCAATACTAAGAAAAAATATGGCACTTACTTCAATGAGGAAGGCTG c.169_170insACACACAGCAGAAAACACCAATACTAAGAAAAAATATGGCACTTACTTCAATGAGGAAGGCTG	p.Arg57delins22 p.Arg57delins22	damaging damaging
SOX15	Mutation	In-Frame	ENST00000250055.2	g.7492921_7492923del g.7492921_7492923del	c.72_74del c.72_74del	p.Ser27del p.Ser27del	damaging damaging
NGEF	Mutation	In-Frame	ENST00000264051.3	g.233785160_233785162del g.233785160_233785162del	c.660_662del c.660_662del	p.Glu226del p.Glu226del	damaging damaging
FAM189A2	Mutation	In-Frame	ENST00000257515.8	g.72003322_72003324del g.72003322_72003324del	c.1105_1107del c.1105_1107del	p.Glu369del p.Glu369del	damaging damaging
GPR61	Mutation	Missense	ENST00000404129.2	g.110086402G>A g.110086402G>A	c.758G>A c.758G>A	p.Arg253Gln p.Arg253Gln	probably damaging probably damaging
CD101	Mutation	Missense	ENST00000256652.4	g.117568514G>A g.117568514G>A	c.2812G>A c.2812G>A	p.Val938Met p.Val938Met	probably damaging probably damaging
CCNL2	Mutation	Missense	ENST00000400809.3	g.1334613G>C g.1334613G>C	c.74C>G c.74C>G	p.Ser25Cys p.Ser25Cys	possibly damaging possibly damaging
TMEM240	Mutation	Missense	ENST00000378733.4	g.1470999C>T g.1470999C>T	c.343G>A c.343G>A	p.Val115Met p.Val115Met	probably damaging probably damaging
CGN	Mutation	Missense	ENST00000271636.7	g.151503083G>T g.151503083G>T	c.2432G>T c.2432G>T	p.Arg811Leu p.Arg811Leu	possibly damaging possibly damaging
FHAD1	Mutation	Missense	ENST00000358897.4	g.15578369T>C g.15578369T>C	c.89T>C c.89T>C	p.Leu30Ser p.Leu30Ser	probably damaging probably damaging
TMEM79	Mutation	Missense	ENST00000295694.5	g.156261328G>A g.156261328G>A	c.1124G>A c.1124G>A	p.Arg375His p.Arg375His	benign benign
HAPLN2	Mutation	Missense	ENST00000255039.1	g.156594985C>T g.156594985C>T	c.832C>T c.832C>T	p.Leu278Phe p.Leu278Phe	probably damaging probably damaging
CRABP2	Mutation	Missense	ENST00000368220.1	g.156670686C>T g.156670686C>T	c.229G>A c.229G>A	p.Val77Met p.Val77Met	probably damaging probably damaging
ATP1A2	Mutation	Missense	ENST00000361216.3	g.160093019G>T g.160093019G>T	c.194G>T c.194G>T	p.Arg65Leu p.Arg65Leu	benign benign
FMO3	Mutation	Missense	ENST00000367755.4	g.171077348C>T g.171077348C>T	c.613C>T c.613C>T	p.Arg205Cys p.Arg205Cys	benign benign
METTL13	Mutation	Missense	ENST00000361735.3	g.171753456G>A g.171753456G>A	c.730G>A c.730G>A	p.Glu244Lys p.Glu244Lys	benign benign
TNR	Mutation	Missense	ENST00000263525.2	g.175375547T>C g.175375547T>C	c.304A>G c.304A>G	p.Met102Val p.Met102Val	benign benign
NPHS2	Mutation	Missense	ENST00000367615.4	g.179533851G>A g.179533851G>A	c.352C>T c.352C>T	p.Pro118Ser p.Pro118Ser	probably damaging probably damaging
QSOX1	Mutation	Missense	ENST00000367600.5	g.180151339G>A g.180151339G>A	c.637G>A c.637G>A	p.Val213Met p.Val213Met	possibly damaging possibly damaging
LHX4	Mutation	Missense	ENST00000263726.2	g.180243701A>C g.180243701A>C	c.1160A>C c.1160A>C	p.His387Pro p.His387Pro	probably damaging probably damaging
RGS8	Mutation	Missense	ENST00000367556.1	g.182635145G>A g.182635145G>A	c.152C>T c.152C>T	p.Thr51Met p.Thr51Met	benign benign
FAM129A	Mutation	Missense	ENST00000367511.3	g.184777288G>A g.184777288G>A	c.1255C>T c.1255C>T	p.Arg419Cys p.Arg419Cys	probably damaging probably damaging
PRG4	Mutation	Missense	ENST00000445192.2	g.186278263A>G g.186278263A>G	c.3412A>G c.3412A>G	p.Met1138Val p.Met1138Val	benign benign

Mutational Signature

Fusion transcripts (16)

Fusion Name	Gene (1)	Chr (1)	Genomic position hg19 (1)	Gene (2)	Chr (2)	Genomic position hg19 (2)	Supporting reads	Consistance fusion	Fusion type
AC079610.1--ERBB4	ERBB4	chr2	212812154	AC079610.1	chr2	213573413	21	straight	DUP
ADCY5--OSBPL11	ADCY5	chr3	123104688	OSBPL11	chr3	125279222	61	inverted	INV
AGAP1--EXOSC3	AGAP1	chr2	236659131	EXOSC3	chr9	37784059	37	straight	TRANS
AGO2--STRN3	AGO2	chr8	141554311	STRN3	chr14	31381387	56	straight	TRANS
BCAR3--ZCCHC17	BCAR3	chr1	94240754	ZCCHC17	chr1	31836876	19	straight	INV
BRAF--PARP12	PARP12	chr7	139746682	BRAF	chr7	140449216	10	straight	DUP
CA5BP1--GS1-594A7.3	CA5BP1	chrX	15693900	GS1-594A7.3	chrX	15639134	18	straight	DUP
CCDC148--CIC	CIC	chr19	42798155	CCDC148	chr2	159150615	168	inverted	TRANS
CD300LD--UNK	CD300LD	chr17	72585512	UNK	chr17	73814491	59	inverted	DUP
CEP55--MYOF	MYOF	chr10	95180419	CEP55	chr10	95266812	27	inverted	DUP
CLINT1--CTC-436K13.6	CLINT1	chr5	157236635	CTC-436K13.6	chr5	157661352	19	straight	DUP
EVX1-AS--SYNRG	SYNRG	chr17	35913216	EVX1-AS	chr7	27284666	115	inverted	TRANS
IQSEC3--WNK1	WNK1	chr12	922979	IQSEC3	chr12	234798	33	straight	DUP
LINC01091--RP11-381N20.2	RP11-381N20.2	chr4	124418098	LINC01091	chr4	124573941	76	NA	DEL
TVP23C--TVP23C-CDRT4	TVP23C	chr17	15449098	TVP23C-CDRT4	chr17	15341516	20	straight	DEL
ZNF787--ZSCAN5B	ZNF787	chr19	56632540	ZSCAN5B	chr19	56709288	61	straight	DUP

HBV RNA fusions (0)

Breakpoint on human genome (hg19)	Affected gene	Breakpoint on HBV genome (X02763)	Nb of paired reads (HG19 HBV)
No records found.

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)

Drugs (35)

DrugFilter by Drug	AUC	GI50
Bortezomib	0.22	0.006
Trametinib	0.37	0.008
Dasatinib	0.42	0.02
Sorafenib_Trametinib	0.42	0.01
Vinblastine	0.53	0.036
Paclitaxel	0.54	0.052
PF.04691502	0.58	0.16
Sorafenib_Refametinib	0.63	0.33
Selumetinib	0.64	0.235
CD532	0.65	0.352
Refametinib	0.67	0.45
Rapamycin	0.7	10.0
Resminostat	0.72	0.767
MK.2206	0.74	1.567
Sorafenib_MK.2206	0.74	1.633

Liver Cancer Cell Lines Database

Cell Line: JHH1

Transcriptomic subgroup: Unclassified

Mutational Signature

Liver Cancer Cell Lines
Database