Liver Cancer Cell Lines
Database

LCCL to predict drug response

Cell Line: JHH1


Cell line description
Cell line nameSynonymsCellosaurus IDTumor typeReferenceSupplierCulture medium
JHH1 CVCL_2785 Hepatocellular Carcinoma Fujise K et al. Hepatogastroenterology (1990) [PMID: 1701409] JCRB - Japan DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

AgeGenderGeographic OriginEthnicityHBVHCV
50 Male Japan Asian No Yes

Transcriptomic subgroup: Unclassified


Mutations and CNAs (303)
Gene nameAlteration typeVariant classAnnotation transcriptgNomencNomenpNomenPPH pr├ędiction
PRDM2MutationIn-FrameENST00000235372.7
g.14105137_14105138insGAT
g.14105137_14105138insGAT
c.847_848insGAT
c.847_848insGAT
p.Asp283delinsGlyTyr
p.Asp283delinsGlyTyr
damaging
damaging
LDHAL6BMutationIn-FrameENST00000307144.4
g.59499770_59499772del
g.59499770_59499772del
c.631_633del
c.631_633del
p.Gly211del
p.Gly211del
damaging
damaging
AATFMutationIn-FrameENST00000225402.5
g.35307591_35307592ins63
g.35307591_35307592ins63
c.169_170insACACACAGCAGAAAACACCAATACTAAGAAAAAATATGGCACTTACTTCAATGAGGAAGGCTG
c.169_170insACACACAGCAGAAAACACCAATACTAAGAAAAAATATGGCACTTACTTCAATGAGGAAGGCTG
p.Arg57delins22
p.Arg57delins22
damaging
damaging
SOX15MutationIn-FrameENST00000250055.2
g.7492921_7492923del
g.7492921_7492923del
c.72_74del
c.72_74del
p.Ser27del
p.Ser27del
damaging
damaging
NGEFMutationIn-FrameENST00000264051.3
g.233785160_233785162del
g.233785160_233785162del
c.660_662del
c.660_662del
p.Glu226del
p.Glu226del
damaging
damaging
FAM189A2MutationIn-FrameENST00000257515.8
g.72003322_72003324del
g.72003322_72003324del
c.1105_1107del
c.1105_1107del
p.Glu369del
p.Glu369del
damaging
damaging
GPR61MutationMissenseENST00000404129.2
g.110086402G>A
g.110086402G>A
c.758G>A
c.758G>A
p.Arg253Gln
p.Arg253Gln
probably damaging
probably damaging
CD101MutationMissenseENST00000256652.4
g.117568514G>A
g.117568514G>A
c.2812G>A
c.2812G>A
p.Val938Met
p.Val938Met
probably damaging
probably damaging
CCNL2MutationMissenseENST00000400809.3
g.1334613G>C
g.1334613G>C
c.74C>G
c.74C>G
p.Ser25Cys
p.Ser25Cys
possibly damaging
possibly damaging
TMEM240MutationMissenseENST00000378733.4
g.1470999C>T
g.1470999C>T
c.343G>A
c.343G>A
p.Val115Met
p.Val115Met
probably damaging
probably damaging
CGNMutationMissenseENST00000271636.7
g.151503083G>T
g.151503083G>T
c.2432G>T
c.2432G>T
p.Arg811Leu
p.Arg811Leu
possibly damaging
possibly damaging
FHAD1MutationMissenseENST00000358897.4
g.15578369T>C
g.15578369T>C
c.89T>C
c.89T>C
p.Leu30Ser
p.Leu30Ser
probably damaging
probably damaging
TMEM79MutationMissenseENST00000295694.5
g.156261328G>A
g.156261328G>A
c.1124G>A
c.1124G>A
p.Arg375His
p.Arg375His
benign
benign
HAPLN2MutationMissenseENST00000255039.1
g.156594985C>T
g.156594985C>T
c.832C>T
c.832C>T
p.Leu278Phe
p.Leu278Phe
probably damaging
probably damaging
CRABP2MutationMissenseENST00000368220.1
g.156670686C>T
g.156670686C>T
c.229G>A
c.229G>A
p.Val77Met
p.Val77Met
probably damaging
probably damaging
ATP1A2MutationMissenseENST00000361216.3
g.160093019G>T
g.160093019G>T
c.194G>T
c.194G>T
p.Arg65Leu
p.Arg65Leu
benign
benign
FMO3MutationMissenseENST00000367755.4
g.171077348C>T
g.171077348C>T
c.613C>T
c.613C>T
p.Arg205Cys
p.Arg205Cys
benign
benign
METTL13MutationMissenseENST00000361735.3
g.171753456G>A
g.171753456G>A
c.730G>A
c.730G>A
p.Glu244Lys
p.Glu244Lys
benign
benign
TNRMutationMissenseENST00000263525.2
g.175375547T>C
g.175375547T>C
c.304A>G
c.304A>G
p.Met102Val
p.Met102Val
benign
benign
NPHS2MutationMissenseENST00000367615.4
g.179533851G>A
g.179533851G>A
c.352C>T
c.352C>T
p.Pro118Ser
p.Pro118Ser
probably damaging
probably damaging
QSOX1MutationMissenseENST00000367600.5
g.180151339G>A
g.180151339G>A
c.637G>A
c.637G>A
p.Val213Met
p.Val213Met
possibly damaging
possibly damaging
LHX4MutationMissenseENST00000263726.2
g.180243701A>C
g.180243701A>C
c.1160A>C
c.1160A>C
p.His387Pro
p.His387Pro
probably damaging
probably damaging
RGS8MutationMissenseENST00000367556.1
g.182635145G>A
g.182635145G>A
c.152C>T
c.152C>T
p.Thr51Met
p.Thr51Met
benign
benign
FAM129AMutationMissenseENST00000367511.3
g.184777288G>A
g.184777288G>A
c.1255C>T
c.1255C>T
p.Arg419Cys
p.Arg419Cys
probably damaging
probably damaging
PRG4MutationMissenseENST00000445192.2
g.186278263A>G
g.186278263A>G
c.3412A>G
c.3412A>G
p.Met1138Val
p.Met1138Val
benign
benign

Mutational Signature



Fusion transcripts (16)
Fusion NameGene (1)Chr (1)Genomic position hg19 (1)Gene (2)Chr (2)Genomic position hg19 (2)Supporting readsConsistance fusionFusion type
AC079610.1--ERBB4ERBB4chr2212812154AC079610.1chr221357341321straightDUP
ADCY5--OSBPL11ADCY5chr3123104688OSBPL11chr312527922261invertedINV
AGAP1--EXOSC3AGAP1chr2236659131EXOSC3chr93778405937straightTRANS
AGO2--STRN3AGO2chr8141554311STRN3chr143138138756straightTRANS
BCAR3--ZCCHC17BCAR3chr194240754ZCCHC17chr13183687619straightINV
BRAF--PARP12PARP12chr7139746682BRAFchr714044921610straightDUP
CA5BP1--GS1-594A7.3CA5BP1chrX15693900GS1-594A7.3chrX1563913418straightDUP
CCDC148--CICCICchr1942798155CCDC148chr2159150615168invertedTRANS
CD300LD--UNKCD300LDchr1772585512UNKchr177381449159invertedDUP
CEP55--MYOFMYOFchr1095180419CEP55chr109526681227invertedDUP
CLINT1--CTC-436K13.6CLINT1chr5157236635CTC-436K13.6chr515766135219straightDUP
EVX1-AS--SYNRGSYNRGchr1735913216EVX1-ASchr727284666115invertedTRANS
IQSEC3--WNK1WNK1chr12922979IQSEC3chr1223479833straightDUP
LINC01091--RP11-381N20.2RP11-381N20.2chr4124418098LINC01091chr412457394176NADEL
TVP23C--TVP23C-CDRT4TVP23Cchr1715449098TVP23C-CDRT4chr171534151620straightDEL
ZNF787--ZSCAN5BZNF787chr1956632540ZSCAN5Bchr195670928861straightDUP

HBV RNA fusions (0)
Breakpoint on human genome (hg19)Affected geneBreakpoint on HBV genome (X02763)Nb of paired reads (HG19 HBV)
No records found.

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)


Drugs (35)
DrugAUCGI50
Bortezomib0.220.006
Trametinib0.370.008
Sorafenib_Trametinib0.420.01
Dasatinib0.420.02
Vinblastine0.530.036
Paclitaxel0.540.052
PF.046915020.580.16
Sorafenib_Refametinib0.630.33
Selumetinib0.640.235
CD5320.650.352
Refametinib0.670.45
Rapamycin0.710.0
Resminostat0.720.767
Sorafenib_MK.22060.741.633
MK.22060.741.567


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