Liver Cancer Cell Lines
Database

LCCL to predict drug response

Cell Line: JHH4


Cell line description
Cell line nameSynonymsCellosaurus IDTumor typeReferenceSupplierCulture medium
JHH4 CVCL_2787 Hepatocellular Carcinoma Fujise K et al. Hepatogastroenterology (1990) [PMID: 1701409] JCRB - Japan DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

AgeGenderGeographic OriginEthnicityHBVHCV
51 Male Japan Asian No Yes

Transcriptomic subgroup: CL3


Mutations and CNAs (477)
Gene nameAlteration typeVariant classAnnotation transcriptgNomencNomenpNomenPPH pr├ędiction
AXDND1MutationIn-FrameENST00000367618.3
g.179504043_179504045del
g.179504043_179504045del
c.2977_2979del
c.2977_2979del
p.Gln993del
p.Gln993del
damaging
damaging
TMEM180MutationIn-FrameENST00000238936.4
g.104230726_104230728del
g.104230726_104230728del
c.556_558del
c.556_558del
p.Lys186del
p.Lys186del
damaging
damaging
TTNMutationIn-FrameENST00000342992.6
g.179422685_179422687del
g.179422685_179422687del
c.79690_79692del
c.79690_79692del
p.Ile26564del
p.Ile26564del
damaging
damaging
NCLMutationIn-FrameENST00000322723.4
g.232325460_232325462del
g.232325460_232325462del
c.729_731del
c.729_731del
p.Glu243del
p.Glu243del
damaging
damaging
PRIMPOLMutationIn-FrameENST00000314970.6
g.185615681_185615683del
g.185615681_185615683del
c.1431_1433del
c.1431_1433del
p.Glu478del
p.Glu478del
damaging
damaging
SYCP1MutationMissenseENST00000369518.1
g.115524039G>A
g.115524039G>A
c.2465G>A
c.2465G>A
p.Arg822Gln
p.Arg822Gln
benign
benign
DRAXINMutationMissenseENST00000294485.5
g.11766524G>A
g.11766524G>A
c.209G>A
c.209G>A
p.Gly70Asp
p.Gly70Asp
possibly damaging
possibly damaging
CLCN6MutationMissenseENST00000312413.6
g.11888268G>A
g.11888268G>A
c.946G>A
c.946G>A
p.Glu316Lys
p.Glu316Lys
benign
benign
GLTPD1MutationMissenseENST00000343938.4
g.1262701G>A
g.1262701G>A
c.203G>A
c.203G>A
p.Arg68Lys
p.Arg68Lys
possibly damaging
possibly damaging
TCHHMutationMissenseENST00000368804.1
g.152080879C>T
g.152080879C>T
c.4814G>A
c.4814G>A
p.Arg1605His
p.Arg1605His
possibly damaging
possibly damaging
KPRPMutationMissenseENST00000368773.1
g.152732959C>T
g.152732959C>T
c.895C>T
c.895C>T
p.Arg299Cys
p.Arg299Cys
probably damaging
probably damaging
CRTC2MutationMissenseENST00000368633.1
g.153921613A>T
g.153921613A>T
c.1652T>A
c.1652T>A
p.Met551Lys
p.Met551Lys
benign
benign
MUC1MutationMissenseENST00000368395.1
g.155159989G>A
g.155159989G>A
c.1145C>T
c.1145C>T
p.Ala382Val
p.Ala382Val
probably damaging
probably damaging
FBLIM1MutationMissenseENST00000332305.5
g.16091618C>T
g.16091618C>T
c.140C>T
c.140C>T
p.Ala47Val
p.Ala47Val
benign
benign
SPENMutationMissenseENST00000375759.3
g.16260782G>A
g.16260782G>A
c.8047G>A
c.8047G>A
p.Val2683Met
p.Val2683Met
probably damaging
probably damaging
ZBTB17MutationMissenseENST00000375733.2
g.16273459C>G
g.16273459C>G
c.365G>C
c.365G>C
p.Gly122Ala
p.Gly122Ala
benign
benign
CDK11AMutationMissenseENST00000378633.1
g.1635549G>T
g.1635549G>T
c.1732C>A
c.1732C>A
p.Pro578Thr
p.Pro578Thr
damaging
damaging
FMO3MutationMissenseENST00000367755.4
g.171077348C>T
g.171077348C>T
c.613C>T
c.613C>T
p.Arg205Cys
p.Arg205Cys
benign
benign
BRINP2MutationMissenseENST00000361539.4
g.177250522G>A
g.177250522G>A
c.2210G>A
c.2210G>A
p.Arg737Gln
p.Arg737Gln
possibly damaging
possibly damaging
CNTN2MutationMissenseENST00000331830.4
g.205035023C>T
g.205035023C>T
c.1802C>T
c.1802C>T
p.Thr601Ile
p.Thr601Ile
possibly damaging
possibly damaging
RASSF5MutationMissenseENST00000355294.4
g.206757771G>A
g.206757771G>A
c.743G>A
c.743G>A
p.Arg248Gln
p.Arg248Gln
probably damaging
probably damaging
RPS6KC1MutationMissenseENST00000366960.3
g.213415059A>G
g.213415059A>G
c.2240A>G
c.2240A>G
p.Lys747Arg
p.Lys747Arg
benign
benign
OBSCNMutationMissenseENST00000284548.11
g.228471318G>A
g.228471318G>A
c.8852G>A
c.8852G>A
p.Gly2951Asp
p.Gly2951Asp
benign
benign
OR2L13MutationMissenseENST00000358120.2
g.248263191G>A
g.248263191G>A
c.514G>A
c.514G>A
p.Ala172Thr
p.Ala172Thr
possibly damaging
possibly damaging
UBXN11MutationMissenseENST00000314675.7
g.26628211C>T
g.26628211C>T
c.74G>A
c.74G>A
p.Arg25Lys (Splice)
p.Arg25Lys (Splice)
benign
benign

Mutational Signature



Fusion transcripts (7)
Fusion NameGene (1)Chr (1)Genomic position hg19 (1)Gene (2)Chr (2)Genomic position hg19 (2)Supporting readsConsistance fusionFusion type
AC002066.1--ADAM22ADAM22chr787607726AC002066.1chr711606737583invertedDEL
ATM--RP11-94P11.4ATMchr11108142132RP11-94P11.4chr1110536697112straightINV
CDK14--MAN2A1MAN2A1chr5109191034CDK14chr79067521187straightTRANS
GOLGA7B--ZFYVE27ZFYVE27chr1099512938GOLGA7Bchr1099627488221straightDEL
LINC00511--LINC00673LINC00511chr1770332805LINC00673chr177058834132NAINV
LINC01605--NRG1NRG1chr832474402LINC01605chr83727908655NAINV
OPCML--TMEM123TMEM123chr11102319542OPCMLchr1113307949545invertedINV

HBV RNA fusions (0)
Breakpoint on human genome (hg19)Affected geneBreakpoint on HBV genome (X02763)Nb of paired reads (HG19 HBV)
No records found.

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)


Drugs (35)
DrugAUCGI50
Bortezomib0.40.03
Vinblastine0.460.032
Paclitaxel0.470.045
PF.046915020.540.11
Doxorubicin0.590.18
Dasatinib0.60.145
Tivantinib0.630.353
Alisertib0.721.167
Sorafenib_Trametinib0.740.53
Rapamycin0.7510.0
Alvespimycin0.781.57
Cabozantinib0.832.111
CD5320.862.314
Sorafenib_MK.22060.872.157
Lenvatinib0.887.02


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