Liver Cancer Cell Lines Database

Cell line description

Cell line name	Synonyms	Cellosaurus ID	Tumor type	Reference	Supplier	Culture medium
JHH4		CVCL_2787	Hepatocellular Carcinoma	Fujise K et al. Hepatogastroenterology (1990) [PMID: 1701409]	JCRB - Japan	DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

Age	Gender	Geographic Origin	Ethnicity	HBV	HCV
51	Male	Japan	Asian	No	Yes

Transcriptomic subgroup: CL3

Mutations and CNAs (477)

Gene nameFilter by Gene name	Alteration type	Variant class	Annotation transcript	gNomen	cNomen	pNomen	PPH prédiction
AXDND1	Mutation	In-Frame	ENST00000367618.3	g.179504043_179504045del g.179504043_179504045del	c.2977_2979del c.2977_2979del	p.Gln993del p.Gln993del	damaging damaging
TMEM180	Mutation	In-Frame	ENST00000238936.4	g.104230726_104230728del g.104230726_104230728del	c.556_558del c.556_558del	p.Lys186del p.Lys186del	damaging damaging
TTN	Mutation	In-Frame	ENST00000342992.6	g.179422685_179422687del g.179422685_179422687del	c.79690_79692del c.79690_79692del	p.Ile26564del p.Ile26564del	damaging damaging
NCL	Mutation	In-Frame	ENST00000322723.4	g.232325460_232325462del g.232325460_232325462del	c.729_731del c.729_731del	p.Glu243del p.Glu243del	damaging damaging
PRIMPOL	Mutation	In-Frame	ENST00000314970.6	g.185615681_185615683del g.185615681_185615683del	c.1431_1433del c.1431_1433del	p.Glu478del p.Glu478del	damaging damaging
SYCP1	Mutation	Missense	ENST00000369518.1	g.115524039G>A g.115524039G>A	c.2465G>A c.2465G>A	p.Arg822Gln p.Arg822Gln	benign benign
DRAXIN	Mutation	Missense	ENST00000294485.5	g.11766524G>A g.11766524G>A	c.209G>A c.209G>A	p.Gly70Asp p.Gly70Asp	possibly damaging possibly damaging
CLCN6	Mutation	Missense	ENST00000312413.6	g.11888268G>A g.11888268G>A	c.946G>A c.946G>A	p.Glu316Lys p.Glu316Lys	benign benign
GLTPD1	Mutation	Missense	ENST00000343938.4	g.1262701G>A g.1262701G>A	c.203G>A c.203G>A	p.Arg68Lys p.Arg68Lys	possibly damaging possibly damaging
TCHH	Mutation	Missense	ENST00000368804.1	g.152080879C>T g.152080879C>T	c.4814G>A c.4814G>A	p.Arg1605His p.Arg1605His	possibly damaging possibly damaging
KPRP	Mutation	Missense	ENST00000368773.1	g.152732959C>T g.152732959C>T	c.895C>T c.895C>T	p.Arg299Cys p.Arg299Cys	probably damaging probably damaging
CRTC2	Mutation	Missense	ENST00000368633.1	g.153921613A>T g.153921613A>T	c.1652T>A c.1652T>A	p.Met551Lys p.Met551Lys	benign benign
MUC1	Mutation	Missense	ENST00000368395.1	g.155159989G>A g.155159989G>A	c.1145C>T c.1145C>T	p.Ala382Val p.Ala382Val	probably damaging probably damaging
FBLIM1	Mutation	Missense	ENST00000332305.5	g.16091618C>T g.16091618C>T	c.140C>T c.140C>T	p.Ala47Val p.Ala47Val	benign benign
SPEN	Mutation	Missense	ENST00000375759.3	g.16260782G>A g.16260782G>A	c.8047G>A c.8047G>A	p.Val2683Met p.Val2683Met	probably damaging probably damaging
ZBTB17	Mutation	Missense	ENST00000375733.2	g.16273459C>G g.16273459C>G	c.365G>C c.365G>C	p.Gly122Ala p.Gly122Ala	benign benign
CDK11A	Mutation	Missense	ENST00000378633.1	g.1635549G>T g.1635549G>T	c.1732C>A c.1732C>A	p.Pro578Thr p.Pro578Thr	damaging damaging
FMO3	Mutation	Missense	ENST00000367755.4	g.171077348C>T g.171077348C>T	c.613C>T c.613C>T	p.Arg205Cys p.Arg205Cys	benign benign
BRINP2	Mutation	Missense	ENST00000361539.4	g.177250522G>A g.177250522G>A	c.2210G>A c.2210G>A	p.Arg737Gln p.Arg737Gln	possibly damaging possibly damaging
CNTN2	Mutation	Missense	ENST00000331830.4	g.205035023C>T g.205035023C>T	c.1802C>T c.1802C>T	p.Thr601Ile p.Thr601Ile	possibly damaging possibly damaging
RASSF5	Mutation	Missense	ENST00000355294.4	g.206757771G>A g.206757771G>A	c.743G>A c.743G>A	p.Arg248Gln p.Arg248Gln	probably damaging probably damaging
RPS6KC1	Mutation	Missense	ENST00000366960.3	g.213415059A>G g.213415059A>G	c.2240A>G c.2240A>G	p.Lys747Arg p.Lys747Arg	benign benign
OBSCN	Mutation	Missense	ENST00000284548.11	g.228471318G>A g.228471318G>A	c.8852G>A c.8852G>A	p.Gly2951Asp p.Gly2951Asp	benign benign
OR2L13	Mutation	Missense	ENST00000358120.2	g.248263191G>A g.248263191G>A	c.514G>A c.514G>A	p.Ala172Thr p.Ala172Thr	possibly damaging possibly damaging
UBXN11	Mutation	Missense	ENST00000314675.7	g.26628211C>T g.26628211C>T	c.74G>A c.74G>A	p.Arg25Lys (Splice) p.Arg25Lys (Splice)	benign benign

Mutational Signature

Fusion transcripts (7)

Fusion Name	Gene (1)	Chr (1)	Genomic position hg19 (1)	Gene (2)	Chr (2)	Genomic position hg19 (2)	Supporting reads	Consistance fusion	Fusion type
AC002066.1--ADAM22	ADAM22	chr7	87607726	AC002066.1	chr7	116067375	83	inverted	DEL
ATM--RP11-94P11.4	ATM	chr11	108142132	RP11-94P11.4	chr11	105366971	12	straight	INV
CDK14--MAN2A1	MAN2A1	chr5	109191034	CDK14	chr7	90675211	87	straight	TRANS
GOLGA7B--ZFYVE27	ZFYVE27	chr10	99512938	GOLGA7B	chr10	99627488	221	straight	DEL
LINC00511--LINC00673	LINC00511	chr17	70332805	LINC00673	chr17	70588341	32	NA	INV
LINC01605--NRG1	NRG1	chr8	32474402	LINC01605	chr8	37279086	55	NA	INV
OPCML--TMEM123	TMEM123	chr11	102319542	OPCML	chr11	133079495	45	inverted	INV

HBV RNA fusions (0)

Breakpoint on human genome (hg19)	Affected gene	Breakpoint on HBV genome (X02763)	Nb of paired reads (HG19 HBV)
No records found.

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)

Drugs (35)

DrugFilter by Drug	AUC	GI50
Bortezomib	0.4	0.03
Vinblastine	0.46	0.032
Paclitaxel	0.47	0.045
PF.04691502	0.54	0.11
Doxorubicin	0.59	0.18
Dasatinib	0.6	0.145
Tivantinib	0.63	0.353
Alisertib	0.72	1.167
Sorafenib_Trametinib	0.74	0.53
Rapamycin	0.75	10.0
Alvespimycin	0.78	1.57
Cabozantinib	0.83	2.111
CD532	0.86	2.314
Sorafenib_MK.2206	0.87	2.157
Lenvatinib	0.88	7.02

Liver Cancer Cell Lines Database

Cell Line: JHH4

Transcriptomic subgroup: CL3

Mutational Signature

Liver Cancer Cell Lines
Database