Liver Cancer Cell Lines
Database

LCCL to predict drug response

Cell Line: JHH5


Cell line description
Cell line nameSynonymsCellosaurus IDTumor typeReferenceSupplierCulture medium
JHH5 CVCL_0364 Hepatocellular Carcinoma Fujise K et al. Hepatogastroenterology (1990) [PMID: 1701409] JCRB - Japan Williams 'Medium E (#22551-022, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin + 1X glutamine

AgeGenderGeographic OriginEthnicityHBVHCV
50 Male Japan Asian No NA

Transcriptomic subgroup: CL1


Mutations and CNAs (404)
Gene nameAlteration typeVariant classAnnotation transcriptgNomencNomenpNomenPPH pr├ędiction
DFFBMutationIn-FrameENST00000338895.3
g.3782500_3782502del
g.3782500_3782502del
c.366_368del
c.366_368del
p.Leu123del
p.Leu123del
damaging
damaging
TP53MutationIn-FrameENST00000269305.4
g.7578269_7578280del
g.7578269_7578280del
c.569_580del
c.569_580del
p.Pro190_His193del
p.Pro190_His193del
damaging
damaging
PLA2R1MutationIn-FrameENST00000283243.7
g.160832734_160832736del
g.160832734_160832736del
c.2438_2440del
c.2438_2440del
p.Asp813del (Splice)
p.Asp813del (Splice)
damaging
damaging
KRTAP6-3MutationIn-FrameNM_181605.3
g.31964928_31964948del
g.31964928_31964948del
c.164_184del
c.164_184del
p.Asp55_Leu61del
p.Asp55_Leu61del
damaging
damaging
CSRNP1MutationIn-FrameENST00000273153.5
g.39185165_39185197del
g.39185165_39185197del
c.1119_1151del
c.1119_1151del
p.His374_Pro384del
p.His374_Pro384del
damaging
damaging
OR6B1MutationIn-FrameENST00000408922.2
g.143701933_143701935del
g.143701933_143701935del
c.844_846del
c.844_846del
p.Ser282del
p.Ser282del
damaging
damaging
AGLMutationMissenseENST00000294724.4
g.100366232C>A
g.100366232C>A
c.3403C>A
c.3403C>A
p.Leu1135Ile
p.Leu1135Ile
probably damaging
probably damaging
EXOSC10MutationMissenseENST00000304457.7
g.11158143T>C
g.11158143T>C
c.182A>G
c.182A>G
p.Asp61Gly
p.Asp61Gly
probably damaging
probably damaging
BCAS2MutationMissenseENST00000369541.3
g.115124190G>A
g.115124190G>A
c.23C>T
c.23C>T
p.Ala8Val
p.Ala8Val
probably damaging
probably damaging
IQGAP3MutationMissenseENST00000361170.2
g.156513961G>A
g.156513961G>A
c.2443C>T
c.2443C>T
p.His815Tyr
p.His815Tyr
benign
benign
OR6K3MutationMissenseENST00000368145.1
g.158687707A>T
g.158687707A>T
c.199T>A
c.199T>A
p.Ser67Thr
p.Ser67Thr
probably damaging
probably damaging
KIAA1751MutationMissenseNM_001080484.1
g.1905486G>A
g.1905486G>A
c.652C>T
c.652C>T
p.Arg218Trp
p.Arg218Trp
probably damaging
probably damaging
IGSF8MutationMissenseENST00000314485.7
g.160068249C>G
g.160068249C>G
c.14G>C
c.14G>C
p.Arg5Thr
p.Arg5Thr
benign
benign
C1orf64MutationMissenseENST00000329454.2
g.16332749G>A
g.16332749G>A
c.418G>A
c.418G>A
p.Val140Met
p.Val140Met
possibly damaging
possibly damaging
PADI3MutationMissenseENST00000375460.3
g.17597417G>A
g.17597417G>A
c.875G>A
c.875G>A
p.Arg292Gln
p.Arg292Gln
probably damaging
probably damaging
CEP350MutationMissenseENST00000367607.3
g.179983580G>T
g.179983580G>T
c.1992G>T
c.1992G>T
p.Leu664Phe
p.Leu664Phe
probably damaging
probably damaging
QSOX1MutationMissenseENST00000367600.5
g.180124188C>A
g.180124188C>A
c.146C>A
c.146C>A
p.Thr49Lys
p.Thr49Lys
possibly damaging
possibly damaging
CR2MutationMissenseENST00000367058.3
g.207653332C>T
g.207653332C>T
c.2945C>T
c.2945C>T
p.Ala982Val
p.Ala982Val
benign
benign
MUL1MutationMissenseENST00000264198.3
g.20827269C>T
g.20827269C>T
c.973G>A
c.973G>A
p.Glu325Lys
p.Glu325Lys
benign
benign
RAB3GAP2MutationMissenseENST00000358951.2
g.220330767C>G
g.220330767C>G
c.3400G>C
c.3400G>C
p.Val1134Leu
p.Val1134Leu
benign
benign
HSPG2MutationMissenseENST00000374695.3
g.22163333C>A
g.22163333C>A
c.10317G>T
c.10317G>T
p.Q3439H
p.Q3439H
benign
benign
MIA3MutationMissenseENST00000344441.6
g.222801037G>A
g.222801037G>A
c.475G>A
c.475G>A
p.Glu159Lys
p.Glu159Lys
probably damaging
probably damaging
TLR5MutationMissenseENST00000342210.6
g.223284519C>T
g.223284519C>T
c.1855G>A
c.1855G>A
p.Val619Ile
p.Val619Ile
benign
benign
DNAH14MutationMissenseENST00000430092.1
g.225334903C>T
g.225334903C>T
c.4841C>T
c.4841C>T
p.Ala1614Val
p.Ala1614Val
probably damaging
probably damaging
LBRMutationMissenseENST00000272163.4
g.225600276C>T
g.225600276C>T
c.964G>A
c.964G>A
p.Val322Met
p.Val322Met
benign
benign

Mutational Signature



Fusion transcripts (4)
Fusion NameGene (1)Chr (1)Genomic position hg19 (1)Gene (2)Chr (2)Genomic position hg19 (2)Supporting readsConsistance fusionFusion type
CAMTA1--RERECAMTA1chr17501240REREchr1848278620invertedDEL
CCT5--FAM173BFAM173Bchr510248415CCT5chr51026272914invertedDUP
EML1--SETD3EML1chr14100259879SETD3chr149988027021straightINV
LINC02015--SHROOM3LINC02015chr3177600386SHROOM3chr47735737243NATRANS

HBV RNA fusions (0)
Breakpoint on human genome (hg19)Affected geneBreakpoint on HBV genome (X02763)Nb of paired reads (HG19 HBV)
No records found.

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)


Drugs (35)
DrugAUCGI50
Bortezomib0.350.015
Sorafenib_Trametinib0.350.01
Paclitaxel0.360.012
Alvespimycin0.40.026
Trametinib0.40.022
Tanespimycin0.410.032
Vinblastine0.520.049
Rapamycin0.589.485
Sorafenib_Refametinib0.620.24
Sorafenib_MK.22060.630.425
CD5320.640.366
Tivantinib0.660.42
Linsitinib0.663.927
PF.046915020.680.24
Sorafenib_Resminostat0.690.88


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