Liver Cancer Cell Lines Database

Cell line description

Cell line name	Synonyms	Cellosaurus ID	Tumor type	Reference	Supplier	Culture medium
JHH5		CVCL_0364	Hepatocellular Carcinoma	Fujise K et al. Hepatogastroenterology (1990) [PMID: 1701409]	JCRB - Japan	Williams 'Medium E (#22551-022, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin + 1X glutamine

Age	Gender	Geographic Origin	Ethnicity	HBV	HCV
50	Male	Japan	Asian	No	NA

Transcriptomic subgroup: CL1

Mutations and CNAs (404)

Gene nameFilter by Gene name	Alteration type	Variant class	Annotation transcript	gNomen	cNomen	pNomen	PPH prédiction
DFFB	Mutation	In-Frame	ENST00000338895.3	g.3782500_3782502del g.3782500_3782502del	c.366_368del c.366_368del	p.Leu123del p.Leu123del	damaging damaging
TP53	Mutation	In-Frame	ENST00000269305.4	g.7578269_7578280del g.7578269_7578280del	c.569_580del c.569_580del	p.Pro190_His193del p.Pro190_His193del	damaging damaging
PLA2R1	Mutation	In-Frame	ENST00000283243.7	g.160832734_160832736del g.160832734_160832736del	c.2438_2440del c.2438_2440del	p.Asp813del (Splice) p.Asp813del (Splice)	damaging damaging
KRTAP6-3	Mutation	In-Frame	NM_181605.3	g.31964928_31964948del g.31964928_31964948del	c.164_184del c.164_184del	p.Asp55_Leu61del p.Asp55_Leu61del	damaging damaging
CSRNP1	Mutation	In-Frame	ENST00000273153.5	g.39185165_39185197del g.39185165_39185197del	c.1119_1151del c.1119_1151del	p.His374_Pro384del p.His374_Pro384del	damaging damaging
OR6B1	Mutation	In-Frame	ENST00000408922.2	g.143701933_143701935del g.143701933_143701935del	c.844_846del c.844_846del	p.Ser282del p.Ser282del	damaging damaging
AGL	Mutation	Missense	ENST00000294724.4	g.100366232C>A g.100366232C>A	c.3403C>A c.3403C>A	p.Leu1135Ile p.Leu1135Ile	probably damaging probably damaging
EXOSC10	Mutation	Missense	ENST00000304457.7	g.11158143T>C g.11158143T>C	c.182A>G c.182A>G	p.Asp61Gly p.Asp61Gly	probably damaging probably damaging
BCAS2	Mutation	Missense	ENST00000369541.3	g.115124190G>A g.115124190G>A	c.23C>T c.23C>T	p.Ala8Val p.Ala8Val	probably damaging probably damaging
IQGAP3	Mutation	Missense	ENST00000361170.2	g.156513961G>A g.156513961G>A	c.2443C>T c.2443C>T	p.His815Tyr p.His815Tyr	benign benign
OR6K3	Mutation	Missense	ENST00000368145.1	g.158687707A>T g.158687707A>T	c.199T>A c.199T>A	p.Ser67Thr p.Ser67Thr	probably damaging probably damaging
KIAA1751	Mutation	Missense	NM_001080484.1	g.1905486G>A g.1905486G>A	c.652C>T c.652C>T	p.Arg218Trp p.Arg218Trp	probably damaging probably damaging
IGSF8	Mutation	Missense	ENST00000314485.7	g.160068249C>G g.160068249C>G	c.14G>C c.14G>C	p.Arg5Thr p.Arg5Thr	benign benign
C1orf64	Mutation	Missense	ENST00000329454.2	g.16332749G>A g.16332749G>A	c.418G>A c.418G>A	p.Val140Met p.Val140Met	possibly damaging possibly damaging
PADI3	Mutation	Missense	ENST00000375460.3	g.17597417G>A g.17597417G>A	c.875G>A c.875G>A	p.Arg292Gln p.Arg292Gln	probably damaging probably damaging
CEP350	Mutation	Missense	ENST00000367607.3	g.179983580G>T g.179983580G>T	c.1992G>T c.1992G>T	p.Leu664Phe p.Leu664Phe	probably damaging probably damaging
QSOX1	Mutation	Missense	ENST00000367600.5	g.180124188C>A g.180124188C>A	c.146C>A c.146C>A	p.Thr49Lys p.Thr49Lys	possibly damaging possibly damaging
CR2	Mutation	Missense	ENST00000367058.3	g.207653332C>T g.207653332C>T	c.2945C>T c.2945C>T	p.Ala982Val p.Ala982Val	benign benign
MUL1	Mutation	Missense	ENST00000264198.3	g.20827269C>T g.20827269C>T	c.973G>A c.973G>A	p.Glu325Lys p.Glu325Lys	benign benign
RAB3GAP2	Mutation	Missense	ENST00000358951.2	g.220330767C>G g.220330767C>G	c.3400G>C c.3400G>C	p.Val1134Leu p.Val1134Leu	benign benign
HSPG2	Mutation	Missense	ENST00000374695.3	g.22163333C>A g.22163333C>A	c.10317G>T c.10317G>T	p.Q3439H p.Q3439H	benign benign
MIA3	Mutation	Missense	ENST00000344441.6	g.222801037G>A g.222801037G>A	c.475G>A c.475G>A	p.Glu159Lys p.Glu159Lys	probably damaging probably damaging
TLR5	Mutation	Missense	ENST00000342210.6	g.223284519C>T g.223284519C>T	c.1855G>A c.1855G>A	p.Val619Ile p.Val619Ile	benign benign
DNAH14	Mutation	Missense	ENST00000430092.1	g.225334903C>T g.225334903C>T	c.4841C>T c.4841C>T	p.Ala1614Val p.Ala1614Val	probably damaging probably damaging
LBR	Mutation	Missense	ENST00000272163.4	g.225600276C>T g.225600276C>T	c.964G>A c.964G>A	p.Val322Met p.Val322Met	benign benign

Mutational Signature

Fusion transcripts (4)

Fusion Name	Gene (1)	Chr (1)	Genomic position hg19 (1)	Gene (2)	Chr (2)	Genomic position hg19 (2)	Supporting reads	Consistance fusion	Fusion type
CAMTA1--RERE	CAMTA1	chr1	7501240	RERE	chr1	8482786	20	inverted	DEL
CCT5--FAM173B	FAM173B	chr5	10248415	CCT5	chr5	10262729	14	inverted	DUP
EML1--SETD3	EML1	chr14	100259879	SETD3	chr14	99880270	21	straight	INV
LINC02015--SHROOM3	LINC02015	chr3	177600386	SHROOM3	chr4	77357372	43	NA	TRANS

HBV RNA fusions (0)

Breakpoint on human genome (hg19)	Affected gene	Breakpoint on HBV genome (X02763)	Nb of paired reads (HG19 HBV)
No records found.

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)

Drugs (35)

DrugFilter by Drug	AUC	GI50
Sorafenib_Trametinib	0.35	0.01
Bortezomib	0.35	0.015
Paclitaxel	0.36	0.012
Trametinib	0.4	0.022
Alvespimycin	0.4	0.026
Tanespimycin	0.41	0.032
Vinblastine	0.52	0.049
Rapamycin	0.58	9.485
Sorafenib_Refametinib	0.62	0.24
Sorafenib_MK.2206	0.63	0.425
CD532	0.64	0.366
Tivantinib	0.66	0.42
Linsitinib	0.66	3.927
PF.04691502	0.68	0.24
Sorafenib_Resminostat	0.69	0.88

Liver Cancer Cell Lines Database

Cell Line: JHH5

Transcriptomic subgroup: CL1

Mutational Signature

Liver Cancer Cell Lines
Database