Liver Cancer Cell Lines
Database

LCCL to predict drug response

Cell Line: SNU182


Cell line description
Cell line nameSynonymsCellosaurus IDTumor typeReferenceSupplierCulture medium
SNU182 CVCL_0090 Hepatocellular Carcinoma Park et al. Int J Cancer (1995) [PMID: 7543080] ATCC - USA DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

AgeGenderGeographic OriginEthnicityHBVHCV
24 Male Korea Asian Yes No

Transcriptomic subgroup: CL3


Mutations and CNAs (688)
Gene nameAlteration typeVariant classAnnotation transcriptgNomencNomenpNomenPPH pr├ędiction
MIER1MutationIn-FrameENST00000371018.3
g.67452100_67452101insCTT
g.67452100_67452101insCTT
c.1357_1358insCTT
c.1357_1358insCTT
p.Leu453delinsProPhe
p.Leu453delinsProPhe
damaging
damaging
TMEM180MutationIn-FrameENST00000238936.4
g.104230726_104230728del
g.104230726_104230728del
c.556_558del
c.556_558del
p.Lys186del
p.Lys186del
damaging
damaging
RP11-166B2.1MutationIn-FrameENST00000399147.4
g.12021341_12021342insTGG
g.12021341_12021342insTGG
c.1082_1083insCCA
c.1082_1083insCCA
p.361_361E>DQ
p.361_361E>DQ
damaging
damaging
FBXL19MutationIn-FrameENST00000380310.2
g.30939160_30939168del
g.30939160_30939168del
c.563_571del
c.563_571del
p.Leu188_Pro190del
p.Leu188_Pro190del
damaging
damaging
RNMTMutationIn-FrameENST00000262173.3
g.13734473_13734475del
g.13734473_13734475del
c.428_430del
c.428_430del
p.Glu143del
p.Glu143del
damaging
damaging
SORT1MutationMissenseENST00000256637.6
g.109898077T>C
g.109898077T>C
c.455A>G
c.455A>G
p.Lys152Arg
p.Lys152Arg
probably damaging
probably damaging
WARS2MutationMissenseENST00000235521.4
g.119575758C>T
g.119575758C>T
c.859G>A
c.859G>A
p.Val287Met
p.Val287Met
possibly damaging
possibly damaging
TAS1R3MutationMissenseENST00000339381.5
g.1268034T>A
g.1268034T>A
c.1123T>A
c.1123T>A
p.Cys375Ser
p.Cys375Ser
benign
benign
LCE3BMutationMissenseENST00000335633.1
g.152586537C>A
g.152586537C>A
c.251C>A
c.251C>A
p.Ala84Asp
p.Ala84Asp
benign
benign
NR1I3MutationMissenseENST00000367982.4
g.161200610G>A
g.161200610G>A
c.922C>T
c.922C>T
p.Arg308Trp
p.Arg308Trp
probably damaging
probably damaging
C1orf226MutationMissenseENST00000458626.2
g.162353370T>G
g.162353370T>G
c.716T>G
c.716T>G
p.Ile239Ser
p.Ile239Ser
benign
benign
NADKMutationMissenseENST00000344463.4
g.1690636C>T
g.1690636C>T
c.479G>A
c.479G>A
p.Arg160Gln
p.Arg160Gln
benign
benign
TNFSF18MutationMissenseENST00000404377.3
g.173010544C>A
g.173010544C>A
c.563G>T
c.563G>T
p.Gly188Val
p.Gly188Val
probably damaging
probably damaging
ATP13A2MutationMissenseENST00000326735.8
g.17320293C>A
g.17320293C>A
c.1580G>T
c.1580G>T
p.Gly527Val
p.Gly527Val
probably damaging
probably damaging
AKR7A2MutationMissenseENST00000235835.3
g.19633883G>A
g.19633883G>A
c.613C>T
c.613C>T
p.Arg205Trp
p.Arg205Trp
probably damaging
probably damaging
FAAP20MutationMissenseNM_001146310.1
g.2116839C>T
g.2116839C>T
c.571G>A
c.571G>A
p.Gly108Arg
p.Gly108Arg
damaging
damaging
EIF4G3MutationMissenseENST00000264211.8
g.21268475A>T
g.21268475A>T
c.1004T>A
c.1004T>A
p.Ile335Lys
p.Ile335Lys
benign
benign
NSL1MutationMissenseENST00000422588.2
g.212939560A>C
g.212939560A>C
c.555T>G
c.555T>G
p.Asp185Glu
p.Asp185Glu
benign
benign
OBSCNMutationMissenseENST00000284548.11
g.228505746G>A
g.228505746G>A
c.14003G>A
c.14003G>A
p.Arg4668Gln
p.Arg4668Gln
possibly damaging
possibly damaging
TRIM67MutationMissenseENST00000366652.2
g.231298879C>T
g.231298879C>T
c.164C>T
c.164C>T
p.Ser55Leu
p.Ser55Leu
benign
benign
FAM76AMutationMissenseENST00000373949.1
g.28059159G>T
g.28059159G>T
c.192G>T
c.192G>T
p.Leu64Phe
p.Leu64Phe
probably damaging
probably damaging
ZBTB8BMutationMissenseENST00000609129.1
g.32937081C>T
g.32937081C>T
c.856C>T
c.856C>T
p.Arg286Cys
p.Arg286Cys
benign
benign
SYNCMutationMissenseENST00000373484.3
g.33160669C>T
g.33160669C>T
c.1030G>A
c.1030G>A
p.Glu344Lys
p.Glu344Lys
probably damaging
probably damaging
SZT2MutationMissenseENST00000562955.1
g.43898419C>T
g.43898419C>T
c.5380C>T
c.5380C>T
p.Arg1794Trp
p.Arg1794Trp
benign
benign
SLC6A9MutationMissenseENST00000360584.2
g.44463398G>A
g.44463398G>A
c.1940C>T
c.1940C>T
p.Ala647Val
p.Ala647Val
possibly damaging
possibly damaging

Mutational Signature



Fusion transcripts (11)
Fusion NameGene (1)Chr (1)Genomic position hg19 (1)Gene (2)Chr (2)Genomic position hg19 (2)Supporting readsConsistance fusionFusion type
AHSP--USP43USP43chr179549452AHSPchr1631539456102straightTRANS
AL121578.2--SYTL5AL121578.2chrX37765861SYTL5chrX3791346585straightDEL
CKB--TRMT61ACKBchr14103986200TRMT61Achr1410399593420invertedDUP
CTD-2334D19.1--PRR16PRR16chr5119800339CTD-2334D19.1chr512012564813straightDEL
GNB1L--SEPT5-GP1BBGNB1Lchr2219794181SEPT5-GP1BBchr221970712444NAINV
GREB1L--TULP3GREB1Lchr1818983954TULP3chr12302992838straightTRANS
PGM5P4--PTCD3PTCD3chr286352204PGM5P4chr211431760470NAINV
PRICKLE1--RP11-547C5.2PRICKLE1chr1242864047RP11-547C5.2chr124337320217straightDUP
RNF5--RNF5P1RNF5chr632146568RNF5P1chr83845858018straightTRANS
SKP2--TTC23LSKP2chr536177393TTC23Lchr53484559125straightDUP
TVP23C--TVP23C-CDRT4TVP23Cchr1715449098TVP23C-CDRT4chr171534151672straightDEL

HBV RNA fusions (2)
Breakpoint on human genome (hg19)Affected geneBreakpoint on HBV genome (X02763)Nb of paired reads (HG19 HBV)
chr1:175,425,072TNR (intron 2)1,8138
chr8:122,656,688HAS2-AS1 (exon 4)2,95311

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)


Drugs (35)
DrugAUCGI50
Vinblastine0.430.015
Paclitaxel0.550.374
Doxorubicin0.570.215
Bortezomib0.640.23
Dasatinib0.681.48
Alvespimycin0.751.785
CD5320.771.559
PF.046915020.812.28
Sorafenib_MK.22060.812.368
Sorafenib_Trametinib0.815.96
Rapamycin0.8310.0
Sorafenib_Resminostat0.864.4
Sorafenib_Refametinib0.874.71
Tivantinib0.875.625
MK.22060.886.266


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