Liver Cancer Cell Lines Database

Cell line description

Cell line name	Synonyms	Cellosaurus ID	Tumor type	Reference	Supplier	Culture medium
SNU182		CVCL_0090	Hepatocellular Carcinoma	Park et al. Int J Cancer (1995) [PMID: 7543080]	ATCC - USA	DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

Age	Gender	Geographic Origin	Ethnicity	HBV	HCV
24	Male	Korea	Asian	Yes	No

Transcriptomic subgroup: CL3

Mutations and CNAs (688)

Gene nameFilter by Gene name	Alteration type	Variant class	Annotation transcript	gNomen	cNomen	pNomen	PPH prédiction
MIER1	Mutation	In-Frame	ENST00000371018.3	g.67452100_67452101insCTT g.67452100_67452101insCTT	c.1357_1358insCTT c.1357_1358insCTT	p.Leu453delinsProPhe p.Leu453delinsProPhe	damaging damaging
TMEM180	Mutation	In-Frame	ENST00000238936.4	g.104230726_104230728del g.104230726_104230728del	c.556_558del c.556_558del	p.Lys186del p.Lys186del	damaging damaging
RP11-166B2.1	Mutation	In-Frame	ENST00000399147.4	g.12021341_12021342insTGG g.12021341_12021342insTGG	c.1082_1083insCCA c.1082_1083insCCA	p.361_361E>DQ p.361_361E>DQ	damaging damaging
FBXL19	Mutation	In-Frame	ENST00000380310.2	g.30939160_30939168del g.30939160_30939168del	c.563_571del c.563_571del	p.Leu188_Pro190del p.Leu188_Pro190del	damaging damaging
RNMT	Mutation	In-Frame	ENST00000262173.3	g.13734473_13734475del g.13734473_13734475del	c.428_430del c.428_430del	p.Glu143del p.Glu143del	damaging damaging
SORT1	Mutation	Missense	ENST00000256637.6	g.109898077T>C g.109898077T>C	c.455A>G c.455A>G	p.Lys152Arg p.Lys152Arg	probably damaging probably damaging
WARS2	Mutation	Missense	ENST00000235521.4	g.119575758C>T g.119575758C>T	c.859G>A c.859G>A	p.Val287Met p.Val287Met	possibly damaging possibly damaging
TAS1R3	Mutation	Missense	ENST00000339381.5	g.1268034T>A g.1268034T>A	c.1123T>A c.1123T>A	p.Cys375Ser p.Cys375Ser	benign benign
LCE3B	Mutation	Missense	ENST00000335633.1	g.152586537C>A g.152586537C>A	c.251C>A c.251C>A	p.Ala84Asp p.Ala84Asp	benign benign
NR1I3	Mutation	Missense	ENST00000367982.4	g.161200610G>A g.161200610G>A	c.922C>T c.922C>T	p.Arg308Trp p.Arg308Trp	probably damaging probably damaging
C1orf226	Mutation	Missense	ENST00000458626.2	g.162353370T>G g.162353370T>G	c.716T>G c.716T>G	p.Ile239Ser p.Ile239Ser	benign benign
NADK	Mutation	Missense	ENST00000344463.4	g.1690636C>T g.1690636C>T	c.479G>A c.479G>A	p.Arg160Gln p.Arg160Gln	benign benign
TNFSF18	Mutation	Missense	ENST00000404377.3	g.173010544C>A g.173010544C>A	c.563G>T c.563G>T	p.Gly188Val p.Gly188Val	probably damaging probably damaging
ATP13A2	Mutation	Missense	ENST00000326735.8	g.17320293C>A g.17320293C>A	c.1580G>T c.1580G>T	p.Gly527Val p.Gly527Val	probably damaging probably damaging
AKR7A2	Mutation	Missense	ENST00000235835.3	g.19633883G>A g.19633883G>A	c.613C>T c.613C>T	p.Arg205Trp p.Arg205Trp	probably damaging probably damaging
FAAP20	Mutation	Missense	NM_001146310.1	g.2116839C>T g.2116839C>T	c.571G>A c.571G>A	p.Gly108Arg p.Gly108Arg	damaging damaging
EIF4G3	Mutation	Missense	ENST00000264211.8	g.21268475A>T g.21268475A>T	c.1004T>A c.1004T>A	p.Ile335Lys p.Ile335Lys	benign benign
NSL1	Mutation	Missense	ENST00000422588.2	g.212939560A>C g.212939560A>C	c.555T>G c.555T>G	p.Asp185Glu p.Asp185Glu	benign benign
OBSCN	Mutation	Missense	ENST00000284548.11	g.228505746G>A g.228505746G>A	c.14003G>A c.14003G>A	p.Arg4668Gln p.Arg4668Gln	possibly damaging possibly damaging
TRIM67	Mutation	Missense	ENST00000366652.2	g.231298879C>T g.231298879C>T	c.164C>T c.164C>T	p.Ser55Leu p.Ser55Leu	benign benign
FAM76A	Mutation	Missense	ENST00000373949.1	g.28059159G>T g.28059159G>T	c.192G>T c.192G>T	p.Leu64Phe p.Leu64Phe	probably damaging probably damaging
ZBTB8B	Mutation	Missense	ENST00000609129.1	g.32937081C>T g.32937081C>T	c.856C>T c.856C>T	p.Arg286Cys p.Arg286Cys	benign benign
SYNC	Mutation	Missense	ENST00000373484.3	g.33160669C>T g.33160669C>T	c.1030G>A c.1030G>A	p.Glu344Lys p.Glu344Lys	probably damaging probably damaging
SZT2	Mutation	Missense	ENST00000562955.1	g.43898419C>T g.43898419C>T	c.5380C>T c.5380C>T	p.Arg1794Trp p.Arg1794Trp	benign benign
SLC6A9	Mutation	Missense	ENST00000360584.2	g.44463398G>A g.44463398G>A	c.1940C>T c.1940C>T	p.Ala647Val p.Ala647Val	possibly damaging possibly damaging

Mutational Signature

Fusion transcripts (11)

Fusion Name	Gene (1)	Chr (1)	Genomic position hg19 (1)	Gene (2)	Chr (2)	Genomic position hg19 (2)	Supporting reads	Consistance fusion	Fusion type
AHSP--USP43	USP43	chr17	9549452	AHSP	chr16	31539456	102	straight	TRANS
AL121578.2--SYTL5	AL121578.2	chrX	37765861	SYTL5	chrX	37913465	85	straight	DEL
CKB--TRMT61A	CKB	chr14	103986200	TRMT61A	chr14	103995934	20	inverted	DUP
CTD-2334D19.1--PRR16	PRR16	chr5	119800339	CTD-2334D19.1	chr5	120125648	13	straight	DEL
GNB1L--SEPT5-GP1BB	GNB1L	chr22	19794181	SEPT5-GP1BB	chr22	19707124	44	NA	INV
GREB1L--TULP3	GREB1L	chr18	18983954	TULP3	chr12	3029928	38	straight	TRANS
PGM5P4--PTCD3	PTCD3	chr2	86352204	PGM5P4	chr2	114317604	70	NA	INV
PRICKLE1--RP11-547C5.2	PRICKLE1	chr12	42864047	RP11-547C5.2	chr12	43373202	17	straight	DUP
RNF5--RNF5P1	RNF5	chr6	32146568	RNF5P1	chr8	38458580	18	straight	TRANS
SKP2--TTC23L	SKP2	chr5	36177393	TTC23L	chr5	34845591	25	straight	DUP
TVP23C--TVP23C-CDRT4	TVP23C	chr17	15449098	TVP23C-CDRT4	chr17	15341516	72	straight	DEL

HBV RNA fusions (2)

Breakpoint on human genome (hg19)	Affected gene	Breakpoint on HBV genome (X02763)	Nb of paired reads (HG19 HBV)
chr1:175,425,072	TNR (intron 2)	1,813	8
chr8:122,656,688	HAS2-AS1 (exon 4)	2,953	11

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)

Drugs (35)

DrugFilter by Drug	AUC	GI50
Vinblastine	0.43	0.015
Paclitaxel	0.55	0.374
Doxorubicin	0.57	0.215
Bortezomib	0.64	0.23
Dasatinib	0.68	1.48
Alvespimycin	0.75	1.785
CD532	0.77	1.559
Sorafenib_Trametinib	0.81	5.96
Sorafenib_MK.2206	0.81	2.368
PF.04691502	0.81	2.28
Rapamycin	0.83	10.0
Sorafenib_Resminostat	0.86	4.4
Sorafenib_Refametinib	0.87	4.71
Tivantinib	0.87	5.625
MK.2206	0.88	6.266

Liver Cancer Cell Lines Database

Cell Line: SNU182

Transcriptomic subgroup: CL3

Mutational Signature

Liver Cancer Cell Lines
Database