Liver Cancer Cell Lines Database

Cell line description

Cell line name	Synonyms	Cellosaurus ID	Tumor type	Reference	Supplier	Culture medium
SNU368		CVCL_3948	Hepatocellular Carcinoma	Park et al. Int J Cancer (1995) [PMID: 7543080]	KCLB - Korea	DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

Age	Gender	Geographic Origin	Ethnicity	HBV	HCV
54	Male	Korea	Asian	Yes	NA

Transcriptomic subgroup: CL2

Mutations and CNAs (615)

Gene nameFilter by Gene name	Alteration type	Variant class	Annotation transcript	gNomen	cNomen	pNomen	PPH prédiction
DEDD	Mutation	In-Frame	ENST00000368006.3	g.161092121_161092122ins60 g.161092121_161092122ins60	c.772_773insTTAAAAGCTTATCGATTATCAAATGTCTCAAAATAATTTCTGAATTTTATATTCTTTTTT c.772_773insTTAAAAGCTTATCGATTATCAAATGTCTCAAAATAATTTCTGAATTTTATATTCTTTTTT	p.Ala258delins21 p.Ala258delins21	damaging damaging
SDS	Mutation	In-Frame	ENST00000257549.4	g.113830948_113830950del g.113830948_113830950del	c.783_785del c.783_785del	p.Asp261del (Splice) p.Asp261del (Splice)	damaging damaging
SPTBN4	Mutation	In-Frame	ENST00000352632.3	g.41074120_41074128del g.41074120_41074128del	c.6888_6896del c.6888_6896del	p.Glu2297_Arg2299del p.Glu2297_Arg2299del	damaging damaging
ALMS1	Mutation	In-Frame	ENST00000264448.6	g.73717400_73717402delTCA g.73717400_73717402delTCA	c.8315_8317del c.8315_8317del	p.S2774del p.S2774del	damaging damaging
UBE4B	Mutation	Missense	ENST00000253251.8	g.10165756C>T g.10165756C>T	c.763C>T c.763C>T	p.Pro255Ser p.Pro255Ser	probably damaging probably damaging
CASQ2	Mutation	Missense	ENST00000261448.5	g.116280896T>G g.116280896T>G	c.481A>C c.481A>C	p.Ile161Leu p.Ile161Leu	benign benign
WDR3	Mutation	Missense	ENST00000349139.5	g.118486168G>T g.118486168G>T	c.1247G>T c.1247G>T	p.Ser416Ile p.Ser416Ile	possibly damaging possibly damaging
ISG20L2	Mutation	Missense	ENST00000313146.6	g.156693245T>A g.156693245T>A	c.958A>T c.958A>T	p.Ser320Cys p.Ser320Cys	probably damaging probably damaging
ISG20L2	Mutation	Missense	ENST00000313146.6	g.156693246C>A g.156693246C>A	c.957G>T c.957G>T	p.Lys319Asn p.Lys319Asn	benign benign
PVRL4	Mutation	Missense	ENST00000368012.3	g.161044518C>T g.161044518C>T	c.883G>A c.883G>A	p.Val295Met p.Val295Met	benign benign
DUSP27	Mutation	Missense	ENST00000271385.5	g.167095864G>A g.167095864G>A	c.1496G>A c.1496G>A	p.Ser499Asn p.Ser499Asn	benign benign
UBR4	Mutation	Missense	ENST00000375217.2	g.19487604G>C g.19487604G>C	c.5213C>G c.5213C>G	p.Ser1738Cys p.Ser1738Cys	probably damaging probably damaging
HTR6	Mutation	Missense	ENST00000289753.1	g.20005620G>A g.20005620G>A	c.1082G>A c.1082G>A	p.Arg361Gln p.Arg361Gln	benign benign
TMCO4	Mutation	Missense	ENST00000294543.6	g.20097862A>G g.20097862A>G	c.293T>C c.293T>C	p.Val98Ala p.Val98Ala	benign benign
SLC26A9	Mutation	Missense	ENST00000340781.4	g.205901160G>T g.205901160G>T	c.380C>A c.380C>A	p.Thr127Asn p.Thr127Asn	probably damaging probably damaging
PIGR	Mutation	Missense	ENST00000356495.4	g.207106335C>T g.207106335C>T	c.1882G>A c.1882G>A	p.Gly628Ser p.Gly628Ser	benign benign
RAP1GAP	Mutation	Missense	ENST00000374763.2	g.21930396T>C g.21930396T>C	c.1438A>G c.1438A>G	p.Ile480Val p.Ile480Val	damaging damaging
CAPN2	Mutation	Missense	ENST00000295006.5	g.223905492T>C g.223905492T>C	c.266T>C c.266T>C	p.Ile89Thr p.Ile89Thr	benign benign
DNAH14	Mutation	Missense	ENST00000430092.1	g.225284926C>T g.225284926C>T	c.3680C>T c.3680C>T	p.Ser1227Phe p.Ser1227Phe	probably damaging probably damaging
DNAH14	Mutation	Missense	ENST00000430092.1	g.225534194T>C g.225534194T>C	c.10855T>C c.10855T>C	p.Cys3619Arg p.Cys3619Arg	probably damaging probably damaging
OBSCN	Mutation	Missense	ENST00000284548.11	g.228463548C>A g.228463548C>A	c.6041C>A c.6041C>A	p.Pro2014Gln p.Pro2014Gln	probably damaging probably damaging
OBSCN	Mutation	Missense	ENST00000422127.1	g.228560647T>C g.228560647T>C	c.22168T>C c.22168T>C	p.Ser7390Pro p.Ser7390Pro	benign benign
URB2	Mutation	Missense	ENST00000258243.2	g.229773793A>G g.229773793A>G	c.3433A>G c.3433A>G	p.Arg1145Gly p.Arg1145Gly	benign benign
TSNAX	Mutation	Missense	ENST00000366639.4	g.231673018C>T g.231673018C>T	c.181C>T c.181C>T	p.Arg61Trp p.Arg61Trp	probably damaging probably damaging
OPN3	Mutation	Missense	ENST00000366554.2	g.241767861G>C g.241767861G>C	c.394C>G c.394C>G	p.Leu132Val p.Leu132Val	probably damaging probably damaging

Mutational Signature

Fusion transcripts (9)

Fusion Name	Gene (1)	Chr (1)	Genomic position hg19 (1)	Gene (2)	Chr (2)	Genomic position hg19 (2)	Supporting reads	Consistance fusion	Fusion type
AGPS--IFI16	AGPS	chr2	178285085	IFI16	chr1	158979792	14	straight	TRANS
AKR1C2--AKR1C3	AKR1C2	chr10	5034022	AKR1C3	chr10	5147786	20	straight	INV
ARNT--PI4KB	ARNT	chr1	150807720	PI4KB	chr1	151274319	10	inverted	INV
ATF2--CHN1	ATF2	chr2	175945387	CHN1	chr2	175816929	17	straight	DEL
ATF6--GBA	ATF6	chr1	161833101	GBA	chr1	155210951	14	straight	INV
ATG4C--RP11-230B22.1	RP11-230B22.1	chr1	63154394	ATG4C	chr1	63269389	11	straight	DEL
CCDC141--TTC21B	TTC21B	chr2	166792688	CCDC141	chr2	179838115	48	inverted	INV
DCAF17--HOXD11	DCAF17	chr2	172314584	HOXD11	chr2	176973634	44	straight	DEL
NIT1--SCN2A	SCN2A	chr2	166237385	NIT1	chr1	161092120	4962	straight	TRANS

HBV RNA fusions (2)

Breakpoint on human genome (hg19)	Affected gene	Breakpoint on HBV genome (X02763)	Nb of paired reads (HG19 HBV)
chr3:88,524,828	intergenic	2,025	5
chr3:88,524,907	intergenic	1,783	48

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)

Drugs (35)

DrugFilter by Drug	AUC	GI50
Bortezomib	0.55	0.097
Alvespimycin	0.65	0.245
PF.04691502	0.73	1.07
Tanespimycin	0.73	5.89
Dasatinib	0.76	7.25
Paclitaxel	0.77	10.0
CD532	0.77	1.593
Vinblastine	0.78	10.0
Tivantinib	0.8	2.05
Sorafenib_MK.2206	0.81	4.832
MK.2206	0.83	7.991
Sorafenib_Trametinib	0.84	9.07
Rapamycin	0.87	10.0
Linsitinib	0.87	10.0
PHA.665752	0.88	6.483

Liver Cancer Cell Lines Database

Cell Line: SNU368

Transcriptomic subgroup: CL2

Mutational Signature

Liver Cancer Cell Lines
Database