Liver Cancer Cell Lines
Database

LCCL to predict drug response

Cell Line: SNU368


Cell line description
Cell line nameSynonymsCellosaurus IDTumor typeReferenceSupplierCulture medium
SNU368 CVCL_3948 Hepatocellular Carcinoma Park et al. Int J Cancer (1995) [PMID: 7543080] KCLB - Korea DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

AgeGenderGeographic OriginEthnicityHBVHCV
54 Male Korea Asian Yes NA

Transcriptomic subgroup: CL2


Mutations and CNAs (615)
Gene nameAlteration typeVariant classAnnotation transcriptgNomencNomenpNomenPPH pr├ędiction
DEDDMutationIn-FrameENST00000368006.3
g.161092121_161092122ins60
g.161092121_161092122ins60
c.772_773insTTAAAAGCTTATCGATTATCAAATGTCTCAAAATAATTTCTGAATTTTATATTCTTTTTT
c.772_773insTTAAAAGCTTATCGATTATCAAATGTCTCAAAATAATTTCTGAATTTTATATTCTTTTTT
p.Ala258delins21
p.Ala258delins21
damaging
damaging
SDSMutationIn-FrameENST00000257549.4
g.113830948_113830950del
g.113830948_113830950del
c.783_785del
c.783_785del
p.Asp261del (Splice)
p.Asp261del (Splice)
damaging
damaging
SPTBN4MutationIn-FrameENST00000352632.3
g.41074120_41074128del
g.41074120_41074128del
c.6888_6896del
c.6888_6896del
p.Glu2297_Arg2299del
p.Glu2297_Arg2299del
damaging
damaging
ALMS1MutationIn-FrameENST00000264448.6
g.73717400_73717402delTCA
g.73717400_73717402delTCA
c.8315_8317del
c.8315_8317del
p.S2774del
p.S2774del
damaging
damaging
UBE4BMutationMissenseENST00000253251.8
g.10165756C>T
g.10165756C>T
c.763C>T
c.763C>T
p.Pro255Ser
p.Pro255Ser
probably damaging
probably damaging
CASQ2MutationMissenseENST00000261448.5
g.116280896T>G
g.116280896T>G
c.481A>C
c.481A>C
p.Ile161Leu
p.Ile161Leu
benign
benign
WDR3MutationMissenseENST00000349139.5
g.118486168G>T
g.118486168G>T
c.1247G>T
c.1247G>T
p.Ser416Ile
p.Ser416Ile
possibly damaging
possibly damaging
ISG20L2MutationMissenseENST00000313146.6
g.156693245T>A
g.156693245T>A
c.958A>T
c.958A>T
p.Ser320Cys
p.Ser320Cys
probably damaging
probably damaging
ISG20L2MutationMissenseENST00000313146.6
g.156693246C>A
g.156693246C>A
c.957G>T
c.957G>T
p.Lys319Asn
p.Lys319Asn
benign
benign
PVRL4MutationMissenseENST00000368012.3
g.161044518C>T
g.161044518C>T
c.883G>A
c.883G>A
p.Val295Met
p.Val295Met
benign
benign
DUSP27MutationMissenseENST00000271385.5
g.167095864G>A
g.167095864G>A
c.1496G>A
c.1496G>A
p.Ser499Asn
p.Ser499Asn
benign
benign
UBR4MutationMissenseENST00000375217.2
g.19487604G>C
g.19487604G>C
c.5213C>G
c.5213C>G
p.Ser1738Cys
p.Ser1738Cys
probably damaging
probably damaging
HTR6MutationMissenseENST00000289753.1
g.20005620G>A
g.20005620G>A
c.1082G>A
c.1082G>A
p.Arg361Gln
p.Arg361Gln
benign
benign
TMCO4MutationMissenseENST00000294543.6
g.20097862A>G
g.20097862A>G
c.293T>C
c.293T>C
p.Val98Ala
p.Val98Ala
benign
benign
SLC26A9MutationMissenseENST00000340781.4
g.205901160G>T
g.205901160G>T
c.380C>A
c.380C>A
p.Thr127Asn
p.Thr127Asn
probably damaging
probably damaging
PIGRMutationMissenseENST00000356495.4
g.207106335C>T
g.207106335C>T
c.1882G>A
c.1882G>A
p.Gly628Ser
p.Gly628Ser
benign
benign
RAP1GAPMutationMissenseENST00000374763.2
g.21930396T>C
g.21930396T>C
c.1438A>G
c.1438A>G
p.Ile480Val
p.Ile480Val
damaging
damaging
CAPN2MutationMissenseENST00000295006.5
g.223905492T>C
g.223905492T>C
c.266T>C
c.266T>C
p.Ile89Thr
p.Ile89Thr
benign
benign
DNAH14MutationMissenseENST00000430092.1
g.225284926C>T
g.225284926C>T
c.3680C>T
c.3680C>T
p.Ser1227Phe
p.Ser1227Phe
probably damaging
probably damaging
DNAH14MutationMissenseENST00000430092.1
g.225534194T>C
g.225534194T>C
c.10855T>C
c.10855T>C
p.Cys3619Arg
p.Cys3619Arg
probably damaging
probably damaging
OBSCNMutationMissenseENST00000284548.11
g.228463548C>A
g.228463548C>A
c.6041C>A
c.6041C>A
p.Pro2014Gln
p.Pro2014Gln
probably damaging
probably damaging
OBSCNMutationMissenseENST00000422127.1
g.228560647T>C
g.228560647T>C
c.22168T>C
c.22168T>C
p.Ser7390Pro
p.Ser7390Pro
benign
benign
URB2MutationMissenseENST00000258243.2
g.229773793A>G
g.229773793A>G
c.3433A>G
c.3433A>G
p.Arg1145Gly
p.Arg1145Gly
benign
benign
TSNAXMutationMissenseENST00000366639.4
g.231673018C>T
g.231673018C>T
c.181C>T
c.181C>T
p.Arg61Trp
p.Arg61Trp
probably damaging
probably damaging
OPN3MutationMissenseENST00000366554.2
g.241767861G>C
g.241767861G>C
c.394C>G
c.394C>G
p.Leu132Val
p.Leu132Val
probably damaging
probably damaging

Mutational Signature



Fusion transcripts (9)
Fusion NameGene (1)Chr (1)Genomic position hg19 (1)Gene (2)Chr (2)Genomic position hg19 (2)Supporting readsConsistance fusionFusion type
AGPS--IFI16AGPSchr2178285085IFI16chr115897979214straightTRANS
AKR1C2--AKR1C3AKR1C2chr105034022AKR1C3chr10514778620straightINV
ARNT--PI4KBARNTchr1150807720PI4KBchr115127431910invertedINV
ATF2--CHN1ATF2chr2175945387CHN1chr217581692917straightDEL
ATF6--GBAATF6chr1161833101GBAchr115521095114straightINV
ATG4C--RP11-230B22.1RP11-230B22.1chr163154394ATG4Cchr16326938911straightDEL
CCDC141--TTC21BTTC21Bchr2166792688CCDC141chr217983811548invertedINV
DCAF17--HOXD11DCAF17chr2172314584HOXD11chr217697363444straightDEL
NIT1--SCN2ASCN2Achr2166237385NIT1chr11610921204962straightTRANS

HBV RNA fusions (2)
Breakpoint on human genome (hg19)Affected geneBreakpoint on HBV genome (X02763)Nb of paired reads (HG19 HBV)
chr3:88,524,828intergenic2,0255
chr3:88,524,907intergenic1,78348

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)


Drugs (35)
DrugAUCGI50
Bortezomib0.550.097
Alvespimycin0.650.245
Tanespimycin0.735.89
PF.046915020.731.07
Dasatinib0.767.25
Paclitaxel0.7710.0
CD5320.771.593
Vinblastine0.7810.0
Tivantinib0.82.05
Sorafenib_MK.22060.814.832
MK.22060.837.991
Sorafenib_Trametinib0.849.07
Rapamycin0.8710.0
Linsitinib0.8710.0
PHA.6657520.886.483


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