Liver Cancer Cell Lines Database

Cell line description

Cell line name	Synonyms	Cellosaurus ID	Tumor type	Reference	Supplier	Culture medium
SNU387		CVCL_0250	Hepatocellular Carcinoma	Park et al. Int J Cancer (1995) [PMID: 7543080]	ATCC - USA	DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

Age	Gender	Geographic Origin	Ethnicity	HBV	HCV
41	Female	Korea	Asian	Yes	No

Transcriptomic subgroup: CL3

Mutations and CNAs (435)

Gene nameFilter by Gene name	Alteration type	Variant class	Annotation transcript	gNomen	cNomen	pNomen	PPH prédiction
FRMD4A	Mutation	In-Frame	ENST00000357447.2	g.13698924_13698925insCGC g.13698924_13698925insCGC	c.2665_2666insCGG c.2665_2666insCGG	p.Gly888_Asp889insAla p.Gly888_Asp889insAla	damaging damaging
TECPR2	Mutation	In-Frame	ENST00000359520.7	g.102904395_102904421del g.102904395_102904421del	c.2431_2457del c.2431_2457del	p.Tyr811_Ser819del p.Tyr811_Ser819del	damaging damaging
MED26	Mutation	In-Frame	ENST00000263390.3	g.16688184_16688185insGGTCACCCC g.16688184_16688185insGGTCACCCC	c.456_457insGGGGTGACC c.456_457insGGGGTGACC	p.Asp152_Gln153insGlyValThr p.Asp152_Gln153insGlyValThr	damaging damaging
OCSTAMP	Mutation	In-Frame	ENST00000279028.2	g.45174858_45174869del g.45174858_45174869del	c.144_155del c.144_155del	p.Thr50_Leu53del p.Thr50_Leu53del	damaging damaging
ARID1A	Mutation	In-Frame	ENST00000324856.7	g.27023923_27023937del g.27023923_27023937del	c.1029_1043del c.1029_1043del	p.Ala345_Ala349del p.Ala345_Ala349del	damaging damaging
PDE4DIP	Mutation	Missense	ENST00000369349.3	g.144916644G>A g.144916644G>A	c.1711C>T c.1711C>T	p.Arg571Cys p.Arg571Cys	probably damaging probably damaging
OTUD7B	Mutation	Missense	ENST00000369135.4	g.149949406G>A g.149949406G>A	c.40C>T c.40C>T	p.Arg14Cys p.Arg14Cys	probably damaging probably damaging
HDGF	Mutation	Missense	ENST00000357325.5	g.156713640T>A g.156713640T>A	c.520A>T c.520A>T	p.Asn174Tyr p.Asn174Tyr	benign benign
DUSP27	Mutation	Missense	ENST00000271385.5	g.167095134C>T g.167095134C>T	c.766C>T c.766C>T	p.Arg256Cys p.Arg256Cys	probably damaging probably damaging
DUSP27	Mutation	Missense	ENST00000271385.5	g.167096035T>C g.167096035T>C	c.1667T>C c.1667T>C	p.Phe556Ser p.Phe556Ser	probably damaging probably damaging
CACNA1S	Mutation	Missense	ENST00000362061.3	g.201058502G>A g.201058502G>A	c.784C>T c.784C>T	p.Arg262Trp p.Arg262Trp	probably damaging probably damaging
URB2	Mutation	Missense	ENST00000258243.2	g.229773866C>T g.229773866C>T	c.3506C>T c.3506C>T	p.Ala1169Val p.Ala1169Val	benign benign
TRIM67	Mutation	Missense	ENST00000366653.5	g.231351163C>T g.231351163C>T	c.2329C>T c.2329C>T	p.Arg777Trp p.Arg777Trp	probably damaging probably damaging
KIAA1804	Mutation	Missense	NM_032435.2	g.233514836C>T g.233514836C>T	c.2084C>T c.2084C>T	p.A695V p.A695V	benign benign
PGBD2	Mutation	Missense	ENST00000329291.5	g.249212090G>A g.249212090G>A	c.1307G>A c.1307G>A	p.Arg436His p.Arg436His	benign benign
LDLRAP1	Mutation	Missense	ENST00000374338.4	g.25880491C>T g.25880491C>T	c.167C>T c.167C>T	p.Thr56Met p.Thr56Met	probably damaging probably damaging
TTC34	Mutation	Missense	ENST00000401095.3	g.2704191G>A g.2704191G>A	c.170C>T c.170C>T	p.Ala57Val p.Ala57Val	benign benign
CLSPN	Mutation	Missense	ENST00000251195.5	g.36217011T>C g.36217011T>C	c.1868A>G c.1868A>G	p.Asp623Gly p.Asp623Gly	probably damaging probably damaging
ABCA4	Mutation	Missense	ENST00000370225.3	g.94487460G>A g.94487460G>A	c.4715C>T c.4715C>T	p.Thr1572Met p.Thr1572Met	possibly damaging possibly damaging
AGRN	Mutation	Missense	ENST00000379370.2	g.984346C>T g.984346C>T	c.4205C>T c.4205C>T	p.Ala1402Val p.Ala1402Val	benign benign
COX15	Mutation	Missense	ENST00000016171.5	g.101474424C>T g.101474424C>T	c.1153G>A c.1153G>A	p.Ala385Thr p.Ala385Thr	probably damaging probably damaging
C10orf2	Mutation	Missense	ENST00000311916.2	g.102749487T>C g.102749487T>C	c.1330T>C c.1330T>C	p.Phe444Leu p.Phe444Leu	possibly damaging possibly damaging
POLL	Mutation	Missense	ENST00000299206.4	g.103339229G>C g.103339229G>C	c.1709C>G c.1709C>G	p.Pro570Arg p.Pro570Arg	probably damaging probably damaging
C10orf95	Mutation	Missense	ENST00000239125.1	g.104210275G>T g.104210275G>T	c.713C>A c.713C>A	p.Ala238Glu p.Ala238Glu	probably damaging probably damaging
CNNM2	Mutation	Missense	ENST00000369875.3	g.104678650C>T g.104678650C>T	c.413C>T c.413C>T	p.Pro138Leu p.Pro138Leu	benign benign

Mutational Signature

Fusion transcripts (3)

Fusion Name	Gene (1)	Chr (1)	Genomic position hg19 (1)	Gene (2)	Chr (2)	Genomic position hg19 (2)	Supporting reads	Consistance fusion	Fusion type
AL121578.2--SYTL5	AL121578.2	chrX	37808657	SYTL5	chrX	37913465	10	straight	DEL
C6orf106--SRPK1	C6orf106	chr6	34628282	SRPK1	chr6	35837943	38	inverted	INV
MYLPF--ZNF771	ZNF771	chr16	30419512	MYLPF	chr16	30386140	81	straight	DUP

HBV RNA fusions (2)

Breakpoint on human genome (hg19)	Affected gene	Breakpoint on HBV genome (X02763)	Nb of paired reads (HG19 HBV)
chr17:45,566,957	MRPL45P2 (intron 3)	1,834	13
chr22:40,440,411	TNRC6B (promoter)	830	6

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)

Drugs (35)

DrugFilter by Drug	AUC	GI50
Bortezomib	0.37	0.024
Sorafenib_Trametinib	0.52	0.1
Paclitaxel	0.56	0.345
Alvespimycin	0.63	0.245
Vinblastine	0.65	5.109
Sorafenib_Refametinib	0.71	1.03
Doxorubicin	0.72	0.835
PF.04691502	0.73	1.015
CD532	0.76	1.09
Dasatinib	0.78	10.0
Tivantinib	0.78	5.705
Rapamycin	0.78	10.0
Refametinib	0.83	10.0
Tanespimycin	0.83	2.76
Trametinib	0.85	10.0

Liver Cancer Cell Lines Database

Cell Line: SNU387

Transcriptomic subgroup: CL3

Mutational Signature

Liver Cancer Cell Lines
Database