Liver Cancer Cell Lines
Database

LCCL to predict drug response

Cell Line: SNU387


Cell line description
Cell line nameSynonymsCellosaurus IDTumor typeReferenceSupplierCulture medium
SNU387 CVCL_0250 Hepatocellular Carcinoma Park et al. Int J Cancer (1995) [PMID: 7543080] ATCC - USA DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

AgeGenderGeographic OriginEthnicityHBVHCV
41 Female Korea Asian Yes No

Transcriptomic subgroup: CL3


Mutations and CNAs (435)
Gene nameAlteration typeVariant classAnnotation transcriptgNomencNomenpNomenPPH pr├ędiction
FRMD4AMutationIn-FrameENST00000357447.2
g.13698924_13698925insCGC
g.13698924_13698925insCGC
c.2665_2666insCGG
c.2665_2666insCGG
p.Gly888_Asp889insAla
p.Gly888_Asp889insAla
damaging
damaging
TECPR2MutationIn-FrameENST00000359520.7
g.102904395_102904421del
g.102904395_102904421del
c.2431_2457del
c.2431_2457del
p.Tyr811_Ser819del
p.Tyr811_Ser819del
damaging
damaging
MED26MutationIn-FrameENST00000263390.3
g.16688184_16688185insGGTCACCCC
g.16688184_16688185insGGTCACCCC
c.456_457insGGGGTGACC
c.456_457insGGGGTGACC
p.Asp152_Gln153insGlyValThr
p.Asp152_Gln153insGlyValThr
damaging
damaging
OCSTAMPMutationIn-FrameENST00000279028.2
g.45174858_45174869del
g.45174858_45174869del
c.144_155del
c.144_155del
p.Thr50_Leu53del
p.Thr50_Leu53del
damaging
damaging
ARID1AMutationIn-FrameENST00000324856.7
g.27023923_27023937del
g.27023923_27023937del
c.1029_1043del
c.1029_1043del
p.Ala345_Ala349del
p.Ala345_Ala349del
damaging
damaging
PDE4DIPMutationMissenseENST00000369349.3
g.144916644G>A
g.144916644G>A
c.1711C>T
c.1711C>T
p.Arg571Cys
p.Arg571Cys
probably damaging
probably damaging
OTUD7BMutationMissenseENST00000369135.4
g.149949406G>A
g.149949406G>A
c.40C>T
c.40C>T
p.Arg14Cys
p.Arg14Cys
probably damaging
probably damaging
HDGFMutationMissenseENST00000357325.5
g.156713640T>A
g.156713640T>A
c.520A>T
c.520A>T
p.Asn174Tyr
p.Asn174Tyr
benign
benign
DUSP27MutationMissenseENST00000271385.5
g.167095134C>T
g.167095134C>T
c.766C>T
c.766C>T
p.Arg256Cys
p.Arg256Cys
probably damaging
probably damaging
DUSP27MutationMissenseENST00000271385.5
g.167096035T>C
g.167096035T>C
c.1667T>C
c.1667T>C
p.Phe556Ser
p.Phe556Ser
probably damaging
probably damaging
CACNA1SMutationMissenseENST00000362061.3
g.201058502G>A
g.201058502G>A
c.784C>T
c.784C>T
p.Arg262Trp
p.Arg262Trp
probably damaging
probably damaging
URB2MutationMissenseENST00000258243.2
g.229773866C>T
g.229773866C>T
c.3506C>T
c.3506C>T
p.Ala1169Val
p.Ala1169Val
benign
benign
TRIM67MutationMissenseENST00000366653.5
g.231351163C>T
g.231351163C>T
c.2329C>T
c.2329C>T
p.Arg777Trp
p.Arg777Trp
probably damaging
probably damaging
KIAA1804MutationMissenseNM_032435.2
g.233514836C>T
g.233514836C>T
c.2084C>T
c.2084C>T
p.A695V
p.A695V
benign
benign
PGBD2MutationMissenseENST00000329291.5
g.249212090G>A
g.249212090G>A
c.1307G>A
c.1307G>A
p.Arg436His
p.Arg436His
benign
benign
LDLRAP1MutationMissenseENST00000374338.4
g.25880491C>T
g.25880491C>T
c.167C>T
c.167C>T
p.Thr56Met
p.Thr56Met
probably damaging
probably damaging
TTC34MutationMissenseENST00000401095.3
g.2704191G>A
g.2704191G>A
c.170C>T
c.170C>T
p.Ala57Val
p.Ala57Val
benign
benign
CLSPNMutationMissenseENST00000251195.5
g.36217011T>C
g.36217011T>C
c.1868A>G
c.1868A>G
p.Asp623Gly
p.Asp623Gly
probably damaging
probably damaging
ABCA4MutationMissenseENST00000370225.3
g.94487460G>A
g.94487460G>A
c.4715C>T
c.4715C>T
p.Thr1572Met
p.Thr1572Met
possibly damaging
possibly damaging
AGRNMutationMissenseENST00000379370.2
g.984346C>T
g.984346C>T
c.4205C>T
c.4205C>T
p.Ala1402Val
p.Ala1402Val
benign
benign
COX15MutationMissenseENST00000016171.5
g.101474424C>T
g.101474424C>T
c.1153G>A
c.1153G>A
p.Ala385Thr
p.Ala385Thr
probably damaging
probably damaging
C10orf2MutationMissenseENST00000311916.2
g.102749487T>C
g.102749487T>C
c.1330T>C
c.1330T>C
p.Phe444Leu
p.Phe444Leu
possibly damaging
possibly damaging
POLLMutationMissenseENST00000299206.4
g.103339229G>C
g.103339229G>C
c.1709C>G
c.1709C>G
p.Pro570Arg
p.Pro570Arg
probably damaging
probably damaging
C10orf95MutationMissenseENST00000239125.1
g.104210275G>T
g.104210275G>T
c.713C>A
c.713C>A
p.Ala238Glu
p.Ala238Glu
probably damaging
probably damaging
CNNM2MutationMissenseENST00000369875.3
g.104678650C>T
g.104678650C>T
c.413C>T
c.413C>T
p.Pro138Leu
p.Pro138Leu
benign
benign

Mutational Signature



Fusion transcripts (3)
Fusion NameGene (1)Chr (1)Genomic position hg19 (1)Gene (2)Chr (2)Genomic position hg19 (2)Supporting readsConsistance fusionFusion type
AL121578.2--SYTL5AL121578.2chrX37808657SYTL5chrX3791346510straightDEL
C6orf106--SRPK1C6orf106chr634628282SRPK1chr63583794338invertedINV
MYLPF--ZNF771ZNF771chr1630419512MYLPFchr163038614081straightDUP

HBV RNA fusions (2)
Breakpoint on human genome (hg19)Affected geneBreakpoint on HBV genome (X02763)Nb of paired reads (HG19 HBV)
chr17:45,566,957MRPL45P2 (intron 3)1,83413
chr22:40,440,411TNRC6B (promoter)8306

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)


Drugs (35)
DrugAUCGI50
Bortezomib0.370.024
Sorafenib_Trametinib0.520.1
Paclitaxel0.560.345
Alvespimycin0.630.245
Vinblastine0.655.109
Sorafenib_Refametinib0.711.03
Doxorubicin0.720.835
PF.046915020.731.015
CD5320.761.09
Dasatinib0.7810.0
Tivantinib0.785.705
Rapamycin0.7810.0
Tanespimycin0.832.76
Refametinib0.8310.0
Trametinib0.8510.0


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