Liver Cancer Cell Lines Database

Cell line description

Cell line name	Synonyms	Cellosaurus ID	Tumor type	Reference	Supplier	Culture medium
SNU398		CVCL_0077	Hepatocellular Carcinoma	Park et al. Int J Cancer (1995) [PMID: 7543080]	ATCC - USA	DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

Age	Gender	Geographic Origin	Ethnicity	HBV	HCV
42	Male	Korea	Asian	Yes	No

Transcriptomic subgroup: CL3

Mutations and CNAs (334)

Gene nameFilter by Gene name	Alteration type	Variant class	Annotation transcript	gNomen	cNomen	pNomen	PPH prédiction
FRRS1	Mutation	Missense	ENST00000287474.5	g.100181170G>C g.100181170G>C	c.1295C>G c.1295C>G	p.Pro432Arg p.Pro432Arg	probably damaging probably damaging
CLCN6	Mutation	Missense	ENST00000346436.6	g.11889290G>A g.11889290G>A	c.1159G>A c.1159G>A	p.Val387Met p.Val387Met	possibly damaging possibly damaging
PRDM2	Mutation	Missense	ENST00000235372.7	g.14108437G>A g.14108437G>A	c.4147G>A c.4147G>A	p.Val1383Met p.Val1383Met	probably damaging probably damaging
ANKRD35	Mutation	Missense	ENST00000355594.4	g.145562029G>A g.145562029G>A	c.1717G>A c.1717G>A	p.Ala573Thr p.Ala573Thr	benign benign
POLR3C	Mutation	Missense	ENST00000334163.3	g.145608572A>T g.145608572A>T	c.235T>A c.235T>A	p.Cys79Ser p.Cys79Ser	benign benign
BOLA1	Mutation	Missense	ENST00000369150.1	g.149871937C>G g.149871937C>G	c.325C>G c.325C>G	p.Arg109Gly p.Arg109Gly	possibly damaging possibly damaging
SLC27A3	Mutation	Missense	ENST00000368661.3	g.153750994G>A g.153750994G>A	c.1553G>A c.1553G>A	p.Arg518Gln p.Arg518Gln	probably damaging probably damaging
GON4L	Mutation	Missense	ENST00000271883.5	g.155735220G>C g.155735220G>C	c.4044C>G c.4044C>G	p.Ile1348Met p.Ile1348Met	possibly damaging possibly damaging
MEF2D	Mutation	Missense	ENST00000348159.4	g.156437790T>C g.156437790T>C	c.1549A>G c.1549A>G	p.Thr517Ala p.Thr517Ala	benign benign
NTRK1	Mutation	Missense	ENST00000524377.1	g.156851255G>A g.156851255G>A	c.2212G>A c.2212G>A	p.Asp738Asn p.Asp738Asn	benign benign
CD5L	Mutation	Missense	ENST00000368174.4	g.157803222A>C g.157803222A>C	c.799T>G c.799T>G	p.Ser267Ala p.Ser267Ala	possibly damaging possibly damaging
ATP1A4	Mutation	Missense	ENST00000368081.4	g.160121869T>A g.160121869T>A	c.39T>A c.39T>A	p.His13Gln p.His13Gln	benign benign
COPA	Mutation	Missense	ENST00000241704.7	g.160260301T>C g.160260301T>C	c.3596A>G c.3596A>G	p.Gln1199Arg p.Gln1199Arg	benign benign
ADCY10	Mutation	Missense	ENST00000367851.4	g.167847771T>C g.167847771T>C	c.1319A>G c.1319A>G	p.Tyr440Cys p.Tyr440Cys	probably damaging probably damaging
RC3H1	Mutation	Missense	ENST00000258349.4	g.173934064C>T g.173934064C>T	c.1529G>A c.1529G>A	p.Arg510Gln p.Arg510Gln	probably damaging probably damaging
PAPPA2	Mutation	Missense	ENST00000367661.3	g.176526264G>A g.176526264G>A	c.806G>A c.806G>A	p.Arg269Gln p.Arg269Gln	possibly damaging possibly damaging
ASTN1	Mutation	Missense	ENST00000361833.2	g.177133577A>G g.177133577A>G	c.236T>C c.236T>C	p.Val79Ala p.Val79Ala	benign benign
LAMC1	Mutation	Missense	ENST00000258341.4	g.183083801T>A g.183083801T>A	c.1157T>A c.1157T>A	p.Phe386Tyr p.Phe386Tyr	benign benign
LAMC2	Mutation	Missense	ENST00000264144.4	g.183194828C>T g.183194828C>T	c.1039C>T c.1039C>T	p.Arg347Cys p.Arg347Cys	probably damaging probably damaging
HMCN1	Mutation	Missense	ENST00000271588.4	g.186031042G>A g.186031042G>A	c.7372G>A c.7372G>A	p.Val2458Ile p.Val2458Ile	benign benign
IGFN1	Mutation	Missense	ENST00000335211.4	g.201196334T>C g.201196334T>C	c.11111T>C c.11111T>C	p.Ile3704Thr (Splice) p.Ile3704Thr (Splice)	benign benign
CR1L	Mutation	Missense	ENST00000508064.2	g.207850773C>T g.207850773C>T	c.137C>T c.137C>T	p.Pro46Leu p.Pro46Leu	benign benign
PTPN14	Mutation	Missense	ENST00000366956.5	g.214557892C>T g.214557892C>T	c.1306G>A c.1306G>A	p.Val436Met p.Val436Met	probably damaging probably damaging
OBSCN	Mutation	Missense	ENST00000570156.2	g.228447336C>A g.228447336C>A	c.4996C>A c.4996C>A	p.L1666M p.L1666M	NA NA
ASAP3	Mutation	Missense	ENST00000336689.3	g.23777981T>C g.23777981T>C	c.464A>G c.464A>G	p.Glu155Gly p.Glu155Gly	probably damaging probably damaging

Mutational Signature

Fusion transcripts (15)

Fusion Name	Gene (1)	Chr (1)	Genomic position hg19 (1)	Gene (2)	Chr (2)	Genomic position hg19 (2)	Supporting reads	Consistance fusion	Fusion type
ABCA12--LOC101928103	LOC101928103	chr2	215698828	ABCA12	chr2	215826533	26	NA	DEL
AHCY--MSANTD2	MSANTD2	chr11	124636576	AHCY	chr20	32891159	25	straight	TRANS
ARHGAP33--SBSN	SBSN	chr19	36017724	ARHGAP33	chr19	36275218	11	inverted	DUP
CIB3--LINC00662	LINC00662	chr19	28283907	CIB3	chr19	16275723	133	straight	DEL
DCTN4--NECTIN2	NECTIN2	chr19	45363321	DCTN4	chr5	150121673	38	NA	TRANS
DMKN--KMT2B	KMT2B	chr19	36224772	DMKN	chr19	36004083	14	straight	INV
KDM4C--PARD6G	KDM4C	chr9	7015928	PARD6G	chr18	77960814	46	straight	TRANS
LOC730183--RNF40	RNF40	chr16	30778129	LOC730183	chr16	30709251	546	NA	INV
NETO2--SHCBP1	SHCBP1	chr16	46649857	NETO2	chr16	47117711	17	straight	DUP
NFIC--PIP5K1C	PIP5K1C	chr19	3638881	NFIC	chr19	3381709	22	straight	INV
PARD3--PLEKHA2	PARD3	chr10	34985244	PLEKHA2	chr8	38826110	91	straight	TRANS
PTK2--RP11-1084E5.1	RP11-1084E5.1	chr8	110043858	PTK2	chr8	141874410	11	inverted	INV
SIN3B--ZNF121	ZNF121	chr19	9694861	SIN3B	chr19	16980270	215	straight	INV
SNAP91--ZNF680	ZNF680	chr7	64004084	SNAP91	chr6	84320395	43	straight	TRANS
SREBF2--UBA2	UBA2	chr19	34951470	SREBF2	chr22	42242210	45	inverted	TRANS

HBV RNA fusions (0)

Breakpoint on human genome (hg19)	Affected gene	Breakpoint on HBV genome (X02763)	Nb of paired reads (HG19 HBV)
No records found.

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)

Drugs (35)

DrugFilter by Drug	AUC	GI50
Paclitaxel	0.29	0.003
Vinblastine	0.37	0.013
Rapamycin	0.42	5.011
Bortezomib	0.54	0.053
Doxorubicin	0.6	0.185
PF.04691502	0.62	0.29
CD532	0.64	0.237
Alvespimycin	0.64	0.4
Tanespimycin	0.67	0.71
Alisertib	0.68	0.188
Sorafenib_Trametinib	0.69	2.18
Tivantinib	0.72	1.08
Sorafenib_Refametinib	0.72	2.11
Trametinib	0.75	10.0
Navitoclax	0.78	8.485

Liver Cancer Cell Lines Database

Cell Line: SNU398

Transcriptomic subgroup: CL3

Mutational Signature

Liver Cancer Cell Lines
Database