Liver Cancer Cell Lines
Database

LCCL to predict drug response

Cell Line: SNU398


Cell line description
Cell line nameSynonymsCellosaurus IDTumor typeReferenceSupplierCulture medium
SNU398 CVCL_0077 Hepatocellular Carcinoma Park et al. Int J Cancer (1995) [PMID: 7543080] ATCC - USA DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

AgeGenderGeographic OriginEthnicityHBVHCV
42 Male Korea Asian Yes No

Transcriptomic subgroup: CL3


Mutations and CNAs (334)
Gene nameAlteration typeVariant classAnnotation transcriptgNomencNomenpNomenPPH pr├ędiction
FRRS1MutationMissenseENST00000287474.5
g.100181170G>C
g.100181170G>C
c.1295C>G
c.1295C>G
p.Pro432Arg
p.Pro432Arg
probably damaging
probably damaging
CLCN6MutationMissenseENST00000346436.6
g.11889290G>A
g.11889290G>A
c.1159G>A
c.1159G>A
p.Val387Met
p.Val387Met
possibly damaging
possibly damaging
PRDM2MutationMissenseENST00000235372.7
g.14108437G>A
g.14108437G>A
c.4147G>A
c.4147G>A
p.Val1383Met
p.Val1383Met
probably damaging
probably damaging
ANKRD35MutationMissenseENST00000355594.4
g.145562029G>A
g.145562029G>A
c.1717G>A
c.1717G>A
p.Ala573Thr
p.Ala573Thr
benign
benign
POLR3CMutationMissenseENST00000334163.3
g.145608572A>T
g.145608572A>T
c.235T>A
c.235T>A
p.Cys79Ser
p.Cys79Ser
benign
benign
BOLA1MutationMissenseENST00000369150.1
g.149871937C>G
g.149871937C>G
c.325C>G
c.325C>G
p.Arg109Gly
p.Arg109Gly
possibly damaging
possibly damaging
SLC27A3MutationMissenseENST00000368661.3
g.153750994G>A
g.153750994G>A
c.1553G>A
c.1553G>A
p.Arg518Gln
p.Arg518Gln
probably damaging
probably damaging
GON4LMutationMissenseENST00000271883.5
g.155735220G>C
g.155735220G>C
c.4044C>G
c.4044C>G
p.Ile1348Met
p.Ile1348Met
possibly damaging
possibly damaging
MEF2DMutationMissenseENST00000348159.4
g.156437790T>C
g.156437790T>C
c.1549A>G
c.1549A>G
p.Thr517Ala
p.Thr517Ala
benign
benign
NTRK1MutationMissenseENST00000524377.1
g.156851255G>A
g.156851255G>A
c.2212G>A
c.2212G>A
p.Asp738Asn
p.Asp738Asn
benign
benign
CD5LMutationMissenseENST00000368174.4
g.157803222A>C
g.157803222A>C
c.799T>G
c.799T>G
p.Ser267Ala
p.Ser267Ala
possibly damaging
possibly damaging
ATP1A4MutationMissenseENST00000368081.4
g.160121869T>A
g.160121869T>A
c.39T>A
c.39T>A
p.His13Gln
p.His13Gln
benign
benign
COPAMutationMissenseENST00000241704.7
g.160260301T>C
g.160260301T>C
c.3596A>G
c.3596A>G
p.Gln1199Arg
p.Gln1199Arg
benign
benign
ADCY10MutationMissenseENST00000367851.4
g.167847771T>C
g.167847771T>C
c.1319A>G
c.1319A>G
p.Tyr440Cys
p.Tyr440Cys
probably damaging
probably damaging
RC3H1MutationMissenseENST00000258349.4
g.173934064C>T
g.173934064C>T
c.1529G>A
c.1529G>A
p.Arg510Gln
p.Arg510Gln
probably damaging
probably damaging
PAPPA2MutationMissenseENST00000367661.3
g.176526264G>A
g.176526264G>A
c.806G>A
c.806G>A
p.Arg269Gln
p.Arg269Gln
possibly damaging
possibly damaging
ASTN1MutationMissenseENST00000361833.2
g.177133577A>G
g.177133577A>G
c.236T>C
c.236T>C
p.Val79Ala
p.Val79Ala
benign
benign
LAMC1MutationMissenseENST00000258341.4
g.183083801T>A
g.183083801T>A
c.1157T>A
c.1157T>A
p.Phe386Tyr
p.Phe386Tyr
benign
benign
LAMC2MutationMissenseENST00000264144.4
g.183194828C>T
g.183194828C>T
c.1039C>T
c.1039C>T
p.Arg347Cys
p.Arg347Cys
probably damaging
probably damaging
HMCN1MutationMissenseENST00000271588.4
g.186031042G>A
g.186031042G>A
c.7372G>A
c.7372G>A
p.Val2458Ile
p.Val2458Ile
benign
benign
IGFN1MutationMissenseENST00000335211.4
g.201196334T>C
g.201196334T>C
c.11111T>C
c.11111T>C
p.Ile3704Thr (Splice)
p.Ile3704Thr (Splice)
benign
benign
CR1LMutationMissenseENST00000508064.2
g.207850773C>T
g.207850773C>T
c.137C>T
c.137C>T
p.Pro46Leu
p.Pro46Leu
benign
benign
PTPN14MutationMissenseENST00000366956.5
g.214557892C>T
g.214557892C>T
c.1306G>A
c.1306G>A
p.Val436Met
p.Val436Met
probably damaging
probably damaging
OBSCNMutationMissenseENST00000570156.2
g.228447336C>A
g.228447336C>A
c.4996C>A
c.4996C>A
p.L1666M
p.L1666M
NA
NA
ASAP3MutationMissenseENST00000336689.3
g.23777981T>C
g.23777981T>C
c.464A>G
c.464A>G
p.Glu155Gly
p.Glu155Gly
probably damaging
probably damaging

Mutational Signature



Fusion transcripts (15)
Fusion NameGene (1)Chr (1)Genomic position hg19 (1)Gene (2)Chr (2)Genomic position hg19 (2)Supporting readsConsistance fusionFusion type
ABCA12--LOC101928103LOC101928103chr2215698828ABCA12chr221582653326NADEL
AHCY--MSANTD2MSANTD2chr11124636576AHCYchr203289115925straightTRANS
ARHGAP33--SBSNSBSNchr1936017724ARHGAP33chr193627521811invertedDUP
CIB3--LINC00662LINC00662chr1928283907CIB3chr1916275723133straightDEL
DCTN4--NECTIN2NECTIN2chr1945363321DCTN4chr515012167338NATRANS
DMKN--KMT2BKMT2Bchr1936224772DMKNchr193600408314straightINV
KDM4C--PARD6GKDM4Cchr97015928PARD6Gchr187796081446straightTRANS
LOC730183--RNF40RNF40chr1630778129LOC730183chr1630709251546NAINV
NETO2--SHCBP1SHCBP1chr1646649857NETO2chr164711771117straightDUP
NFIC--PIP5K1CPIP5K1Cchr193638881NFICchr19338170922straightINV
PARD3--PLEKHA2PARD3chr1034985244PLEKHA2chr83882611091straightTRANS
PTK2--RP11-1084E5.1RP11-1084E5.1chr8110043858PTK2chr814187441011invertedINV
SIN3B--ZNF121ZNF121chr199694861SIN3Bchr1916980270215straightINV
SNAP91--ZNF680ZNF680chr764004084SNAP91chr68432039543straightTRANS
SREBF2--UBA2UBA2chr1934951470SREBF2chr224224221045invertedTRANS

HBV RNA fusions (0)
Breakpoint on human genome (hg19)Affected geneBreakpoint on HBV genome (X02763)Nb of paired reads (HG19 HBV)
No records found.

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)


Drugs (35)
DrugAUCGI50
Paclitaxel0.290.003
Vinblastine0.370.013
Rapamycin0.425.011
Bortezomib0.540.053
Doxorubicin0.60.185
PF.046915020.620.29
Alvespimycin0.640.4
CD5320.640.237
Tanespimycin0.670.71
Alisertib0.680.188
Sorafenib_Trametinib0.692.18
Tivantinib0.721.08
Sorafenib_Refametinib0.722.11
Trametinib0.7510.0
Navitoclax0.788.485


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