Liver Cancer Cell Lines
Database

LCCL to predict drug response

Cell Line: SNU449


Cell line description
Cell line nameSynonymsCellosaurus IDTumor typeReferenceSupplierCulture medium
SNU449 CVCL_0454 Hepatocellular Carcinoma Park et al. Int J Cancer (1995) [PMID: 7543080] ATCC - USA DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

AgeGenderGeographic OriginEthnicityHBVHCV
52 Male Korea Asian Yes No

Transcriptomic subgroup: CL3


Mutations and CNAs (398)
Gene nameAlteration typeVariant classAnnotation transcriptgNomencNomenpNomenPPH pr├ędiction
ARID1AMutationIn-FrameENST00000324856.7
g.27100182_27100183insGCA
g.27100182_27100183insGCA
c.3978_3979insGCA
c.3978_3979insGCA
p.Pro1326_Gln1327insAla
p.Pro1326_Gln1327insAla
damaging
damaging
TMEM132BMutationIn-FrameENST00000299308.3
g.126139196_126139197ins54
g.126139196_126139197ins54
c.3177_3178insATTTTAAAATGTACAATTAAATTATTATTGACTATAATCATAGTCACCCTGCTG
c.3177_3178insATTTTAAAATGTACAATTAAATTATTATTGACTATAATCATAGTCACCCTGCTG
p.Met1059_Gly1060ins18
p.Met1059_Gly1060ins18
damaging
damaging
KRTAP9-1MutationIn-FrameENST00000398470.1
g.39346414_39346428del
g.39346414_39346428del
c.276_290del
c.276_290del
p.Ser93_Gly97del
p.Ser93_Gly97del
damaging
damaging
ADRA2BMutationIn-FrameENST00000409345.3
g.96780975_96780977delTCC
g.96780975_96780977delTCC
c.912_914del
c.912_914del
p.307_308EE>E
p.307_308EE>E
damaging
damaging
MYLKMutationIn-FrameENST00000360304.3
g.123337614_123337616del
g.123337614_123337616del
c.5370_5372del
c.5370_5372del
p.Glu1790del
p.Glu1790del
damaging
damaging
MAGEC2MutationIn-FrameENST00000247452.3
g.141291659_141291667del
g.141291659_141291667del
c.107_115del
c.107_115del
p.Glu36_Glu38del
p.Glu36_Glu38del
damaging
damaging
WDR3MutationMissenseENST00000349139.5
g.118481173C>T
g.118481173C>T
c.571C>T
c.571C>T
p.Arg191Trp
p.Arg191Trp
probably damaging
probably damaging
TCHHMutationMissenseENST00000368804.1
g.152083976C>T
g.152083976C>T
c.1717G>A
c.1717G>A
p.Glu573Lys
p.Glu573Lys
benign
benign
NPR1MutationMissenseENST00000368680.3
g.153651622G>T
g.153651622G>T
c.38G>T
c.38G>T
p.Arg13Leu
p.Arg13Leu
benign
benign
CRTC2MutationMissenseENST00000368633.1
g.153923872G>C
g.153923872G>C
c.1268C>G
c.1268C>G
p.Ala423Gly
p.Ala423Gly
possibly damaging
possibly damaging
CD1DMutationMissenseENST00000368171.3
g.158152727G>C
g.158152727G>C
c.667G>C
c.667G>C
p.Val223Leu
p.Val223Leu
probably damaging
probably damaging
ARHGAP30MutationMissenseENST00000368013.3
g.161018629T>G
g.161018629T>G
c.2182A>C
c.2182A>C
p.Ser728Arg
p.Ser728Arg
benign
benign
CD247MutationMissenseENST00000362089.5
g.167407839G>A
g.167407839G>A
c.268C>T
c.268C>T
p.Arg90Cys
p.Arg90Cys
probably damaging
probably damaging
SCYL3MutationMissenseENST00000367770.1
g.169823662C>A
g.169823662C>A
c.1918G>T
c.1918G>T
p.Val640Leu
p.Val640Leu
benign
benign
KIFAP3MutationMissenseENST00000361580.2
g.169952413T>C
g.169952413T>C
c.1504A>G
c.1504A>G
p.Ile502Val (Splice)
p.Ile502Val (Splice)
benign
benign
MROH9MutationMissenseENST00000367759.4
g.170993603A>G
g.170993603A>G
c.1976A>G
c.1976A>G
p.Tyr659Cys
p.Tyr659Cys
probably damaging
probably damaging
SUCOMutationMissenseENST00000263688.3
g.172579065A>G
g.172579065A>G
c.3431A>G
c.3431A>G
p.Gln1144Arg
p.Gln1144Arg
possibly damaging
possibly damaging
ENAHMutationMissenseENST00000366843.2
g.225706905C>G
g.225706905C>G
c.797G>C
c.797G>C
p.Ser266Thr
p.Ser266Thr
benign
benign
OBSCNMutationMissenseENST00000284548.11
g.228402024G>T
g.228402024G>T
c.1408G>T
c.1408G>T
p.Ala470Ser
p.Ala470Ser
benign
benign
RASSF10MutationMissenseNM_001080521.2
g.13031542C>T
g.13031542C>T
c.419C>T
c.419C>T
p.Pro140Leu
p.Pro140Leu
probably damaging
probably damaging
DNAJC6MutationMissenseENST00000395325.3
g.65851433C>G
g.65851433C>G
c.668C>G
c.668C>G
p.Pro223Arg
p.Pro223Arg
probably damaging
probably damaging
IL23RMutationMissenseENST00000347310.5
g.67724660C>T
g.67724660C>T
c.1739C>T
c.1739C>T
p.Pro580Leu
p.Pro580Leu
benign
benign
CAMTA1MutationMissenseENST00000303635.7
g.7725149G>A
g.7725149G>A
c.2542G>A
c.2542G>A
p.Val848Ile
p.Val848Ile
probably damaging
probably damaging
USP33MutationMissenseENST00000357428.1
g.78191442T>C
g.78191442T>C
c.1234A>G
c.1234A>G
p.Ile412Val
p.Ile412Val
benign
benign
SYDE2MutationMissenseENST00000341460.5
g.85630370C>A
g.85630370C>A
c.2924G>T
c.2924G>T
p.Cys975Phe
p.Cys975Phe
possibly damaging
possibly damaging

Mutational Signature



Fusion transcripts (3)
Fusion NameGene (1)Chr (1)Genomic position hg19 (1)Gene (2)Chr (2)Genomic position hg19 (2)Supporting readsConsistance fusionFusion type
ABCA12--LOC101928103LOC101928103chr2215698828ABCA12chr221582653313NADEL
EYS--HELLSHELLSchr1096306254EYSchr66479189424straightTRANS
LINC02246--NRIP1NRIP1chr2116415815LINC02246chr211623002816NADEL

HBV RNA fusions (4)
Breakpoint on human genome (hg19)Affected geneBreakpoint on HBV genome (X02763)Nb of paired reads (HG19 HBV)
chr1:203,721,569intergenic1,3625
chr10:37,693,567intergenic1,8034
chr12:105,585,128APPL2 (intron 14)1,81017
chr12:105,589,038APPL2 (intron 14)49041

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)


Drugs (35)
DrugAUCGI50
Bortezomib0.370.02
PF.046915020.70.455
Vinblastine0.735.285
Paclitaxel0.755.324
Alvespimycin0.823.56
Sorafenib_Trametinib0.823.58
Tivantinib0.8410.0
Doxorubicin0.863.0
CD5320.871.392
Tanespimycin0.8710.0
Sorafenib_MK.22060.884.026
Sorafenib_Refametinib0.894.02
Rapamycin0.8910.0
Dasatinib0.9110.0
Sorafenib_Resminostat0.924.615


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