Liver Cancer Cell Lines Database

Cell line description

Cell line name	Synonyms	Cellosaurus ID	Tumor type	Reference	Supplier	Culture medium
SNU449		CVCL_0454	Hepatocellular Carcinoma	Park et al. Int J Cancer (1995) [PMID: 7543080]	ATCC - USA	DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

Age	Gender	Geographic Origin	Ethnicity	HBV	HCV
52	Male	Korea	Asian	Yes	No

Transcriptomic subgroup: CL3

Mutations and CNAs (398)

Gene nameFilter by Gene name	Alteration type	Variant class	Annotation transcript	gNomen	cNomen	pNomen	PPH prédiction
ARID1A	Mutation	In-Frame	ENST00000324856.7	g.27100182_27100183insGCA g.27100182_27100183insGCA	c.3978_3979insGCA c.3978_3979insGCA	p.Pro1326_Gln1327insAla p.Pro1326_Gln1327insAla	damaging damaging
TMEM132B	Mutation	In-Frame	ENST00000299308.3	g.126139196_126139197ins54 g.126139196_126139197ins54	c.3177_3178insATTTTAAAATGTACAATTAAATTATTATTGACTATAATCATAGTCACCCTGCTG c.3177_3178insATTTTAAAATGTACAATTAAATTATTATTGACTATAATCATAGTCACCCTGCTG	p.Met1059_Gly1060ins18 p.Met1059_Gly1060ins18	damaging damaging
KRTAP9-1	Mutation	In-Frame	ENST00000398470.1	g.39346414_39346428del g.39346414_39346428del	c.276_290del c.276_290del	p.Ser93_Gly97del p.Ser93_Gly97del	damaging damaging
ADRA2B	Mutation	In-Frame	ENST00000409345.3	g.96780975_96780977delTCC g.96780975_96780977delTCC	c.912_914del c.912_914del	p.307_308EE>E p.307_308EE>E	damaging damaging
MYLK	Mutation	In-Frame	ENST00000360304.3	g.123337614_123337616del g.123337614_123337616del	c.5370_5372del c.5370_5372del	p.Glu1790del p.Glu1790del	damaging damaging
MAGEC2	Mutation	In-Frame	ENST00000247452.3	g.141291659_141291667del g.141291659_141291667del	c.107_115del c.107_115del	p.Glu36_Glu38del p.Glu36_Glu38del	damaging damaging
WDR3	Mutation	Missense	ENST00000349139.5	g.118481173C>T g.118481173C>T	c.571C>T c.571C>T	p.Arg191Trp p.Arg191Trp	probably damaging probably damaging
TCHH	Mutation	Missense	ENST00000368804.1	g.152083976C>T g.152083976C>T	c.1717G>A c.1717G>A	p.Glu573Lys p.Glu573Lys	benign benign
NPR1	Mutation	Missense	ENST00000368680.3	g.153651622G>T g.153651622G>T	c.38G>T c.38G>T	p.Arg13Leu p.Arg13Leu	benign benign
CRTC2	Mutation	Missense	ENST00000368633.1	g.153923872G>C g.153923872G>C	c.1268C>G c.1268C>G	p.Ala423Gly p.Ala423Gly	possibly damaging possibly damaging
CD1D	Mutation	Missense	ENST00000368171.3	g.158152727G>C g.158152727G>C	c.667G>C c.667G>C	p.Val223Leu p.Val223Leu	probably damaging probably damaging
ARHGAP30	Mutation	Missense	ENST00000368013.3	g.161018629T>G g.161018629T>G	c.2182A>C c.2182A>C	p.Ser728Arg p.Ser728Arg	benign benign
CD247	Mutation	Missense	ENST00000362089.5	g.167407839G>A g.167407839G>A	c.268C>T c.268C>T	p.Arg90Cys p.Arg90Cys	probably damaging probably damaging
SCYL3	Mutation	Missense	ENST00000367770.1	g.169823662C>A g.169823662C>A	c.1918G>T c.1918G>T	p.Val640Leu p.Val640Leu	benign benign
KIFAP3	Mutation	Missense	ENST00000361580.2	g.169952413T>C g.169952413T>C	c.1504A>G c.1504A>G	p.Ile502Val (Splice) p.Ile502Val (Splice)	benign benign
MROH9	Mutation	Missense	ENST00000367759.4	g.170993603A>G g.170993603A>G	c.1976A>G c.1976A>G	p.Tyr659Cys p.Tyr659Cys	probably damaging probably damaging
SUCO	Mutation	Missense	ENST00000263688.3	g.172579065A>G g.172579065A>G	c.3431A>G c.3431A>G	p.Gln1144Arg p.Gln1144Arg	possibly damaging possibly damaging
ENAH	Mutation	Missense	ENST00000366843.2	g.225706905C>G g.225706905C>G	c.797G>C c.797G>C	p.Ser266Thr p.Ser266Thr	benign benign
OBSCN	Mutation	Missense	ENST00000284548.11	g.228402024G>T g.228402024G>T	c.1408G>T c.1408G>T	p.Ala470Ser p.Ala470Ser	benign benign
RASSF10	Mutation	Missense	NM_001080521.2	g.13031542C>T g.13031542C>T	c.419C>T c.419C>T	p.Pro140Leu p.Pro140Leu	probably damaging probably damaging
DNAJC6	Mutation	Missense	ENST00000395325.3	g.65851433C>G g.65851433C>G	c.668C>G c.668C>G	p.Pro223Arg p.Pro223Arg	probably damaging probably damaging
IL23R	Mutation	Missense	ENST00000347310.5	g.67724660C>T g.67724660C>T	c.1739C>T c.1739C>T	p.Pro580Leu p.Pro580Leu	benign benign
CAMTA1	Mutation	Missense	ENST00000303635.7	g.7725149G>A g.7725149G>A	c.2542G>A c.2542G>A	p.Val848Ile p.Val848Ile	probably damaging probably damaging
USP33	Mutation	Missense	ENST00000357428.1	g.78191442T>C g.78191442T>C	c.1234A>G c.1234A>G	p.Ile412Val p.Ile412Val	benign benign
SYDE2	Mutation	Missense	ENST00000341460.5	g.85630370C>A g.85630370C>A	c.2924G>T c.2924G>T	p.Cys975Phe p.Cys975Phe	possibly damaging possibly damaging

Mutational Signature

Fusion transcripts (3)

Fusion Name	Gene (1)	Chr (1)	Genomic position hg19 (1)	Gene (2)	Chr (2)	Genomic position hg19 (2)	Supporting reads	Consistance fusion	Fusion type
ABCA12--LOC101928103	LOC101928103	chr2	215698828	ABCA12	chr2	215826533	13	NA	DEL
EYS--HELLS	HELLS	chr10	96306254	EYS	chr6	64791894	24	straight	TRANS
LINC02246--NRIP1	NRIP1	chr21	16415815	LINC02246	chr21	16230028	16	NA	DEL

HBV RNA fusions (4)

Breakpoint on human genome (hg19)	Affected gene	Breakpoint on HBV genome (X02763)	Nb of paired reads (HG19 HBV)
chr1:203,721,569	intergenic	1,362	5
chr10:37,693,567	intergenic	1,803	4
chr12:105,585,128	APPL2 (intron 14)	1,810	17
chr12:105,589,038	APPL2 (intron 14)	490	41

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)

Drugs (35)

DrugFilter by Drug	AUC	GI50
Bortezomib	0.37	0.02
PF.04691502	0.7	0.455
Vinblastine	0.73	5.285
Paclitaxel	0.75	5.324
Sorafenib_Trametinib	0.82	3.58
Alvespimycin	0.82	3.56
Tivantinib	0.84	10.0
Doxorubicin	0.86	3.0
Tanespimycin	0.87	10.0
CD532	0.87	1.392
Sorafenib_MK.2206	0.88	4.026
Sorafenib_Refametinib	0.89	4.02
Rapamycin	0.89	10.0
Dasatinib	0.91	10.0
Sorafenib_Resminostat	0.92	4.615

Liver Cancer Cell Lines Database

Cell Line: SNU449

Transcriptomic subgroup: CL3

Mutational Signature

Liver Cancer Cell Lines
Database