Liver Cancer Cell Lines Database

Cell line description

Cell line name	Synonyms	Cellosaurus ID	Tumor type	Reference	Supplier	Culture medium
SNU475		CVCL_0497	Hepatocellular Carcinoma	Park et al. Int J Cancer (1995) [PMID: 7543080]	ATCC - USA	DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

Age	Gender	Geographic Origin	Ethnicity	HBV	HCV
43	Male	Korea	Asian	Yes	No

Transcriptomic subgroup: CL3

Mutations and CNAs (454)

Gene nameFilter by Gene name	Alteration type	Variant class	Annotation transcript	gNomen	cNomen	pNomen	PPH prédiction
PHYKPL	Mutation	In-Frame	ENST00000308158.5	g.177651658_177651660del g.177651658_177651660del	c.484_486del c.484_486del	p.Lys162del p.Lys162del	damaging damaging
ZSCAN21	Mutation	In-Frame	ENST00000292450.4	g.99661860_99661862del g.99661860_99661862del	c.1042_1044del c.1042_1044del	p.Leu348del p.Leu348del	damaging damaging
BCOR	Mutation	In-Frame	ENST00000342274.4	g.39933662_39933664del g.39933662_39933664del	c.935_937del c.935_937del	p.Gln312del p.Gln312del	damaging damaging
AGL	Mutation	Missense	ENST00000294724.4	g.100346860T>G g.100346860T>G	c.2014T>G c.2014T>G	p.Ser672Ala p.Ser672Ala	benign benign
PIFO	Mutation	Missense	ENST00000369738.4	g.111893921T>C g.111893921T>C	c.548T>C c.548T>C	p.Val183Ala p.Val183Ala	possibly damaging possibly damaging
IVL	Mutation	Missense	ENST00000368764.3	g.152882758A>G g.152882758A>G	c.485A>G c.485A>G	p.His162Arg p.His162Arg	possibly damaging possibly damaging
NPR1	Mutation	Missense	ENST00000368680.3	g.153651594C>T g.153651594C>T	c.10C>T c.10C>T	p.Pro4Ser p.Pro4Ser	benign benign
UBAP2L	Mutation	Missense	ENST00000343815.6	g.154221895C>T g.154221895C>T	c.1195C>T c.1195C>T	p.Pro399Ser p.Pro399Ser	benign benign
FHAD1	Mutation	Missense	ENST00000358897.4	g.15679377C>T g.15679377C>T	c.2393C>T c.2393C>T	p.Ser798Leu p.Ser798Leu	benign benign
INSRR	Mutation	Missense	ENST00000368195.3	g.156816453C>G g.156816453C>G	c.1668G>C c.1668G>C	p.Gln556His p.Gln556His	probably damaging probably damaging
AIM1L	Mutation	Missense	ENST00000475866.2	g.26672371C>T g.26672371C>T	c.778G>A c.778G>A	p.Gly260Arg p.Gly260Arg	unknown unknown
TRMT1L	Mutation	Missense	ENST00000367506.5	g.185125655C>T g.185125655C>T	c.190G>A c.190G>A	p.Ala64Thr p.Ala64Thr	benign benign
UBR4	Mutation	Missense	ENST00000375217.2	g.19487604G>C g.19487604G>C	c.5213C>G c.5213C>G	p.Ser1738Cys p.Ser1738Cys	probably damaging probably damaging
MINOS1	Mutation	Missense	ENST00000322753.6	g.19949995C>G g.19949995C>G	c.140C>G c.140C>G	p.Ser47Cys p.Ser47Cys	probably damaging probably damaging
IGFN1	Mutation	Missense	ENST00000335211.4	g.201181729G>T g.201181729G>T	c.7708G>T c.7708G>T	p.Gly2570Trp p.Gly2570Trp	damaging damaging
RNF186	Mutation	Missense	ENST00000375121.2	g.20141292G>T g.20141292G>T	c.303C>A c.303C>A	p.Asp101Glu p.Asp101Glu	probably damaging probably damaging
VWA5B1	Mutation	Missense	ENST00000289815.8	g.20640961A>C g.20640961A>C	c.439A>C c.439A>C	p.Thr147Pro p.Thr147Pro	probably damaging probably damaging
C1orf116	Mutation	Missense	ENST00000359470.5	g.207196627G>A g.207196627G>A	c.482C>T c.482C>T	p.Pro161Leu p.Pro161Leu	benign benign
DNAH14	Mutation	Missense	ENST00000430092.1	g.225239246G>A g.225239246G>A	c.2173G>A c.2173G>A	p.Ala725Thr p.Ala725Thr	probably damaging probably damaging
OBSCN	Mutation	Missense	ENST00000284548.11	g.228505423C>T g.228505423C>T	c.13820C>T c.13820C>T	p.Pro4607Leu p.Pro4607Leu	probably damaging probably damaging
PGBD5	Mutation	Missense	NM_001258311.1	g.230459215C>T g.230459215C>T	c.1531G>A c.1531G>A	p.Val511Ile p.Val511Ile	possibly damaging possibly damaging
C1orf168	Mutation	Missense	ENST00000343433.6	g.57189268C>T g.57189268C>T	c.1967G>A c.1967G>A	p.Arg656Lys p.Arg656Lys	benign benign
TNFRSF9	Mutation	Missense	ENST00000377507.3	g.8000035T>C g.8000035T>C	c.20A>G c.20A>G	p.Asn7Ser p.Asn7Ser	benign benign
COL24A1	Mutation	Missense	ENST00000370571.2	g.86591297T>G g.86591297T>G	c.722A>C c.722A>C	p.Gln241Pro p.Gln241Pro	benign benign
CCDC18	Mutation	Missense	ENST00000557479.1	g.93721899A>T g.93721899A>T	c.3704A>T c.3704A>T	p.Lys1235Ile p.Lys1235Ile	probably damaging probably damaging

Mutational Signature

Fusion transcripts (2)

Fusion Name	Gene (1)	Chr (1)	Genomic position hg19 (1)	Gene (2)	Chr (2)	Genomic position hg19 (2)	Supporting reads	Consistance fusion	Fusion type
GPR143--TBL1X	TBL1X	chrX	9469888	GPR143	chrX	9727336	20	inverted	DEL
LINC01478--LINC01601	LINC01478	chr18	41906446	LINC01601	chr18	42129442	39	NA	DEL

HBV RNA fusions (2)

Breakpoint on human genome (hg19)	Affected gene	Breakpoint on HBV genome (X02763)	Nb of paired reads (HG19 HBV)
chr11:95,807,765	MAML2 (intron 2)	1,236	11
chr11:95,807,989	MAML2 (intron 2)	1,824	8

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)

Drugs (35)

DrugFilter by Drug	AUC	GI50
Bortezomib	0.43	0.042
Alvespimycin	0.58	0.168
Paclitaxel	0.63	0.804
Vinblastine	0.66	3.555
Rapamycin	0.7	10.0
PF.04691502	0.72	0.833
Tivantinib	0.75	1.07
Dasatinib	0.8	10.0
Tanespimycin	0.8	10.0
CD532	0.82	1.397
Navitoclax	0.84	5.038
Sorafenib_Trametinib	0.85	9.67
Cabozantinib	0.87	10.0
Sorafenib_Refametinib	0.88	10.0
Nutlin.3	0.91	10.0

Liver Cancer Cell Lines Database

Cell Line: SNU475

Transcriptomic subgroup: CL3

Mutational Signature

Liver Cancer Cell Lines
Database