Liver Cancer Cell Lines
Database

LCCL to predict drug response

Cell Line: SNU475


Cell line description
Cell line nameSynonymsCellosaurus IDTumor typeReferenceSupplierCulture medium
SNU475 CVCL_0497 Hepatocellular Carcinoma Park et al. Int J Cancer (1995) [PMID: 7543080] ATCC - USA DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

AgeGenderGeographic OriginEthnicityHBVHCV
43 Male Korea Asian Yes No

Transcriptomic subgroup: CL3


Mutations and CNAs (454)
Gene nameAlteration typeVariant classAnnotation transcriptgNomencNomenpNomenPPH pr├ędiction
PHYKPLMutationIn-FrameENST00000308158.5
g.177651658_177651660del
g.177651658_177651660del
c.484_486del
c.484_486del
p.Lys162del
p.Lys162del
damaging
damaging
ZSCAN21MutationIn-FrameENST00000292450.4
g.99661860_99661862del
g.99661860_99661862del
c.1042_1044del
c.1042_1044del
p.Leu348del
p.Leu348del
damaging
damaging
BCORMutationIn-FrameENST00000342274.4
g.39933662_39933664del
g.39933662_39933664del
c.935_937del
c.935_937del
p.Gln312del
p.Gln312del
damaging
damaging
AGLMutationMissenseENST00000294724.4
g.100346860T>G
g.100346860T>G
c.2014T>G
c.2014T>G
p.Ser672Ala
p.Ser672Ala
benign
benign
PIFOMutationMissenseENST00000369738.4
g.111893921T>C
g.111893921T>C
c.548T>C
c.548T>C
p.Val183Ala
p.Val183Ala
possibly damaging
possibly damaging
IVLMutationMissenseENST00000368764.3
g.152882758A>G
g.152882758A>G
c.485A>G
c.485A>G
p.His162Arg
p.His162Arg
possibly damaging
possibly damaging
NPR1MutationMissenseENST00000368680.3
g.153651594C>T
g.153651594C>T
c.10C>T
c.10C>T
p.Pro4Ser
p.Pro4Ser
benign
benign
UBAP2LMutationMissenseENST00000343815.6
g.154221895C>T
g.154221895C>T
c.1195C>T
c.1195C>T
p.Pro399Ser
p.Pro399Ser
benign
benign
FHAD1MutationMissenseENST00000358897.4
g.15679377C>T
g.15679377C>T
c.2393C>T
c.2393C>T
p.Ser798Leu
p.Ser798Leu
benign
benign
INSRRMutationMissenseENST00000368195.3
g.156816453C>G
g.156816453C>G
c.1668G>C
c.1668G>C
p.Gln556His
p.Gln556His
probably damaging
probably damaging
AIM1LMutationMissenseENST00000475866.2
g.26672371C>T
g.26672371C>T
c.778G>A
c.778G>A
p.Gly260Arg
p.Gly260Arg
unknown
unknown
TRMT1LMutationMissenseENST00000367506.5
g.185125655C>T
g.185125655C>T
c.190G>A
c.190G>A
p.Ala64Thr
p.Ala64Thr
benign
benign
UBR4MutationMissenseENST00000375217.2
g.19487604G>C
g.19487604G>C
c.5213C>G
c.5213C>G
p.Ser1738Cys
p.Ser1738Cys
probably damaging
probably damaging
MINOS1MutationMissenseENST00000322753.6
g.19949995C>G
g.19949995C>G
c.140C>G
c.140C>G
p.Ser47Cys
p.Ser47Cys
probably damaging
probably damaging
IGFN1MutationMissenseENST00000335211.4
g.201181729G>T
g.201181729G>T
c.7708G>T
c.7708G>T
p.Gly2570Trp
p.Gly2570Trp
damaging
damaging
RNF186MutationMissenseENST00000375121.2
g.20141292G>T
g.20141292G>T
c.303C>A
c.303C>A
p.Asp101Glu
p.Asp101Glu
probably damaging
probably damaging
VWA5B1MutationMissenseENST00000289815.8
g.20640961A>C
g.20640961A>C
c.439A>C
c.439A>C
p.Thr147Pro
p.Thr147Pro
probably damaging
probably damaging
C1orf116MutationMissenseENST00000359470.5
g.207196627G>A
g.207196627G>A
c.482C>T
c.482C>T
p.Pro161Leu
p.Pro161Leu
benign
benign
DNAH14MutationMissenseENST00000430092.1
g.225239246G>A
g.225239246G>A
c.2173G>A
c.2173G>A
p.Ala725Thr
p.Ala725Thr
probably damaging
probably damaging
OBSCNMutationMissenseENST00000284548.11
g.228505423C>T
g.228505423C>T
c.13820C>T
c.13820C>T
p.Pro4607Leu
p.Pro4607Leu
probably damaging
probably damaging
PGBD5MutationMissenseNM_001258311.1
g.230459215C>T
g.230459215C>T
c.1531G>A
c.1531G>A
p.Val511Ile
p.Val511Ile
possibly damaging
possibly damaging
C1orf168MutationMissenseENST00000343433.6
g.57189268C>T
g.57189268C>T
c.1967G>A
c.1967G>A
p.Arg656Lys
p.Arg656Lys
benign
benign
TNFRSF9MutationMissenseENST00000377507.3
g.8000035T>C
g.8000035T>C
c.20A>G
c.20A>G
p.Asn7Ser
p.Asn7Ser
benign
benign
COL24A1MutationMissenseENST00000370571.2
g.86591297T>G
g.86591297T>G
c.722A>C
c.722A>C
p.Gln241Pro
p.Gln241Pro
benign
benign
CCDC18MutationMissenseENST00000557479.1
g.93721899A>T
g.93721899A>T
c.3704A>T
c.3704A>T
p.Lys1235Ile
p.Lys1235Ile
probably damaging
probably damaging

Mutational Signature



Fusion transcripts (2)
Fusion NameGene (1)Chr (1)Genomic position hg19 (1)Gene (2)Chr (2)Genomic position hg19 (2)Supporting readsConsistance fusionFusion type
GPR143--TBL1XTBL1XchrX9469888GPR143chrX972733620invertedDEL
LINC01478--LINC01601LINC01478chr1841906446LINC01601chr184212944239NADEL

HBV RNA fusions (2)
Breakpoint on human genome (hg19)Affected geneBreakpoint on HBV genome (X02763)Nb of paired reads (HG19 HBV)
chr11:95,807,765MAML2 (intron 2)1,23611
chr11:95,807,989MAML2 (intron 2)1,8248

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)


Drugs (35)
DrugAUCGI50
Bortezomib0.430.042
Alvespimycin0.580.168
Paclitaxel0.630.804
Vinblastine0.663.555
Rapamycin0.710.0
PF.046915020.720.833
Tivantinib0.751.07
Dasatinib0.810.0
Tanespimycin0.810.0
CD5320.821.397
Navitoclax0.845.038
Sorafenib_Trametinib0.859.67
Cabozantinib0.8710.0
Sorafenib_Refametinib0.8810.0
Nutlin.30.9110.0


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