Liver Cancer Cell Lines Database

Cell line description

Cell line name	Synonyms	Cellosaurus ID	Tumor type	Reference	Supplier	Culture medium
HCC.1.2	1,2	CVCL_0C53	Hepatocellular Carcinoma	Sagmeister et al. Br J Cancer (2008) [PMID: 18594539]	Gift from Bettina Grasl-Kraupp (Austria)	DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

Age	Gender	Geographic Origin	Ethnicity	HBV	HCV
56	Male	Austria	European	No	Yes

Transcriptomic subgroup: CL1

Mutations and CNAs (376)

Gene nameFilter by Gene name	Alteration type	Variant class	Annotation transcript	gNomen	cNomen	pNomen	PPH prédiction
OR10K1	Mutation	Missense	ENST00000289451.2	g.158435924C>A g.158435924C>A	c.573C>A c.573C>A	p.His191Gln p.His191Gln	benign benign
KCNJ10	Mutation	Missense	ENST00000368089.3	g.160012318G>A g.160012318G>A	c.5C>T c.5C>T	p.Thr2Met p.Thr2Met	benign benign
CD244	Mutation	Missense	ENST00000368033.3	g.160811258G>A g.160811258G>A	c.412C>T c.412C>T	p.Arg138Cys p.Arg138Cys	benign benign
SPEN	Mutation	Missense	ENST00000375759.3	g.16260264C>T g.16260264C>T	c.7529C>T c.7529C>T	p.Ala2510Val p.Ala2510Val	benign benign
IER5	Mutation	Missense	ENST00000367577.4	g.181058232C>T g.181058232C>T	c.194C>T c.194C>T	p.Ala65Val p.Ala65Val	probably damaging probably damaging
OBSCN	Mutation	Missense	ENST00000284548.11	g.228432266A>T g.228432266A>T	c.3475A>T c.3475A>T	p.Ile1159Phe p.Ile1159Phe	possibly damaging possibly damaging
MEGF6	Mutation	Missense	ENST00000356575.4	g.3422087G>C g.3422087G>C	c.1952C>G c.1952C>G	p.Ser651Trp p.Ser651Trp	probably damaging probably damaging
ZFP69B	Mutation	Missense	ENST00000411995.2	g.40928278C>A g.40928278C>A	c.622C>A c.622C>A	p.Gln208Lys p.Gln208Lys	benign benign
KLF17	Mutation	Missense	ENST00000372299.3	g.44595221T>C g.44595221T>C	c.278T>C c.278T>C	p.Leu93Pro p.Leu93Pro	possibly damaging possibly damaging
GLIS1	Mutation	Missense	ENST00000312233.2	g.53972314G>A g.53972314G>A	c.1841C>T c.1841C>T	p.Pro614Leu p.Pro614Leu	probably damaging probably damaging
GLIS1	Mutation	Missense	ENST00000312233.2	g.53972315G>A g.53972315G>A	c.1840C>T c.1840C>T	p.Pro614Ser p.Pro614Ser	possibly damaging possibly damaging
TACSTD2	Mutation	Missense	ENST00000371225.2	g.59042002C>T g.59042002C>T	c.827G>A c.827G>A	p.Gly276Asp p.Gly276Asp	possibly damaging possibly damaging
GPAM	Mutation	Missense	ENST00000348367.4	g.113940284G>A g.113940284G>A	c.172C>T c.172C>T	p.Arg58Trp p.Arg58Trp	probably damaging probably damaging
ABLIM1	Mutation	Missense	ENST00000277895.5	g.116417737A>G g.116417737A>G	c.223T>C c.223T>C	p.Cys75Arg p.Cys75Arg	benign benign
ECHDC3	Mutation	Missense	ENST00000379215.4	g.11797518G>A g.11797518G>A	c.502G>A c.502G>A	p.Asp168Asn p.Asp168Asn	benign benign
WDR11	Mutation	Missense	ENST00000263461.6	g.122630836G>C g.122630836G>C	c.1449G>C c.1449G>C	p.M483I p.M483I	benign benign
ADARB2	Mutation	Missense	ENST00000381312.1	g.1262964C>T g.1262964C>T	c.1609G>A c.1609G>A	p.Ala537Thr p.Ala537Thr	benign benign
TCERG1L	Mutation	Missense	ENST00000368642.4	g.132944911C>A g.132944911C>A	c.1047G>T c.1047G>T	p.Trp349Cys p.Trp349Cys	probably damaging probably damaging
ITGA8	Mutation	Missense	ENST00000378076.3	g.15650284G>T g.15650284G>T	c.1559C>A c.1559C>A	p.Ser520Tyr p.Ser520Tyr	possibly damaging possibly damaging
CUBN	Mutation	Missense	ENST00000377833.4	g.16982150C>T g.16982150C>T	c.5429G>A c.5429G>A	p.Arg1810Gln p.Arg1810Gln	probably damaging probably damaging
SVIL	Mutation	Missense	ENST00000355867.4	g.29821019G>A g.29821019G>A	c.1921C>T c.1921C>T	p.Arg641Cys p.Arg641Cys	probably damaging probably damaging
ANKRD30A	Mutation	Missense	ENST00000361713.1	g.37454054G>T g.37454054G>T	c.1867G>T c.1867G>T	p.Asp623Tyr p.Asp623Tyr	probably damaging probably damaging
FBXO18	Mutation	Missense	ENST00000362091.4	g.5948434G>C g.5948434G>C	c.592G>C c.592G>C	p.Gly198Arg p.Gly198Arg	probably damaging probably damaging
PLCE1	Mutation	Missense	ENST00000260766.3	g.96064329G>A g.96064329G>A	c.5549G>A c.5549G>A	p.Cys1850Tyr p.Cys1850Tyr	probably damaging probably damaging
TMPRSS5	Mutation	Missense	ENST00000299882.5	g.113563965C>G g.113563965C>G	c.792G>C c.792G>C	p.Arg264Ser p.Arg264Ser	probably damaging probably damaging

Mutational Signature

Fusion transcripts (10)

Fusion Name	Gene (1)	Chr (1)	Genomic position hg19 (1)	Gene (2)	Chr (2)	Genomic position hg19 (2)	Supporting reads	Consistance fusion	Fusion type
CPPED1--KIAA0556	CPPED1	chr16	12756077	KIAA0556	chr16	27660055	12	inverted	DUP
DAGLA--STAM	STAM	chr10	17738701	DAGLA	chr11	61490431	20	inverted	TRANS
DLEU1--DLEU7	DLEU1	chr13	51007685	DLEU7	chr13	51286673	10	inverted	DEL
DSCR4--KCNJ6	DSCR4	chr21	39492400	KCNJ6	chr21	39213010	12	straight	DEL
ELL2--LOC101929710	ELL2	chr5	95231331	LOC101929710	chr5	95465180	297	NA	DUP
EP300--LINC01181	EP300	chr22	41548353	LINC01181	chr8	104144820	46	NA	TRANS
LOC407835--MAP2K2	MAP2K2	chr19	4110356	LOC407835	chr7	128767018	68	NA	TRANS
RP11-179A16.1--TENM4	RP11-179A16.1	chr11	82114720	TENM4	chr11	78437266	16	straight	DEL
SLC26A4--ST7-OT3	ST7-OT3	chr7	116849990	SLC26A4	chr7	107350498	35	NA	DUP
SLC36A1--SLC36A2	SLC36A2	chr5	150724294	SLC36A1	chr5	150838348	110	inverted	DEL

HBV RNA fusions (0)

Breakpoint on human genome (hg19)	Affected gene	Breakpoint on HBV genome (X02763)	Nb of paired reads (HG19 HBV)
No records found.

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)

Drugs (35)

DrugFilter by Drug	AUC	GI50
Paclitaxel	0.31	0.005
Bortezomib	0.33	0.02
Vinblastine	0.39	0.009
Sorafenib_Trametinib	0.41	0.03
Trametinib	0.45	0.047
Alvespimycin	0.48	0.05
PF.04691502	0.57	0.175
Tanespimycin	0.59	0.14
Dasatinib	0.63	0.285
Rapamycin	0.64	10.0
Doxorubicin	0.68	0.41
Sorafenib_Refametinib	0.68	0.54
Navitoclax	0.7	1.555
Tivantinib	0.71	0.615
Refametinib	0.78	2.15

Liver Cancer Cell Lines Database

Cell Line: HCC.1.2

Transcriptomic subgroup: CL1

Mutational Signature

Liver Cancer Cell Lines
Database