Liver Cancer Cell Lines
Database

LCCL to predict drug response

Cell Line: HCC.1.2


Cell line description
Cell line nameSynonymsCellosaurus IDTumor typeReferenceSupplierCulture medium
HCC.1.2 1,2 CVCL_0C53 Hepatocellular Carcinoma Sagmeister et al. Br J Cancer (2008) [PMID: 18594539] Gift from Bettina Grasl-Kraupp (Austria) DMEM, high glucose pyruvate (#41966-052, Thermo Fisher Scientific) + 10% FBS + 1X penicillin/streptomycin

AgeGenderGeographic OriginEthnicityHBVHCV
56 Male Austria European No Yes

Transcriptomic subgroup: CL1


Mutations and CNAs (376)
Gene nameAlteration typeVariant classAnnotation transcriptgNomencNomenpNomenPPH pr├ędiction
OR10K1MutationMissenseENST00000289451.2
g.158435924C>A
g.158435924C>A
c.573C>A
c.573C>A
p.His191Gln
p.His191Gln
benign
benign
KCNJ10MutationMissenseENST00000368089.3
g.160012318G>A
g.160012318G>A
c.5C>T
c.5C>T
p.Thr2Met
p.Thr2Met
benign
benign
CD244MutationMissenseENST00000368033.3
g.160811258G>A
g.160811258G>A
c.412C>T
c.412C>T
p.Arg138Cys
p.Arg138Cys
benign
benign
SPENMutationMissenseENST00000375759.3
g.16260264C>T
g.16260264C>T
c.7529C>T
c.7529C>T
p.Ala2510Val
p.Ala2510Val
benign
benign
IER5MutationMissenseENST00000367577.4
g.181058232C>T
g.181058232C>T
c.194C>T
c.194C>T
p.Ala65Val
p.Ala65Val
probably damaging
probably damaging
OBSCNMutationMissenseENST00000284548.11
g.228432266A>T
g.228432266A>T
c.3475A>T
c.3475A>T
p.Ile1159Phe
p.Ile1159Phe
possibly damaging
possibly damaging
MEGF6MutationMissenseENST00000356575.4
g.3422087G>C
g.3422087G>C
c.1952C>G
c.1952C>G
p.Ser651Trp
p.Ser651Trp
probably damaging
probably damaging
ZFP69BMutationMissenseENST00000411995.2
g.40928278C>A
g.40928278C>A
c.622C>A
c.622C>A
p.Gln208Lys
p.Gln208Lys
benign
benign
KLF17MutationMissenseENST00000372299.3
g.44595221T>C
g.44595221T>C
c.278T>C
c.278T>C
p.Leu93Pro
p.Leu93Pro
possibly damaging
possibly damaging
GLIS1MutationMissenseENST00000312233.2
g.53972314G>A
g.53972314G>A
c.1841C>T
c.1841C>T
p.Pro614Leu
p.Pro614Leu
probably damaging
probably damaging
GLIS1MutationMissenseENST00000312233.2
g.53972315G>A
g.53972315G>A
c.1840C>T
c.1840C>T
p.Pro614Ser
p.Pro614Ser
possibly damaging
possibly damaging
TACSTD2MutationMissenseENST00000371225.2
g.59042002C>T
g.59042002C>T
c.827G>A
c.827G>A
p.Gly276Asp
p.Gly276Asp
possibly damaging
possibly damaging
GPAMMutationMissenseENST00000348367.4
g.113940284G>A
g.113940284G>A
c.172C>T
c.172C>T
p.Arg58Trp
p.Arg58Trp
probably damaging
probably damaging
ABLIM1MutationMissenseENST00000277895.5
g.116417737A>G
g.116417737A>G
c.223T>C
c.223T>C
p.Cys75Arg
p.Cys75Arg
benign
benign
ECHDC3MutationMissenseENST00000379215.4
g.11797518G>A
g.11797518G>A
c.502G>A
c.502G>A
p.Asp168Asn
p.Asp168Asn
benign
benign
WDR11MutationMissenseENST00000263461.6
g.122630836G>C
g.122630836G>C
c.1449G>C
c.1449G>C
p.M483I
p.M483I
benign
benign
ADARB2MutationMissenseENST00000381312.1
g.1262964C>T
g.1262964C>T
c.1609G>A
c.1609G>A
p.Ala537Thr
p.Ala537Thr
benign
benign
TCERG1LMutationMissenseENST00000368642.4
g.132944911C>A
g.132944911C>A
c.1047G>T
c.1047G>T
p.Trp349Cys
p.Trp349Cys
probably damaging
probably damaging
ITGA8MutationMissenseENST00000378076.3
g.15650284G>T
g.15650284G>T
c.1559C>A
c.1559C>A
p.Ser520Tyr
p.Ser520Tyr
possibly damaging
possibly damaging
CUBNMutationMissenseENST00000377833.4
g.16982150C>T
g.16982150C>T
c.5429G>A
c.5429G>A
p.Arg1810Gln
p.Arg1810Gln
probably damaging
probably damaging
SVILMutationMissenseENST00000355867.4
g.29821019G>A
g.29821019G>A
c.1921C>T
c.1921C>T
p.Arg641Cys
p.Arg641Cys
probably damaging
probably damaging
ANKRD30AMutationMissenseENST00000361713.1
g.37454054G>T
g.37454054G>T
c.1867G>T
c.1867G>T
p.Asp623Tyr
p.Asp623Tyr
probably damaging
probably damaging
FBXO18MutationMissenseENST00000362091.4
g.5948434G>C
g.5948434G>C
c.592G>C
c.592G>C
p.Gly198Arg
p.Gly198Arg
probably damaging
probably damaging
PLCE1MutationMissenseENST00000260766.3
g.96064329G>A
g.96064329G>A
c.5549G>A
c.5549G>A
p.Cys1850Tyr
p.Cys1850Tyr
probably damaging
probably damaging
TMPRSS5MutationMissenseENST00000299882.5
g.113563965C>G
g.113563965C>G
c.792G>C
c.792G>C
p.Arg264Ser
p.Arg264Ser
probably damaging
probably damaging

Mutational Signature



Fusion transcripts (10)
Fusion NameGene (1)Chr (1)Genomic position hg19 (1)Gene (2)Chr (2)Genomic position hg19 (2)Supporting readsConsistance fusionFusion type
CPPED1--KIAA0556CPPED1chr1612756077KIAA0556chr162766005512invertedDUP
DAGLA--STAMSTAMchr1017738701DAGLAchr116149043120invertedTRANS
DLEU1--DLEU7DLEU1chr1351007685DLEU7chr135128667310invertedDEL
DSCR4--KCNJ6DSCR4chr2139492400KCNJ6chr213921301012straightDEL
ELL2--LOC101929710ELL2chr595231331LOC101929710chr595465180297NADUP
EP300--LINC01181EP300chr2241548353LINC01181chr810414482046NATRANS
LOC407835--MAP2K2MAP2K2chr194110356LOC407835chr712876701868NATRANS
RP11-179A16.1--TENM4RP11-179A16.1chr1182114720TENM4chr117843726616straightDEL
SLC26A4--ST7-OT3ST7-OT3chr7116849990SLC26A4chr710735049835NADUP
SLC36A1--SLC36A2SLC36A2chr5150724294SLC36A1chr5150838348110invertedDEL

HBV RNA fusions (0)
Breakpoint on human genome (hg19)Affected geneBreakpoint on HBV genome (X02763)Nb of paired reads (HG19 HBV)
No records found.

RNA expression (20715)

microRNA expression (2332)

Protein expression (126)


Drugs (35)
DrugAUCGI50
Paclitaxel0.310.005
Bortezomib0.330.02
Vinblastine0.390.009
Sorafenib_Trametinib0.410.03
Trametinib0.450.047
Alvespimycin0.480.05
PF.046915020.570.175
Tanespimycin0.590.14
Dasatinib0.630.285
Rapamycin0.6410.0
Doxorubicin0.680.41
Sorafenib_Refametinib0.680.54
Navitoclax0.71.555
Tivantinib0.710.615
Refametinib0.782.15


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