Liver Cancer Cell Lines Database

LCCL to predict drug response

Data files

ItemDataDetails
Cell linesLCCL_descriptionDescription of liver cancer cell lines.
Cell linesProtein_expressionExpression of 126 proteins analyzed by RPPA in 34 liver cancer cell lines (log2-transformed).
Cell linesmicroRNAseq_RPMmicroRNA expression in 34 liver cancer cell lines (RPM)
Cell linesmicroRNAseq_vsnmicroRNA expression in 34 liver cancer cell lines (vsn)
Cell linesRNAseq_FPMKRNA expression in 34 liver cancer cell lines (FPKM)
Cell linesRNAseq_vsnRNA expression in 34 liver cancer cell lines (vsn)
Cell linesDriversList of the 252 cancer driver genes used to analyze association between drug sensitivity and genetic alterations in 34 liver cancer cell lines.
Cell linesHBV_fusionsHBV RNA fusions identified by RNA-sequencing among 34 liver cancer cell lines.
Cell linesFusion_transcriptsFusion transcripts identified in 34 liver cancer cell lines by RNA-sequencing.
Cell linesSomatic_alterationsList of putative somatic genomic alterations identified in 34 Liver Cancer Cell Lines by whole-exome sequencing.
Cell lines/DrugsAUCDrug sensitivity in 34 liver cancer cell lines. Table of AUC values for each drug
Cell lines/DrugsGI50Drug sensitivity in 34 liver cancer cell lines. Table of GI50 values for each drug
DrugsScreened_compoundsDescription of screened compounds.
For further information please refer to:
S. Caruso*, A-L. Calatayud*, J. Pilet*, T. La Bella, S. Rekik, S. Imbeaud, E. Letouzé, L. Meunier, Q. Bayard, N. Rohr-Udilova, C. Péneau, B. Grasl-Kraupp, L. de Koning, B. Ouine, P. Bioulac-Sage, G. Couchy, J. Calderaro, J-C. Nault, J. Zucman-Rossi, S. Rebouissou.
"Analysis of Liver Cancer Cell Lines Identifies Agents With Likely Efficacy Against Hepatocellular Carcinoma and Markers of Response." Gastroenterology 2019. DOI: 10.1053/j.gastro.2019.05.001. PMID: 31063779